H. Joachim Deeg

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COS Expertise®
Fred Hutchinson Cancer Research Center
Clinical Research
Member
University of Washington
School of Medicine
Medicine
Oncology
ProfessorAppointed: 1994
Professional Headshot of H. Joachim Deeg

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D1-100
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-5985
Fax: (206) 667-6124
jdeeg@fhcrc.org

Qualifications

M.D., Friedrich Wilhelms Universitaet, 1972.

Expertise and Research Interests

Myelodysplastic syndrome and programmed cell death

The term myelodysplastic syndrome (MDS) describes a broad spectrum of clonal marrow disorders. Our research is focused on the characterization of the underlying pathophysiology and mechanisms of marrow failure, with the aim of developing biologically rational therapeutic strategies. TNF-alpha, Fas/Fas-ligand, and TRAIL (TNF-related apoptosis inducing ligand) and its agonistic and decoy receptors are upregulated MDS, and marrow cells from patients with early stages of the disease show increased rates of programmed cell death (apoptosis) in both clonal and non-clonal hemopoietic precursors. With disease progression, the ratio of TNF receptors R1 and R2 on clonal cells shifts in favor of R2. Since R1 can trigger both pro-apoptotic (via caspase-8) and cytoprotective signals (via NF-kB), R2, however, which lacks a death domain, only cytoprotective signals, the result is a decline in apoptosis in clonal precursors. This appears to be one factor contributing to treatment resistance and clonal expansion with advanced MDS. Hence, differential manipulation of R1 and R2 initiated signals may offer one therapeutic strategy.

Additional studies are aimed at characterizing the role of cytoplasmatic adaptor molecules such as FLIP (long and short), which controls Fas- and TRAIL-induced apoptosis, and which is regulated via NF-kB. One rather controversial question is that of the role of the marrow microenvironment in the dysregulation of hemopoiesis in MDS. There is evidence, however, that gene expression in marrow stroma is modified by TNF-alpha, and preliminary data suggest effects on jagged1 (a ligand for Notch), and the insulin-like growth factor (IGF) binding protein 3 (BP3). These molecules are involved in myeloid differentiation and proliferation, respectively. Therefore, another series of experiments is directed at defining the relevance of stroma-derived signals for the propagation of clonal as compared to non-clonal hemopoietic precursors. Those studies are being pursued, using wild type and genetically modified human stroma cells in vitro and in a murine model (NOD/SCID/β2mnull) in vivo. In addition to functional studies, this work also includes genomic and proteomic analyses.

A second focus is on newly recognized properties of Transferrin (Tf), a central component of iron transport and metabolism. Our studies show that Tf exerts potent cytoprotective/anti-apoptotic functions. Tf protects lympho-hemopoietic cells against apoptosis mediated by TNF-alpha, Fas, or gamma-irradiation. Tf also protects mice against otherwise fatal Fas-mediated hepatic failure. The mechanism involves modulation of the mitochondrial pathway of apoptosis (BID translocation, cytochrome c release, caspase-9 activation).The observed effects are iron independent; in fact holo-Tf triggers pro-apoptotic signals. The role of changes in redox status of the cell is unclear, although changes in GSH/GSSG levels are observed. The relative importance of Tf receptor 1 (CD71) as compared to Tf receptor 2 remains to be determined.

Other Expertise

Graft-versus-Host Disease; hemopoietic stem cell transplantation.

Keywords

COS Keywords:

Cancer or Carcinogenesis, Metabolism, Oncology, Organ Transplantation, Pathophysiology.

Additional Terms:

Transplantation.

Publications

  • Witherspoon RP, Deeg HJ, Storb R, Appelbaum FR., Secondary leukemia or myelodysplasia treated by bone marrow transplantation, Acute Leukemias VII: Prognostic Factors and Treatment Strategies., 655-659, 2001
  • Witherspoon RP, Deeg HJ, Storb R, Appelbaum FR., Secondary leukemia or myelodysplasia treated by bone marrow transplantation, Acute Leukemias VII: Prognostic Factors and Treatment Strategies., 655-659, 2001
  • Jurado M, Deeg HJ, Gooley T, Anasetti C, Chauncey T, Flowers MED, Myerson D, Storb R, Appelbaum FR., Haemopoietic stem cell transplantation for advanced polycythaemia vera or essential thrombocythaemia, British Journal of Haematology, 112, 392-396, 2001
  • Deeg HJ, Amylon MD, Harris RE, Collins R, Beatty PG, Feig S, Ramsay N, Territo M, Khan SP, Pamphilon D, Leis JF, Burdach S, Anasetti C, Hackman R, Storer B, Mueller B., Marrow transplants from unrelated donors for patients with aplastic anemia: Minimum effective dose of total body irradiation, Biology of Blood and Marrow Transplantation, 7, 208-215, 2001
  • Lesnikov V, Lesnikova M, Deeg HJ, Pro- and anti-apoptotic effects of transferin and Tf-derived glycans on hematopoietic cells and lymphocytes, Experimental Hematology, 29, 477-489, 2001
  • Lesnikova M, Lesnikov V, Arrighi S, Kistler G, Pierpaoli W, Deeg HJ, Upregulation of interleukin-10 and inhibition of alloantigen responses by transferrin and transferrin-derived glycans, Journal of Hematotherapy and Stem Cell Research, 9(3), 381-92, June 2000 Abstract
  • Deeg HJ, Beckham C, Loken MR, Bryant E, Lesnikova M, Shulman HM, Gooley T, Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome, Leukemia and Lymphoma, 37(3-4), 405-14, April 2000 Abstract
  • Deeg HJ, Yamaguchi M., Acute graft-versus-host disease, Clinical Bone Marrow and Blood Stem Cell Transplantion, 2nd Edition (Book Chapter 53), 681-699, 2000
  • Deeg HJ, Hematopoietic stem cell transplantation for nonmalignant diseases, Hematology: Basic Principles and Practice, 3rd Edition (Book Chapter 85), 1553-1573, 2000
  • McCann SR, Passweg JR, Storb R, Deeg HJ., HLA-identical sibling bone marrow transplantation to treat severe aplstic anemia, Aplastic Anemia Pathophysiology and Treatment (Book Chapter), 230-257, 2000
  • Witherspoon RP, Deeg HJ, Fisher L, Schoch G, Storb R., Secondary malignancies after allogeneic or autologous marrow transplantation, Secondary Neoplasias following Chemotherapy, Radiotherapy, and Immunosuppression., 55, 203-224, 2000
  • Deeg HJ., Graft-versus-host disease: facts and thoughts on recent developments, Current Opinion in Organ Transplantation, 5, 352-357, 2000
  • Woolfrey AE, Petersdorf EW, Anasetti C, Martin PJ, Deeg J, Bensinger W, Sanders JE, Hansen JA., Matched unrelated marrow transplantation: The true indications, Handbook of Bone Marrow Transplantation, 3, 41-64, 2000
  • Carnevale-Schianca F, Martin P, Sullivan K, Flowers M, Gooley T, Anasetti C, Deeg J, Furlong T, McSweeney P, Storb R, Nash RA., Changing cyclosporine to tacrolimus as salvage therapy for chronic graft-versus-host disease, Biology of Blood and Marrow Transplantation, 6, 613-620, 2000
  • Huss R, Theis S, Deeg HJ, CDK-inhibitor independent cell cycle progression in an experimental haematopoietic stem cell leukaemia despite unaltered Rb-phosphorylation, British Journal of Cancer, 81(5), 808-13, November 1999 Abstract
  • Curtis RE, Travis LB, Rowlings PA, Socie G, Kingma DW, Banks PM, Jaffe ES, Sale GE, Horowitz MM, Witherspoon RP, Shriner DA, Weisdorf DJ, Kolb HJ, Sullivan KM, Sobocinski KA, Gale RP, Hoover RN, Fraumeni JF, Deeg HJ, Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study, Blood, 94(7), 2208-16, 1999 Abstract
  • Storb R, Yu C, Barnett T, Wagner JL, Deeg HJ, Nash RA, Kiem HP, McSweeney P, Seidel K, Georges G, Zaucha JM, Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantation., Blood, 94(3), 1131-6, 1 Aug 1999 Abstract
  • Guardiola P, Anderson JE, Bandini G, Cervantes F, Runde V, Arcese W, Bacigalupo A, Przepiorka D, O''Donnell MR, Polchi P, Buzyn A, Sutton L, Cazals-Hatem D, Sale G, de Witte T, Deeg HJ, Gluckman E, Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto de, Blood, 93(9), 2831-8, 1 May 1999 Abstract
  • Deeg HJ, Seidel K, Casper J, Anasetti C, Davies S, Gajeweski JL, Territo M, Ramsay N, Harris RE, Catro-Malaspina H, Collins R, Champlin R, Schoch G, King R, Howe C, Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy., Biology of Blood and Marrow Transplantation, 5(4), 243-52, 1999 Abstract
  • Storb R, Raff RF, Graham T, Appelbaum FR, Deeg HJ, Schuening FG, Sale G, Seidel K, Dose rate-dependent marrow toxicity of TBI in dogs and marrow sparing effect at high dose rate by dose fractionation., Biology of Blood and Marrow Transplantation, 5(3), 155-61, 1999 Abstract
  • Feinstein LC, Seidel K, Jocum J, Bowden RA, Anasetti C, Deeg HJ, Flowers ME, Kansu E, Martin PJ, Nash RA, Storek J, Etzioni R, Applebaum FR, Hansen JA, Storb R, Sullivan KM, Reduced dose intravenous immunoglobulin does not decrease transplant-related complications in adults given related donor marrow allografts., Biology of Blood and Marrow Transplantation, 5(6), 369-78, 1999 Abstract
  • Deeg HJ, Delayed complications after hematopoietic cell transplantation, Hematopoietic Cell Transplantation, 2nd Edition (Book Chapter 66), 776-788, 1999
  • Deeg HJ, Witherspoon RP, Sullivan KM, Flowers M., Long-term observations following hematopoietic cell transplantation, Autologous Blood and Marrow Transplantation, Proceedings of the Ninth International Symposium, Arlington, Texas., 507-509, 1999
  • Gersuk GM, Beckham C, Loken MR, Kiener P, Anderson JE, Farrand A, Troutt AB, Ledbetter JA, Deeg HJ, A role for tumour necrosis factor-alpha, Fas and Fas-Ligand in marrow failure associated with myelodysplastic syndrome., British Journal of Haematology, 103(1), 176-88, October 1998 Abstract
  • Deeg HJ, Leisenring W, Storb R, Nims J, Flowers ME, Witherspoon RP, Sanders J, Sullivan KM, Long-term outcome after marrow transplantation for severe aplastic anemia., Blood, 91(10), 3637-45, 15 1998 Abstract
  • Yu C, Seidel K, Nash R A, Deeg H J, Sandmaier B M, Barsoukov A, Santos E, Storb R, Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease among lethally irradiated dogs given DLA-nonidentical unrelated marrow grafts., Blood, 91(7), 2581-7, 1 Apr 1998 Abstract
  • Deeg H J, Socie G, Malignancies after hematopoietic stem cell transplantation: many questions, some answers., Blood, 91(6), 1833-44, 15 Mar 1998 Abstract
  • Storb R, Raff R, Deeg H J, Graham T, Appelbaum F R, Schuening F G, Shulman H, Seidel K, Leisenring W, Dose rate-dependent sparing of the gastrointestinal tract by fractionated total body irradiation in dogs given marrow autografts., International Journal of Radiation Oncology, Biology, Physics, 40(4), 961-6, 1 Mar 1998 Abstract
  • Deeg HJ, Klingemann HG, Phillips GL, Van Zant G., , A Guide to Blood and Marrow Transplantation, 3rd, Completely Revised Edition, 1998
  • Deeg HJ, Bowden R., Introduction to marrow and blood stem cell transplantation, Transplant Infections (Book Chapter), 1-12, 1998
  • Schuler US, Ehrsam M, Schneider A, Schmidt H, Deeg J, Ehninger G., Pharmacokinetics of intravenous busulfan and evaluation of the bioavailability of the oral formulation in conditioning for haematopoietic stem cell transplantation, Bone Marrow Transplantation, 22, 241-244, 1998
  • Greenberg P, Bishop M, Deeg J, Estey E, Erba H, Gore S, Nimer S, O'Donnell M, Stone R, Tallman M, Bennett J., NCCN practice guidelines for the myelodysplastic syndromes, Oncology, 12, 53-79, 1998
  • Schuening F G, von Kalle C, Kiem H P, Appelbaum F R, Deeg H J, Pepe M, Gooley T, Graham T C, Hackman R C, Storb R, Effect of recombinant canine stem cell factor, a c-kit ligand, on hematopoietic recovery after DLA-identical littermate marrow transplants in dogs., Experimental Hematology, 25(12), 1240-5, November 1997 Abstract
  • Storb R, Leisenring W, Anasetti C, Appelbaum F R, Deeg H J, Doney K, Martin P, Sullivan K M, Witherspoon R, Pettinger M, Bensinger W, Buckner C D, Clift R, Flowers M E, Hansen J A, Pepe M, Chauncey T, Sanders J, Thomas E D, Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine?, Biology of Blood and Marrow Transplantation, 3(4), 194-201, October 1997 Abstract
  • Lee J W, Gersuk G M, Kiener P A, Beckham C, Ledbetter J A, Deeg H J, HLA-DR-triggered inhibition of hemopoiesis involves Fas/Fas ligand interactions and is prevented by c-kit ligand., Journal of Immunology, 159(7), 3211-9, 1 Oct 1997 Abstract
  • Lee J W, Beckham C, Michel B R, Rosen H, Deeg H J, HLA-DR-mediated signals for hematopoiesis and induction of apoptosis involve but are not limited to a nitric oxide pathway., Blood, 90(1), 217-25, 1 Jul 1997 Abstract
  • Huss R, Myerson D H, Deeg H J, Haematopoietic progenitor cells transfected with a differentiation antigen show cellular transformation and tumour growth in mice., International Journal of Experimental Pathology, 78(3), 177-85, June 1997 Abstract
  • Deeg H J, Lin D, Leisenring W, Boeckh M, Anasetti C, Appelbaum F R, Chauncey T R, Doney K, Flowers M, Martin P, Nash R, Schoch G, Sullivan K M, Witherspoon R P, Storb R, Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: a prospective, randomized trial., Blood, 89(10), 3880-7, 15 May 1997 Abstract
  • Storb R, Leisenring W, Anasetti C, Appelbaum F R, Buckner C D, Bensinger W I, Chauncey T, Clift R A, Deeg H J, Doney K C, Flowers M E, Hansen J A, Martin P J, Sanders J E, Sullivan K M, Witherspoon R P, Long-term follow-up of allogeneic marrow transplants in patients with aplastic anemia conditioned by cyclophosphamide combined with antithymocyte globulin, Blood, 89(10), 3890-1, 15 May 1997 Abstract
  • Slattery J T, Clift R A, Buckner C D, Radich J, Storer B, Bensinger W I, Soll E, Anasetti C, Bowden R, Bryant E, Chauncey T, Deeg H J, Doney K C, Flowers M, Gooley T, Hansen J A, Martin P J, McDonald G B, Nash R, Petersdorf E W, Sanders J E, Schoch G, Stewart P, Storb R, Appelba, Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation., Blood, 89(8), 3055-60, 15 Apr 1997 Abstract
  • Storb R, Yu C, Wagner J L, Deeg H J, Nash R A, Kiem H P, Leisenring W, Shulman H, Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation., Blood, 89(8), 3048-54, 15 Apr 1997 Abstract
  • Curtis R E, Rowlings P A, Deeg H J, Shriner D A, Socie G, Travis L B, Horowitz M M, Witherspoon R P, Hoover R N, Sobocinski K A, Fraumeni J F Jr, Boice J D Jr, Solid cancers after bone marrow transplantation, New England Journal of Medicine, 336(13), 897-904, 27 Mar 1997 Abstract
  • Deeg H J, Seidel K, Hong D S, Yu C, Huss R, Schuening F G, Ewel C H, Storb R, In vivo radioprotective effect of AcSDKP on canine myelopoiesis., Annals of Hematology, 74(3), 117-22, March 1997 Abstract
  • Huss R, Deeg H J, Intrathymic maturation of CD4+ T-lymphocytes in an MHC class II deficient transplant model., Tissue Antigens, 49(1), 70-3, January 1997 Abstract
  • Lee JW, Deeg HJ., Choosing a regimen for prophylaxis of graft-versus-host disease, BioDrugs, 7, 15-22, 1997
  • Huss R, Deeg HJ, Lohrs U., Leukamoide transformation von hamatopoetischen stammzellen durch die transfektion eines differenzierungsantigens, Verhandlungen Der Deutschen Gesellschaft Fur Pathologie, 81, 1, 1997
  • Sandmaier B M, Storb R, Liu Y, Santos E B, Bryant E, Schuening F G, Deeg H J, Seidel K, Graham T, An anti-CD44 antibody does not enhance engraftment of DLA-identical marrow after low-dose total body irradiation., Transplant Immunology, 4(4), 271-4, December 1996 Abstract
  • Nash R A, Pineiro L A, Storb R, Deeg H J, Fitzsimmons W E, Furlong T, Hansen J A, Gooley T, Maher R M, Martin P, McSweeney P A, Sullivan K M, Anasetti C, Fay J W, FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors., Blood, 88(9), 3634-41, 1 Nov 1996 Abstract
  • Huss R, Deeg H J, Gooley T, Bryant E, Leisenring W, Clift R, Buckner C D, Martin P, Storb R, Appelbaum F R, Effect of mixed chimerism on graft-versus-host disease, disease recurrence and survival after HLA-identical marrow transplantation for aplastic anemia or chronic myelogenous leukemia., Bone Marrow Transplantation, 18(4), 767-76, October 1996 Abstract
  • Schuening F G, Graham T C, Hackman R, Deeg H J, Storb R, DLA-nonidentical unrelated marrow grafts after high-dose total body irradiation: granulocyte colony-stimulating factor treatment after transplant does not enhance engraftment, Blood, 88(5), 1900-2, 1 Sep 1996 Abstract
  • Kiem H P, Leisenring W, Raff R, Deeg H J, Schuening F G, Appelbaum F R, Storb R, Failure of recombinant stem cell factor to enhance engraftment of L-leucyl-L-leucine methyl ester treated canine marrow after irradiation, Blood, 88(5), 1896-7, 1 Sep 1996 Abstract
  • Martin P J, Nelson B J, Appelbaum F R, Anasetti C, Deeg H J, Hansen J A, McDonald G B, Nash R A, Sullivan K M, Witherspoon R P, Scannon P J, Friedmann N, Storb R, Evaluation of a CD5-specific immunotoxin for treatment of acute graft-versus-host disease after allogeneic marrow transplantation., Blood, 88(3), 824-30, 1 Aug 1996 Abstract
  • Gersuk G M, Lee J W, Beckham C A, Anderson J, Deeg H J, Fas (CD95) receptor and Fas-ligand expression in bone marrow cells from patients with myelodysplastic syndrome, Blood, 88(3), 1122-3, 1 Aug 1996 Abstract
  • Deeg H J, Pierpaoli W, Arrighi S, Seidel K, Graham T, Huss R, Yu C, Myerson D, Schuening F, Storb R, Facilitation of DLA-incompatible marrow grafts by donor-specific serum transferrin?, Transplant Immunology, 4(2), 113-6, June 1996 Abstract
  • Flowers M E, Sullivan K M, Deeg H J, Graft-versus-host reactions: anti-leukemia effects of donor T cells., Transplantation Proceedings, 28(3), 1184-5, June 1996 Abstract
  • Deeg H J, Seidel K, Yu C, Nash R, Huss R, Schuening F, Storb R, Delay of radiation-induced decline and recovery of hematopoiesis following treatment with anti-HLA-DR antibody., Biology of Blood and Marrow Transplantation, 2(2), 105-11, May 1996 Abstract
  • Kiem H P, McDonald G B, Myerson D, Spurgeon C L, Deeg H J, Sanders J E, Doney K, Appelbaum F R, Sullivan K M, Witherspoon R P, Storb R, Marrow transplantation for hepatitis-associated aplastic anemia: a follow-up of long-term survivors., Biology of Blood and Marrow Transplantation, 2(2), 93-9, May 1996 Abstract
  • Sandmaier B M, Storb R, Santos E B, Krizanac-Bengez L, Lian T, McSweeney P A, Yu C, Schuening F G, Deeg H J, Graham T, Allogenic transplant of canine peripheral blood stem cells mobilized by recombinant canine hematopoietic growth factors., Blood, 87(8), 3508-13, 15 Apr 1996 Abstract
  • Yu C, Storb R, Deeg H J, Graham T C, Scheuning F G, Huss R, Seidel K, Fitzsimmons W E, Tacrolimus (FK506) and methotrexate regimens to prevent graft-versus-host disease after unrelated dog leukocyte antigen (DLA) nonidentical marrow transplantation., Bone Marrow Transplantation, 17(4), 649-53, April 1996 Abstract
  • Sanders J E, Hawley J, Levy W, Gooley T, Buckner C D, Deeg H J, Doney K, Storb R, Sullivan K, Witherspoon R, Appelbaum F R, Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation., Blood, 87(7), 3045-52, 1 Apr 1996 Abstract
  • Huss R, Hong D S, Beckham C, Storb R, Broudy V C, Deeg H J, Neutralization of stem cell factor in vitro and in vivo: dose-dependent inhibition of stromal cells and induction of granulocyte/monocyte differentiation., Annals of Hematology, 72(4), 253-9, April 1996 Abstract
  • Langston A A, Sanders J E, Deeg H J, Crawford S W, Anasetti C, Sullivan K M, Flowers M E, Storb R, Allogeneic marrow transplantation for aplastic anaemia associated with dyskeratosis congenita., British Journal of Haematology, 92(3), 758-65, March 1996 Abstract
  • Flowers M E, Zanis J, Pasquini R, Deeg H J, Ribeiro R, Longton G, Medeiros C R, Doney K, Sanders J, Bryant J, et al, Marrow transplantation for Fanconi anaemia: conditioning with reduced doses of cyclophosphamide without radiation, British Journal of Haematology, 92(3), 699-706, March 1996 Abstract
  • Sullivan K M, Storek J, Kopecky K J, Jocom J, Longton G, Flowers M, Siadak M, Nims J, Witherspoon R P, Anasetti C, Appelbaum F R, Bowden R A, Buckner C D, Crawford S W, Deeg H J, Hansen J A, McDonald G B, Sanders J E, Storb R, A controlled trial of long-term administration of intravenous immunoglobulin to prevent late infection and chronic graft-vs.-host disease after marrow transplantation: clinical outcome and effect on s, Biology of Blood and Marrow Transplantation, 2(1), 44-53, February 1996 Abstract
  • Michallet M, Archimbaud E, Bandini G, Rowlings P A, Deeg H J, Gahrton G, Montserrat E, Rozman C, Gratwohl A, Gale R P, HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia. European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplan, Annals of Internal Medicine, 124(3), 311-5, 1 Feb 1996 Abstract
  • Bean M A, Graham T, Appelbaum F R, Deeg H J, Schuening F, Sale G E, Leisenring W, Pepe M, Storb R, Gamma radiation of blood products prevents rejection of subsequent DLA-identical marrow grafts. Tolerance versus abrogation of sensitization to non-DLA antigens., Transplantation, 61(2), 334-5, 27 Jan 1996 Abstract
  • Wagner J L, Deeg H J, Seidel K, Anasetti C, Doney K, Sanders J, Sullivan K M, Storb R, Bone marrow transplantation for severe aplastic anemia from genotypically HLA-nonidentical relatives. An update of the Seattle experience., Transplantation, 61(1), 54-61, 15 Jan 1996 Abstract
  • Deeg H J, Socie G, Schoch G, Henry-Amar M, Witherspoon R P, Devergie A, Sullivan K M, Gluckman E, Storb R, Malignancies after marrow transplantation for aplastic anemia and fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients., Blood, 87(1), 386-92, 1 Jan 1996 Abstract
  • Anderson J E, Appelbaum F R, Schoch G, Gooley T, Anasetti C, Bensinger W I, Bryant E, Buckner C D, Chauncey T, Clift R A, Deeg H J, Doney K, Flowers M, Hansen J A, Martin P J, Matthews D C, Nash R A, Sanders J E, Shulmann H, Sullivan K M, Witherspoon R P, Storb R, Allogeneic marrow transplantation for myelodysplastic syndrome with advanced disease morphology: a phase II study of busulfan, cyclophosphamide, and total-body irradiation and analysis of prognostic f, Journal of Clinical Oncology, 14, 220-6, January 1996 Abstract
  • Storb R, Deeg H J, Raff R, Schuening F, Yu C, Sandmaier B M, Graham T, Prevention of graft-versus-host disease. Studies in a canine model., Annals of The New York Academy of Sciences, 770, 149-64, 29 Dec 1995 Abstract
  • Yu C, Storb R, Mathey B, Deeg H J, Schuening F G, Graham T C, Seidel K, Burnett R, Wagner J L, Shulman H, et al, DLA-identical bone marrow grafts after low-dose total body irradiation: effects of high-dose corticosteroids and cyclosporine on engraftment., Blood, 86(11), 4376-81, 1 Dec 1995 Abstract
  • Hong D S, Beckham C, Huss R, Lee J W, Hockenbery D, Ledbetter J A, Deeg H J, Major histocompatibility complex class II-mediated inhibition of hematopoiesis in long-term marrow cultures involves apoptosis and is prevented by c-kit ligand, Blood, 86(9), 3341-52, 1 Nov 1995 Abstract
  • Huss R, Firpo E, Deeg H J, Stem cell factor-induced expression of p27kip-1 during hematopoietic differentiation., Experimental and Molecular Pathology, 63(2), 129-34, October 1995 Abstract
  • Huss R, Smith F O, Myerson D H, Deeg H J, Homing and immunogenicity of murine stromal cells transfected with xenogeneic MHC class II genes., Cell Transplantation, 4(5), 483-91, Autumn 1995 Abstract
  • Nash R A, Burstein S A, Storb R, Yang W, Abrams K, Appelbaum F R, Boone T, Deeg H J, Durack L D, Schuening F G, Thrombocytopenia in dogs induced by granulocyte-macrophage colony-stimulating factor: increased destruction of circulating platelets., Blood, 86(5), 1765-75, 1 Sep 1995 Abstract
  • Bader P, Klingebiel T, Klingel K, Foll J, Beck J, Handgretinger R, Ehninger G, Deeg H J, Niethammer D, Remission of a lymphoproliferative disorder occurring after second BMT from an unrelated donor in a 5-year-old boy with severe aplastic anemia., Bone Marrow Transplantation, 16(3), 479-81, September 1995 Abstract
  • Yu C, Storb R, Braude I, Deeg H J, Schuening F G, Huss R, Graham T C, Corticotropin releasing factor with or without methotrexate for prevention of graft-versus-host disease in DLA-nonidentical unrelated canine marrow grafts., Transplantation, 60(4), 384-6, 27 Aug 1995 Abstract
  • Crawford S W, Pepe M, Lin D, Benedetti F, Deeg H J, Abnormalities of pulmonary function tests after marrow transplantation predict nonrelapse mortality., American Journal of Respiratory and Critical Care Medicine, 152(2), 690-5, August 1995 Abstract
  • Doney K C, Storb R, Beach K, Anasetti C, Deeg H J, Hansen J A, Martin P J, Nash R A, Schubert M M, Sullivan K M, et al, A toxicity study of trimetrexate used in combination with cyclosporine as acute graft-versus-host disease prophylaxis in HLA-mismatched, related donor bone marrow transplants., Transplantation, 60(1), 55-8, 15 Jul 1995 Abstract
  • Demirer T, Petersen F B, Appelbaum F R, Barnett T A, Sanders J, Deeg H J, Storb R, Doney K, Bensinger W I, Shannon-Dorcy K, et al, Allogeneic marrow transplantation following cyclophosphamide and escalating doses of hyperfractionated total body irradiation in patients with advanced lymphoid malignancies: a Phase I/II trial., International Journal of Radiation Oncology, Biology, Physics, 32(4), 1103-9, 15 Jul 1995 Abstract
  • Mathey B, Yu C, Sandmaier B M, Deeg H J, Graham T, Schuening F G, Nash R A, Stor B, Failure of interleukin-1 and granulocyte-macrophage colony-stimulating factor to enhance allogeneic marrow engraftment and survival in irradiated dogs, Blood, 86(2), 833-4, 15 Jul 1995 Abstract
  • Hong D S, Graham T, Ewel C, Storb R, Deeg H J, Inhibition of hematopoiesis in long-term marrow cultures established on adherent layers from AcSDKP-treated dogs., Experimental Hematology, 23(7), 639-44, July 1995 Abstract
  • Benyunes M C, Sullivan K M, Deeg H J, Mori M, Meyer W, Fisher L, Bensinger R, Jack M K, Hicks J, Witherspoon R, et al, Cataracts after bone marrow transplantation: long-term follow-up of adults treated with fractionated total body irradiation., International Journal of Radiation Oncology, Biology, Physics, 32(3), 661-70, 15 Jun 1995 Abstract
  • Ehninger G, Schuler U, Renner U, Ehrsam M, Zeller K P, Blanz J, Storb R, Deeg H J, Use of a water-soluble busulfan formulation--pharmacokinetic studies in a canine model., Blood, 85(11), 3247-9, 1 Jun 1995 Abstract
  • Nemunaitis J, Rosenfeld C S, Ash R, Freedman M H, Deeg H J, Appelbaum F, Singer J W, Flomenberg N, Dalton W, Elfenbein G J, et al, Phase III randomized, double-blind placebo-controlled trial of rhGM-CSF following allogeneic bone marrow transplantation., Bone Marrow Transplantation, 15(6), 949-54, June 1995 Abstract
  • Huss R, Nepom G T, Deeg H J, Defective CD4+ T-lymphocyte reconstitution in major histocompatibility complex class II-deficient transplant models, Blood, 85(11), 3354-6, 1 Jun 1995 Abstract
  • Storb R, Raff R F, Deeg H J, Graham T C, Schuening F G, Shulman H, Bryant E, DLA-identical marrow grafts after low-dose total-body irradiation. Addition of viable donor peripheral blood mononuclear cells does not enhance engraftment., Transplantation, 59(10), 1481-2, 27 May 1995 Abstract
  • Huss R, Hoy C A, Deeg H J, Contact- and growth factor-dependent survival in a canine marrow-derived stromal cell line., Blood, 85(9), 2414-21, 1 May 1995 Abstract
  • Nash R A, Seidel K, Storb R, Slichter S, Schuening F G, Appelbaum F R, Becker A B, Bolles L, Deeg H J, Graham T, et al, Effects of rhIL-11 on normal dogs and after sublethal radiation., Experimental Hematology, 23(5), 389-96, May 1995 Abstract
  • Deeg H J, Seidel K, Bruemmer B, Pepe M S, Appelbaum F R, Impact of patient weight on non-relapse mortality after marrow transplantation., Bone Marrow Transplantation, 15(3), 461-8, March 1995 Abstract
  • Rossetti F, Deeg H J, Hackman R C, Early pulmonary recurrence of non-Hodgkin's lymphoma after autologous marrow transplantation: evidence for reinfusion of lymphoma cells?, Bone Marrow Transplantation, 15(3), 429-32, March 1995 Abstract
  • Huss R, Hoy C A, Ottinger H, Grosse-Wilde H, Deeg H J, Cyclosporine-induced apoptosis in CD4+ T lymphocytes and computer-simulated analysis: modeling a treatment scenario for HIV infection., Research In Immunology, 146(2), 101-8, February 1995 Abstract
  • Hong D S, Huss R, Beckham C, Hoy C A, Storb R, Deeg H J, Major histocompatibility complex class II-mediated inhibition of hemopoiesis in vitro and in vivo is abrogated by c-kit ligand., Transplantation Proceedings, 27(1), 642-3, February 1995 Abstract
  • Huss R, Hong D S, McSweeney P A, Hoy C A, Deeg H J, Differentiation of canine bone marrow cells with hemopoietic characteristics from an adherent stromal cell precursor., Proceedings of the National Academy of Sciences (USA), 92(3), 748-52, 31 Jan 1995 Abstract
  • Huss R, Hong D S, Beckham C, Kimball L, Myerson D H, Storb R, Deeg H J, Ultrastructural localization of stem cell factor in canine marrow-derived stromal cells., Experimental Hematology, 23(1), 33-40, January 1995 Abstract
  • Huss R, Beckham C, Storb R, Deeg H J, Major histocompatibility complex class II expression is required for posttransplant immunological but not hemopoietic reconstitution in mice., Transplantation, 58(12), 1366-71, 27 Dec 1994 Abstract
  • Clift R A, Buckner C D, Thomas E D, Bryant E, Anasetti C, Bensinger W I, Bowden R, Deeg H J, Doney K C, Fisher L D, et al, Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia., Blood, 84(12), 4368-73, 15 Dec 1994 Abstract
  • Weaver C H, Petersen F B, Appelbaum F R, Bensinger W I, Press O, Martin P, Sandmaier B, Deeg H J, Hansen J A, Brunvand M, et al, High-dose fractionated total-body irradiation, etoposide, and cyclophosphamide followed by autologous stem-cell support in patients with malignant lymphoma., Journal of Clinical Oncology, 12(12), 2559-66, December 1994 Abstract
  • Weaver C H, Clift R A, Deeg H J, Storb R, Appelbaum F R, Bensinger W, Doney K, Hansen J A, Martin P O, Sanders J, et al, Effect of graft-versus-host disease prophylaxis on relapse in patients transplanted for acute myeloid leukemia., Bone Marrow Transplantation, 14(6), 885-93, December 1994 Abstract
  • Storb R, Raff R F, Appelbaum F R, Deeg H J, Graham T C, Schuening F G, Shulman H, Yu C, Bryant E, Burnett R, et al, DLA-identical bone marrow grafts after low-dose total body irradiation: the effect of canine recombinant hematopoietic growth factors., Blood, 84(10), 3558-66, 15 Nov 1994 Abstract
  • Clift R A, Buckner C D, Thomas E D, Bensinger W I, Bowden R, Bryant E, Deeg H J, Doney K C, Fisher L D, Hansen J A, et al, Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide., Blood, 84(6), 2036-43, 15 Sep 1994 Abstract
  • Huss R, Deeg H J, MHC antigens and haemopoiesis., Transplant Immunology, 2(3), 171-5, September 1994 Abstract
  • Witherspoon R P, Deeg H J, Storb R, Secondary malignancies after marrow transplantation for leukemia or aplastic anemia., Transplantation Science, 4(1), 33-41, September 1994 Abstract
  • Anasetti C, Hansen J A, Waldmann T A, Appelbaum F R, Davis J, Deeg H J, Doney K, Martin P J, Nash R, Storb R, et al, Treatment of acute graft-versus-host disease with humanized anti-Tac: an antibody that binds to the interleukin-2 receptor., Blood, 84(4), 1320-7, 15 Aug 1994 Abstract
  • Storb R, Etzioni R, Anasetti C, Appelbaum F R, Buckner C D, Bensinger W, Bryant E, Clift R, Deeg H J, Doney K, et al, Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia., Blood, 84(3), 941-9, 1 Aug 1994 Abstract
  • Storb R, Raff R F, Appelbaum F R, Deeg H J, Graham T C, Schuening F G, Sale G, Bryant E, Seidel K, Fractionated versus single-dose total body irradiation at low and high dose rates to condition canine littermates for DLA-identical marrow grafts., Blood, 83(11), 3384-9, 1 Jun 1994 Abstract
  • Deeg H J, Anasetti C, Petersdorf E, Storb R, Doney K, Hansen J A, Sanders J, Sullivan K M, Appelbaum F R, Cyclophosphamide plus ATG conditioning is insufficient for sustained hematopoietic reconstitution in patients with severe aplastic anemia transplanted with marrow from HLA-A, B, DRB matched unrelated, Blood, 83(11), 3417-8, 1 Jun 1994 Abstract
  • Witherspoon R P, Deeg H J, Storb R, Secondary malignancies after marrow transplantation for leukemia or aplastic anemia., Transplantation, 57(10), 1413-8, 27 May 1994 Abstract
  • Storb R, Leisenring W, Deeg H J, Anasetti C, Appelbaum F, Bensinger W, Buckner C D, Clift R, Doney K, Hansen J, et al, Long-term follow-up of a randomized trial of graft-versus-host disease prevention by methotrexate/cyclosporine versus methotrexate alone in patients given marrow grafts for severe aplastic anemia [let, Blood, 83(9), 2749-50, 1 May 1994 Abstract
  • Spitzer T R, Peters C, Ortlieb M, Tefft M C, Torrisi J, Cahill R, Gadner H, Urban C, Deeg H J, Etoposide in combination with cyclophosphamide and total body irradiation or busulfan as conditioning for marrow transplantation in adults and children., International Journal of Radiation Oncology, Biology, Physics, 29(1), 39-44, 30 Apr 1994 Abstract
  • Deeg H J, Beckham C, Huss R, Myerson D, Greinix H, Appelbaum F R, Graham T, Schuening F, Storb R, Rescue from anti-MHC class II antibody-mediated marrow graft failure by c-kit ligand., Blood, 83(8), 2352-9, 15 Apr 1994 Abstract
  • Nash R A, Schuening F G, Seidel K, Appelbaum F R, Boone T, Deeg H J, Graham T C, Hackman R, Sullivan-Pepe M, Storb R, Effect of recombinant canine granulocyte-macrophage colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation., Blood, 83(7), 1963-70, 1 Apr 1994 Abstract
  • Kiem H P, Darovsky B, von Kalle C, Goehle S, Stewart D, Graham T, Hackman R, Appelbaum F R, Deeg H J, Miller A D, et al, Retrovirus-mediated gene transduction into canine peripheral blood repopulating cells., Blood, 83(6), 1467-73, 15 Mar 1994 Abstract
  • Sanders J E, Storb R, Anasetti C, Deeg H J, Doney K, Sullivan K M, Witherspoon R P, Hansen J, Marrow transplant experience for children with severe aplastic anemia., American Journal of Pediatric hematology/oncology, 16(1), 43-9, February 1994 Abstract
  • Bean M A, Graham T, Appelbaum F R, Deeg H J, Schuening F, Sale G E, Storb R, Gamma-irradiation of pretransplant blood transfusions from unrelated donors prevents sensitization to minor histocompatibility antigens on dog leukocyte antigen-identical canine marrow grafts., Transplantation, 57(3), 423-6, February 1994 Abstract
  • Hong D S, Deeg H J, Hemopoietic stem cells: sources and applications., Medical Oncology, 11(2), 63-8, 1994 Abstract
  • Deeg H J, Prophylaxis and treatment of acute graft-versus-host disease: current state, implications of new immunopharmacologic compounds and future strategies to prevent and treat acute GVHD in high-risk patien, Bone Marrow Transplantation, 14 Suppl 4, S56-60, 1994 Abstract
  • Deeg H J, Huss R, Major histocompatibility complex class II molecules, hemopoiesis and the marrow microenvironment., Bone Marrow Transplantation, 12(5), 425-30, November 1993 Abstract
  • Doney K, Buckner C D, Fisher L, Petersen F B, Sanders J, Appelbaum F R, Anasetti C, Badger C, Bensinger W, Deeg H J, et al, Autologous bone marrow transplantation for acute lymphoblastic leukemia., Bone Marrow Transplantation, 12(4), 315-21, October 1993 Abstract
  • Deeg H J, Graft-versus-host disease: host and donor views., Seminars In Hematology, 30(4 Suppl 4), 110-7; discussion 11, October 1993 Abstract
  • Storb R, Raff R F, Appelbaum F R, Deeg H J, Fitzsimmons W, Graham T C, Pepe M, Pettinger M, Sale G, van der Jagt R, et al, FK-506 and methotrexate prevent graft-versus-host disease in dogs given 9.2 Gy total body irradiation and marrow grafts from unrelated dog leukocyte antigen-nonidentical donors., Transplantation, 56(4), 800-7, October 1993 Abstract
  • Greinix H T, Storb R, Sanders J E, Deeg H J, Doney K C, Sullivan K M, Witherspoon R P, Long-term survival and cure after marrow transplantation for congenital hypoplastic anaemia (Diamond-Blackfan syndrome)., British Journal of Haematology, 84(3), 515-20, July 1993 Abstract
  • Storb R, Raff R F, Graham T, Appelbaum F R, Deeg H J, Schuening F G, Shulman H, Pepe M, Marrow toxicity of fractionated vs. single dose total body irradiation is identical in a canine model [see comments], International Journal of Radiation Oncology, Biology, Physics, 26(2), 275-83, 20 May 1993 Abstract
  • Deeg H J, Witherspoon R P, Risk factors for the development of secondary malignancies after marrow transplantation., hematology/oncology Clinics of North America, 7(2), 417-29, April 1993 Abstract
  • Raff R F, Storb R, Graham T, Deeg H J, Pepe M, Schaffer R, Sale G E, Schuening F, Appelbaum F R, What role for 15-deoxyspergualin in enhancing engraftment of unrelated, histoincompatible canine marrow grafts and preventing graft-versus-host disease?, Transplantation, 55(3), 684-8, March 1993 Abstract
  • Loughran T P Jr, Deeg H J, Storb R, Inhibition of canine NK activity by anti-CD18 monoclonal antibody, UV irradiation and cyclosporine., Experimental Hematology, 21(3), 411-3, March 1993 Abstract
  • Ringden O, Horowitz M M, Sondel P, Gale R P, Biggs J C, Champlin R E, Deeg H J, Dicke K, Masaoka T, Powles R L, et al, Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia?, Blood, 81(4), 1094-101, 15 Feb 1993 Abstract
  • Schuening F, Bean M A, Deeg H J, Storb R, Prevention of graft failure in patients with aplastic anemia., Bone Marrow Transplantation, 12 Suppl 3, S48-9, 1993 Abstract
  • Schuening F G, Appelbaum F R, Deeg H J, Sullivan-Pepe M, Graham T C, Hackman R, Zsebo K M, Storb R, Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation., Blood, 81(1), 20-6, 1 Jan 1993 Abstract
  • Raff R F, Storb R, Graham T, Fidler J M, Sale G E, Johnston B, Deeg H J, Pepe M, Schuening F, Appelbaum F R, et al, Pharmacologic, toxicologic, and marrow transplantation studies in dogs given succinyl acetone [see comments], Transplantation, 54(5), 813-20, November 1992 Abstract
  • Raff R F, Storb R, Graham T, Sale G, Shulman H, Pepe M, Deeg H J, Schuening F, Appelbaum F R, Fidler J M, et al, Succinyl acetone plus methotrexate as graft-versus-host disease prophylaxis in DLA-haploidentical canine littermate marrow grafts [comment], Transplantation, 54(5), 947-8, November 1992 Abstract
  • Nash R A, Pepe M S, Storb R, Longton G, Pettinger M, Anasetti C, Appelbaum F R, Bowden R A, Deeg H J, Doney K, et al, Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate [see comments], Blood, 80(7), 1838-45, 1 Oct 1992 Abstract
  • Appelbaum F R, Brown P A, Sandmaier B M, Storb R, Fisher D R, Shulman H M, Graham T C, Schuening F G, Deeg H J, Bianco J A, et al, Specific marrow ablation before marrow transplantation using an aminophosphonic acid conjugate 166Ho-EDTMP., Blood, 80(6), 1608-13, 15 Sep 1992 Abstract
  • Storb R, Pepe M, Deeg H J, Anasetti C, Appelbaum F R, Bensinger W, Buckner C D, Cliff R A, Doney K, Hansen J, et al, Long-term follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with cyclosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-id, Blood, 80(2), 560-1, 15 Jul 1992 Abstract
  • Spitzer T R, Cottler-Fox M, Sullivan P, Lynch M, Tefft M C, Pickle L W, Cirenza E, Cahill R, Deeg H J, Sacher R, Continuous infusion intravenous immunoglobulin is associated with a reduced incidence of infection and achieves higher serum immunoglobulin G levels than intermittent infusion following bone marrow tr, Seminars In Hematology, 29(3 Suppl 2), 123-6, July 1992 Abstract
  • Petersen F B, Buckner C D, Appelbaum F R, Sanders J E, Bensinger W I, Storb R, Deeg H J, Witherspoon R P, Sullivan K M, Clift R A, et al, Etoposide, cyclophosphamide and fractionated total body irradiation as a preparative regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study., Bone Marrow Transplantation, 10(1), 83-8, July 1992 Abstract
  • Storb R, Martin P, Deeg H J, Sanders J E, Pepe M, Singer J, Anasetti C, Stewart P, Appelbaum F R, Sullivan K M, et al, Long-term follow-up of three controlled trials comparing cyclosporine versus methotrexate for graft-versus-host disease prevention in patients given marrow grafts for leukemia [letter], Blood, 79(11), 3091-2, 1 Jun 1992 Abstract
  • Nevill T J, Tirgan M H, Deeg H J, Klingemann H G, Reece D E, Shepherd J D, Barnett M J, Phillips G L, Influence of post-methotrexate folinic acid rescue on regimen-related toxicity and graft-versus-host disease after allogeneic bone marrow transplantation [see comments], Bone Marrow Transplantation, 9(5), 349-54, May 1992 Abstract
  • Deeg H J, Modification of allointeractions after blood transfusion and marrow transplantation by ultraviolet light., Seminars In Hematology, 29(2), 95-101, April 1992 Abstract
  • Flowers M E, Doney K C, Storb R, Deeg H J, Sanders J E, Sullivan K M, Bryant E, Witherspoon R P, Appelbaum F R, Buckner C D, et al, Marrow transplantation for Fanconi anemia with or without leukemic transformation: an update of the Seattle experience., Bone Marrow Transplantation, 9(3), 167-73, March 1992 Abstract
  • Petersdorf E W, Deeg H J, Diagnostic use of molecular probes before and after marrow transplantation [published erratum appears in Clin Lab Med 1992 Sep;12(3):xiii], Clinics In Laboratory Medicine, 12(1), 113-28, March 1992 Abstract
  • Deeg H J, Erickson K, Storb R, Sullivan K M, Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation., Blood Cells, 18(1), 151-61; discussion 1, 1992 Abstract
  • Petersen F B, Deeg H J, Buckner C D, Appelbaum F R, Storb R, Clift R A, Sanders J E, Bensinger W I, Witherspoon R P, Sullivan K M, et al, Marrow transplantation following escalating doses of fractionated total body irradiation and cyclophosphamide--a phase I trial., International Journal of Radiation Oncology, Biology, Physics, 23(5), 1027-32, 1992 Abstract
  • Storb R, Longton G, Anasetti C, Appelbaum F R, Beatty P, Bensinger W, Crawford S, Deeg H J, Doney K, Fefer A, et al, Changing trends in marrow transplantation for aplastic anemia., Bone Marrow Transplantation, 10 Suppl 1, 45-52, 1992 Abstract
  • Appelbaum F R, Badger C C, Bernstein I D, Buckner C D, Deeg H J, Eary J F, Matthews D C, Press O W, Storb R, Thomas E D, Is there a better way to deliver total body irradiation?, Bone Marrow Transplantation, 10 Suppl 1, 77-81, 1992 Abstract
  • Bazar L S, Deeg H J, Ultraviolet B-induced DNA fragmentation (apoptosis) in activated T-lymphocytes and Jurkat cells is augmented by inhibition of RNA and protein synthesis., Experimental Hematology, 20(1), 80-6, January 1992 Abstract
  • Cohn M L, Cahill R A, Deeg H J, Hematopoietic reconstitution and prevention of graft-versus-host disease with UVB-irradiated haploidentical murine spleen and marrow cells., Blood, 78(12), 3317-22, 15 Dec 1991 Abstract
  • Greinix H T, Ladiges W C, Graham T C, Maslan S, Raff R F, Sandmaier B M, Appelbaum F R, Schuening F G, Deeg H J, Storb R, Late failure of autologous marrow grafts in lethally irradiated dogs given anti-class II monoclonal antibody., Blood, 78(8), 2131-8, 15 Oct 1991 Abstract
  • Cottler-Fox M, Himoe E, Blancato J K, Deeg H J, Documentation of allogeneic marrow engraftment by DNA analysis of urinary leucocytes., British Journal of Haematology, 79(1), 122-3, September 1991 Abstract
  • Storb R, Sanders J E, Pepe M, Anasetti C, Appelbaum F R, Buckner C D, Deeg H J, Doney K, Hansen J, Martin P, et al, Graft-versus-host disease prophylaxis with methotrexate/cyclosporine in children with severe aplastic anemia treated with cyclophosphamide and HLA-identical marrow grafts, Blood, 78(4), 1144-5, 15 Aug 1991 Abstract
  • Storb R, Anasetti C, Appelbaum F, Bensinger W, Buckner C D, Clift R, Deeg H J, Doney K, Hansen J, Loughran T, et al, Marrow transplantation for severe aplastic anemia and thalassemia major., Seminars In Hematology, 28(3), 235-9, July 1991 Abstract
  • Cottler-Fox M, Lynch M, Pickle L W, Cahill R, Spitzer T R, Deeg H J, Some but not all benefits of intravenous immunoglobulin therapy after marrow transplantation appear to correlate with IgG trough levels., Bone Marrow Transplantation, 8(1), 27-33, July 1991 Abstract
  • deGast G C, Beatty P G, Amos D, Mickelson E M, Sullivan K M, Anderson J E, Giblett E R, Appelbaum F, Storb R, Deeg H J, et al, Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease., Bone Marrow Transplantation, 7(4), 293-5, April 1991 Abstract
  • Deeg H J, Spitzer T R, Cottler-Fox M, Cahill R, Pickle L W, Conditioning-related toxicity and acute graft-versus-host disease in patients given methotrexate/cyclosporine prophylaxis., Bone Marrow Transplantation, 7(3), 193-8, March 1991 Abstract
  • Klingemann H G, Storb R, Deeg H J, Inhibition of cluster formation and lymphocyte proliferation by anti-fibronectin antiserum., Journal of Leukocyte Biology, 49(2), 152-7, February 1991 Abstract
  • Spitzer T R, Swain S M, Lippman M E, Deeg H J, Reimbursement for solid tumor autologous bone marrow transplantation trials: a strategy for ensuring continuation of a promising therapy., Cancer Investigation, 9(1), 93-7, 1991 Abstract
  • Cahill R A, Zhao Y, Murphy R, Sala A, Foegh M, Spitzer T, Deeg H J, High urinary leukotriene E4 (LTE4) and thromboxane 2 (TXB2) levels are associated with capillary leak syndrome in bone marrow transplant patients., Advances In Prostaglandin, Thromboxane, and Leukotriene Research, 21B, 525-8, 1991 Abstract
  • Spitzer T R, Cahill R, Cottler-Fox M, Treat J, Sacher R, Deeg H J, Transfusion-induced graft-versus-host disease in patients with malignant lymphoma. A case report and review of the literature., Cancer, 66(11), 2346-9, 1 Dec 1990 Abstract
  • Capon S M, Sacher R A, Deeg H J, Effective ultraviolet irradiation of platelet concentrates in teflon bags., Transfusion, 30(8), 678-81, October 1990 Abstract
  • Areman E M, Sacher R A, Deeg H J, Processing and storage of human bone marrow: a survey of current practices in North America., Bone Marrow Transplantation, 6(3), 203-9, September 1990 Abstract
  • Spitzer T R, Himoe E, Cottler-Fox M, Cahill R, Deeg H J, Long-term stable mixed chimaerism following allogeneic marrow transplantation for severe aplastic anaemia, British Journal of Haematology, 76(1), 146-7, September 1990 Abstract
  • Slichter S J, Deeg H J, Osborne W R, Inhibition of the enzyme purine nucleoside phosphorylase (PNP) reduces refractoriness to transfused platelets in a dog model., British Journal of Haematology, 75(4), 591-7, August 1990 Abstract
  • Falchuk S C, Spitzer T R, Deeg H J, Pseudotumor cerebri after ABMT, Bone Marrow Transplantation, 6(2), 152-3, August 1990 Abstract
  • Areman E M, Sacher R A, Deeg H J, Bone marrow storage and processing: is it time to set standards?, Transfusion, 30(6), 574-5, Summer 1990 Abstract
  • Greenspan A, Deeg H J, Cottler-Fox M, Sirdofski M, Spitzer T R, Kattah J, Incapacitating peripheral neuropathy as a manifestation of chronic graft-versus-host disease., Bone Marrow Transplantation, 5(5), 349-52, May 1990 Abstract
  • Deeg H J, Shulman H M, Albrechtsen D, Graham T C, Storb R, Koppang N, Batten's disease: failure of allogeneic bone marrow transplantation to arrest disease progression in a canine model., Clinical Genetics, 37(4), 264-70, April 1990 Abstract
  • Cottler-Fox M, Torrisi J, Spitzer T R, Deeg H J, Increased toxicity of total body irradiation in patients receiving interferon for leukaemia, Lancet, 335(8682), 174, 20 Jan 1990 Abstract
  • Areman E M, Sacher R A, Deeg H J, Cryopreservation and storage of human bone marrow: a survey of current practices., Progress In Clinical and Biological Research, 333, 523-9, 1990 Abstract
  • Areman E M, Cullis H, Sacher R A, Cottler-Fox M, Deeg H J, Automated isolation of mononuclear cells using the Fenwal CS3000 blood cell separator., Progress In Clinical and Biological Research, 333, 379-85, 1990 Abstract
  • Cottler-Fox M, Bazar L S, Deeg H J, Isolation of hemopoietic precursor cells from human marrow by negative selection using monoclonal antibodies and immunomagnetic beads., Progress In Clinical and Biological Research, 333, 277-84, 1990 Abstract
  • Aprile J, Gerhard-Miller L, Deeg H J, Cluster formation of canine dendritic cells and lymphocytes is calcium dependent and not inhibited by cyclosporine., Experimental Hematology, 18(1), 32-6, January 1990 Abstract
  • Shields A F, Applebaum F R, Graham T, Deeg H J, Allalunis-Turner J, Chapman J D, Storb R, Bone marrow toxicity of total-body irradiation combined with radiosensitizers., Radiation Research, 120(2), 364-9, November 1989 Abstract
  • Appelbaum F R, Raff R F, Storb R, Deeg H J, Graham T C, Sandmaier B, Schuening F, Use of trimetrexate for the prevention of graft-versus-host disease., Bone Marrow Transplantation, 4(4), 421-4, July 1989 Abstract
  • Storb R, Deeg H J, Pepe M, Appelbaum F, Anasetti C, Beatty P, Bensinger W, Berenson R, Buckner C D, Clift R, et al, Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled tri, Blood, 73(6), 1729-34, 1 May 1989 Abstract
  • Cottler-Fox M, Lynch M, Deeg H J, Koss L G, Human polyomavirus: lack of relationship of viruria to prolonged or severe hemorrhagic cystitis after bone marrow transplant., Bone Marrow Transplantation, 4(3), 279-82, May 1989 Abstract
  • Raschko J W, Cottler-Fox M, Abbondanzo S L, Torrisi J R, Spitzer T R, Deeg H J, Pulmonary fibrosis after bone marrow transplantation responsive to treatment with prednisone and cyclosporine., Bone Marrow Transplantation, 4(2), 201-5, March 1989 Abstract
  • Deeg H J, Koppang N, Shulman H M, Albrechtsen D, Graham T C, Storb R, Allogeneic bone marrow transplantation for canine ceroid lipofuscinosis., Transplantation Proceedings, 21(1 Pt 3), 3082-3, February 1989 Abstract
  • Ladiges W C, Deeg H J, Raff R F, Storb R, Immunogenetic aspects of a canine breeding colony., Laboratory Animal Science, 35(1), 58-62, February 1985 Abstract
  • Deeg H J, Acute and delayed toxicities of total body irradiation. Seattle Marrow Transplant Team., International Journal of Radiation Oncology, Biology, Physics, 9(12), 1933-9, December 1983 Abstract
  • Deeg HJ., Long-term complications after high-dose therapy and hematopoietic cell transplantation, Harwood Academic (In Press)
  • Deeg HJ, Heimfeld S., Alternative sources of hemopoietic stem cells and their clinical applications, Neoplastic diseases of the Blood, 4th Edition. (In Press)
  • Schuler US, Renner U, Kroschinsky F, Johne C, Jenke A, Naumann R, Bornhauser M, Deeg HJ, Ehninger G., Intravenous busulfan for conditioning before autologous or allogeneic human blood stem cell transplantation, British Journal of Haematology (in press)
  • Deeg HJ., Cytokines in graft-vs-host disease and the graft-vs-leukemia reaction, International Journal of Hematology (in press)
  • Anderson JE, Tefferi A, Craig F, Holberg L, Chauncey T, Appelbaum FR, Guardiola P, Callander N, Freytes C, Gazitt Y, Razvillas B, Deeg HJ., Myeloblation and autologous peripheral blood stem cell rescue results in hematological and clinical responses in patients with myeloid metaplasia with myelofibrosis, Blood (In Press)
  • Deeg HJ, Blazar BR, Bolwell BJ, Long GD, Schuening F, Cunningham J, Rifkin RM, Abhyankar S, Briggs AD, Burt R, Lipani J, Roskos LK, White JM, Havrilla N, Schwab G, Heslop HE., Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody, ABX-CBL, Blood (In Press)
  • Klingemann H-G, Deeg HJ., Stem cell transplantation for myelodysplasia, Myelodysplastic Syndromes and Secondary Acute Myelogenous Leukemia: Directions for the New Millenium, Cancer Treatment and Research. (In Press)
  • Benito AI, Furlong T, Martin PJ, Anasetti C, Appelbaum FR, Doney K, Nash RA, Papayannopoulou T, Storb R, Sullivan KM, Witherspoon RP, Deeg HJ., Sirolimus (Rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease, Transplantation (In Press)
  • Zang DY, Goodwin RG, Loken MR, Bryant E, Deeg HJ, Expression of TRIAL (tumor necrosis factor-related apoptosis inducing ligand) and its receptors on marrow cells in myelodysplastic syndrome - effects on in vitro hemopoiesis, Blood (In Press)

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Last Updated: 4/28/2005

COS Expertise ID #135355
Reference this profile directly: http://myprofile.cos.com/DEEG