Alan Chait

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University of Washington
School of Medicine
Medicine
Metabolism, Endocrinology, and Nutrition
ProfessorAppointed: 1985

Mailing Address

University of Washington
Department of Medicine
Box 356426
Seattle, Washington 98195-6426
United States

Contact Information

Phone: (206) 543-3158
Fax: (206) 685-8346
achait@u.washington.edu

Qualifications

M.D., South Africa-University of Cape Town Fac Med, 1967.

Expertise and Research Interests

Lipids, lipoproteins and atherosclerosis;
Diabetes and atherosclerosis.

Keywords

COS Keywords:

Arteriosclerosis Or Atherosclerosis, Cardiovascular Biology, Diabetes, Endocrinologic Diseases, Endocrinology, Epidemiology, Hypertension, Medical Diagnosis, Oncology, Pathobiology, Vascular Biology.

Additional Terms:

Aging/gerontology, Calcium in the Regulation of Tissue/cell Function, Cancer/tumor Biology/oncology, Cardiac Disease, Cardiovascular Biology, Cellular, Diabetes, Diagnosis/prevention, Diseases, Endocrinologic Diseases, Endocrinology, Epidemiology, Hypertension, Lipid Metabolism/lipoproteins, Nephrology/tract/urinary Biolo, Nutrition/diet/obesity, Pathobiolo, Pathobiology, Therapy, Tissue and Organ, Vascular Biology.

Memberships

American Diabetes Association
American Heart Association
American Society for Clinical Investigation
American Society for Clinical Nutrition
American Society for Nutritional Sciences
Association of American Physicians

Publications

  • Olin KL, Potter-Perigo S, Barrett PH, Wight TN, Chait A, Lipoprotein lipase enhances the binding of native and oxidized low density lipoproteins to versican and biglycan synthesized by cultured arterial smooth muscle cells., Journal of Biological Chemistry, 274(49), 34629-36, 3 Dec 1999 Abstract
  • Crawford RS, Mudaliar SR, Henry RR, Chait A, Inhibition of LDL oxidation in vitro but not ex vivo by troglitazone., Diabetes, 48(4), 783-90, April 1999 Abstract
  • Crawford R S, Kirk E A, Rosenfeld M E, LeBoeuf R C, Chait A, Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouse., Arteriosclerosis, Thrombosis, and Vascular Biology, 18(9), 1506-13, September 1998 Abstract
  • O'Brien K D, Olin K L, Alpers C E, Chiu W, Ferguson M, Hudkins K, Wight T N, Chait A, Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins., Circulation, 98(6), 519-27, 11 Aug 1998 Abstract
  • Steinberg F M, Chait A, Antioxidant vitamin supplementation and lipid peroxidation in smokers., American Journal of Clinical Nutrition, 68(2), 319-27, August 1998 Abstract
  • Chang M Y, Olin K L, Tsoi C, Wight T N, Chait A, Human monocyte-derived macrophages secrete two forms of proteoglycan-macrophage colony-stimulating factor that differ in their ability to bind low density lipoproteins., Journal of Biological Chemistry, 273(26), 15985-92, 26 Jun 1998 Abstract
  • Boren J, Olin K, Lee I, Chait A, Wight T N, Innerarity T L, Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding., Journal of Clinical Investigation, 101(12), 2658-64, 15 Jun 1998 Abstract
  • Kirk E A, Sutherland P, Wang S A, Chait A, LeBoeuf R C, Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice., Journal of Nutrition, 128(6), 954-9, June 1998 Abstract
  • Brown B G, Zhao X Q, Chait A, Frohlich J, Cheung M, Heise N, Dowdy A, DeAngelis D, Fisher L D, Albers J, Lipid altering or antioxidant vitamins for patients with coronary disease and very low HDL cholesterol? The HDL-Atherosclerosis Treatment Study Design., Canadian Journal of Cardiology, 14 Suppl A, 6A-13A, April 1998 Abstract
  • Cader A A, Steinberg F M, Mazzone T, Chait A, Mechanisms of enhanced macrophage apoE secretion by oxidized LDL., Journal of Lipid Research, 38(5), 981-91, May 1997 Abstract
  • Kusuhara M, Chait A, Cader A, Berk B C, Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages., Arteriosclerosis, Thrombosis, and Vascular Biology, 17(1), 141-8, January 1997 Abstract
  • O'Brien K D, Alpers C E, Hokanson J E, Wang S, Chait A, Oxidation-specific epitopes in human coronary atherosclerosis are not limited to oxidized low-density lipoprotein., Circulation, 94(6), 1216-25, 15 Sep 1996 Abstract
  • Steinberg F M, Tsai E C, Brunzell J D, Chait A, ApoE enhances lipid uptake by macrophages in lipoprotein lipase deficiency during pregnancy., Journal of Lipid Research, 37(5), 972-84, May 1996 Abstract
  • O'Brien K D, McDonald T O, Chait A, Allen M D, Alpers C E, Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content., Circulation, 93(4), 672-82, 15 Feb 1996 Abstract
  • Krauss R M, Chait A, Stone N J, Soy protein and serum lipids [letter; comment], New England Journal of Medicine, 333(25), 1715-6, 21 Dec 1995 Abstract
  • Chang M Y, Sasahara M, Chait A, Raines E W, Ross R, Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. II. Cellular composition and proliferation., Arteriosclerosis, Thrombosis, and Vascular Biology, 15(10), 1631-40, October 1995 Abstract
  • Bonet B, Chait A, Gown A M, Knopp R H, Metabolism of modified LDL by cultured human placental cells., Atherosclerosis, 112(2), 125-36, 20 Jan 1995 Abstract
  • Chait A, Heinecke J W, Lipoprotein modification: cellular mechanisms., Current Opinion In Lipidology, 5(5), 365-70, October 1994 Abstract
  • O'Brien K D, Ferguson M, Gordon D, Deeb S S, Chait A, Lipoprotein lipase is produced by cardiac myocytes rather than interstitial cells in human myocardium., Arteriosclerosis and Thrombosis, 14(9), 1445-51, September 1994 Abstract
  • Kawamura M, Heinecke J W, Chait A, Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway., Journal of Clinical Investigation, 94(2), 771-8, August 1994 Abstract
  • Tsai E C, Hirsch I B, Brunzell J D, Chait A, Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM., Diabetes, 43(8), 1010-4, August 1994 Abstract
  • Sasahara M, Raines E W, Chait A, Carew T E, Steinberg D, Wahl P W, Ross R, Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation?, Journal of Clinical Investigation, 94(1), 155-64, July 1994 Abstract
  • O'Brien K D, Deeb S S, Ferguson M, McDonald T O, Allen M D, Alpers C E, Chait A, Apolipoprotein E localization in human coronary atherosclerotic plaques by in situ hybridization and immunohistochemistry and comparison with lipoprotein lipase., American Journal of Pathology, 144(3), 538-48, March 1994 Abstract
  • Chait A, Gilmore M, Kawamura M, Inhibition of low density lipoprotein oxidation in vitro by the 6- and 7-hydroxy-metabolites of doxazosin, an alpha 1-adrenergic antihypertensive agent., American Journal of Hypertension, 7(2), 159-67, February 1994 Abstract
  • Tribble D L, van den Berg J J, Motchnik P A, Ames B N, Lewis D M, Chait A, Krauss R M, Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content., Proceedings of the National Academy of Sciences (USA), 91(3), 1183-7, 1 Feb 1994 Abstract
  • O'Brien K D, Chait A, The biology of the artery wall in atherogenesis., Medical Clinics of North America, 78(1), 41-67, January 1994 Abstract
  • Heinecke J W, Kawamura M, Suzuki L, Chait A, Oxidation of low density lipoprotein by thiols: superoxide-dependent and -independent mechanisms., Journal of Lipid Research, 34(12), 2051-61, December 1993 Abstract
  • Chait A, Brunzell J D, Denke M A, Eisenberg D, Ernst N D, Franklin F A Jr, Ginsberg H, Kotchen T A, Kuller L, Mullis R M, et al, Rationale of the diet-heart statement of the American Heart Association. Report of the Nutrition Committee [see comments], Circulation, 88(6), 3008-29, December 1993 Abstract
  • O'Brien K D, Allen M D, McDonald T O, Chait A, Harlan J M, Fishbein D, McCarty J, Ferguson M, Hudkins K, Benjamin C D, et al, Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis [see comments], Journal of Clinical Investigation, 92(2), 945-51, August 1993 Abstract
  • Chait A, Brazg R L, Tribble D L, Krauss R M, Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B [see comments], American Journal of Medicine, 94(4), 350-6, April 1993 Abstract
  • Sugiyama N, Marcovina S, Gown A M, Seftel H, Joffe B, Chait A, Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia., American Journal of Pathology, 141(1), 99-106, July 1992 Abstract
  • O'Brien K D, Gordon D, Deeb S, Ferguson M, Chait A, Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques., Journal of Clinical Investigation, 89(5), 1544-50, May 1992 Abstract
  • Chait A, Brunzell J D, Chylomicronemia syndrome., Advances In Internal Medicine, 37, 249-73, 1992 Abstract
  • Rosen H, Michel B R, Chait A, Phagocytosis of opsonized oil droplets by neutrophils. Adaptation to a microtiter plate format., Journal of Immunological Methods, 144(1), 117-25, 5 Nov 1991 Abstract
  • Heinecke J W, Suits A G, Aviram M, Chait A, Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events., Arteriosclerosis and Thrombosis, 11(6), 1643-51, November 1991 Abstract
  • Malden L T, Chait A, Raines E W, Ross R, The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages., Journal of Biological Chemistry, 266(21), 13901-7, 25 Jul 1991 Abstract
  • O'Brien K, Nagano Y, Gown A, Kita T, Chait A, Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits., Arteriosclerosis and Thrombosis, 11(3), 751-9, May 1991 Abstract
  • Domin W S, Chait A, Deeb S S, Transcriptional activation of the lipoprotein lipase gene in macrophages by dexamethasone., Biochemistry, 30(10), 2570-4, 12 Mar 1991 Abstract
  • Chait A, Brunzell J D, Acquired hyperlipidemia (secondary dyslipoproteinemias)., Endocrinology and Metabolism Clinics of North America, 19(2), 259-78, June 1990 Abstract
  • Faust R A, Tollefson J H, Chait A, Albers J J, Regulation of LTP-I secretion from human monocyte-derived macrophages by differentiation and cholesterol accumulation in vitro., Biochimica Et Biophysica Acta, 1042(3), 404-9, 23 Feb 1990 Abstract
  • Jialal I, Chait A, Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively, Journal of Lipid Research, 30(10), 1561-8, October 1989 Abstract
  • Auwerx J H, Chait A, Wolfbauer G, Deeb S S, Involvement of second messengers in regulation of the low-density lipoprotein receptor gene., Molecular and Cellular Biology, 9(6), 2298-302, June 1989 Abstract

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Last Updated: 8/1/2007

COS Expertise ID #135312
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