Dr. Eric Boerwinkle

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University of Texas Health Science Center at Houston
School of Public Health
Biological Sciences
Professor
University of Texas Health Science Center at Houston
UTHSC Centers, Institutes and Programs
Human Genetics Center
DirectorAppointed: 1998
University of Texas Health Science Center at Houston
Institute of Molecular Medicine
Research Center for Human Genetics
Professor/Director
Professional Headshot of Eric Boerwinkle

Mailing Address

RAS E447
1200 Herman Pressler Dr.
Houston, Texas 77030
United States

Contact Information

Phone: (713) 500-9800
Eric.Boerwinkle@uth.tmc.edu

Qualifications

Ph.D., University of Michigan-Ann Arbor, Biology, 1985.
M.S., University of Michigan, Biology, 1985.
M.A., University of Michigan, Biology, 1984.
B.S., University of Cincinnati, Biology, 1980.

Expertise and Research Interests

The objective of research in this laboratory is to understand the role of individual genes in complex physiological systems characterized by gene-gene and gene-environment interactions. The model system used is lipid metabolism and its contribution to atherosclerosis. The particular focus is on the role of DNA variation in the loci coding for 7-alpha hydroxylase, apolipoproteins B and E, and apolipoprotein (A) in contributingto inter-individual variation in lipid levels. The effects of these genes on fasting lipid levels and on various diets are considered. In addition, these investigators are examining the role of these genes in determining the response of lipid levels to a standard meal. As a tool used to follow targeted genes as they segregate among related individuals, this laboratory also has experience in typing and characterizing DNA variation in highly repetitive and polymorphic VNTR loci. One valuable application of such information DNA markers is genetic linkage analysis. The laboratory has several linkage projects to localize genes contributing to hypertension, diabetes, and gallbladder disease.

Other Expertise

HONOR/AWARD: American Heart Association Established Investigatorship, Ciba Foundation Bursary Award (1986-87), National Institutes of Health Research Career Development Award, University of Nancy, France Visiting Professorship (1989-90)EDITORIAL REVIEWER: American Journal of Epidemiology GRANT REVIEWER: National Institutes of Health EDC-1 & 2

Keywords

COS Keywords:

DNA, Genes, Genetics, Heart Diseases, Lipid Metabolism.

Additional Terms:

Apolipoprotein Genes, DNA Variation, Heart Disease, Human Genetics, Lipid Metabolism, VNTR Loci.

Funding Received

  • NHLBI: Genetic Determinants of High BP in Three Racial Groups, Sep 29, 2001 to Jun 30, 2005.
  • NHLBI: Molecular Epidemiology of Essential Hypertension, Jul 8, 1994 to May 31, 2004.

Publications

  • Turner ST, Schwartz GL, Chapman AB, Boerwinkle E, Use of gene markers to guide antihypertensive therapy, Current Hypertension Reports, 3(5), 410-5, October 2001 Abstract
  • Hallman DM, Srinivasan SR, Elkasabany A, Boerwinkle E, Berenson GS, The Ser(447)-Stop polymorphism of lipoprotein lipase is associated with variation in longitudinal serum high-density lipoprotein-cholesterol profiles: the Bogalusa Heart Study, Metabolism: Clinical and Experimental, 50(8), 894-904, August 2001 Abstract
  • Bray MS, Boerwinkle E, Doris PA, High-throughput multiplex SNP genotyping with MALDI-TOF mass spectrometry: practice, problems and promise, Human Mutation, 17(4), 296-304, April 2001 Abstract
  • Morrison AC, Doris PA, Folsom AR, Nieto FJ, Boerwinkle E, Atherosclerosis Risk in Communities Study, G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke, Stroke; a Journal of Cerebral Circulation, 32(4), 822-9, April 2001 Abstract
  • Turner ST, Schwartz GL, Chapman AB, Boerwinkle E, C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diuretic, Hypertension, 37(2 Part 2), 739-43, February 2001 Abstract
  • Huang Q, Morrison AC, Boerwinkle E, Linkage disequilibrium structure and its impact on the localization of a candidate functional mutation, Genetic Epidemiology, 21 Suppl 1, S620-5, 2001 Abstract
  • Xiong M, Jin L, Li W, Boerwinkle E, Computational methods for gene expression-based tumor classification, Biotechniques, 29(6), 1264-8, 1270, December 2000 Abstract
  • Turner ST, Boerwinkle E, Genetics of hypertension, target-organ complications, and response to therapy, Circulation, 102(20 Suppl 4), IV40-5, November 2000 Abstract
  • Boerwinkle E, Hixson JE, Hanis CL, Peeking under the peaks: following up genome-wide linkage analyses, Circulation, 102(16), 1877-8, October 2000 Abstract
  • Boerwinkle E, Family Blood Pressure Program, All for one and one for all: introduction to a coordinated analysis of the Gly-460-Trp alpha-adducin polymorphism, American Journal of Hypertension : Journal of the American Society of Hypertension, 13(6 Pt 1), 734-5, June 2000 Abstract
  • Larson N, Hutchinson R, Boerwinkle E, Lack of association of 3 functional gene variants with hypertension in African Americans, Hypertension, 35(6), 1297-300, June 2000 Abstract
  • Bray MS, Boerwinkle E, Hanis CL, Sequence variation within the neuropeptide Y gene and obesity in Mexican Americans, Obesity Research, 8(3), 219-26, May 2000 Abstract
  • Li R, Boerwinkle E, Olshan AF, Chambless LE, Pankow JS, Tyroler HA, Bray M, Pittman GS, Bell DA, Heiss G, Glutathione S-transferase genotype as a susceptibility factor in smoking-related coronary heart disease, Atherosclerosis, 149(2), 451-62, April 2000 Abstract
  • Bray MS, Boerwinkle E, The role of beta(2)-adrenergic receptor variation in human hypertension, Current Hypertension Reports, 2(1), 39-43, February 2000 Abstract
  • Templeton AR, Clark AG, Weiss KM, Nickerson DA, Boerwinkle E, Sing CF, Recombinational and mutational hotspots within the human lipoprotein lipase gene, American Journal of Human Genetics, 66(1), 69-83, Jan 2000 Abstract
  • Krushkal J, Ferrell R, Mockrin SC, Turner ST, Sing CF, Boerwinkle E, Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings., Circulation, 99(11), 1407-10, 23 Mar 1999 Abstract
  • Bray MS, Boerwinkle E, Hanis CL, Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas., Genetic Epidemiology, 16(4), 397-411, 1999 Abstract
  • Krushkal J, Xiong M, Ferrell R, Sing C F, Turner S T, Boerwinkle E, Linkage and association of adrenergic and dopamine receptor genes in the distal portion of the long arm of chromosome 5 with systolic blood pressure variation., Human Molecular Genetics, 7(9), 1379-83, September 1998 Abstract
  • Xiong MM, Krushkal J, Boerwinkle E, TDT statistics for mapping quantitative trait loci., Annals of Human Genetics, 62 \( Pt 5\), 431-52, September 1998 Abstract
  • Nickerson D A, Taylor S L, Weiss K M, Clark A G, Hutchinson R G, Steng ard J, Salomaa V, Vartiainen E, Boerwinkle E, Sing C F, DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene [see comments], Nature Genetics, 19(3), 233-40, July 1998 Abstract
  • Fornage M, Amos C I, Kardia S, Sing C F, Turner S T, Boerwinkle E, Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males [comment] [see comments], Circulation, 97(18), 1773-9, 12 May 1998 Abstract
  • Page G P, Amos C I, Boerwinkle E, The quantitative LOD score: test statistic and sample size for exclusion and linkage of quantitative traits in human sibships., American Journal of Human Genetics, 62(4), 962-8, April 1998 Abstract
  • Kastelein J J, Groenemeyer B E, Hallman D M, Henderson H, Reymer P W, Gagne S E, Jansen H, Seidell J C, Kromhout D, Jukema J W, Bruschke A V, Boerwinkle E, Hayden M R, The Asn9 variant of lipoprotein lipase is associated with the -93G promoter mutation and an increased risk of coronary artery disease. The Regress Study Group., Clinical Genetics, 53(1), 27-33, Jan 1998 Abstract
  • Hwang S J, Ballantyne C M, Sharrett A R, Smith L C, Davis C E, Gotto A M Jr, Boerwinkle E, Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study., Circulation, 96(12), 4219-25, 16 Dec 1997 Abstract
  • Hallman DM, Ellsworth DL, Boerwinkle E, Molecular and genetic approaches to the study of cardiovascular disease., Journal of Cardiovascular Risk, 4(5-6), 325-31, October 1997 Abstract
  • Groenemeijer B E, Hallman M D, Reymer P W, Gagne E, Kuivenhoven J A, Bruin T, Jansen H, Lie K I, Bruschke A V, Boerwinkle E, Hayden M R, Kastelein J J, Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease, Circulation, 95(12), 2628-35, 17 Jun 1997 Abstract
  • Amos C I, Krushkal J, Thiel T J, Young A, Zhu D K, Boerwinkle E, de Andrade M, Comparison of model-free linkage mapping strategies for the study of a complex trait., Genetic Epidemiology, 14(6), 743-8, 1997 Abstract
  • Ellsworth D L, Hallman D M, Boerwinkle E, Impact of the Human Genome Project on epidemiologic research., Epidemiologic Reviews, 19(1), 3-13, 1997 Abstract
  • Bray M S, Boerwinkle E, Hanis C L, OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas., Human Genetics, 98(5), 590-5, November 1996 Abstract
  • Chen L, Patsch W, Boerwinkle E, HindIII DNA polymorphism in the lipoprotein lipase gene and plasma lipid phenotypes and carotid artery atherosclerosis., Human Genetics, 98(5), 551-6, November 1996 Abstract
  • Boerwinkle E, A contemporary research paradigm for the genetic analysis of a common chronic disease., Annals of Medicine, 28(5), 451-7, October 1996 Abstract
  • Raffel L J, Robbins D C, Norris J M, Boerwinkle E, DeFronzo R A, Elbein S C, Fujimoto W, Hanis C L, Kahn S E, Permutt M A, Chiu K C, Cruz J, Ehrmann D A, Robertson R P, Rotter J I, Buse J, The GENNID Study. A resource for mapping the genes that cause NIDDM., Diabetes Care, 19(8), 864-72, August 1996 Abstract
  • Surguchov A P, Page G P, Smith L, Patsch W, Boerwinkle E, Polymorphic markers in apolipoprotein C-III gene flanking regions and hypertriglyceridemia., Arteriosclerosis, Thrombosis, and Vascular Biology, 16(8), 941-7, August 1996 Abstract
  • Hanis C L, Boerwinkle E, Chakraborty R, Ellsworth D L, Concannon P, Stirling B, Morrison V A, Wapelhorst B, Spielman R S, Gogolin-Ewens K J, Shepard J M, Williams S R, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzch H, Schroder H E, Schulze J, Cox N J, Menzel, A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 [see comments], Nature Genetics, 13(2), 161-6, June 1996 Abstract
  • Amos C I, Zhu D K, Boerwinkle E, Assessing genetic linkage and association with robust components of variance approaches., Annals of Human Genetics, 60 ( Pt 2), 143-60, March 1996 Abstract
  • Boerwinkle E, Ellsworth D L, Hallman D M, Biddinger A, Genetic analysis of atherosclerosis: a research paradigm for the common chronic diseases., Human Molecular Genetics, 5 Spec No, 1405-10, 1996 Abstract
  • Shriver M D, Jin L, Boerwinkle E, Deka R, Ferrell R E, Chakraborty R, A novel measure of genetic distance for highly polymorphic tandem repeat loci., Molecular Biology and Evolution, 12(5), 914-20, September 1995 Abstract
  • Fornage M, Turner S T, Sing C F, Boerwinkle E, Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota., Human Genetics, 96(3), 295-300, September 1995 Abstract
  • Surguchov A P, Boerwinkle E, Sharrett A R, Patsch W, Effect of apolipoprotein E polymorphism on fasting retinyl palmitate level., Biochemical and Molecular Medicine, 55(2), 156-7, August 1995 Abstract
  • Moliterno D J, Jokinen E V, Miserez A R, Lange R A, Willard J E, Boerwinkle E, Hillis L D, Hobbs H H, No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans., Arteriosclerosis, Thrombosis, and Vascular Biology, 15(7), 850-5, July 1995 Abstract
  • de Andrade M, Thandi I, Brown S, Gotto A Jr, Patsch W, Boerwinkle E, Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis., American Journal of Human Genetics, 56(6), 1379-90, June 1995 Abstract
  • Ellsworth D L, Shriver M D, Boerwinkle E, Nucleotide sequence analysis of the apolipoprotein B 3' VNTR., Human Molecular Genetics, 4(5), 937-44, May 1995 Abstract
  • Mooser V, Mancini F P, Bopp S, Petho-Schramm A, Guerra R, Boerwinkle E, Muller H J, Hobbs H H, Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma., Human Molecular Genetics, 4(2), 173-81, February 1995 Abstract
  • Carrejo M H, Sharrett R, Patsch W, Boerwinkle E, No association of apolipoprotein A-IV codon 347 and 360 variation with atherosclerosis and lipid transport in a sample of mixed hyperlipidemics., Genetic Epidemiology, 12(4), 371-80, 1995 Abstract
  • Gaw A, Boerwinkle E, Cohen J C, Hobbs H H, Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus., Journal of Clinical Investigation, 93(6), 2526-34, June 1994 Abstract
  • Patsch W, Sharrett A R, Chen I Y, Lin-Lee Y C, Brown S A, Gotto A M Jr, Boerwinkle E, Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans., Arteriosclerosis and Thrombosis, 14(6), 874-83, June 1994 Abstract
  • Surguchov A P, Boerwinkle E, Sharett A R, Patsch W P, Apolipoprotein E genotype and lipid transport: insight into the role of the epsilon 4 allele [letter], Atherosclerosis, 106(1), 119-21, March 1994 Abstract
  • Boerwinkle E, Brown S, Sharrett A R, Heiss G, Patsch W, Apolipoprotein E polymorphism influences postprandial retinyl palmitate but not triglyceride concentrations., American Journal of Human Genetics, 54(2), 341-60, February 1994 Abstract
  • Hallman D M, Visvikis S, Steinmetz J, Boerwinkle E, The effect of variation in the apolipoprotein B gene on plasmid lipid and apolipoprotein B levels. I. A likelihood-based approach to cladistic analysis., Annals of Human Genetics, 58 ( Pt 1), 35-64, January 1994 Abstract
  • Brown S A, Morrisett J D, Boerwinkle E, Hutchinson R, Patsch W, The relation of lipoprotein[a] concentrations and apolipoprotein[a] phenotypes with asymptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) Study., Arteriosclerosis and Thrombosis, 13(11), 1558-66, November 1993 Abstract
  • Moliterno D J, Lange R A, Meidell R S, Willard J E, Leffert C C, Gerard R D, Boerwinkle E, Hobbs H H, Hillis L D, Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction., Circulation, 88(3), 935-40, September 1993 Abstract
  • Brown S A, Hutchinson R, Morrisett J, Boerwinkle E, Davis C E, Gotto A M Jr, Patsch W, Plasma lipid, lipoprotein cholesterol, and apoprotein distributions in selected US communities. The Atherosclerosis Risk in Communities (ARIC) Study., Arteriosclerosis and Thrombosis, 13(8), 1139-58, August 1993 Abstract
  • Shriver M D, Jin L, Chakraborty R, Boerwinkle E, VNTR allele frequency distributions under the stepwise mutation model: a computer simulation approach., Genetics, 134(3), 983-93, July 1993 Abstract
  • Shriver M D, Siest G, Boerwinkle E, Length and sequence variation in the apolipoprotein B intron 20 Alu repeat., Genomics, 14(2), 449-54, October 1992 Abstract
  • Sandholzer C, Saha N, Kark J D, Rees A, Jaross W, Dieplinger H, Hoppichler F, Boerwinkle E, Utermann G, Apo(a) isoforms predict risk for coronary heart disease. A study in six populations., Arteriosclerosis and Thrombosis, 12(10), 1214-26, October 1992 Abstract
  • Chan L, Boerwinkle E, Structure, function, molecular genetics, and epidemiology of apolipoprotein B., Seminars In Liver Disease, 12(3), 311-20, August 1992 Abstract
  • Boerwinkle E, Leffert C C, Lin J, Lackner C, Chiesa G, Hobbs H H, Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations., Journal of Clinical Investigation, 90(1), 52-60, July 1992 Abstract
  • Sandholzer C, Boerwinkle E, Saha N, Tong M C, Utermann G, Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart dise, Journal of Clinical Investigation, 89(3), 1040-6, March 1992 Abstract
  • Steinmetz J, Boerwinkle E, Gueguen R, Visvikis S, Henny J, Siest G, Multivariate genetic analysis of high density lipoprotein particles., Atherosclerosis, 92(2-3), 219-27, February 1992 Abstract
  • Fornage M, Chan L, Siest G, Boerwinkle E, Allele frequency distribution of the (TG)n(AG)m microsatellite in the apolipoprotein C-II gene., Genomics, 12(1), 63-8, January 1992 Abstract
  • Boerwinkle E, Brown S A, Rohrbach K, Gotto A M Jr, Patsch W, Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol., American Journal of Human Genetics, 49(6), 1145-54, December 1991 Abstract
  • Boerwinkle E, Chen S H, Visvikis S, Hanis C L, Siest G, Chan L, Signal peptide-length variation in human apolipoprotein B gene. Molecular characteristics and association with plasma glucose levels., Diabetes, 40(11), 1539-44, November 1991 Abstract
  • Hallman D M, Boerwinkle E, Saha N, Sandholzer C, Menzel H J, Csazar A, Utermann G, The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations [see comments], American Journal of Human Genetics, 49(2), 338-49, August 1991 Abstract
  • Lackner C, Boerwinkle E, Leffert C C, Rahmig T, Hobbs H H, Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis [published erratum appears in J Clin Invest 1991 Aug;88(2):723], Journal of Clinical Investigation, 87(6), 2153-61, June 1991 Abstract
  • Sandholzer C, Hallman D M, Saha N, Sigurdsson G, Lackner C, Csaszar A, Boerwinkle E, Utermann G, Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups., Human Genetics, 86(6), 607-14, April 1991 Abstract
  • Shriver M D, Boerwinkle E, Hewett-Emmett D, Hanis C L, Frequency and effects of apolipoprotein E polymorphism in Mexican-American NIDDM subjects., Diabetes, 40(3), 334-7, March 1991 Abstract
  • Chakraborty R, Fornage M, Gueguen R, Boerwinkle E, Population genetics of hypervariable loci: analysis of PCR based VNTR polymorphism within a population., Exs, 58, 127-43, 1991 Abstract
  • Boerwinkle E, Hanis C L, Chan L, A unique length polymorphism in the signal peptide region of the apolipoprotein B gene in Mexican-Americans., Nucleic Acids Research, 18(23), 7193, 11 Dec 1990 Abstract
  • de Temmerman P, Visvikis S, Boerwinkle E, Siest G, Study of the sequence tagged site (STS) in the beginning of human apo A4 gene region., Nucleic Acids Research, 18(18), 5576, 25 Sep 1990 Abstract
  • Boerwinkle E, Visvikis S, Chan L, Two polymorphisms for amino acid substitutions in the APOA4 gene., Nucleic Acids Research, 18(16), 4966, 25 Aug 1990 Abstract
  • Visvikis S, Steinmetz J, Boerwinkle E, Gueguen R, Galteau M M, Siest G, Frequency and effects of the apolipoprotein A-IV polymorphism., Clinical Genetics, 37(6), 435-41, June 1990 Abstract
  • Seed M, Hoppichler F, Reaveley D, McCarthy S, Thompson G R, Boerwinkle E, Utermann G, Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia [see comments], New England Journal of Medicine, 322(21), 1494-9, 24 May 1990 Abstract
  • Boerwinkle E, Lee S S, Butler R, Schumaker V N, Chan L, Rapid typing of apolipoprotein B DNA polymorphisms by DNA amplification. Association between Ag epitopes of human apolipoprotein B-100, a signal peptide insertion/deletion polymorphism, and a 3'flanki, Atherosclerosis, 81(3), 225-32, April 1990 Abstract
  • Visvikis S, Chan L, Siest G, Drouin P, Boerwinkle E, An insertion deletion polymorphism in the signal peptide of the human apolipoprotein B gene., Human Genetics, 84(4), 373-5, March 1990 Abstract
  • Menzel H J, Sigurdsson G, Boerwinkle E, Schrangl-Will S, Dieplinger H, Utermann G, Frequency and effect of human apolipoprotein A-IV polymorphism on lipid and lipoprotein levels in an Icelandic population., Human Genetics, 84(4), 344-6, March 1990 Abstract
  • Brown S A, Boerwinkle E, Kashanian F K, Swanson N, Patsch W, Variation in concentration of lipids, lipoprotein lipids, and apolipoproteins A-I and B in plasma from healthy women., Clinical Chemistry, 36(2), 207-10, February 1990 Abstract
  • Utermann G, Hoppichler F, Dieplinger H, Seed M, Thompson G, Boerwinkle E, Defects in the low density lipoprotein receptor gene affect lipoprotein (a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis., Proceedings of the National Academy of Sciences (USA), 86(11), 4171-4, June 1989 Abstract
  • Boerwinkle E, Chan L, A three codon insertion/deletion polymorphism in the signal peptide region of the human apolipoprotein B (APOB) gene directly typed by the polymerase chain reaction., Nucleic Acids Research, 17(10), 4003, 25 May 1989 Abstract
  • Boerwinkle E, Menzel H J, Kraft H G, Utermann G, Genetics of the quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation., Human Genetics, 82(1), 73-8, April 1989 Abstract
  • Shriver, M.D., Jin, L., Chakraborty, R., BOERWINKLE VNTR allele frequency distributions under the stepwise mutation model - a computer simulation approach. Genetics 134(3):983-993, Jul 1993
  • Talmud, P.J., BOERWINKLE, E., Xu, C.F., Tikkanen, M.J., Pietinen, P., Huttunen, J.K., Humphries, S. Dietary intake and gene variation influence the response of plasma lipids to dietary intervention. Genet Epid 9(4):249-260, 1992
  • Shriver, M.D., Siest, G., BOERWINKLE, E. Length and sequence variation in the apolipoprotein-B intron-20 alu repeat. Genomics 14(2):449-454, Oct 1992
  • Sandholz., C., Saha, N., Kark, J.D., Rees, A., Jaross, W., Diepling., H., Hoppichl., F., BOERWINKLE, E., Utermann, G. APO(A) isoforms preduct risk for coronary heart disease - a study of six populations. Arter Throm 12(10):1214- 1226, Oct 1992
  • Ashizawa, T., Dubel, J.R., Dunne, P.W., Dunne, C.J., Fu, Y.H., Pizzuti, A., Caskey, C.T., BOERWINKLE, E., Perryman, M.B., Epstein, H.F. Anticipation in myotonic dystrophy. 1. Complex relationships between clinical and findings of the GCT repeat. Neurology 42(10):1877-1883, Oct 1992

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