Samir S. Deeb

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University of Washington
College of Arts and Sciences
Genetics
Adjunct Research ProfessorAppointed: 1992

Mailing Address

Box 357360
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-1706
Fax: (206) 543-0754
deeb@genetics.washington.edu

Qualifications

Ph.D., University of Illinois, Urbana, IL, 1964.

Expertise and Research Interests

My expertise is in the following areas:genetic factors predisposing to hyperlipidemia and coronary artery disease.

Keywords

COS Keywords:

Genetics.

Additional Terms:

Coronary Artery Disease, Genetic Factors Predisposing to Hyperlipidemia.

Publications

  • Deeb SS, Diller LC, Williams DR, Dacey DM, Interindividual and topographical variation of L:M cone ratios in monkey retinas., Journal of Opt Soc Am A Opt Image Sci Vis, 17(3), 538-44, 2000 Abstract
  • Deeb SS, Peng R, The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity., Journal of Lipid Research, 41(1), 155-8, 2000 Abstract
  • Knopp EA, Arndt TL, Eng KL, Caldwell M, LeBoeuf RC, Deeb SS, O''Brien KD, Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping., Mammalian Genome, 10(6), 601-5, June 1999 Abstract
  • Hayashi T, Motulsky AG, Deeb SS, Position of a ''green-red'' hybrid gene in the visual pigment array determines colour-vision phenotype., Nat. Genet., 22(1), 90-3, May 1999 Abstract
  • Castro E, Ogburn CE, Hunt KE, Tilvis R, Louhija J, Penttinen R, Erkkola R, Panduro A, Riestra R, Piussan C, Deeb SS, Wang L, Edland SD, Martin GM, Oshima J, Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cy/Arg, and its stability in a population of Finnish centenarians., American Journal of Medical Genetics, 82(5), 399-403, 19 Feb 1999 Abstract
  • Crognale MA, Teller DY, Yamaguchi T, Motulsky AG, Deeb SS, Analysis of red/green color discrimination in subjects with a single X-linked photopigment gene., Vision Research, 39(4), 707-19, February 1999 Abstract
  • Crognale MA, Teller DY, Motulsky AG, Deeb SS, Severity of color vision defects: electroretinographic \(ERG\), molecular and behavioral studies., Vision Research, 38(21), 3377-85, November 1998 Abstract
  • Rissanen J, Saarinen L, Heikkinen S, Kekalainen P, Mykkanen L, Kuusisto J, Deeb S S, Laakso M, Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns., Diabetes Care, 21(7), 1194-7, July 1998 Abstract
  • Shaaban S A, Deeb S S, Functional analysis of the promoters of the human red and green visual pigment genes., Investigative Ophthalmology and Visual Science, 39(6), 885-96, May 1998 Abstract
  • Shaaban S A, Crognale M A, Calderone J B, Huang J, Jacobs G H, Deeb S S, Transgenic mice expressing a functional human photopigment., Investigative Ophthalmology and Visual Science, 39(6), 1036-43, May 1998 Abstract
  • Busca R, Martinez M, Vilella E, Peinado J, Gelpi J L, Deeb S, Auwerx J, Reina M, Vilaro S, The carboxy-terminal region of human lipoprotein lipase is necessary for its exit from the endoplasmic reticulum., Journal of Lipid Research, 39(4), 821-33, April 1998 Abstract
  • Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Lebel P, Dallongeville J, Deeb S, Auwerx J, Amouyel P, A genetic polymorphism of the peroxisome proliferator-activated receptor gamma gene influences plasma leptin levels in obese humans., Human Molecular Genetics, 7(3), 435-40, March 1998 Abstract
  • Wijsman E M, Brunzell J D, Jarvik G P, Austin M A, Motulsky A G, Deeb S S, Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex., Arteriosclerosis, Thrombosis, and Vascular Biology, 18(2), 215-26, February 1998 Abstract
  • Malkki M, Laakso M, Deeb S S, The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM., Diabetologia, 40(12), 1461-9, December 1997 Abstract
  • Lotfi K, Sund G, Lowe R, Graham J, Landin-Olsson M, Kockum I, Deeb S, Lernmark A, The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS)., Diabetologia, 40(8), 959-62, August 1997 Abstract
  • Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre A M, Saladin R, Najib J, Laville M, Fruchart J C, Deeb S, Vidal-Puig A, Flier J, Briggs M R, Staels B, Vidal H, Auwerx J, The organization, promoter analysis, and expression of the human PPARgamma gene., Journal of Biological Chemistry, 272(30), 18779-89, 25 Jul 1997 Abstract
  • Jarvik G P, Goode E L, Austin M A, Auwerx J, Deeb S, Schellenberg G D, Reed T, Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis., American Journal of Human Genetics, 61(1), 171-81, July 1997 Abstract
  • Sanocki E, Teller D Y, Deeb S S, Rayleigh match ranges of red/green color-deficient observers: psychophysical and molecular studies., Vision Research, 37(14), 1897-907, July 1997 Abstract
  • Yamaguchi T, Motulsky A G, Deeb S S, Visual pigment gene structure and expression in human retinae., Human Molecular Genetics, 6(7), 981-90, July 1997 Abstract
  • Meagher M J, Jorgensen A L, Deeb S S, Sequence and evolutionary history of the length polymorphism in intron 1 of the human red photopigment gene., Journal of Molecular Evolution, 43(6), 622-30, December 1996 Abstract
  • Yang W S, Nevin D N, Iwasaki L, Peng R, Brown B G, Brunzell J D, Deeb S S, Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease., Journal of Lipid Research, 37(12), 2627-37, December 1996 Abstract
  • Schoonjans K, Peinado-Onsurbe J, Lefebvre A M, Heyman R A, Briggs M, Deeb S, Staels B, Auwerx J, PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene., Embo Journal, 15(19), 5336-48, 1 Oct 1996 Abstract
  • Fukuchi K, Ho L, Younkin S G, Kunkel D D, Ogburn C E, LeBoeuf R C, Furlong C E, Deeb S S, Nochlin D, Wegiel J, Wisniewski H M, Martin G M, High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice., American Journal of Pathology, 149(1), 219-27, July 1996 Abstract
  • Deeb S S, Motulsky A G, Molecular genetics of human color vision., Behavior Genetics, 26(3), 195-207, May 1996 Abstract
  • Stone L M, Kahn S E, Fujimoto W Y, Deeb S S, Porte D Jr, A variation at position -30 of the beta-cell glucokinase gene promoter is associated with reduced beta-cell function in middle-aged Japanese-American men., Diabetes, 45(4), 422-8, April 1996 Abstract
  • Busca R, Martinez M, Vilella E, Pognonec P, Deeb S, Auwerx J, Reina M, Vilaro S, The mutation Gly142-->Glu in human lipoprotein lipase produces a missorted protein that is diverted to lysosomes., Journal of Biological Chemistry, 271(4), 2139-46, 26 Jan 1996 Abstract
  • Deeb S S, Nevin D N, Iwasaki L, Brunzell J D, Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity., Human Mutation, 8(4), 319-25, 1996 Abstract
  • Busca R, Peinado J, Vilella E, Auwerx J, Deeb S S, Vilaro S, Reina M, The mutant Asn291-->Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin., Febs Letters, 367(3), 257-62, 3 Jul 1995 Abstract
  • Yang W S, Nevin D N, Peng R, Brunzell J D, Deeb S S, A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity [published erratum appears in Proc Natl Acad Sci U S A 1996 Jan, Proceedings of the National Academy of Sciences (USA), 92(10), 4462-6, 9 May 1995 Abstract
  • Deeb S S, Alvarez A, Malkki M, Motulsky A G, Molecular patterns and sequence polymorphisms in the red and green visual pigment genes of Japanese men., Human Genetics, 95(5), 501-6, May 1995 Abstract
  • Busca R, Pujana M A, Pognonec P, Auwerx J, Deeb S S, Reina M, Vilaro S, Absence of N-glycosylation at asparagine 43 in human lipoprotein lipase induces its accumulation in the rough endoplasmic reticulum and alters this cellular compartment., Journal of Lipid Research, 36(5), 939-51, May 1995 Abstract
  • Laakso M, Malkki M, Kekalainen P, Kuusisto J, Deeb S S, Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance., Diabetologia, 38(5), 617-22, May 1995 Abstract
  • Laakso M, Malkki M, Deeb S S, Amino acid substitutions in hexokinase II among patients with NIDDM., Diabetes, 44(3), 330-4, March 1995 Abstract
  • Laakso M, Malkki M, Kekalainen P, Kuusisto J, Mykkanen L, Deeb S S, Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance., Diabetes Care, 18(3), 398-400, March 1995 Abstract
  • Tu A Y, Deeb S S, Iwasaki L, Day J R, Albers J J, Organization of human phospholipid transfer protein gene., Biochemical and Biophysical Research Communications, 207(2), 552-8, 15 Feb 1995 Abstract
  • Reed T, Carmelli D, Swan G E, Breitner J C, Welsh K A, Jarvik G P, Deeb S, Auwerx J, Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele., Archives of Neurology, 51(12), 1189-92, December 1994 Abstract
  • Stone L M, Kahn S E, Deeb S S, Fujimoto W Y, Porte D Jr, Glucokinase gene variations in Japanese-Americans with a family history of NIDDM., Diabetes Care, 17(12), 1480-3, December 1994 Abstract
  • Malkki M, Laakso M, Deeb S S, Structure of the human hexokinase II gene., Biochemical and Biophysical Research Communications, 205(1), 490-6, 30 Nov 1994 Abstract
  • O'Brien K D, Ferguson M, Gordon D, Deeb S S, Chait A, Lipoprotein lipase is produced by cardiac myocytes rather than interstitial cells in human myocardium., Arteriosclerosis and Thrombosis, 14(9), 1445-51, September 1994 Abstract
  • Laakso M, Malkki M, Kekalainen P, Kuusisto J, Deeb S S, Insulin receptor substrate-1 variants in non-insulin-dependent diabetes., Journal of Clinical Investigation, 94(3), 1141-6, September 1994 Abstract
  • Deeb S S, Jorgensen A L, Battisti L, Iwasaki L, Motulsky A G, Sequence divergence of the red and green visual pigments in great apes and humans., Proceedings of the National Academy of Sciences (USA), 91(15), 7262-6, 19 Jul 1994 Abstract
  • Nevin D N, Brunzell J D, Deeb S S, The LPL gene in individuals with familial combined hyperlipidemia and decreased LPL activity., Arteriosclerosis and Thrombosis, 14(6), 869-73, June 1994 Abstract
  • Fukuchi K, Hearn M G, Deeb S S, Smith A C, Dang N, Miyazaki J, Bothwell M, Martin G M, Activity assays of nine heterogeneous promoters in neural and other cultured cells., In Vitro Cellular and Developmental biology. Animal, 30A(5), 300-5, May 1994 Abstract
  • O'Brien K D, Deeb S S, Ferguson M, McDonald T O, Allen M D, Alpers C E, Chait A, Apolipoprotein E localization in human coronary atherosclerotic plaques by in situ hybridization and immunohistochemistry and comparison with lipoprotein lipase., American Journal of Pathology, 144(3), 538-48, March 1994 Abstract
  • Jarvik G P, Austin M A, Fabsitz R R, Auwerx J, Reed T, Christian J C, Deeb S, Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects., Genetic Epidemiology, 11(4), 375-84, 1994 Abstract
  • Deeb S S, Malkki M, Laakso M, Human hexokinase II: sequence and homology to other hexokinases., Biochemical and Biophysical Research Communications, 197(1), 68-74, 30 Nov 1993 Abstract
  • Sanocki E, Lindsey D T, Winderickx J, Teller D Y, Deeb S S, Motulsky A G, Serine/alanine amino acid polymorphism of the L and M cone pigments: effects on Rayleigh matches among deuteranopes, protanopes and color normal observers., Vision Research, 33(15), 2139-52, October 1993 Abstract
  • Fukuchi K, Ogburn C E, Smith A C, Kunkel D D, Furlong C E, Deeb S S, Nochlin D, Sumi S M, Martin G M, Transgenic animal models for Alzheimer's disease., Annals of The New York Academy of Sciences, 695, 217-23, 24 Sep 1993 Abstract
  • Winderickx J, Battisti L, Hibiya Y, Motulsky A G, Deeb S S, Haplotype diversity in the human red and green opsin genes: evidence for frequent sequence exchange in exon 3., Human Molecular Genetics, 2(9), 1413-21, September 1993 Abstract
  • Schoonjans K, Staels B, Devos P, Szpirer J, Szpirer C, Deeb S, Verhoeven G, Auwerx J, Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site., Febs Letters, 329(1-2), 89-95, 23 Aug 1993 Abstract
  • Farrell D F, Hamilton S R, Knauss T A, Sanocki E, Deeb S S, X-linked adrenoleukodystrophy: adult cerebral variant., Neurology, 43(8), 1518-22, August 1993 Abstract
  • Deeb S S, Genetic determinants of visual functions., Current Opinion In Neurobiology, 3(4), 506-12, August 1993 Abstract
  • Reina M, Brunzell J D, Deeb S S, Molecular basis of familial chylomicronemia: mutations in the lipoprotein lipase and apolipoprotein C-II genes., Journal of Lipid Research, 33(12), 1823-32, December 1992 Abstract
  • Fukuchi K, Kamino K, Deeb S S, Furlong C E, Sundstrom J A, Smith A C, Martin G M, Expression of a carboxy-terminal region of the beta-amyloid precursor protein in a heterogeneous culture of neuroblastoma cells: evidence for altered processing and selective neurotoxicity., Brain research. Molecular Brain Research, 16(1-2), 37-46, November 1992 Abstract
  • Peinado-Onsurbe J, Staels B, Deeb S, Auwerx J, Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A., Biochemistry, 31(41), 10121-8, 20 Oct 1992 Abstract
  • Winderickx J, Battisti L, Motulsky A G, Deeb S S, Selective expression of human X chromosome-linked green opsin genes., Proceedings of the National Academy of Sciences (USA), 89(20), 9710-4, 15 Oct 1992 Abstract
  • Deeb S S, Lindsey D T, Hibiya Y, Sanocki E, Winderickx J, Teller D Y, Motulsky A G, Genotype-phenotype relationships in human red/green color-vision defects: molecular and psychophysical studies., American Journal of Human Genetics, 51(4), 687-700, October 1992 Abstract
  • Reina M, Deeb S, SSCP polymorphism in the human hepatic triglyceride lipase (LIPC) gene., Human Molecular Genetics, 1(6), 453, September 1992 Abstract
  • Peinado-Onsurbe J, Staels B, Deeb S, Ramirez I, Llobera M, Auwerx J, Neonatal extinction of liver lipoprotein lipase expression., Biochimica Et Biophysica Acta, 1131(3), 281-6, 15 Jul 1992 Abstract
  • Winderickx J, Sanocki E, Lindsey D T, Teller D Y, Motulsky A G, Deeb S S, Defective colour vision associated with a missense mutation in the human green visual pigment gene., Nature Genetics, 1(4), 251-6, July 1992 Abstract
  • Fukuchi K, Deeb S S, Kamino K, Ogburn C E, Snow A D, Sekiguchi R T, Wight T N, Piussan H, Martin G M, Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells., Journal of Neurochemistry, 58(5), 1863-73, May 1992 Abstract
  • O'Brien K D, Gordon D, Deeb S, Ferguson M, Chait A, Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques., Journal of Clinical Investigation, 89(5), 1544-50, May 1992 Abstract
  • Winderickx J, Lindsey D T, Sanocki E, Teller D Y, Motulsky A G, Deeb S S, Polymorphism in red photopigment underlies variation in colour matching., Nature, 356(6368), 431-3, 2 Apr 1992 Abstract
  • Wilson B E, Deeb S, Florant G L, Seasonal changes in hormone-sensitive and lipoprotein lipase mRNA concentrations in marmot white adipose tissue., American Journal of Physiology, 262(2 Pt 2), R177-81, February 1992 Abstract
  • Deeb S S, Failor R A, Brown B G, Brunzell J D, Albers J J, Motulsky A G, Wijsman E, Association of apolipoprotein B gene variants with plasma apoB and low density lipoprotein (LDL) cholesterol levels., Human Genetics, 88(4), 463-70, February 1992 Abstract
  • Fukuchi K, Kamino K, Deeb S S, Smith A C, Dang T, Martin G M, Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity., Biochemical and Biophysical Research Communications, 182(1), 165-73, 15 Jan 1992 Abstract
  • Deeb S S, Cheung M C, Peng R L, Wolf A C, Stern R, Albers J J, Knopp R H, A mutation in the human apolipoprotein A-I gene. Dominant effect on the level and characteristics of plasma high density lipoproteins., Journal of Biological Chemistry, 266(21), 13654-60, 25 Jul 1991 Abstract
  • Domin W S, Chait A, Deeb S S, Transcriptional activation of the lipoprotein lipase gene in macrophages by dexamethasone., Biochemistry, 30(10), 2570-4, 12 Mar 1991 Abstract
  • Austin M A, Wijsman E, Guo S W, Krauss R M, Brunzell J D, Deeb S, Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia., Genetic Epidemiology, 8(5), 287-97, 1991 Abstract
  • Monsalve M V, Henderson H, Roederer G, Julien P, Deeb S, Kastelein J J, Peritz L, Devlin R, Bruin T, Murthy M R, et al, A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries., Journal of Clinical Investigation, 86(3), 728-34, September 1990 Abstract
  • Jorgensen A L, Deeb S S, Motulsky A G, Molecular genetics of X chromosome-linked color vision among populations of African and Japanese ancestry: high frequency of a shortened red pigment gene among Afro-Americans., Proceedings of the National Academy of Sciences (USA), 87(17), 6512-6, September 1990 Abstract
  • Deeb S S, Takata K, Peng R L, Kajiyama G, Albers J J, A splice-junction mutation responsible for familial apolipoprotein A-II deficiency., American Journal of Human Genetics, 46(4), 822-7, April 1990 Abstract
  • Auwerx J H, Babirak S P, Hokanson J E, Stahnke G, Will H, Deeb S S, Brunzell J D, Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family., American Journal of Human Genetics, 46(3), 470-7, March 1990 Abstract
  • Devlin R H, Deeb S, Brunzell J, Hayden M R, Partial gene duplication involving exon-Alu interchange results in lipoprotein lipase deficiency., American Journal of Human Genetics, 46(1), 112-9, January 1990 Abstract
  • Fukuchi K, Martin G M, Deeb S S, Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus., Nucleic Acids Research, 17(13), 5396, 11 Jul 1989 Abstract
  • Auwerx J H, Chait A, Wolfbauer G, Deeb S S, Involvement of second messengers in regulation of the low-density lipoprotein receptor gene., Molecular and Cellular Biology, 9(6), 2298-302, June 1989 Abstract
  • Langlois S, Deeb S, Brunzell J D, Kastelein J J, Hayden M R, A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency., Proceedings of the National Academy of Sciences (USA), 86(3), 948-52, February 1989 Abstract

Profile Details

Last Updated: 9/14/1998

COS Expertise ID #308456
Reference this profile directly: http://myprofile.cos.com/DEEB