Thomas R. Chauncey

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VA Puget Sound Health Care System
Medical Oncology
Fred Hutchinson Cancer Research Center
Associate MemberAppointed: 2001
University of Washington
School of Medicine
Medicine
Oncology
Associate ProfessorAppointed: 2000

Mailing Address

Marrow Transplant Unit (S-111-MTU)
VA Puget Sound Health Care System
1660 South Columbian Way
Seattle, Washington 98108
United States

Contact Information

Phone: (206) 764-2709
Fax: (206) 764-2851
tchaunce@u.washington.edu

Qualifications

M.D., Rush Medical College, 1985.
Ph.D., University of Chicago, 1981.

Expertise and Research Interests

AML increases with advancing age, yet therapeutic outcome falls with age, due both to decreased tolerance for aggressive cytotoxic therapy as well as inherent biological resistance at the cellular level. Working with laboratory studies examining cellular resistance profiles and their correlation with clinical characteristics, clinical trials have been designed to target some of these biological characteristics. Since P-glycoprotein mediated resistance is increased in AML occurring in older patients and those with relapsed disease, efforts to overcome this biological resistance have utilized compounds known to block or reverse Pgp.

Other clinical strategies being developed include alternate drug administration schedules to enhance antileukemic activity and minimize clinical toxicities, while another strategy being evaluated is consolidation with non-myeloablative allogeneic transplant during first or subsequent remissions. Non-transplant AML studies are performed in the Southwest Oncology Group (SWOG). In addition, ongoing retrospective clinical analysis of SWOG AML trials is being performed to determine clinical and biological prognostic factors for use in future trial development.

Hematopoietic stem cell transplantation investigations are aimed at improving outcome for patients with multiple myeloma, non-Hodgkin's lymphoma, and Hodgkin's disease using autologous transplant techniques. Select patients may also be candidates for autologous and non-myeloablative allogeneic transplantation performed in tandem fashion. Other efforts are
directed at improving therapeutic outcomes with better supportive care and alternative preparative regimens for patients with a variety of hematologic malignancies undergoing allogeneic transplant from matched sibling, family matched or unrelated donors.

Keywords

COS Keywords:

Cancer or Carcinogenesis, Gerontology, Oncology.

Publications

  • Feinstein L, Sandmaier B, Maloney D, McSweeney PA, Maris M, Flowers C, Radich J, Little MT, Nash RA, Chauncey T, Woolfrey A, Georges G, Kiem HP, Zaucha JM, Blume KG, Shizuru J, Niederwieser D, Storb R, Nonmyeloablative hematopoietic cell transplantation. Replacing high-dose cytotoxic therapy by the graft-versus-tumor effect, Annals of the New York Academy of Sciences, 938, 328-37, June 2001 Abstract
  • Jurado M, Deeg H, Gooley T, Anasetti C, Chauncey T, Flowers M, Myerson D, Storb R, Appelbaum F, Haemopoietic stem cell transplantation for advanced polycythaemia vera or essential thrombocythaemia, British Journal of Haematology, 112(2), 392-6, February 2001 Abstract
  • Bensinger WI, Martin PJ, Storer B, Clift R, Forman SJ, Negrin R, Kashyap A, Flowers ME, Lilleby K, Chauncey TR, Storb R, Appelbaum FR, Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers, New England Journal of Medicine, 344(3), 175-81, 2001 Abstract
  • Chauncey TR, Drug resistance mechanisms in acute leukemia, Current Opinion in Oncology, 13(1), 21-6, Jan 2001 Abstract
  • Anderson JE, Appelbaum FR, Schoch G, Barnett T, Chauncey TR, Flowers ME, Storb R, Relapse after allogeneic bone marrow transplantation for refractory anemia is increased by shielding lungs and liver during total body irradiation, Biology of Blood and Marrow Transplantation, 7(3), 163-70, 2001 Abstract
  • Storb R, Blume KG, O'Donnell MR, Chauncey T, Forman SJ, Deeg HJ, Hu WW, Appelbaum FR, Doney K, Flowers ME, Sanders J, Leisenring W, Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers, Biology of Blood and Marrow Transplantation, 7(1), 39-44, 2001 Abstract
  • McSweeney PA, Niederwieser D, Shizuru JA, Sandmaier BM, Molina AJ, Maloney DG, Chauncey TR, et al, Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects, Blood, 97(11), 3390-400, 2001
  • Schwartz DL, Schechter GP, Seltzer S, Chauncey TR, Radiation myelitis following allogeneic stem cell transplantation and consolidation radiotherapy for non-Hodgkin's lymphoma, Bone Marrow Transplantation, 26(12), 1355-9, December 2000 Abstract
  • Chauncey TR, Gooley TA, Lloid ME, Schubert MM, Lilleby K, Holmberg L, Bensinger WI, Pilot trial of cytoprotection with amifostine given with high-dose chemotherapy and autologous peripheral blood stem cell transplantation, American Journal of Clinical Oncology, 23(4), 406-11, August 2000 Abstract
  • Saunders MD, Shulman HM, Murakami CS, Chauncey TR, Bensinger WI, McDonald GB, Bile duct apoptosis and cholestasis resembling acute graft-versus-host disease after autologous hematopoietic cell transplantation, American Journal of Surgical Pathology, 24(7), 1004-8, July 2000 Abstract
  • Chauncey TR, Rankin C, Anderson JE, Chen I, Kopecky KJ, Godwin JE, Kalaycio ME, Moore DF, Shurafa MS, Petersdorf SH, Kraut EH, Leith CP, Head DR, Luthardt FW, Willman CL, Appelbaum FR, A phase I study of induction chemotherapy for older patients with newly diagnosed acute myeloid leukemia (AML) using mitoxantrone, etoposide, and the MDR modulator PSC 833: a southwest oncology group, Leukemia Research, 24(7), 567-74, July 2000 Abstract
  • Radich JP, Gooley T, Sanders JE, Anasetti C, Chauncey T, Appelbaum FR, Second allogeneic transplantation after failure of first autologous transplantation, Biology of Blood and Marrow Transplantation, 6(3), 272-9, 2000 Abstract
  • Flower ME, Leisenring W, Beach K, Riddell S, Radich JP, Higano CS, Rowley SD, Chauncey TR, Sanders JE, Anasetti C, Storb R, Wade J, Appelbaum FR, Martin P, Granulocyte colony-stimulating factor given to donors before apheresis does not prevent aplasia in patients treated with donor leukocyte infusion for recurrent chronic myeloid leukemia after bone marr, Biology of Blood and Marrow Transplantation, 6(3A), 321-6, 2000 Abstract
  • Martin PJ, Rowley SD, Anasetti C, Chauncey TR, Gooley T, Petersdorf EW, van Burik JA, Flowers ME, Storb R, Appelbaum FR, Hansen JA, A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients, Blood, 94(7), 2192-9, 1999 Abstract
  • Hansen JA, Gooley TA, Martin PJ, Appelbaum F, Chauncey TR, Clift RA, Petersdorf EW, Radich J, Sanders JE, Storb RF, Sullivan KM, Anasetti C, Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia, New England Journal of Medicine, 338(14), 962-8, 1998 Abstract
  • Garrido SM, Chauncey TR, Neuroleptic malignant syndrome following autologous peripheral blood stem cell transplantation, Bone Marrow Transplantation, 21(4), 427-8, February 1998 Abstract
  • Storek J, Gooley T, Siadak M, Bensinger WI, Maloney DG, Chauncey TR, Flowers M, Sullivan KM, Witherspoon RP, Rowley SD, Hansen JA, Storb R, Appelbaum FR, Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease, Blood, 90(12), 4705-9, 15 Dec 1997 Abstract
  • Schiffman K, Buckner CD, Maziarz R, Maloney DG, Appelbaum FR, Press O, Gooley T, Holmberg L, Lilleby K, Clift R, Zuckerman N, Klarnet J, Weaver C, Chauncey T, Bensinger WI, High-dose busulfan, melphalan, and thiotepa followed by autologous peripheral blood stem cell transplantation in patients with aggressive lymphoma or relapsed Hodgkin's disease, Biology of Blood and Marrow Transplantation, 3(5), 261-6, November 1997 Abstract
  • Storb R, Leisenring W, Anasetti C, Appelbaum FR, Deeg HJ, Doney K, Martin P, Sullivan KM, Witherspoon R, Pettinger M, Bensinger W, Buckner CD, Clift R, Flowers ME, Hansen JA, Pepe M, Chauncey T, Sanders J, Thomas ED, Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine?, Biology of Blood and Marrow Transplantation, 3(4), 194-201, October 1997 Abstract
  • Sierra J, Storer B, Hansen JA, Bjerke JW, Martin PJ, Petersdorf EW, Appelbaum FR, Bryant E, Chauncey TR, Sale G, Sanders JE, Storb R, Sullivan KM, Anasetti C, Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose., Blood, 89(11), 4226-35, 1 1997 Abstract
  • Deeg HJ, Lin D, Leisenring W, Boeckh M, Anasetti C, Appelbaum FR, Chauncey TR, Doney K, Flowers M, Martin P, Nash R, Schoch G, Sullivan KM, Witherspoon RP, Storb R, Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: a prospective, randomized trial., Blood, 89(10), 3880-7, 15 1997 Abstract
  • Storek J, Witherspoon RP, Maloney DG, Chauncey TR, Storb R, Improved reconstitution of CD4 T cells and B cells but worsened reconstitution of serum IgG levels after allogeneic transplantation of blood stem cells instead of marrow, Blood, 89(10), 3891-3, 1997 Abstract
  • Storb R, Leisenring W, Anasetti C, Appelbaum FR, Buckner CD, Bensinger WI, Chauncey T, Clift RA, Deeg HJ, Doney KC, Flowers ME, Hansen JA, Martin PJ, Sanders JE, Sullivan KM, Witherspoon RP, Long-term follow-up of allogeneic marrow transplants in patients with aplastic anemia conditioned by cyclophosphamide combined with antithymocyte globulin, Blood, 89(10), 3890-1, 1997 Abstract
  • Robinson N, Benyunes MC, Thompson JA, York A, Petersdorf S, Press O, Lindgren C, Chauncey T, Buckner CD, Bensinger WI, Appelbaum FR, Fefer A, Interleukin-2 after autologous stem cell transplantation for hematologic malignancy: a phase I/II study, Bone Marrow Transplantation, 19(5), 435-42, March 1997 Abstract
  • Demirer T, Buckner CD, Gooley T, Appelbaum FR, Rowley S, Chauncey T, Lilleby K, Storb R, Bensinger WI, Factors influencing collection of peripheral blood stem cells in patients with multiple myeloma, Bone Marrow Transplantation, 17(6), 937-41, June 1996 Abstract
  • Bensinger WI, Rowley SD, Demirer T, Lilleby K, Schiffman K, Clift RA, Appelbaum FR, Fefer A, Barnett T, Storb R, Chauncey T, Maziarz RT, Klarnet J, McSweeney P, Holmberg L, Maloney DG, Weaver CH, Buckner CD, High-dose therapy followed by autologous hematopoietic stem-cell infusion for patients with multiple myeloma, Journal of Clinical Oncology, 14(5), 1447-56, May 1996 Abstract
  • Anderson JE, Appelbaum FR, Schoch G, Gooley T, Anasetti C, Bensinger WI, Bryant E, Buckner CD, Chauncey TR, Clift RA, Doney K, Flowers M, Hansen JA, Martin PJ, Matthews DC, Sanders JE, Shulman H, Sullivan KM, Witherspoon RP, Storb R, Allogeneic marrow transplantation for refractory anemia: a comparison of two preparative regimens and analysis of prognostic factors., Blood, 87(1), 51-8, 1 1996 Abstract
  • Anderson JE, Appelbaum FR, Schoch G, Gooley T, Anasetti C, Bensinger WI, Bryant E, Buckner CD, Chauncey T, Clift RA, Allogeneic marrow transplantation for myelodysplastic syndrome with advanced disease morphology: a phase II study of busulfan, cyclophosphamide, and total-body irradiation and analysis of prognostic f, Journal of Clinical Oncology, 14(1), 220-6, January 1996 Abstract
  • Chauncey TR, Westley J, The catalytic mechanism of yeast thiosulfate reductase, Journal of Biological Chemistry, 258(24), 15037-45, 1983 Abstract
  • Lange Y, Molinaro AL, Chauncey TR, Steck TL, On the mechanism of transfer of cholesterol between human erythrocytes and plasma, Journal of Biological Chemistry, 258(11), 6920-6, 1983 Abstract

Profile Details

Last Updated: 2/8/2002

COS Expertise ID #135353
Reference this profile directly: http://myprofile.cos.com/CHAUNCEY