Robb W. Glenny

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University of Washington
School of Medicine
Physiology and Biophysics
Associate ProfessorAppointed: 1997
University of Washington
School of Medicine
Medicine
Pulmonary and Critical Care Medicine
Associate ProfessorAppointed: 1997

Mailing Address

Box 356522
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-7063
Fax: (206) 685-8673
glenny@u.washington.edu

Qualifications

M.D., University of Virginia, 1984.
M.A., Duke University, Computer Science, 1980.
B.S., Duke University, Biomedical Engineering, 1979.

Expertise and Research Interests

The pulmonary circulation is generally regarded as a largely passive circuit in which blood flow distribution is predominantly determined by the hydrostatic gradient due to gravity; a perspective that has dominated both the interpretation and direction ofstudies related to pulmonary perfusion for the past three decades. As the spatial resolution of perfusion measurements has improved, it has become evident that there is a great deal of variability in regional blood flow distribution not attributable to gravitational effects alone. Fractal analysis, a new mathematical science, provides the insights and tools for constructing a more accurate model of perfusion distribution in the lung. Until recently, observed pulmonary perfusion heterogeneity has been interpreted within the context of the gravitational model as random noise.
The fractal revolution has revealed that this ''error'' can be analyzed as a fundamental property of the biologic system. We are currently exploring the determinants of both spatialand temporal heterogeneity of pulmonary perfusion, using fractal analysis to characterize and interpret our findings. By providing a geometric framework for the description of these apparently irregular patterns, fractals capture both the richness of physiologic structure and its function in a single model.

Keywords

COS Keywords:

Anesthesiology, Blood Flow, Mathematics, Physiological Controls and Systems, Pulmonary Diseases.

Additional Terms:

Anesthesia: Ventilation Perfusion, Respiratory Biology, Respiratory Biology: Lung, Respiratory Biology: Respiratory Airways.

Publications

  • Altemeier WA, Robertson HT, McKinney S, Glenny RW, Pulmonary embolization causes hypoxemia by redistributing regional blood flow without changing ventilation., Journal of Applied Physiology, 85(6), 2337-43, December 1998 Abstract
  • Altemeier WA, Robertson HT, Glenny RW, Pulmonary gas-exchange analysis by using simultaneous deposition of aerosolized and injected microspheres., Journal of Applied Physiology, 85(6), 2344-51, December 1998 Abstract
  • Luchtel DL, Boykin JC, Bernard SL, Glenny RW, Histological methods to determine blood flow distribution with fluorescent microspheres., Biotechnic and Histochemistry, 73(6), 291-309, November 1998 Abstract
  • Mure M, Domino K B, Robertson T, Hlastala M P, Glenny R W, Pulmonary blood flow does not redistribute in dogs with reposition from supine to left lateral position., Anesthesiology, 89(2), 483-92, August 1998 Abstract
  • Limaye AP, Schmidt RA, Glenny RW, Davis CL, Kowdley KV, Successful treatment of severe hepatitis C-associated pulmonary vasculitis in a liver transplant recipient., Transplantation, 65(7), 998-1000, April 1998 Abstract
  • Hlastala MP, Chornuk MA, Self DA, Kallas HJ, Burns JW, Bernard S, Polissar NL, Glenny RW, Pulmonary blood flow redistribution by increased gravitational force., Journal of Applied Physiology, 84(4), 1278-88, April 1998 Abstract
  • Henig NR, Glenny RW, Aitken ML, A hypertrophied bronchial circulatory system may participate in gas exchange [letter], Lancet, 351(9096), 113, Jan 1998 Abstract
  • Walther SM, Domino KB, Glenny RW, Hlastala MP, Pulmonary blood flow distribution in sheep: effects of anesthesia, mechanical ventilation, and change in posture., Anesthesiology, 87(2), 335-42, August 1997 Abstract
  • Hillier SC, Graham JA, Hanger CC, Godbey PS, Glenny RW, Wagner WW Jr, Hypoxic vasoconstriction in pulmonary arterioles and venules., Journal of Applied Physiology, 82(4), 1084-90, April 1997 Abstract
  • Tonelli M, Stern EJ, Glenny RW, HRCT evident fibrosis in isolated pulmonary emphysema., Journal of Computer Assisted Tomography, 21(2), 322-3, 1997 Abstract
  • Glenny RW, McKinney S, Robertson HT, Spatial pattern of pulmonary blood flow distribution is stable over days., Journal of Applied Physiology, 82(3), 902-7, March 1997 Abstract
  • Robertson HT, Glenny RW, Stanford D, McInnes LM, Luchtel DL, Covert D, High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres., Journal of Applied Physiology, 82(3), 943-53, March 1997 Abstract
  • Walther SM, Domino KB, Glenny RW, Polissar NL, Hlastala MP, Pulmonary blood flow distribution has a hilar-to-peripheral gradient in awake, prone sheep., Journal of Applied Physiology, 82(2), 678-85, February 1997 Abstract
  • Bernard SL, Glenny RW, Erickson HH, Fedde MR, Polissar N, Basaraba RJ, Hlastala MP, Minimal redistribution of pulmonary blood flow with exercise in racehorses [see comments], Journal of Applied Physiology, 81(3), 1062-70, September 1996 Abstract
  • Hlastala MP, Bernard SL, Erickson HH, Fedde MR, Gaughan EM, McMurphy R, Emery MJ, Polissar N, Glenny RW, Pulmonary blood flow distribution in standing horses is not dominated by gravity [see comments], Journal of Applied Physiology, 81(3), 1051-61, September 1996 Abstract
  • Bernard SL, Luchtel DL, Glenny RW, Lakshminarayan S, Bronchial circulation in the marsupial opossum, Didelphis marsupialis., Respiration Physiology, 105(1-2), 77-83, August 1996 Abstract
  • Bernard SL, Glenny RW, Polissar NL, Luchtel DL, Lakshminarayan S, Distribution of pulmonary and bronchial blood supply to airways measured by fluorescent microspheres., Journal of Applied Physiology, 80(2), 430-6, February 1996 Abstract
  • Glenny RW, Polissar NL, McKinney S, Robertson HT, Temporal heterogeneity of regional pulmonary perfusion is spatially clustered., Journal of Applied Physiology, 79(3), 986-1001, September 1995 Abstract
  • Hanger CC, Hillier SC, Presson RG Jr, Glenny RW, Wagner WW Jr, Measuring pulmonary microvessel diameters using video image analysis., Journal of Applied Physiology, 79(2), 526-32, August 1995 Abstract
  • Presson RG Jr, Graham JA, Hanger CC, Godbey PS, Gebb SA, Sidner RA, Glenny RW, Wagner WW Jr, Distribution of pulmonary capillary red blood cell transit times., Journal of Applied Physiology, 79(2), 382-8, August 1995 Abstract
  • Glenny RW, Robertson HT, A computer simulation of pulmonary perfusion in three dimensions., Journal of Applied Physiology, 79(1), 357-69, July 1995 Abstract
  • Prinzen FW, Glenny RW, Developments in non-radioactive microsphere techniques for blood flow measurement., Cardiovascular Research, 28(10), 1467-75, October 1994 Abstract
  • Presson RG Jr, Okada O, Hanger CC, Godbey PS, Graham JA, Glenny RW, Capen RL, Wagner WW Jr, Stability of alveolar capillary opening pressures., Journal of Applied Physiology, 77(4), 1630-7, October 1994 Abstract
  • Hopkins SR, McKenzie DC, Schoene RB, Glenny RW, Robertson HT, Pulmonary gas exchange during exercise in athletes. I. Ventilation-perfusion mismatch and diffusion limitation., Journal of Applied Physiology, 77(2), 912-7, August 1994 Abstract
  • Stern EJ, Frank MS, Schmutz JF, Glenny RW, Schmidt RA, Godwin JD, Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans., AJR American Journal of Roentgenology, 162(3), 555-60, March 1994 Abstract
  • Glenny RW, Bernard S, Brinkley M, Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion., Journal of Applied Physiology, 74(5), 2585-97, May 1993 Abstract
  • Goodwin SD, Glenny RW, Nonsteroidal anti-inflammatory drug-associated pulmonary infiltrates with eosinophilia. Review of the literature and Food and Drug Administration Adverse Drug Reaction reports., Archives of Internal Medicine, 152(7), 1521-4, July 1992 Abstract
  • Glenny RW, Spatial correlation of regional pulmonary perfusion., Journal of Applied Physiology, 72(6), 2378-86, June 1992 Abstract
  • Glenny RW, Pierson DJ, Cost reduction in diagnosing Pneumocystis carinii pneumonia. Sputum induction versus bronchoalveolar lavage as the initial diagnostic procedure., American Review of Respiratory Disease, 145(6), 1425-8, June 1992 Abstract
  • Glenny RW, Polissar L, Robertson HT, Relative contribution of gravity to pulmonary perfusion heterogeneity., Journal of Applied Physiology, 71(6), 2449-52, December 1991 Abstract
  • Glenny RW, Lamm WJ, Albert RK, Robertson HT, Gravity is a minor determinant of pulmonary blood flow distribution [see comments], Journal of Applied Physiology, 71(2), 620-9, August 1991 Abstract
  • Glenny RW, Robertson HT, Yamashiro S, Bassingthwaighte JB, Applications of fractal analysis to physiology., Journal of Applied Physiology, 70(6), 2351-67, June 1991 Abstract
  • Glenny RW, Robertson HT, Fractal modeling of pulmonary blood flow heterogeneity., Journal of Applied Physiology, 70(3), 1024-30, March 1991 Abstract
  • Schmidt RA, Glenny RW, Godwin JD, Hampson NB, Cantino ME, Reichenbach DD, Panlobular emphysema in young intravenous Ritalin abusers., American Review of Respiratory Disease, 143(3), 649-56, March 1991 Abstract
  • Glenny RW, Robertson HT, Fractal properties of pulmonary blood flow: characterization of spatial heterogeneity., Journal of Applied Physiology, 69(2), 532-45, August 1990 Abstract
  • Glenny RW, Blood flow distribution in the lung., Chest, 114(1 Suppl), 8S-16S Abstract
  • Mure M, Glenny RW, Domino KB, Hlastala MP, Pulmonary gas exchange improves in the prone position with abdominal distension., American Journal of Respiratory and Critical Care Medicine, 157(6 Pt 1), 1785-90 Abstract
  • Kallas HJ, Domino KB, Glenny RW, Anderson EA, Hlastala MP, Pulmonary blood flow redistribution with low levels of positive end-expiratory pressure., Anesthesiology, 88(5), 1291-9 Abstract
  • Van Oosterhout MF, Prinzen FW, Sakurada S, Glenny RW, Hales JR, Fluorescent microspheres are superior to radioactive microspheres in chronic blood flow measurements., American Journal of Physiology, 275(1 Pt 2), H110-5 Abstract
  • Mann CM, Domino KB, Walther SM, Glenny RW, Polissar NL, Hlastala MP, Redistribution of pulmonary blood flow during unilateral hypoxia in prone and supine dogs., Journal of Applied Physiology, 84(6), 2010-9 Abstract
  • Wagner WW Jr, Todoran TM, Tanabe N, Wagner TM, Glenny RW, Presson RG Jr, Robust design of the lung: fractal patterns and capillary independence., Chest, 114(1 Suppl), 16S-17S Abstract

Profile Details

Last Updated: 9/5/2000

COS Expertise ID #135393
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