Nathan Kuppermann

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University of California, Davis
School of Medicine
Emergency Medicine and Pediatrics
ProfessorAppointed: 2005
Professional Headshot of Nathan  Kuppermann

Mailing Address

Departments of Emergency Medicine and Pediatrics
UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, California 95817
United States

Contact Information

Phone: (916) 734-1535
Fax: (916) 734-7950
nkuppermann@ucdavis.edu

Qualifications

M.P.H., Harvard University, Epidemiology and Statistics, 1993.
M.D., University of California, San Francisco, Medicine, 1985.
B.Sc., Stanford University, Biology, 1981.

Expertise and Research Interests

Pediatric infectious emergencies
Pediatric traumatic emergencies
Clinical epidemiology
Pediatric diabetic ketoacidosis and cerebral edema
Multivariable statistical modelling

Other Expertise

I have experience in coordinating multicenter research in pediatric emergency medicine (PEM). I am currently involved in a PEM collaborative research initiative entitled EMSC Network Development Demonstration Project, sponsored by EMSC and the Maternal and Child Health Bureau.

Future Research

I am currently involved in clinical epidemilogical studies pertaining to the clinical evaluation of the pediatric trauma patient. These include studies pertaining to the use of computerized tomography for the evaluation of mild-moderate head injury, and abdominal ultrasound evaluation of the pediatric patient sustaining blunt torso trauma.

In addition, I am collaboarting on research projects pertaining to the evaluation and treatment of pediatric patients with diabetic ketoacidosis.

Keywords

COS Keywords:

Bacterial Infections, Diabetes, Emergency Health Services, Epidemiology, Infectious Diseases or Agents, Pediatrics, Statistics, Trauma, Traumatic Brain or Head Injury.

Additional Terms:

Abdominal Trauma, Cerebral Edema, Diabetic Ketoacidosis, Head Trauma, Infectious Emergencies.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Portuguese: (Functional, Basic, Fluent)
Spanish: (Functional, Basic, Fluent)
Hebrew: (Basic, None, Basic)

Memberships

Ambulatory Pediatric Association
American Academy of Pediatrics
American Pediatric Society
Society for Academic Emergency Medicine
Society for Pediatric Research
Western Society for Pediatric Research

Honors and Awards

2003-2004, DeanĀ’s Award for Excellence in Research and Clinical Mentoring, School of Medicine, University of California, Davis
2000-2001, Outstanding Consultant, Annals of Emergency Medicine
2003, Fulbright Distinguished Scholar, Fulbright Association

Previous Positions

2000-2005, Associate Professor, University of California, Davis, School of Medicine, Emergency Medicine and Pediatrics
1995-2000, Assistant Professor, University of California, Davis, School of Medicine, Pediatrics and Internal Medicine, Emergency Medicine
1994-1995, Attending Physician, Children's Hospital and Health Center, San Diego, Pediatrics, Emergency Medicine
1990-1993, Fellow, Children's Hospital of Boston, Harvard Medical School, Pediatrics, Emergency Medicine
1985-1990, Resident, Harbor-UCLA Medical Center, Pediatrics
1985-1990, Chief Resident, Harbor-UCLA Medical Center, Pediatrics

Funding Received

  • Maternal and Child Health Bureau: EMSC Network Development Demonstration Project, $1,783,295, Oct 1, 2001 to Sep 30, 2004.
  • American Diabetes Association: Cerebral Edema and Cerebral Ischemia in Children with Diabetic Ketoacidosis, $255,714, Jul 1, 2001 to Jun 30, 2004.
  • UC Davis School of Medicine Health System Research Award: Cerebral Ischemia and Cerebral Edema in Children with Diabetic Ketoacidosis, $148,878, Jul 1, 2001 to Jun 30, 2003.
  • Emergency Medical Services Program of the Maternal and Child Health Bureau: EMSC Network Development Demonstration Project, $2,100,000, 2005 to 2008.
  • Emergency Medical Services for Children Program and the Maternal and Child Health Bureau: Childhood Head Trauma: A Neuroimaging Decision Rule, $1,639,623, 2004 to 2006.
  • National Institutes of Health (NIH): Cerebral Edema in Pediatric Diabetic Ketoacidosis, $1,738,750, 2004 to 2009.
  • Children's Miracle Network: The evaluation of the use of head CT scans for children with head trauma, $19,500, 1999 to 2000.
  • Hibbard Williams Grant, UC Davis School of Medicine: The evaluation of the use of head CT scans for children with head trauma, $23,188, 1998 to 2000.
  • Ambulatory Pediatric Association: Risk factors for cerebral edema complicating pediatric DKA, $7,100, 1997 to 2000.
  • Children's Miracle Network: Risk factors for cerebral edema complicating pediatric DKA, $6,600, 1997 to 2000.

Publications

  • Gorelick MH, Alpern ER, Singh T, Snowdon D, Holubkov R, Dean JM, Kuppermann N, for the Pediatric Emergency Care Applied Research Network (PECARN)., Availability of Pediatric Emergency Visit Data From Existing Data Sources, Acad Emerg Med, in press, 2005
  • Holmes JF, Palchak MJ, Conklin MJ, Kuppermann N., Performance of the Pediatric Glasgow Coma Scale in Pediatric Head Trauma, Acad Emerg Med, 12, 814-819, 2005
  • Sokolove PE, Kuppermann N, Holmes JF., Association Between the Seat Belt Sign and Intra-abdominal Injury in Children With Blunt Torso Trauma, Acad Emerg Med, 12, 808-813, 2005
  • Zorc J, Levine D, Platt S, Dayan P, Macias C, Krief W, Schor J, Bank D, Fefferman N, Shaw K and Kuppermann N., Clinical and Demographic Factors Associated With Urinary Tract Infections in Young Febrile Infants, Pediatrics, 116, 644-648, 2005
  • Rose JS, Richards JR, Bair AE, Batistella F, Kuppermann N., The FAST Is Positive, Now What? Derivation of Clinical Decision Rule to Determine the Need for Therapeutic Laparotomy Given a Positive Trauma Ultrasound., J Emerg Med, 29, 15-21, 2005
  • Wootton-Gorges S, Buonocore M, Kuppermann N, Marcin J, DiCarlo J, Neely EK, Barnes P, Glaser N., Detection of Cerebral Beta-hydroxy Butyrate, Acetoacetate and Lactate By Proton Magnetic Resonance Spectroscopy in Children With Diabetic Ketoacidosis, Am J Neuroradiology, 26, 1286-1291, 2005
  • Nigrovic LE, Kuppermann N, McAdam AJ, Malley R, Cerebrospinal Latex Agglutination Fails to Contribute to the Microbiologic Diagnosis of Pretreated Children With Meningitis, Pediatr Infect Dis J, 23, 786-788, 2004
  • Glaser N, Kuppermann N, The Evaluation and Management of Children With Diabetic Ketoacidosis in the Emergency Department, Pediatr Emerg Care, 20, 477-482, 2004
  • Dayan PS, Vitale M, Ruzal-Shapiro C, Langsam DJ, Kuppermann N, Miller SZ., Derivation of Clinical Prediction Rules for Identifying Children With Fractures After Acute Twisting Injuries of the Ankle, Acad Emerg Med, 11, 736-743, 2004
  • Glaser N, Gorges S, Marcin J, Buonocore M, DiCarlo J, Neely EK, Barnes P, Bottomly J, Kuppermann N, Mechanism of Cerebral Edema in Children With Diabetic Ketoacidosis, J Pediatr, 145, 164-171, 2004
  • Palchak M, Holmes J, Vance C, Gelber R, Schauer B, Harrison M, Willis-Shore J, Wooten-Gorges S, Derlet R, and Kuppermann N, Does An Isolated History of Loss of Consciousness Or Amnesia Predict Brain Injuries in Children After Blunt Head Trauma?, Pediatrics, 113, e507-e513, 2004
  • Levine D, Platt S, Dayan P, Macias C, Zorc J, Krief W, Schor J, Bank D, Fefferman N, Shaw K and Kuppermann N., The Risk of Serious Bacterial Infection in Young Febrile Infants With Respiratory Syncytial Virus Infections, Pediatrics, 113, 1728-1734, 2004
  • Holmes J, Palchak M, Conklin M, Kuppermann N, Do Children Require Hospitalization After Post-Traumatic Seizures?, Ann Emerg Med, 43, 706-710, 2004
  • Palchak M, Holmes J, Vance C, Gelber R, Schauer B, Harrison M, Willis-Shore J, Wooten-Gorges S, Derlet R, and Kuppermann N, A Decision Rule for Identifying Children At Low Risk for Brain Injuries After Blunt Head Trauma., Ann Emerg Med, 42, 492-506, 2003
  • The Pediatric Emergency Care Applied Research Network, The Pediatric Emergency Care Applied Research Network (PECARN): Rationale, Development, and First Steps., Acad Emeg Med, 10, 661-668, 2003
  • Bair AE, Laurin EG, Karchin A, Richards JR, Kuppermann N, Cricoid Ring Integrity: Implications for Cricothyrotomy, Ann Emerg Med, 41, 331-337, 2003
  • Yang J, Kuppermann N, Rosas A, Child Abuse Presenting As Pseudo-Renal Failure After a Fall From a Bicycle, Pediatr Emerg Care, 18, 91-92, 2002
  • Nguyen TP, Malley R, Inkelis S, Kuppermann N, Prediction of Adverse Outcome in Pediatric Meningococcal Disease Using Artificial Neural Networks Or Logistic Regression , Journal of Clinical Epidemiology, 55, 687-695, 2002
  • Marcin JP, Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N, Clinical and Therapeutic Factors Associated With Adverse Outcomes in Children With DKA-related Cerebral Edema, J Pediatr, 141, 793-797, 2002
  • Nigrovic LE, Kuppermann N, Malley R., Development and Validation of a Multivariable Predictive Model to Distinguish Bacterial From Aseptic Meningitis in Children in the Post-Haemophilus Influenzae Era., Pediatrics, 110, 712-719, 2002
  • Inkelis SH, O’Leary D, Wang V, Malley R, Nicholson MK, Kuppermann N, Extremity Pain and Refusal to Walk in Children With Invasive Meningococcal Disease, Pediatrics, 110, e3, 2002
  • West DC, Andrade E, Rangaswami AA, Azari R, Kuppermann N., Predictors of Bacteremia in Febrile Children With Sickle Cell Disease, J Pediatr Hematol Oncol, 24, 279-283, 2002
  • Holmes JF, Sokolove PE, Palchak M, Vance C, Owings J, Kuppermann N., Identification of Children With Intra-Abdominal Injury After Blunt Trauma, Ann Emerg Med, 9, 500-509, 2002
  • Holmes JF, Sokolove PE, Brant WE, Kuppermann N., Clinical Predictors of Thoracic Injuries Among Children Sustaining Blunt Torso Trauma, Ann Emerg Med, 39, 492-499, 2002
  • Holmes JF, Goodwin H, Land C, Kuppermann N., Coagulation Testing in Pediatric Blunt Trauma Patients, Pediatric Emergency Care, 17, 324-328, 2001
  • Holmes JF, Brant WE, Bogren HG, London KL, Kuppermann N., Prevalence AndImportance of Pneumothoraces Visualized on Abdominal CT in Children With Blunt Trauma, Journal of Trauma, 50, 516-520, 2001
  • Wang V, Kuppermann N, Malley R, Barnett E, Meissner C, Schmidt E, Fleisher GR., Meningococcal Disease Among Children in a Large Metropolitan Area, 1981-1996, Clinical Infectious Diseases, 32, 1004-1009, 2001
  • Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N, Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis, New England Journal of Medicine, 344, 264-269, 2001
  • Holmes JF, Brant WE, Bond WF, Sokolove PE, Kuppermann N., Emergency Department Abdominal Ultrasound in the Evaluation of Hypotensive and Normotensive Children with Blunt Trauma, Journal of Pediatric Surgery, 36, 968-973, 2001
  • Wang V, Malley R, Fleisher G, Inkelis S, Kuppermann N, Treatment of Unsuspected Meningococcal Disease, Archives of Pediatrics and Adolescent Medicine, 154, 556-560, June 2000
  • Kuppermann N, O'Dea T, Pinckney L, Hoecker C, Predictors of intussusception in young children, Archives of Pediatrics and Adolescent Medicine, 154(3), 250-5, March 2000 Abstract
  • Green SM, Kuppermann N, Rothrock SG, Hummel CB, Ho M, Predictors of adverse events with intramuscular ketamine sedation in children, Annals of Emergency Medicine, 35(1), 35-42, Jan 2000 Abstract
  • Holmes JF, London K, Brant WE, Kuppermann N, Isolated intraperitoneal fluid on abdominal computerized tomography in children with blunt trauma, Academic Emergency Medicine, 7, 335-341, 2000
  • Kuppermann N, Occult Bacteremia in Young Febrile Children, Pediatric Clinics of North America, 46(6), 1073-109, December 1999
  • Holmes JF, Sokolove PE, Land C, Kuppermann N, Identification of intra-abdominal injuries in children hospitalized following blunt torso trauma, Academic Emergency Medicine, 6(8), 799-806, August 1999 Abstract
  • Kuppermann N, Walton EA, Immature Neutrophils in the Blood Smears of Young Febrile Children, Archives of Pediatrics and Adolescent Medicine, 153(3), 261-6, March 1999
  • Kuppermann N, Malley R, Inkelis SH, Fleisher GR, Clinical and hematologic features do not reliably identify children with unsuspected meningococcal disease, Pediatrics, 103(2), E20, February 1999 Abstract
  • Tamariz V, Kuppermann N, Federal funding opportunities for research in pediatric emergency medicine, Pediatric Emergency Care, 15(6), 451-456, 1999
  • Nelson DG, Leake J, Bradley J, Kuppermann N, Evaluation of febrile children with petechial rashes: is there consensus among pediatricians?, Pediatric Infectious Disease Journal, 17(12), 1135-40, December 1998 Abstract
  • Malley R, Inkelis SH, Coelho P, Huskins WC, Kuppermann N, Cerebrospinal fluid pleocytosis and prognosis in invasive meningococcal disease in children, Pediatric Infectious Disease Journal, 17(10), 855-9, October 1998 Abstract
  • Kuppermann N, Fleisher GR, Jaffe DM, Predictors of Occult Pneumococcal Bacteremia in Young Febrile Children, Annals of Emergency Medicine, 31(6), 679-87, 1998
  • Barnett P L, Caputo G L, Baskin M, Kuppermann N, Intravenous Versus Oral Corticosteroids in the Management of Acute Asthma in Children, Annals of Emergency Medicine, 29(2), 212-7, February 1997
  • Quayle K, Jaffe D, Kuppermann N, et al, Diagnostic Testing for Acute Head Injury in Children: When are Head CT and Skull Radiographs Indicated?, Pediatrics (electronic), 99(5), 1-8, 1997
  • Shad G, Francis K, Kuppermann N, Atypical Presentations of Henoch-Schoenlein Purpura in Children, American Journal of Emergency Medicine, 15, 375-9, 1997
  • Glaser NS, Kuppermann N, Yee CKJ, Schwartz DL, Styne DM, Variation in the Management of Pediatric Diabetic Ketoacidosis by Specialty Training, Archives of Pediatrics and Adolescent Medicine, 151, 1125-32, 1997
  • Kuppermann N, Bank DE, Walton EA, Senac MO, McCaslin I, Risk of Occult Bacterial Infections in Febrile Infants with Bronchiolitis, Archives of Pediatrics and Adolescent Medicine, 151, 1207-14, 1997
  • Bird L, Jones M, Kuppermann N, Huskins W, Gram-negative Bacteremia in Four Patients with Klippel-Trenaunay-Weber Syndrome, Pediatrics, 97, 739-41, 1996
  • Weiner D, Kuppermann N, Fleisher G, Thompson C, Sattler F, Siber G, Saladino R, A Comparison of Early and Late Treatment with an Endotoxin Neutralizing Protein in a Rat Model of E. Coli Sepsis, Critical Care Medicine, 24, 1514-7, 1996
  • Malley R, Huskins C, Kuppermann N, Multivariable Predictive Models for Adverse Outcome from Invasive Meningococcal Disease in Children, Journal of Pediatrics, 129, 702-10, 1996
  • Nelson D, Kuppermann N, Fleisher G, Hammer B, Thompson C, Garcia C, Novitsky T, Parsonnet J, Siber G, Saladino R, Recombinant Endotoxin Neutralizing Protein Improves Survival from E. Coli Sepsis in a Rat Model, Critical Care Medicine, 23, 92-8, 1995
  • Kinnane J, Priebe C, Caty M, Kuppermann N, Perforation of the Colon in an Adolescent Girl, Pediatric Emergency Care, 11, 230-2, 1995
  • Kuppermann N, Nelson D, Fleisher G, Thompson C, Parsonnet J, Sattler F, Novitsky T, Siber G, Saladino R, A Comparison of a Recombinant Endotoxin Neutralizing Protein Versus a Human Monoclonal Antibody to Endotoxin for the Treatment of E. Coli Sepsis in a Rat Model, Journal of Infectious Diseases, 170, 630-5, 1994
  • Kuppermann N, Inkelis SH, Saladino R., The Role of Heparin in the Prevention of Extremity and Digit Necrosis in Meningococcal Purpura Fulminans, Pediatric Infectious Disease Journal, 13, 867-73, 1994
  • Davis JM, Kuppermann N, Fleisher GR., Serious Sports Injuries in a Pediatric Emergency Department, AJDC, 147, 1001-4, 1993
  • Kuppermann N, Anand S., Transient Infantile Hypertension, Western Journal of Medicine, 153, 197-9, 1990

Profile Details

Last Verified: 9/30/2005

COS Expertise ID #701080
Reference this profile directly: http://myprofile.cos.com/Nathan