R. Bruce Montgomery

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University of Washington
School of Medicine
Associate ProfessorAppointed: 1997
Professional Headshot of R. Bruce Montgomery

Mailing Address

Box 358280 (111ONC)
University of Washington
1959 NE Pacific St. SP1301
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 598-0860
Fax: (206) 598-6986
rbmontgo@u.washington.edu

Qualifications

Fellowship, Oncology, Fred Hutchinson Cancer Research Center, 1993.
Residency, Internal medicine, Brigham and Women's Hospital, Medicine, 1990.
M.D., Duke University, 1987.
B.A., Dartmouth College, 1983.

Expertise and Research Interests

Genitourinary malignancy

Keywords

COS Keywords:

Cell Biology, Drug Resistance, Growth Factor Receptors, Oncology, Prostate Cancer.

Additional Terms:

Androgens, Cell Biology, Cell Biology: Transformation.

Memberships

American Society of Clinical Oncology
Southwest Oncology Group

Publications

  • de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, Doyle GV, Terstappen LW, Pienta KJ, Raghavan D (Oct 2008) Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer., Clinical cancer research : an official journal of the American Association for Cancer Research, 14 (19), 6302-9 Abstract
  • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS (Jun 2008) Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth., Cancer research, 68 (11), 4447-54 Abstract
  • Montgomery RB, Goldman B, Tangen CM, Hussain M, Petrylak DP, Page S, Klein EA, Crawford ED (Nov 2007) Association of body mass index with response and survival in men with metastatic prostate cancer: Southwest Oncology Group trials 8894 and 9916., The Journal of urology, 178 (5), 1946-51; discussion Abstract
  • Plymate SR, Haugk K, Coleman I, Woodke L, Vessella R, Nelson P, Montgomery RB, Ludwig DL, Wu JD (Nov 2007) An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer., Clinical cancer research : an official journal of the American Association for Cancer Research, 13 (21), 6429-39 Abstract
  • Montgomery RB, Nelson PS, Lin D, Ryan CW, Garzotto M, Beer TM (Sep 2007) Diethylstilbestrol and docetaxel: a Phase II study of tubulin active agents in patients with metastatic, androgen-independent prostate cancer., Cancer, 110 (5), 996-1002 Abstract
  • Hall SA, Page ST, Travison TG, Montgomery RB, Link CL, McKinlay JB (Aug 2007) Do statins affect androgen levels in men? Results from the Boston area community health survey., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 16 (8), 1587-94 Abstract
  • Mostaghel EA, Montgomery RB, Lin DW (May 2007) The basic biochemistry and molecular events of hormone therapy., Current urology reports, 8 (3), 224-32 Abstract
  • Wu JD, Haugk K, Coleman I, Woodke L, Vessella R, Nelson P, Montgomery RB, Ludwig DL, Plymate SR (Oct 2006) Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors., Clinical cancer research : an official journal of the American Association for Cancer Research, 12 (20 Pt 1), 6153-60 Abstract
  • Wright JL, Lin DW, Dewan P, Montgomery RB (Nov 2005) Tumor lysis syndrome in a patient with metastatic, androgen independent prostate cancer., International journal of urology : official journal of the Japanese Urological Association, 12 (11), 1012-3 Abstract
  • Montgomery RB, Bonham M, Nelson PS, Grim J, Makary E, Vessella R, Stahl WL (Oct 2005) Estrogen effects on tubulin expression and taxane mediated cytotoxicity in prostate cancer cells., The Prostate, 65 (2), 141-50 Abstract
  • Montgomery RB, Bonham M, Nelson PS, Grim J, Makary E, Vessella R, Stahl WL (2005) Estrogen effects on tubulin expression and taxane mediated cytotoxicity in prostate cancer cells., The Prostate, 65 (2), 141-50
  • Schwartz DL, Montgomery RB, Yueh B, Donahue M, Anzai Y, Canby R, Buelna R, Anderson L, Boyd C, Hutson J, Keegan K (2005) Phase I and initial phase II results from a trial investigating weekly docetaxel and carboplatin given neoadjuvantly and then concurrently with concomitant boost radiotherapy for locally advanced squamous cell carcinoma of the head and n, Cancer, 103 (12), 2534-43
  • Montgomery RB, Makary E, Schiffman K, Goodell V, Disis ML (2005) Endogenous anti-HER2 antibodies block HER2 phosphorylation and signaling through extracellular signal-regulated kinase., Cancer Research, 65 (2), 650-6
  • Zecha G, Lin DW, Montgomery RB (Mar 2004) The increasing role of CAM in prostate cancer., JAAPA : official journal of the American Academy of Physician Assistants, 17 (3), 37-40, 43-4 Abstract
  • Nelson PS, Montgomery B (2003) Unconventional therapy for prostate cancer: good, bad or questionable?, Nature Reviews. Cancer, 3 (11), 845-58
  • Bonham MJ, Galkin A, Montgomery B, Stahl WL, Agus D, Nelson PS (Nov 2002) Effects of the herbal extract PC-SPES on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition, Journal of the National Cancer Institute, 94 (21), 1641-7
  • Montgomery RB (Sep 2002) Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function, International Journal of Cancer, 101 (2), 111-7
  • Bonham M, Arnold H, Montgomery B, Nelson PS (Jul 2002) Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma, Cancer Research, 62 (14), 3920-4
  • Billingsley KG, Schwartz DL, Lentz S, Vallieres E, Montgomery RB, Schubach W, Penson D, Yueh B, Chansky H, Zink C, Parayno D, Starkebaum G (2002) The development of a telemedical cancer center within the Veterans Affairs Health Care System: a report of preliminary clinical results., Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association., 8 (1), 123-30
  • Weinrobe MC, Montgomery B (Oct 2001) Acquired bleeding diathesis in a patient taking PC-SPES., The New England Journal of Medicine, 345 (16), 1213-4
  • Munshi HG, Montgomery RB (April 2000) Severe neutropenia: a diagnostic approach, Western Journal of Medicine, 172 (4), 248-52
  • Montgomery R.B, Guzman J, O'Rourke D.M, Stahl W.L. (2000) Constitutive epidermal growth factor receptor kinase activity induces paclitaxel resistance and alters beta-tubulin isotype expression, Journal of Biological Chemistry, 275, 17358-17363.
  • Moscatello DK, Holgado-Madruga M, Emlet DR, Montgomery RB, Wong AJ (Jan 1998) Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor, Journal of Biological Chemistry, 273 (1), 200-6
  • Montgomery, R.B, Moscatello, D.K, Wong, A.J, Stahl, W.L. (1997) Epidermal growth factor receptor stimulation of diacylglycerol kinase, Biochemical and Biophysical Research Communications, 232 (1), 111-6
  • Moscatello, D.K, Montgomery, R.B, Sundareshan,P, McDanel, H, Wong, A.J. (1996) Transformation and altered signal transduction by a naturally occurring mutant EGF receptor, Oncogene, 13 (1), 85-96
  • Montgomery, R.B, Moscatello, D.K, Wong, A.J, Cooper, J.A. (1995) Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor, Journal of Biological Chemistry, 270 (51), 30562-6
  • Montgomery B, Bianco JA, Jacobsen A, Singer JW (Jul 1991) Localization of transfused neutrophils to site of infection during treatment with recombinant human granulocyte-macrophage colony-stimulating factor and pentoxifylline., Blood, 78 (2), 533-4
  • Montgomery, R.B, Kurtzberg, J, Rhinehardt-Clark, A, Haleen, A, Ramakrishnan, S, Olsen, G.A, Peters, W.P, Smith, C.A, Haynes, B.F, Houston, L.L, Bast, R.C. (1990) Elimination of malignant clonogenic T cells from human bone using chemoimmunoseparation with 2'-deoxycoformycin deoxyadenosine and an immunotoxin, Bone Marrow Transplantation, 5 (6), 395-402

Profile Details

Last Updated: 6/1/2009

COS Expertise ID #135370
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