Dr. Philippe A. Grandjean

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University of Southern Denmark
Faculty of Health Sciences
Environmental Medicine
ProfessorAppointed: 1982
Harvard University
School of Public Health
Environmental Health
Adjunct ProfessorAppointed: 2003
National Board of Health
Toxicology
ConsultantAppointed: 1983
Professional Headshot of Philippe A. Grandjean

Mailing Address

Department of Environmental Health
Harvard School of Public Health
Landmark Center, East, Room 3-110
401 Park Drive - P.O. Box 15967
Boston, Massachusetts 02215
United States

Contact Information

Phone: (617) 384-8907
Fax: (617) 384-8994
pgrand@hsph.harvard.edu
http://www1.sdu.dk/health/IPH/environ/staff/pgrandjean/index.htm

Qualifications

D.M.Sc., University of Copenhagen, 1978.
M.D., University of Copenhagen, 1974.

Expertise and Research Interests

Dr. Grandjean has long-term experience in environmental epidemiology and has contributed to the development and validation of various biomarkers and clinical tests of early dysfunctions, mainly in regard to the nervous system. Research efforts have focused on long-term health implications of exposures to environmental chemicals, including lead, methylmercury, nickel, and organochlorine compounds. Current studies emphasize the significance of prenatal exposures for the development of the nervous system, the cardiovascular system, and immune functions in children, and possible hormone-disrupting effects of pesticides and persistent halogenated hydrocarbons. The implications of research in this area are explored in the light of the precautionary pronciple.

Other Expertise

Dr. Grandjean has served as Vice-Dean and Institute Chairman at Odense University and as member of the Danish Medical Research Council. He is founding editor of the web-based journal Environmental Health (http://www.ehjournal.net) and has served as European Editor of the Archives of Environmental Health and is currently a member of editorial boards of ten scientific journals. He has been elected Fellow of the American Association for the Advancement of Science, and was elected to the Board of Collegium Ramazzini in 2005. Past committee memberships include the U.S.Environmental Protection Agency SAB/SAP Endocrine Disruptor Screening Program Subcommittee, the Danish Committee on Scientific Dishonesty, the Panel on Contaminants of the European Food Safety Authority, and the chair of the Commission on Toxicology of IUPAC, and the Danish Commission on Non-Ionizing Radiation Research, as well as advisory tasks for several international organizations.

Future Research

Early human development is particularly vulnerable to adverse effects of environmental chemicals, especially neurotoxicants. These issues will be explored in prospective studies of birth cohorts with well defined exposures to specific chemicals, including methylmercury, PCBs, pesticides, and endocrine disruptors.

Industrial Relevance

The research undertaken is of key interest with regard to setting exposure limits and preventing adverse health effects from industrial exposures and emissions.

Keywords

COS Keywords:

Biomarkers, Breast Cancer, Cardiovascular System, Clinical Research or Studies, Community Health, Environmental Health, Epidemiology, Human Development, Immune System, Nervous System, Neurology, Occupational Health and Safety, Pesticides, Toxicology.

Additional Terms:

Environment, Epidemiology, Neurobehavioral Function, Toxicology.

Languages

(Reading, Writing, Speaking)

Danish: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)
Swedish: (Fluent, Basic, Functional)
French: (Functional, Basic, Basic)
German: (Functional, Basic, Basic)

Memberships

American Association for the Advancement of Science
American Public Health Association
Association of Clinical Scientists
Collegium Ramazzini
Danish Medical Association
Faroese Society of Science and Letters
International Commission on Occupational Health
International Epidemiological Association
International Society for Environmental Epidemiology
Society for Occupational and Environmental Health

Honors and Awards

2003, Knight of Dannebrog, First Degree, Queen of Denmark
1994, Fellow, American Association for the Advancement of Science
1990, Knight of Dannebrog, Queen of Denmark
1978-1979, Senior Research Scholarship, Fulbright Commission

Previous Positions

1994-2002, Adjunct Professor, Boston University, Schools of Medicine and Public Health, Neurology and Environmental Health
1980-1982, Director, Danish National Institute of Occupational Health, Occupational Medicine
1978-1980, Visiting Fellow, City College of New York, The City University of New York, Mt Sinai School of Medicine, Community Medicine, Environmental Sciences Laboratory
1978-1980, Fullbright Senior Scholar, City College of New York, The City University of New York, Mt Sinai School of Medicine, Community Medicine, Environmental Sciences Laboratory

Funding Received

  • National Institutes of Health (NIH): Mercury-Associated Neurobehavioral Deficit in Children, $2,026,729, 2007 to 2012.
  • National Institutes of Health (NIH): Three-generation human study of reproductive effects of narine food contaminants, $2,485,000, 2006 to 2011.
  • European Commission (EC): Public Health Impact of Metals Exposure (PHIME), Euro 776,000, 2006 to 2011.
  • National Institutes of Health (NIH): Health effects of lifetime exposure to food contaminants, $1,262,000, 2006 to 2010.
  • National Institutes of Health (NIH): Epidemiology of Immunotoxicant Exposure in Children, $1,163,538, 2004 to 2008.
  • Environmental Protection Agency (EPA): Children's vulnerability to environmental immunotoxicant exposure, $750,000, 2003 to 2006.
  • Danish Medical Research Council: Environmental epidemiology research, $170,000, 2002 to 2004.
  • European Commission: Assessment of Neurobehavioural Endpoints and Markers Of Neurotoxicant Exposures (ANEMONE), Euro 1.1 million, 2002 to 2004.
  • National Institutes of Health (NIH): Effects of perinatal endocrine disruption in children, $1,000,000, 2001 to 2006.
  • National Institutes of Health (NIH): Mercury-associated neurobehavioral deficit in children, $1,585,000, 2000 to 2006.
  • Danish Medical Research Council: Neurotoxic effects of pollutants, DKK 2,000,000, 1998 to 2001.
  • National Institutes of Health (NIH): Neurobehavioral effects of environmental PCB exposure, $830,000, 1996 to 2000.
  • Danish Strategic Environmental Research Programme: Health effects of hormone disruptors, DKK 4,000,000, 1996 to 2000.
  • Occupational Health Foundation (Denmark): Occupational aluminum neurotoxicity, DKK 1,000,000, 1996 to 2000.
  • National Institutes of Health (NIH): Serum PCB concentrations in breast cancer patients, $290,000, 1995 to 1997.
  • Joint Ministerial Pesticide Research Initiative (Denmark): Evaluation of estrogenic effects, DKK 912,000, 1995 to 1997.
  • Commission of the European Communities: Neonatal PCB exposure and neurodevelopmental deficit, $321,000, 1994 to 1998.
  • Commission of the European Communities: Detection of early neurotoxicity in children with environmental methylmercury exposure, $250,000, 1993 to 1995.
  • Danish Strategic Environmental Research Programme: Center for Biochemical and Occupational Epidemiology, DKK 2,677,000, 1993 to 1996.
  • Danish Medical Research Council: Environmental epidemiology, DKK 3,750,000, 1993 to 1997.
  • National Institutes of Health (NIH): Neurobehavioral effects of intrauterine mercury exposure, $547,300, 1992 to 1995.

Publications

  • Jensen TK, Grandjean P, Jorgensen EB, White RF, Debes F, Weihe P (Sep 2005) Effects of breast feeding on neuropsychological development in a community with methylmercury exposure from seafood, Journal of Exposure Analysis and Environmental Epidemiology, 15 (5), 423-30
  • Halling J, Petersen MS, Damkier P, Nielsen F, Grandjean P, Weihe P, Lundgren S, Lundblad MS, Brosen K (2005) Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population, European Journal of Clinical Pharmacology, 61, 491-7
  • Fangstrom B, Strid A, Grandjean P, Weihe P, Bergman A (2005) A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands, Environmental Health, 4 (12)
  • Grandjean P, Budtz-Jorgensen E, Jorgensen PJ, Weihe P (Jul 2005) Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury, Environmental Health Perspectives, 113 (7), 905-8
  • Weihe P, Grandjean P, Jorgensen PJ, Application of Hair-mercury Analysis to Determine the Impact of a Seafood Advisory., Environmental Research, 97(2), 200-7, Feb 2005 Abstract
  • Budtz-Jorgensen E, Keiding N, Grandjean P, Effects of Exposure Imprecision on Estimation of the Benchmark Dose., Risk Analysis : An Official Publication of the Society for Risk Analysis, 24(6), 1689-96, Dec 2004 Abstract
  • Budtz-Jorgensen E, Grandjean P, Jorgensen PJ, Weihe P, Keiding N, Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages, Environmental Research, 95(3), 385-93, July 2004 Abstract
  • Grandjean P, Olsen JH, Extended follow-up of cancer incidence in fluoride-exposed workers, Journal of the National Cancer Institute, 96(10), 802-3, May 2004 Abstract
  • Grandjean P, Bailar JC, Gee D, Needleman HL, Ozonoff DM, Richter E, Sofritti M, Soskolne CL, Implications of the Precautionary Principle in research and policy-making, American Journal of Industrial Medicine, 45(4), 382-5, April 2004 Abstract
  • Nielsen JB, Grandjean P, Criteria for skin notation in different countries, American Journal of Industrial Medicine, 45(3), 275-80, March 2004 Abstract
  • Grandjean P, Murata K, Budtz-Jørgensen E, Weihe P, Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort, Journal of Pediatrics, 144(2), 169-76, February 2004
  • Murata K, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Grandjean P, Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury, Journal of Pediatrics, 144(2), 177-83, February 2004
  • Grandjean P, Implications of the precautionary principle for primary prevention and research, Annual Review of Public Health, 25, 199-223, 2004 Abstract
  • Grandjean P, Implications of the Precautionary Principle for public health practice and research, International Journal of Occupational Medicine and Environmental Health, 17(1), 5-7, 2004 Abstract
  • Grandjean P, Budtz-Jorgensen E, Keiding N, Weihe P, Underestimation of risk due to exposure misclassification, International Journal of Occupational Medicine and Environmental Health, 17(1), 131-6, 2004 Abstract
  • Grandjean P, Implications of the Precautionary Principle for Primary Prevention And Research., Annual Review of Public Health, 25, 199-223, 2004 Abstract
  • Grandjean P, Budtz-Jorgensen E, Keiding N, Weihe P, Underestimation of Risk Due to Exposure Misclassification., International Journal of Occupational Medicine and Environmental Health, 17(1), 131-6, 2004 Abstract
  • Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P, White RF, Consequences of exposure measurement error for confounder identification in environmental epidemiology, Statistics in Medicine, 22(19), 3089-100, October 2003 Abstract
  • Grandjean P, Budtz-Jorgensen E, Steuerwald U, Heinzow B, Needham LL, Jorgensen PJ, Weihe P, Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls, The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 17(6), 699-701, April 2003 Abstract
  • Grandjean P, Weihe P, Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure, The American Journal of Clinical Nutrition, 77(3), 715-9, March 2003 Abstract
  • Grandjean P, White RF, Weihe P, Jorgensen PJ, Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood, Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association., 3(1), 18-23, 2003 Abstract
  • Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglas-Kuperus N, Hertz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma ER, Altshul LM, Heinzow B, Pagano JJ et al., Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment, Environmental Health Perspectives, 111(1), 65-70, January 2003 Abstract
  • Grandjean P, Budtz-Jørgensen E, Keiding N, Weihe P, Underestimation of risk due to exposure misclassification, European Journal of Oncology, 165-72, 2003
  • Fangstrom B, Athanasiadou M, Grandjean P, Weihe P, Bergman A, Hydroxylated PCB Metabolites and PCBs in Serum from Pregnant Faroese Women, Environmental Health Perspectives, 110(9), 895-9, Aug 2002 Abstract
  • Murata K, Budtz-Jorgensen E, Grandjean P, Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children, Risk Analysis : an Official Publication of the Society for Risk Analysis, 22(3), 465-74, June 2002 Abstract
  • Mol NM, Sorensen N, Weihe P, Andersson AM, Jorgensen N, Skakkebaek NE, Keiding N, Grandjean P, Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls, European Journal of Endocrinology, 146(3), 357-63, March 2002
  • Weihe P, Hansen JC, Murata K, Debes F, Jorgensen P, Steuerwald U, White RF, Grandjean P, Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury, International Journal of Circumpolar Health, 61(1), 41-9, February 2002 Abstract
  • Axelson O, Castleman B, Epstein S, Franco G, Giannasi F, Grandjean P, et al., Re: Implementation of WHO Guidelines on Disclosure of Interest by members of WHO Expert Panels, International Journal of Occupational and Environmental Health, 8(3), 271-3, 2002 Abstract
  • Grandjean P, Bjerve KS, Weihe P, Steuerwald U, Birthweight in a fishing community: significance of essential fatty acids and marine food contaminants, International Journal of Epidemiology, 30(6), 1272-8, December 2001 Abstract
  • Budtz-Jorgensen E, Keiding N, Grandjean P, Benchmark dose calculation from epidemiological data, Biometrics, 57(3), 698-706, September 2001 Abstract
  • Grandjean P, Weihe P, Burse VW, Needham LL, Storr-Hansen E, Heinzow B, Debes F, Murata K, Simonsen H, Ellefsen P, Budtz-Jorgensen E, Keiding N, White RF, Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants, Neurotoxicology and Teratology, 23(4), 305-17, 2001 Abstract
  • Grandjean P, White RF, Sullivan K, Debes F, Murata K, Otto DA, Weihe P, Impact of contrast sensitivity performance on visually presented neurobehavioral tests in mercury-exposed children, Neurotoxicology and Teratology, 23(2), 141-6, 2001 Abstract
  • Hoyer AP, Jorgensen T, Rank F, Grandjean P, Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested case-control study, Bmc Cancer [electronic Resource], 1(1), 8, 2001 Abstract
  • Hoyer AP, Jorgensen T, Grandjean P, Breast cancer and dieldrin, Lancet, 356(9244), 1852-3, 2000 Abstract
  • Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P, Selection bias in determining the age dependence of waiting time to pregnancy, American Journal of Epidemiology, 152(6), 565-72, September 2000 Abstract
  • Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, Budtz-Jorgensen E, Grandjean P, Maternal seafood diet, methylmercury exposure, and neonatal neurologic function [see comments], Journal of Pediatrics, 136(5), 599-605, May 2000 Abstract
  • Andersen HR, Nielsen JB, Grandjean P, Toxicologic evidence of developmental neurotoxicity of environmental chemicals, Toxicology, 144(1-3), 121-7, April 2000 Abstract
  • Nielsen GD, Nielsen JB, Andersen KE, Grandjean P, Effects of industrial detergents on the barrier function of human skin, International Journal of Occupational and Environmental Health, 6(2), 138-42, 2000 Abstract
  • Hoyer AP, Jorgensen T, Brock JW, Grandjean P, Organochlorine exposure and breast cancer survival, Journal of Clinical Epidemiology, 53(3), 323-30, March 2000 Abstract
  • Budtz-Jorgensen E, Grandjean P, Keiding N, White RF, Weihe P, Benchmark dose calculations of methylmercury-associated neurobehavioural deficits, Toxicology Letters, 112-113, 193-9, March 2000 Abstract
  • Hoyer AP, Jorgensen T, Grandjean P, Hartvig HB, Repeated measurements of organochlorine exposure and breast cancer risk (Denmark), Cancer Causes and Control, 11(2), 177-84, February 2000 Abstract
  • Biernat H, Ellias SA, Wermuth L, Cleary D, de Oliveira Santos EC, Jorgensen PJ, Feldman RG, Grandjean P, Tremor frequency patterns in mercury vapor exposure, compared with early Parkinson's disease and essential tremor, Neurotoxicology, 20(6), 945-52, December 1999 Abstract
  • Grandjean P, Mercury risks: controversy or just uncertainty?, Public Health Reports, 114(6), 512-5, November 1999 Abstract
  • Grandjean P, Budtz-Jorgensen E, White RF, Jorgensen PJ, Weihe P, Debes F, Keiding N, Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years, American Journal of Epidemiology, 150(3), 301-5, August 1999 Abstract
  • Sorensen N, Murata K, Budtz-Jorgensen E, Weihe P, Grandjean P, Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age, Epidemiology, 10(4), 370-5, July 1999 Abstract
  • Murata K, Weihe P, Araki S, Budtz-Jorgensen E, Grandjean P, Evoked potentials in Faroese children prenatally exposed to methylmercury, Neurotoxicology and Teratology, 21(4), 471-2, 1999 Abstract
  • Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P, Fecundability in relation to body mass and menstrual cycle patterns, Epidemiology, 10(4), 422-8, July 1999 Abstract
  • Grandjean P, White RF, Nielsen A, Cleary D, de Oliveira Santos EC, Methylmercury neurotoxicity in Amazonian children downstream from gold mining, Environmental Health Perspectives, 107(7), 587-91, July 1999 Abstract
  • Murata K, Weihe P, Renzoni A, Debes F, Vasconcelos R, Zino F, Araki S, Jorgensen PJ, White RF, Grandjean P, Delayed evoked potentials in children exposed to methylmercury from seafood, Neurotoxicology and Teratology, 21(4), 343-8, 1999 Abstract
  • Budtz-Jorgensen E, Keiding N, Grandjean P, White RF, Methylmercury neurotoxicity independent of PCB exposure, Environmental Health Perspectives, 107(5), A236-7, May 1999 Abstract
  • Grandjean P, White RF, Effects of methylmercury exposure on neurodevelopment, Jama, 281(10), 896; discussion 897, March 1999 Abstract
  • Viskum S, Rabjerg L, Jorgensen PJ, Grandjean P, Improvement in semen quality associated with decreasing occupational lead exposure, American Journal of Industrial Medicine, 35(3), 257-63, March 1999 Abstract
  • Nielsen GD, Soderberg U, Jorgensen PJ, Templeton DM, Rasmussen SN, Andersen KE, Grandjean P, Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity, Toxicology and Applied Pharmacology, 154(1), 67-75, Jan 1999 Abstract
  • Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB, Organochlorine exposure and risk of breast cancer, Lancet, 352(9143), 1816-20, December 1998 Abstract
  • Grandjean P, Weihe P, White RF, Debes F, Cognitive performance of children prenatally exposed to 'safe' levels of methylmercury, Environmental Research, 77(2), 165-72, May 1998 Abstract
  • Akagi H, Grandjean P, Takizawa Y, Weihe P, Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease, Environmental Research, 77(2), 98-103, May 1998 Abstract
  • Nielsen JB, Grandjean P, Jorgensen PJ, Predictors of blood lead concentrations in the lead-free gasoline era, Scandinavian Journal of Work, Environment and Health, 24(2), 153-6, April 1998 Abstract
  • Netterstrom B, Grandjean P, Occupational and environmental medicine in Denmark, International Archives of Occupational and Environmental Health, 71(1), 3-6, February 1998 Abstract
  • Castleman B, Dement J, Frank AL, Frumkin H, Giannasi F, Gochfeld M, Goldstein BD, Grandjean P, Greenberg M, LaDou J, Lemen RA, Levy BS, Maltoni C, McDiarmid M, Silbergeld EK, Teitelbaum DT, Thebaud-Mony A, Upton AC, Wegman DH, Salud Ocupacional, International Journal of Occupational and Environmental Health, 4(2), 131-3, 1998
  • Weihe P, Grandjean P, Methylmercury risks [letter; comment], Science, 279(5351), 639; discussion 641, Jan 1998 Abstract
  • Grandjean P, Mercurial uncertainties in environmental health, Annals of the New York Academy of Sciences, 837, 239-45, December 1997 Abstract
  • Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ, Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury, Neurotoxicology and Teratology, 19(6), 417-28, 1997 Abstract
  • Grandjean P, Guldager B, Larsen IB, Jorgensen PJ, Holmstrup P, Placebo response in environmental disease. Chelation therapy of patients with symptoms attributed to amalgam fillings, Journal of Occupational and Environmental Medicine, 39(8), 707-14, August 1997 Abstract
  • Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P, Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors, Clinical Chemistry, 43(7), 1209-14, July 1997 Abstract
  • Andersen HR, Nielsen JB, Nielsen F, Grandjean P, Antioxidative enzyme activities in human erythrocytes, Clinical Chemistry, 43(4), 562-8, April 1997 Abstract
  • Lynge E, Andersen A, Nilsson R, Barlow L, Pukkala E, Nordlinder R, Boffetta P, Grandjean P, Heikkila P, Horte LG, Jakobsson R, Lundberg I, Moen B, Partanen T, Riise T, Risk of cancer and exposure to gasoline vapors, American Journal of Epidemiology, 145(5), 449-58, March 1997 Abstract
  • Guldager B, Jorgensen PJ, Grandjean P, Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA, Clinical Chemistry, 42(12), 1938-42, December 1996 Abstract
  • Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ Jr, Jegou B, Jensen TK, Jouannet P, Keiding N, Leffers H, McLachlan JA, Meyer O, Muller J, Rajpert-De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE, Male reproductive health and environmental xenoestrogens, Environmental Health Perspectives, 104 Suppl 4, 741-803, August 1996 Abstract
  • Weihe P, Grandjean P, Debes F, White R, Health implications for Faroe islanders of heavy metals and PCBs from pilot whales, Science of the Total Environment, 186(1-2), 141-8, July 1996 Abstract
  • Dahl R, White RF, Weihe P, Sorensen N, Letz R, Hudnell HK, Otto DA, Grandjean P, Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year-old children, Neurotoxicology and Teratology, 18(4), 413-9, 1996 Abstract
  • Grandjean P, Sorsa M, Ethical aspects of genetic predisposition to environmentally-related disease, Science of the Total Environment, 184(1-2), 37-43, May 1996 Abstract
  • Grandjean P, White RF, Weihe P, Neurobehavioral epidemiology: application in risk assessment, Environmental Health Perspectives, 104 Suppl 2, 397-400, April 1996 Abstract
  • Grandjean P, Biomarkers in epidemiology, Clinical Chemistry, 41(12 Pt 2), 1800-3, December 1995 Abstract
  • Grandjean P, Brown SS, Reavey P, Young DS, Biomarkers in environmental toxicology: state of the art, Clinical Chemistry, 41(12 Pt 2), 1902-4, December 1995 Abstract
  • Grandjean P, Weihe P, Needham LL, Burse VW, Patterson DG Jr, Sampson EJ, Jorgensen PJ, Vahter M, Relation of a seafood diet to mercury, selenium, arsenic, and polychlorinated biphenyl and other organochlorine concentrations in human milk, Environmental Research, 71(1), 29-38, October 1995 Abstract
  • Grandjean P, Individual susceptibility in occupational and environmental toxicology, Toxicology Letters, 77(1-3), 105-8, May 1995 Abstract
  • Grandjean P, Weihe P, White RF, Milestone development in infants exposed to methylmercury from human milk, Neurotoxicology, 16(1), 27-33, Spring 1995 Abstract
  • Johnson BL, Grandjean P, Amler RW, Neurobehavioral testing and hazardous chemical sites, Neurotoxicology and Teratology, 16(5), 485-7, 1994 Abstract
  • Grandjean P, Weihe P, Nielsen JB, Methylmercury: significance of intrauterine and postnatal exposures, Clinical Chemistry, 40(7 Pt 2), 1395-400, July 1994 Abstract
  • Grandjean P, Brown SS, Reavey P, Young DS, Biomarkers of chemical exposure: state of the art, Clinical Chemistry, 40(7 Pt 2), 1360-2, July 1994 Abstract
  • Nielsen JB, Andersen O, Grandjean P, Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice, Archives of Toxicology, 68(5), 317-21, 1994 Abstract
  • Olsen SF, Grandjean P, Weihe P, Videro T, Frequency of seafood intake in pregnancy as a determinant of birth weight: evidence for a dose dependent relationship, Journal of Epidemiology and Community Health, 47(6), 436-40, December 1993 Abstract
  • Grandjean P, Cardoso B, Guimaraes G, Mercury poisoning [letter], Lancet, 342(8877), 991, October 1993 Abstract
  • Grandjean P, International perspectives of lead exposure and lead toxicity, Neurotoxicology, 14(2-3), 9-14, 1993 Abstract
  • Damm D, Grandjean P, Lyngbye T, Trillingsgaard A, Hansen ON, Early lead exposure and neonatal jaundice: relation to neurobehavioral performance at 15 years of age, Neurotoxicology and Teratology, 15(3), 173-81, 1993 Abstract
  • Grandjean P, Weihe P, Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias, Environmental Research, 61(1), 176-83, April 1993 Abstract
  • Grandjean P, Olsen JH, Juel K, Excess cancer incidence among workers exposed to fluoride, Scandinavian Journal of Work, Environment and Health, 19 Suppl 1, 108-9, 1993 Abstract
  • Grandjean P, Individual susceptibility to toxicity, Toxicology Letters, 64-65 Spec No, 43-51, December 1992 Abstract
  • Grandjean P, Olsen JH, Jensen OM, Juel K, Cancer incidence and mortality in workers exposed to fluoride, Journal of the National Cancer Institute, 84(24), 1903-9, December 1992 Abstract
  • Grandjean P, Nielsen GD, Jorgensen PJ, Horder M, Reference intervals for trace elements in blood: significance of risk factors, Scandinavian Journal of Clinical and Laboratory Investigation, 52(4), 321-37, June 1992 Abstract
  • Grandjean P, Weihe P, Jorgensen PJ, Clarkson T, Cernichiari E, Videro T, Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead, Archives of Environmental Health, 47(3), 185-95, 1992 Abstract
  • Grandjean P, Lyngbye T, Hansen ON, Lessons from a Danish study on neuropsychological impairment related to lead exposure, Environmental Health Perspectives, 94, 111-5, August 1991 Abstract
  • Grandjean P, Sandoe SH, Kimbrough RD, Non-specificity of clinical signs and symptoms caused by environmental chemicals, Human and Experimental Toxicology, 10(3), 167-73, May 1991 Abstract
  • Grandjean P, Jorgensen PJ, Viskum S, Temporal and interindividual variation in erythrocyte zinc-protoporphyrin in lead exposed workers, British Journal of Industrial Medicine, 48(4), 254-7, April 1991 Abstract
  • Grandjean P, Jacobsen IA, Jorgensen PJ, Chronic lead poisoning treated with dimercaptosuccinic acid, Pharmacology and Toxicology, 68(4), 266-9, April 1991 Abstract
  • Lyngbye T, Hansen ON, Grandjean P, Lead concentration in deciduous teeth from Danish school children, Danish Medical Bulletin, 38(1), 89-93, February 1991 Abstract
  • Grandjean P, Effects on reserve capacity: significance for exposure limits, Science of the Total Environment, 101(1-2), 25-32, January 1991 Abstract
  • Grandjean P, Andersen O, Lung cancer in filling station attendants, American Journal of Industrial Medicine, 20(6), 763-8, 1991 Abstract
  • Grandjean P, Jorgensen PJ, Retention of lead and cadmium in prehistoric and modern human teeth, Environmental Research, 53(1), 6-15, October 1990 Abstract
  • Lyngbye T, Jorgensen PJ, Grandjean P, Hansen ON, Validity and interpretation of blood lead levels: a study of Danish school children, Scandinavian Journal of Clinical and Laboratory Investigation, 50(4), 441-9, June 1990 Abstract
  • Jensen BM, Sando SH, Grandjean P, Wiggers P, Dalhoj J, Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors, Clinical Chemistry, 36(6), 846-8, June 1990 Abstract
  • Lyngbye T, Hansen ON, Trillingsgaard A, Beese I, Grandjean P, Learning disabilities in children: significance of low-level lead-exposure and confounding factors, Acta Paediatrica Scandinavica, 79(3), 352-60, March 1990 Abstract
  • Nielsen GD, Jepsen LV, Jorgensen PJ, Grandjean P, Brandrup F, Nickel-sensitive patients with vesicular hand eczema: oral challenge with a diet naturally high in nickel, British Journal of Dermatology, 122(3), 299-308, March 1990 Abstract
  • Lyngbye T, Hansen ON, Grandjean P, Predictors of tooth-lead level with special reference to traffic. A study of lead-exposure in children, International Archives of Occupational and Environmental Health, 62(6), 417-22, 1990 Abstract
  • Grandjean P, Horder M, Thomassen Y, Fluoride, aluminum, and phosphate kinetics in cryolite workers, Journal of Occupational Medicine, 32(1), 58-63, January 1990 Abstract
  • Grandjean P, Kristensen K, Jorgensen PJ, Nielsen GD, Andersen O, Trace element status in alcoholism before and during disulfiram treatment, Annals of Clinical and Laboratory Science, 20(1), 28-35, 1990 Abstract
  • Bonde I, Beck HI, Jorgensen PJ, Grandjean P, Brandrup F, Nickel in intercellular fluid. Comparison between nickel-allergic patients and controls, Acta Dermato-venereologica, 70(4), 300-3, 1990 Abstract
  • Grandjean P, Jensen BM, Sando SH, Jogensen PJ, Antonsen S, Delayed blood regeneration in lead exposure: an effect on reserve capacity, American Journal of Public Health, 79(10), 1385-8, October 1989 Abstract
  • Hansen ON, Trillingsgaard A, Beese I, Lyngbye T, Grandjean P, A neuropsychological study of children with elevated dentine lead level: assessment of the effect of lead in different socio-economic groups, Neurotoxicology and Teratology, 11(3), 205-13, 1989 Abstract
  • Grandjean P, Hollnagel H, Hedegaard L, Christensen JM, Larsen S, Blood lead-blood pressure relations: alcohol intake and hemoglobin as confounders, American Journal of Epidemiology, 129(4), 732-9, April 1989 Abstract
  • Andersen O, Grandjean P, Effects of tetraethylthiuram disulfide on the toxicokinetics of cadmium in mice, Pharmacology and Toxicology, 64(2), 210-5, February 1989 Abstract
  • Lyngbye T, Hansen ON, Grandjean P, Neurological deficits in children: medical risk factors and lead exposure, Neurotoxicology and Teratology, 10(6), 531-7, 1988 Abstract
  • Madsen HH, Skjodt T, Jorgensen PJ, Grandjean P, Blood lead levels in patients with lead shot retained in the appendix, Acta Radiologica, 29(6), 745-6, 1988 Abstract
  • Lyngbye T, Hansen O, Grandjean P, Trillingsgaard A, Beese I, Traffic a source of lead exposure in childhood, Science of the Total Environment, 71(3), 461-7, June 1988 Abstract
  • Christoffersen J, Christoffersen MR, Larsen R, Rostrup E, Tingsgaard P, Andersen O, Grandjean P, Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases, Calcified Tissue International, 42(5), 331-9, May 1988 Abstract
  • Grandjean P, Ancient skeletons as silent witnesses of lead exposures in the past, Critical Reviews in Toxicology, 19(1), 11-21, 1988 Abstract
  • Lyngbye T, Hansen ON, Grandjean P, Bias from non-participation: a study of low-level lead exposure in children, Scandinavian Journal of Social Medicine, 16(4), 209-15, 1988 Abstract
  • Grandjean P, Andersen O, Nielsen GD, Carcinogenicity of occupational nickel exposures: an evaluation of the epidemiological evidence, American Journal of Industrial Medicine, 13(2), 193-209, 1988 Abstract
  • Grandjean P, Berlin A, Gilbert M, Penning W, Preventing percutaneous absorption of industrial chemicals: the 'skin' denotation, American Journal of Industrial Medicine, 14(1), 97-107, 1988 Abstract
  • Grandjean P, Bach E, Indirect exposures: the significance of bystanders at work and at home, American Industrial Hygiene Association Journal, 47(12), 819-24, December 1986 Abstract
  • Grandjean P, Reference intervals for toxic metals: problems and prospects. Abraham J. Gitlitz memorial lecture, Annals of Clinical and Laboratory Science, 16(1), 67-74, 1986 Abstract
  • Grandjean P, Lyngbye T, Hansen ON, Lead concentration in deciduous teeth: variation related to tooth type and analytical technique, Journal of Toxicology and Environmental Health, 19(3), 437-44, 1986 Abstract
  • Grandjean P, Juel K, Jensen OM, Mortality and cancer morbidity after heavy occupational fluoride exposure, American Journal of Epidemiology, 121(1), 57-64, January 1985 Abstract
  • Grandjean P, Hansen ON, Lyngbye K, Analysis of lead in circumpulpal dentin of deciduous teeth, Annals of Clinical and Laboratory Science, 14(4), 270-5, 1984 Abstract
  • Grandjean P, Lead poisoning: hair analysis shows the calendar of events, Human Toxicology, 3(3), 223-8, June 1984 Abstract
  • Eskildsen J, Grandjean P, Lead exposure from lead pellets: age-related accumulation in mute swans, Toxicology Letters, 21(2), 225-9, May 1984 Abstract
  • Grandjean P, Human exposure to nickel, Iarc Scientific Publications, 469-85, 1984 Abstract
  • Grandjean P, Thomsen G, Reversibility of skeletal fluorosis, British Journal of Industrial Medicine, 40(4), 456-61, November 1983 Abstract
  • Grandjean P, Wulf HC, Niebuhr E, Sister chromatid exchange in response to variations in occupational lead exposure, Environmental Research, 32(1), 199-204, October 1983 Abstract
  • Grandjean P, Storage depots in the body: passive retention or time bomb? [editorial], American Journal of Industrial Medicine, 4(6), 689-90, 1983 Abstract
  • Grandjean P, Andersen O, Toxicity of lead additives [letter], Lancet, 2(8293), 333-4, August 1982 Abstract
  • Grandjean P, Occupational fluorosis through 50 years: clinical and epidemiological experiences, American Journal of Industrial Medicine, 3(2), 227-36, 1982 Abstract
  • Grandjean P, Hollnagel H, Olsen NB, Occupationally related lead exposure in the general population. A population study of 40-year-old men, Scandinavian Journal of Work, Environment and Health, 7(4), 298-301, December 1981 Abstract
  • Olsen NB, Hollnagel H, Grandjean P, Indicators of lead exposure in an adult Danish suburban population, Danish Medical Bulletin, 28(4), 168-76, September 1981 Abstract
  • Grandjean P, Blood lead concentrations reconsidered [news], Nature, 291(5812), 188, May 1981 Abstract
  • Hertz MM, Bolwig TG, Grandjean P, Westergaard E, Lead poisoning and the blood-brain barrier, Acta Neurologica Scandinavica, 63(5), 286-96, May 1981 Abstract
  • Grandjean P, Kon SH, Lead exposure of welders and bystanders in a ship repair yard, American Journal of Industrial Medicine, 2(1), 65-70, 1981 Abstract
  • Grandjean P, Olsen NB, Hollnagel H, Influence of smoking and alcohol consumption on blood lead levels, International Archives of Occupational and Environmental Health, 48(4), 391-7, 1981 Abstract
  • Arnvig E, Grandjean P, Beckmann J, Neurotoxic effects of heavy lead exposure determined with psychological tests, Toxicology Letters, 5(6), 399-404, May 1980 Abstract
  • Grandjean P, Selikoff IJ, Shen SK, Sunderman FW Jr, Nickel concentrations in plasma and urine of shipyard workers, American Journal of Industrial Medicine, 1(2), 181-9, 1980 Abstract
  • Grandjean P, Occupational lead exposure in Denmark: screening with the haematofluorometer, British Journal of Industrial Medicine, 36(1), 52-8, February 1979 Abstract
  • Grandjean P, Nielsen T, Organolead compounds: environmental health aspects, Residue Reviews, 72, 97-148, 1979 Abstract
  • Grandjean P, Nielsen OV, Shapiro IM, Lead retention in ancient Nubian and contemporary populations, Journal of Environmental Pathology and Toxicology, 2(3), 781-7, 1979 Abstract
  • Grandjean P, Arnvig E, Beckmann J, Psychological dysfunctions in lead-exposed workers. Relation to biological parameters of exposure, Scandinavian Journal of Work, Environment and Health, 4(4), 295-303, December 1978 Abstract
  • Grandjean P, Lead concentration in single hairs as a monitor of occupational lead exposure, International Archives of Occupational and Environmental Health, 42(2), 69-81, November 1978 Abstract
  • Grandjean P, Lintrup J, Erythrocyte-Zn-protoporphyrin as an indicator of lead exposure, Scandinavian Journal of Clinical and Laboratory Investigation, 38(7), 669-75, November 1978 Abstract
  • Grandjean P, Widening perspectives of lead toxicity. A review of health effects of lead exposure in adults, Environmental Research, 17(2), 303-21, October 1978 Abstract
  • Nielsen T, Jensen KA, Grandjean P, Organic lead in normal human brains, Nature, 274(5671), 602-3, August 1978 Abstract
  • Grandjean P, Possible effect of lead on egg-shell thickness in kestrels 1874-1974, Bulletin of Environmental Contamination and Toxicology, 16(1), 101-6, July 1976 Abstract
  • Grandjean P, Lead in danes. Historical and toxicological studies, Environmental Quality and Safety. Supplement, 2, 6-75, 1975 Abstract

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