Dr. Philippe A. Grandjean | |
University of Southern Denmark Faculty of Health Sciences Environmental Medicine ProfessorAppointed: 1982 Harvard University School of Public Health Environmental Health Adjunct ProfessorAppointed: 2003 National Board of Health Toxicology ConsultantAppointed: 1983 |  |
QualificationsD.M.Sc., University of Copenhagen, 1978. M.D., University of Copenhagen, 1974. Expertise and Research InterestsDr. Grandjean has long-term experience in environmental epidemiology and has contributed to the development and validation of various biomarkers and clinical tests of early dysfunctions, mainly in regard to the nervous system. Research efforts have focused on long-term health implications of exposures to environmental chemicals, including lead, methylmercury, nickel, and organohalogen compounds. Current studies emphasize the significance of prenatal exposures for the development of the nervous system, the cardiovascular system, and immune functions in children, and possible hormone-disrupting effects of pesticides and persistent halogenated hydrocarbons. The implications of research in this area are explored in the light of the precautionary pronciple. Other ExpertiseDr. Grandjean has served as Vice-Dean and Institute Chairman at Odense University and as member of the Danish Medical Research Council. He is founding editor of the web-based journal Environmental Health (http://www.ehjournal.net) and has served as European Editor of the Archives of Environmental Health and is currently a member of editorial boards of ten scientific journals. He has been elected Fellow of the American Association for the Advancement of Science, and was elected to the Board of Collegium Ramazzini in 2005. Past committee memberships include the U.S.Environmental Protection Agency SAB/SAP Endocrine Disruptor Screening Program Subcommittee, the Danish Committee on Scientific Dishonesty, the Panel on Contaminants of the European Food Safety Authority, and the chair of the Commission on Toxicology of IUPAC, and the Danish Commission on Non-Ionizing Radiation Research, as well as advisory tasks for several international organizations. Future ResearchEarly human development is particularly vulnerable to adverse effects of environmental chemicals, especially neurotoxicants. These issues will be explored in prospective studies of birth cohorts with well defined exposures to specific chemicals, including methylmercury, PCBs, pesticides, and endocrine disruptors. Industrial RelevanceThe research undertaken is of key interest with regard to setting exposure limits and preventing adverse health effects from industrial exposures and emissions. KeywordsCOS Keywords:Biomarkers, Breast Cancer, Cardiovascular System, Clinical Research or Studies, Community Health, Environmental Health, Epidemiology, Human Development, Immune System, Nervous System, Neurology, Occupational Health and Safety, Pesticides, Toxicology.Additional Terms:Environment, Epidemiology, Neurobehavioral Function, Toxicology.Languages(Reading, Writing, Speaking)Danish: (Fluent, Fluent, Fluent) English: (Fluent, Fluent, Fluent) Swedish: (Fluent, Basic, Functional) French: (Functional, Basic, Basic) German: (Functional, Basic, Basic) MembershipsAmerican Association for the Advancement of Science American Public Health Association Association of Clinical Scientists Collegium Ramazzini Danish Medical Association Faroese Society of Science and Letters International Commission on Occupational Health International Epidemiological Association International Society for Environmental Epidemiology Society for Occupational and Environmental Health Honors and Awards2003, Knight of Dannebrog, First Degree,
Queen of Denmark
1994, Fellow,
American Association for the Advancement of Science
1990, Knight of Dannebrog,
Queen of Denmark
1978-1979,
Senior Research Scholarship,
Fulbright Commission
Previous Positions1994-2002, Adjunct Professor,
Boston University,
Schools of Medicine and Public Health,
Neurology and Environmental Health
1980-1982, Director,
Danish National Institute of Occupational Health,
Occupational Medicine
1978-1980, Visiting Fellow,
City College of New York, The City University of New York,
Mt Sinai School of Medicine,
Community Medicine,
Environmental Sciences Laboratory
1978-1980, Fullbright Senior Scholar,
City College of New York, The City University of New York,
Mt Sinai School of Medicine,
Community Medicine,
Environmental Sciences Laboratory
Funding Received- National Institutes of Health (NIH):
Mercury-Associated Neurobehavioral Deficit in Children,
$2,026,729,
2007
to 2012.
- National Institutes of Health (NIH):
Three-generation human study of reproductive effects of narine food contaminants,
$2,485,000,
2006
to 2011.
- European Commission (EC):
Public Health Impact of Metals Exposure (PHIME),
Euro 776,000,
2006
to 2011.
- National Institutes of Health (NIH):
Health effects of lifetime exposure to food contaminants,
$1,262,000,
2006
to 2010.
- National Institutes of Health (NIH):
Epidemiology of Immunotoxicant Exposure in Children,
$1,163,538,
2004
to 2008.
- Environmental Protection Agency (EPA):
Children's vulnerability to environmental immunotoxicant exposure,
$750,000,
2003
to 2006.
- Danish Medical Research Council:
Environmental epidemiology research,
$170,000,
2002
to 2004.
- European Commission:
Assessment of Neurobehavioural Endpoints and Markers Of Neurotoxicant Exposures (ANEMONE),
Euro 1.1 million,
2002
to 2004.
- National Institutes of Health (NIH):
Effects of perinatal endocrine disruption in children,
$1,000,000,
2001
to 2006.
- National Institutes of Health (NIH):
Mercury-associated neurobehavioral deficit in children,
$1,585,000,
2000
to 2006.
- Danish Medical Research Council:
Neurotoxic effects of pollutants,
DKK 2,000,000,
1998
to 2001.
- National Institutes of Health (NIH):
Neurobehavioral effects of environmental PCB exposure,
$830,000,
1996
to 2000.
- Danish Strategic Environmental Research Programme:
Health effects of hormone disruptors,
DKK 4,000,000,
1996
to 2000.
- Occupational Health Foundation (Denmark):
Occupational aluminum neurotoxicity,
DKK 1,000,000,
1996
to 2000.
- National Institutes of Health (NIH):
Serum PCB concentrations in breast cancer patients,
$290,000,
1995
to 1997.
- Joint Ministerial Pesticide Research Initiative (Denmark):
Evaluation of estrogenic effects,
DKK 912,000,
1995
to 1997.
- Commission of the European Communities:
Neonatal PCB exposure and neurodevelopmental deficit,
$321,000,
1994
to 1998.
- Commission of the European Communities:
Detection of early neurotoxicity in children with environmental methylmercury exposure,
$250,000,
1993
to 1995.
- Danish Strategic Environmental Research Programme:
Center for Biochemical and Occupational Epidemiology,
DKK 2,677,000,
1993
to 1996.
- Danish Medical Research Council:
Environmental epidemiology,
DKK 3,750,000,
1993
to 1997.
- National Institutes of Health (NIH):
Neurobehavioral effects of intrauterine mercury exposure,
$547,300,
1992
to 1995.
Publications- Pouzaud F, Ibbou A, Blanchemanche S, Grandjean P, Krempf M, Philippe HJ, Verger P (Mar 2009) Use of advanced cluster analysis to characterize fish consumption patterns and methylmercury dietary exposures from fish and other sea foods among pregnant women., Journal of exposure science & environmental epidemiology
 - Chevrier C, Sullivan K, White RF, Comtois C, Cordier S, Grandjean P (Jan 2009) Qualitative assessment of visuospatial errors in mercury-exposed Amazonian children., Neurotoxicology, 30 (1), 37-46
 - Grandjean P, Heindel JJ (Oct 2008) In utero and early-life conditions and adult health and disease., The New England journal of medicine, 359 (14), 1523; author reply 1
 - Grandjean P, Budtz-Jørgensen E, Barr DB, Needham LL, Weihe P, Heinzow B (Sep 2008) Elimination half-lives of polychlorinated biphenyl congeners in children., Environmental science & technology, 42 (18), 6991-6
 - Wermuth L, Bech S, Petersen MS, Joensen P, Weihe P, Grandjean P (Aug 2008) Prevalence and incidence of Parkinson's disease in The Faroe Islands., Acta neurologica Scandinavica, 118 (2), 126-31
 - Weihe P, Kato K, Calafat AM, Nielsen F, Wanigatunga AA, Needham LL, Grandjean P (Aug 2008) Serum concentrations of polyfluoroalkyl compounds in Faroese whale meat consumers., Environmental science & technology, 42 (16), 6291-5
 - Petersen MS, Halling J, Bech S, Wermuth L, Weihe P, Nielsen F, Jørgensen PJ, Budtz-Jørgensen E, Grandjean P (Jul 2008) Impact of dietary exposure to food contaminants on the risk of Parkinson's disease., Neurotoxicology, 29 (4), 584-90
 - Petersen MS, Weihe P, Choi A, Grandjean P (Jul 2008) Increased prenatal exposure to methylmercury does not affect the risk of Parkinson's disease., Neurotoxicology, 29 (4), 591-5
 - Choi AL, Budtz-Jørgensen E, Jørgensen PJ, Steuerwald U, Debes F, Weihe P, Grandjean P (May 2008) Selenium as a potential protective factor against mercury developmental neurotoxicity., Environmental research, 107 (1), 45-52
 - Andersen HR, Schmidt IM, Grandjean P, Jensen TK, Budtz-Jørgensen E, Kjaerstad MB, Baelum J, Nielsen JB, Skakkebaek NE, Main KM (Apr 2008) Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy., Environmental health perspectives, 116 (4), 566-72
 - Halling J, Petersen MS, Grandjean P, Weihe P, Brosen K (Mar 2008) Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands., Pharmacogenetics and genomics, 18 (3), 209-12
 - Grandjean P (Feb 2008) Late insights into early origins of disease., Basic & clinical pharmacology & toxicology, 102 (2), 94-9
 - Grandjean P, Choi A (Jan 2008) The delayed appearance of a mercurial warning., Epidemiology (Cambridge, Mass.), 19 (1), 10-1
 - Grandjean P (Jan 2008) Seven deadly sins of environmental epidemiology and the virtues of precaution., Epidemiology (Cambridge, Mass.), 19 (1), 158-62
 - Bjørling-Poulsen M, Andersen HR, Grandjean P (2008) Potential developmental neurotoxicity of pesticides used in Europe., Environmental health : a global access science source, 7, 50
 - Choi AL, Cordier S, Weihe P, Grandjean P (2008) Negative confounding in the evaluation of toxicity: the case of methylmercury in fish and seafood., Critical reviews in toxicology, 38 (10), 877-93
 - Landrigan P, Nordberg M, Lucchini R, Nordberg G, Grandjean P, Iregren A, Alessio L (Oct 2007) The Declaration of Brescia on prevention of the neurotoxicity of metals June 18, 2006., American journal of industrial medicine, 50 (10), 709-11
 - Murata K, Grandjean P, Dakeishi M (Oct 2007) Neurophysiological evidence of methylmercury neurotoxicity., American journal of industrial medicine, 50 (10), 765-71
 - Andersen HR, Nielsen F, Nielsen JB, Kjaerstad MB, Baelum J, Grandjean P (Oct 2007) Xeno-oestrogenic activity in serum as marker of occupational pesticide exposure., Occupational and environmental medicine, 64 (10), 708-14
 - Grandjean P, Budtz-Jørgensen E (Oct 2007) Total imprecision of exposure biomarkers: implications for calculating exposure limits., American journal of industrial medicine, 50 (10), 712-9
 - Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brøsen K (Oct 2007) Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults., Toxicology and applied pharmacology, 224 (2), 202-6
 - Grandjean P (Aug 2007) [Effect of industrial chemicals on development of the nerve system--secondary publication], Ugeskrift for laeger, 169 (34), 2782-4
 - Budtz-Jørgensen E, Grandjean P, Weihe P (Mar 2007) Separation of risks and benefits of seafood intake., Environmental health perspectives, 115 (3), 323-7
 - Budtz-Jørgensen E, Keiding N, Grandjean P, Weihe P (Jan 2007) Confounder selection in environmental epidemiology: assessment of health effects of prenatal mercury exposure., Annals of epidemiology, 17 (1), 27-35
 - Grandjean P, Murata K (Jan 2007) Developmental arsenic neurotoxicity in retrospect., Epidemiology (Cambridge, Mass.), 18 (1), 25-6
 - Grandjean P, Ozonoff D (2007) Environmental Health: the first five years., Environmental health : a global access science source, 6, 27
 - Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brøsen K (Dec 2006) Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls., European journal of clinical pharmacology, 62 (12), 1041-8
 - Grandjean P, Landrigan PJ (Dec 2006) Developmental neurotoxicity of industrial chemicals., Lancet, 368 (9553), 2167-78
 - Murata K, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Grandjean P (Oct 2006) Correction for "Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury" by Murata et al., The Journal of pediatrics, 149 (4), 583-4
 - Heilmann C, Grandjean P, Weihe P, Nielsen F, Budtz-Jørgensen E (Aug 2006) Reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls., PLoS medicine, 3 (8), e311
 - Coccini T, Randine G, Castoldi AF, Grandjean P, Ostendorp G, Heinzow B, Manzo L (Jul 2006) Effects of developmental co-exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) on cholinergic muscarinic receptors in rat brain., Neurotoxicology, 27 (4), 468-77
 - Baris YI, Grandjean P (Mar 2006) Prospective study of mesothelioma mortality in Turkish villages with exposure to fibrous zeolite., Journal of the National Cancer Institute, 98 (6), 414-7
 - Barr DB, Weihe P, Davis MD, Needham LL, Grandjean P (Feb 2006) Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort., Chemosphere, 62 (7), 1167-82
 - Dietz R, Riget F, Born EW, Sonne C, Grandjean P, Kirkegaard M, Olsen MT, Asmund G, Renzoni A, Baagøe H, Andreasen C (Feb 2006) Trends in mercury in hair of Greenlandic polar bears (Ursus maritimus) during 1892-2001., Environmental science & technology, 40 (4), 1120-5
 - Dakeishi M, Murata K, Grandjean P (2006) Long-term consequences of arsenic poisoning during infancy due to contaminated milk powder., Environmental health : a global access science source, 5, 31
 - Grandjean P (Dec 2005) Contaminants in fish oil., The American journal of clinical nutrition, 82 (6), 1354; author reply 1
 - Fängström B, Hovander L, Bignert A, Athanassiadis I, Linderholm L, Grandjean P, Weihe P, Bergman A (Dec 2005) Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later., Environmental science & technology, 39 (24), 9457-63
 - Grandjean P (Sep 2005) Non-precautionary aspects of toxicology., Toxicology and applied pharmacology, 207 (2 Suppl), 652-7
 - Jensen TK, Grandjean P, Jorgensen EB, White RF, Debes F, Weihe P (Sep 2005) Effects of breast feeding on neuropsychological development in a community
with methylmercury exposure from seafood, Journal of Exposure Analysis and Environmental Epidemiology, 15 (5), 423-30
- Fängström B, Athanasiadou M, Athanassiadis I, Bignert A, Grandjean P, Weihe P, Bergman A (Aug 2005) Polybrominated diphenyl ethers and traditional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe Islands., Chemosphere, 60 (7), 836-43
 - Halling J, Petersen MS, Damkier P, Nielsen F, Grandjean P, Weihe P, Lundgren S, Lundblad MS, Brosen K (2005) Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population, European Journal of Clinical Pharmacology, 61, 491-7
- Grandjean P, Budtz-Jorgensen E, Jorgensen PJ, Weihe P (Jul 2005) Umbilical cord mercury concentration as biomarker of prenatal exposure to
methylmercury, Environmental Health Perspectives, 113 (7), 905-8
- Fangstrom B, Strid A, Grandjean P, Weihe P, Bergman A (2005) A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands, Environmental Health, 4 (12)
- Grandjean P, Klein G (Mar 2005) Epidemiology and precaution 150 years before snow., Epidemiology (Cambridge, Mass.), 16 (2), 271-2
 - Weihe P, Grandjean P, Jorgensen PJ, Application of Hair-mercury Analysis to Determine the Impact of a Seafood
Advisory., Environmental Research, 97(2), 200-7, Feb 2005
 - Fängström B, Strid A, Grandjean P, Weihe P, Bergman A (2005) A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands., Environmental health : a global access science source, 4, 12
 - Budtz-Jorgensen E, Keiding N, Grandjean P, Effects of Exposure Imprecision on Estimation of the Benchmark Dose., Risk Analysis : An Official Publication of the Society for Risk Analysis, 24(6), 1689-96, Dec 2004
 - Budtz-Jorgensen E, Grandjean P, Jorgensen PJ, Weihe P, Keiding N, Association between mercury concentrations in blood and hair in
methylmercury-exposed subjects at different ages, Environmental Research, 95(3), 385-93, July 2004
 - Grandjean P, Olsen JH, Extended follow-up of cancer incidence in fluoride-exposed workers, Journal of the National Cancer Institute, 96(10), 802-3, May 2004
 - Grandjean P, Bailar JC, Gee D, Needleman HL, Ozonoff DM, Richter E, Sofritti M, Soskolne CL, Implications of the Precautionary Principle in research and policy-making, American Journal of Industrial Medicine, 45(4), 382-5, April 2004
 - Nielsen JB, Grandjean P, Criteria for skin notation in different countries, American Journal of Industrial Medicine, 45(3), 275-80, March 2004
 - Grandjean P, Murata K, Budtz-Jørgensen E, Weihe P, Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort, Journal of Pediatrics, 144(2), 169-76, February 2004
- Murata K, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Grandjean P, Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury, Journal of Pediatrics, 144(2), 177-83, February 2004
- Grandjean P, Implications of the precautionary principle for primary prevention and
research, Annual Review of Public Health, 25, 199-223, 2004
 - Grandjean P, Implications of the Precautionary Principle for public health practice and
research, International Journal of Occupational Medicine and Environmental Health, 17(1), 5-7, 2004
 - Grandjean P, Budtz-Jorgensen E, Keiding N, Weihe P, Underestimation of risk due to exposure misclassification, International Journal of Occupational Medicine and Environmental Health, 17(1), 131-6, 2004
 - Grandjean P, Implications of the Precautionary Principle for Primary Prevention And
Research., Annual Review of Public Health, 25, 199-223, 2004
 - Grandjean P, Budtz-Jorgensen E, Keiding N, Weihe P, Underestimation of Risk Due to Exposure Misclassification., International Journal of Occupational Medicine and Environmental Health, 17(1), 131-6, 2004
 - Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P, White RF, Consequences of exposure measurement error for confounder identification
in environmental epidemiology, Statistics in Medicine, 22(19), 3089-100, October 2003
 - Grandjean P, Budtz-Jorgensen E, Steuerwald U, Heinzow B, Needham LL, Jorgensen PJ, Weihe P, Attenuated growth of breast-fed children exposed to increased
concentrations of methylmercury and polychlorinated
biphenyls, The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 17(6), 699-701, April 2003
 - Grandjean P, Weihe P, Arachidonic acid status during pregnancy is associated with
polychlorinated biphenyl exposure, The American Journal of Clinical Nutrition, 77(3), 715-9, March 2003
 - Grandjean P, White RF, Weihe P, Jorgensen PJ, Neurotoxic risk caused by stable and variable exposure to methylmercury
from seafood, Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association., 3(1), 18-23, 2003
 - Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglas-Kuperus N, Hertz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma ER, Altshul LM, Heinzow B, Pagano JJ et al., Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment, Environmental Health Perspectives, 111(1), 65-70, January 2003
 - Grandjean P, Budtz-Jørgensen E, Keiding N, Weihe P, Underestimation of risk due to exposure misclassification, European Journal of Oncology, 165-72, 2003
- Fangstrom B, Athanasiadou M, Grandjean P, Weihe P, Bergman A, Hydroxylated PCB Metabolites and PCBs in Serum from Pregnant Faroese
Women, Environmental Health Perspectives, 110(9), 895-9, Aug 2002
 - Murata K, Budtz-Jorgensen E, Grandjean P, Benchmark dose calculations for methylmercury-associated delays on evoked
potential latencies in two cohorts of children, Risk Analysis : an Official Publication of the Society for Risk Analysis, 22(3), 465-74, June 2002
 - Mol NM, Sorensen N, Weihe P, Andersson AM, Jorgensen N, Skakkebaek NE, Keiding N, Grandjean P, Spermaturia and serum hormone concentrations at the age of puberty in boys prenatally exposed to polychlorinated biphenyls, European Journal of Endocrinology, 146(3), 357-63, March 2002
- Weihe P, Hansen JC, Murata K, Debes F, Jorgensen P, Steuerwald U, White RF, Grandjean P, Neurobehavioral performance of Inuit children with increased prenatal
exposure to methylmercury, International Journal of Circumpolar Health, 61(1), 41-9, February 2002
 - Axelson O, Castleman B, Epstein S, Franco G, Giannasi F, Grandjean P, et al., Re: Implementation of WHO Guidelines on Disclosure of Interest by members of WHO Expert Panels, International Journal of Occupational and Environmental Health, 8(3), 271-3, 2002
 - Grandjean P, Bjerve KS, Weihe P, Steuerwald U, Birthweight in a fishing community: significance of essential fatty acids
and marine food contaminants, International Journal of Epidemiology, 30(6), 1272-8, December 2001
 - Budtz-Jorgensen E, Keiding N, Grandjean P, Benchmark dose calculation from epidemiological data, Biometrics, 57(3), 698-706, September 2001
 - Grandjean P, Weihe P, Burse VW, Needham LL, Storr-Hansen E, Heinzow B, Debes F, Murata K, Simonsen H, Ellefsen P, Budtz-Jorgensen E, Keiding N, White RF, Neurobehavioral deficits associated with PCB in 7-year-old children
prenatally exposed to seafood neurotoxicants, Neurotoxicology and Teratology, 23(4), 305-17, 2001
 - Grandjean P, White RF, Sullivan K, Debes F, Murata K, Otto DA, Weihe P, Impact of contrast sensitivity performance on visually presented neurobehavioral tests in mercury-exposed children, Neurotoxicology and Teratology, 23(2), 141-6, 2001
 - Hoyer AP, Jorgensen T, Rank F, Grandjean P, Organochlorine exposures influence on breast cancer risk and survival
according to estrogen receptor status: a Danish cohort-nested case-control
study, Bmc Cancer [electronic Resource], 1(1), 8, 2001
 - Hoyer AP, Jorgensen T, Grandjean P, Breast cancer and dieldrin, Lancet, 356(9244), 1852-3, 2000
 - Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P, Selection bias in determining the age dependence of waiting time to pregnancy, American Journal of Epidemiology, 152(6), 565-72, September 2000
 - Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, Budtz-Jorgensen E, Grandjean P, Maternal seafood diet, methylmercury exposure, and neonatal neurologic function [see comments], Journal of Pediatrics, 136(5), 599-605, May 2000
 - Andersen HR, Nielsen JB, Grandjean P, Toxicologic evidence of developmental neurotoxicity of environmental chemicals, Toxicology, 144(1-3), 121-7, April 2000
 - Nielsen GD, Nielsen JB, Andersen KE, Grandjean P, Effects of industrial detergents on the barrier function of human skin, International Journal of Occupational and Environmental Health, 6(2), 138-42, 2000
 - Hoyer AP, Jorgensen T, Brock JW, Grandjean P, Organochlorine exposure and breast cancer survival, Journal of Clinical Epidemiology, 53(3), 323-30, March 2000
 - Budtz-Jorgensen E, Grandjean P, Keiding N, White RF, Weihe P, Benchmark dose calculations of methylmercury-associated neurobehavioural deficits, Toxicology Letters, 112-113, 193-9, March 2000
 - Hoyer AP, Jorgensen T, Grandjean P, Hartvig HB, Repeated measurements of organochlorine exposure and breast cancer risk (Denmark), Cancer Causes and Control, 11(2), 177-84, February 2000
 - Biernat H, Ellias SA, Wermuth L, Cleary D, de Oliveira Santos EC, Jorgensen PJ, Feldman RG, Grandjean P, Tremor frequency patterns in mercury vapor exposure, compared with early
Parkinson's disease and essential tremor, Neurotoxicology, 20(6), 945-52, December 1999
 - Grandjean P, Mercury risks: controversy or just uncertainty?, Public Health Reports, 114(6), 512-5, November 1999
 - Grandjean P, Budtz-Jorgensen E, White RF, Jorgensen PJ, Weihe P, Debes F, Keiding N, Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years, American Journal of Epidemiology, 150(3), 301-5, August 1999
 - Sorensen N, Murata K, Budtz-Jorgensen E, Weihe P, Grandjean P, Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age, Epidemiology, 10(4), 370-5, July 1999
 - Murata K, Weihe P, Araki S, Budtz-Jorgensen E, Grandjean P, Evoked potentials in Faroese children prenatally exposed to methylmercury, Neurotoxicology and Teratology, 21(4), 471-2, 1999
 - Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P, Fecundability in relation to body mass and menstrual cycle patterns, Epidemiology, 10(4), 422-8, July 1999
 - Grandjean P, White RF, Nielsen A, Cleary D, de Oliveira Santos EC, Methylmercury neurotoxicity in Amazonian children downstream from gold mining, Environmental Health Perspectives, 107(7), 587-91, July 1999
 - Murata K, Weihe P, Renzoni A, Debes F, Vasconcelos R, Zino F, Araki S, Jorgensen PJ, White RF, Grandjean P, Delayed evoked potentials in children exposed to methylmercury from seafood, Neurotoxicology and Teratology, 21(4), 343-8, 1999
 - Budtz-Jorgensen E, Keiding N, Grandjean P, White RF, Methylmercury neurotoxicity independent of PCB exposure, Environmental Health Perspectives, 107(5), A236-7, May 1999
 - Viskum S, Rabjerg L, Jorgensen PJ, Grandjean P, Improvement in semen quality associated with decreasing occupational lead exposure, American Journal of Industrial Medicine, 35(3), 257-63, March 1999
 - Grandjean P, White RF, Effects of methylmercury exposure on neurodevelopment, Jama, 281(10), 896; discussion 897, March 1999
 - Nielsen GD, Soderberg U, Jorgensen PJ, Templeton DM, Rasmussen SN, Andersen KE, Grandjean P, Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity, Toxicology and Applied Pharmacology, 154(1), 67-75, Jan 1999
 - Hoyer AP, Grandjean P, Jorgensen T, Brock JW, Hartvig HB, Organochlorine exposure and risk of breast cancer, Lancet, 352(9143), 1816-20, December 1998
 - Grandjean P, Weihe P, White RF, Debes F, Cognitive performance of children prenatally exposed to 'safe' levels of methylmercury, Environmental Research, 77(2), 165-72, May 1998
 - Akagi H, Grandjean P, Takizawa Y, Weihe P, Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease, Environmental Research, 77(2), 98-103, May 1998
 - Nielsen JB, Grandjean P, Jorgensen PJ, Predictors of blood lead concentrations in the lead-free gasoline era, Scandinavian Journal of Work, Environment and Health, 24(2), 153-6, April 1998
 - Netterstrom B, Grandjean P, Occupational and environmental medicine in Denmark, International Archives of Occupational and Environmental Health, 71(1), 3-6, February 1998
 - Weihe P, Grandjean P, Methylmercury risks [letter; comment], Science, 279(5351), 639; discussion 641, Jan 1998
 - Castleman B, Dement J, Frank AL, Frumkin H, Giannasi F, Gochfeld M, Goldstein BD, Grandjean P, Greenberg M, LaDou J, Lemen RA, Levy BS, Maltoni C, McDiarmid M, Silbergeld EK, Teitelbaum DT, Thebaud-Mony A, Upton AC, Wegman DH, Salud Ocupacional, International Journal of Occupational and Environmental Health, 4(2), 131-3, 1998
- Grandjean P, Mercurial uncertainties in environmental health, Annals of the New York Academy of Sciences, 837, 239-45, December 1997
 - Grandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ, Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury, Neurotoxicology and Teratology, 19(6), 417-28, 1997
 - Grandjean P, Guldager B, Larsen IB, Jorgensen PJ, Holmstrup P, Placebo response in environmental disease. Chelation therapy of patients with symptoms attributed to amalgam fillings, Journal of Occupational and Environmental Medicine, 39(8), 707-14, August 1997
 - Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P, Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors, Clinical Chemistry, 43(7), 1209-14, July 1997
 - Andersen HR, Nielsen JB, Nielsen F, Grandjean P, Antioxidative enzyme activities in human erythrocytes, Clinical Chemistry, 43(4), 562-8, April 1997
 - Lynge E, Andersen A, Nilsson R, Barlow L, Pukkala E, Nordlinder R, Boffetta P, Grandjean P, Heikkila P, Horte LG, Jakobsson R, Lundberg I, Moen B, Partanen T, Riise T, Risk of cancer and exposure to gasoline vapors, American Journal of Epidemiology, 145(5), 449-58, March 1997
 - Guldager B, Jorgensen PJ, Grandjean P, Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA, Clinical Chemistry, 42(12), 1938-42, December 1996
 - Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ Jr, Jegou B, Jensen TK, Jouannet P, Keiding N, Leffers H, McLachlan JA, Meyer O, Muller J, Rajpert-De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE, Male reproductive health and environmental xenoestrogens, Environmental Health Perspectives, 104 Suppl 4, 741-803, August 1996
 - Weihe P, Grandjean P, Debes F, White R, Health implications for Faroe islanders of heavy metals and PCBs from pilot whales, Science of the Total Environment, 186(1-2), 141-8, July 1996
 - Dahl R, White RF, Weihe P, Sorensen N, Letz R, Hudnell HK, Otto DA, Grandjean P, Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year-old children, Neurotoxicology and Teratology, 18(4), 413-9, 1996
 - Grandjean P, Sorsa M, Ethical aspects of genetic predisposition to environmentally-related disease, Science of the Total Environment, 184(1-2), 37-43, May 1996
 - Grandjean P, White RF, Weihe P, Neurobehavioral epidemiology: application in risk assessment, Environmental Health Perspectives, 104 Suppl 2, 397-400, April 1996
 - Grandjean P, Biomarkers in epidemiology, Clinical Chemistry, 41(12 Pt 2), 1800-3, December 1995
 - Grandjean P, Brown SS, Reavey P, Young DS, Biomarkers in environmental toxicology: state of the art, Clinical Chemistry, 41(12 Pt 2), 1902-4, December 1995
 - Grandjean P, Weihe P, Needham LL, Burse VW, Patterson DG Jr, Sampson EJ, Jorgensen PJ, Vahter M, Relation of a seafood diet to mercury, selenium, arsenic, and polychlorinated biphenyl and other organochlorine concentrations in human milk, Environmental Research, 71(1), 29-38, October 1995
 - Grandjean P, Individual susceptibility in occupational and environmental toxicology, Toxicology Letters, 77(1-3), 105-8, May 1995
 - Grandjean P, Weihe P, White RF, Milestone development in infants exposed to methylmercury from human milk, Neurotoxicology, 16(1), 27-33, Spring 1995
 - Johnson BL, Grandjean P, Amler RW, Neurobehavioral testing and hazardous chemical sites, Neurotoxicology and Teratology, 16(5), 485-7, 1994
 - Grandjean P, Weihe P, Nielsen JB, Methylmercury: significance of intrauterine and postnatal exposures, Clinical Chemistry, 40(7 Pt 2), 1395-400, July 1994
 - Grandjean P, Brown SS, Reavey P, Young DS, Biomarkers of chemical exposure: state of the art, Clinical Chemistry, 40(7 Pt 2), 1360-2, July 1994
 - Nielsen JB, Andersen O, Grandjean P, Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice, Archives of Toxicology, 68(5), 317-21, 1994
 - Olsen SF, Grandjean P, Weihe P, Videro T, Frequency of seafood intake in pregnancy as a determinant of birth weight: evidence for a dose dependent relationship, Journal of Epidemiology and Community Health, 47(6), 436-40, December 1993
 - Grandjean P, Cardoso B, Guimaraes G, Mercury poisoning [letter], Lancet, 342(8877), 991, October 1993
 - Grandjean P, International perspectives of lead exposure and lead toxicity, Neurotoxicology, 14(2-3), 9-14, 1993
 - Damm D, Grandjean P, Lyngbye T, Trillingsgaard A, Hansen ON, Early lead exposure and neonatal jaundice: relation to neurobehavioral performance at 15 years of age, Neurotoxicology and Teratology, 15(3), 173-81, 1993
 - Grandjean P, Weihe P, Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias, Environmental Research, 61(1), 176-83, April 1993
 - Grandjean P, Olsen JH, Juel K, Excess cancer incidence among workers exposed to fluoride, Scandinavian Journal of Work, Environment and Health, 19 Suppl 1, 108-9, 1993
 - Grandjean P, Individual susceptibility to toxicity, Toxicology Letters, 64-65 Spec No, 43-51, December 1992
 - Grandjean P, Olsen JH, Jensen OM, Juel K, Cancer incidence and mortality in workers exposed to fluoride, Journal of the National Cancer Institute, 84(24), 1903-9, December 1992
 - Grandjean P, Nielsen GD, Jorgensen PJ, Horder M, Reference intervals for trace elements in blood: significance of risk factors, Scandinavian Journal of Clinical and Laboratory Investigation, 52(4), 321-37, June 1992
 - Grandjean P, Weihe P, Jorgensen PJ, Clarkson T, Cernichiari E, Videro T, Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead, Archives of Environmental Health, 47(3), 185-95, 1992
 - Grandjean P, Lyngbye T, Hansen ON, Lessons from a Danish study on neuropsychological impairment related to lead exposure, Environmental Health Perspectives, 94, 111-5, August 1991
 - Grandjean P, Sandoe SH, Kimbrough RD, Non-specificity of clinical signs and symptoms caused by environmental chemicals, Human and Experimental Toxicology, 10(3), 167-73, May 1991
 - Grandjean P, Jorgensen PJ, Viskum S, Temporal and interindividual variation in erythrocyte zinc-protoporphyrin in lead exposed workers, British Journal of Industrial Medicine, 48(4), 254-7, April 1991
 - Grandjean P, Jacobsen IA, Jorgensen PJ, Chronic lead poisoning treated with dimercaptosuccinic acid, Pharmacology and Toxicology, 68(4), 266-9, April 1991
 - Lyngbye T, Hansen ON, Grandjean P, Lead concentration in deciduous teeth from Danish school children, Danish Medical Bulletin, 38(1), 89-93, February 1991
 - Grandjean P, Effects on reserve capacity: significance for exposure limits, Science of the Total Environment, 101(1-2), 25-32, January 1991
 - Grandjean P, Andersen O, Lung cancer in filling station attendants, American Journal of Industrial Medicine, 20(6), 763-8, 1991
 - Grandjean P, Jorgensen PJ, Retention of lead and cadmium in prehistoric and modern human teeth, Environmental Research, 53(1), 6-15, October 1990
 - Lyngbye T, Jorgensen PJ, Grandjean P, Hansen ON, Validity and interpretation of blood lead levels: a study of Danish school children, Scandinavian Journal of Clinical and Laboratory Investigation, 50(4), 441-9, June 1990
 - Jensen BM, Sando SH, Grandjean P, Wiggers P, Dalhoj J, Screening with zinc protoporphyrin for iron deficiency in non-anemic female blood donors, Clinical Chemistry, 36(6), 846-8, June 1990
 - Lyngbye T, Hansen ON, Trillingsgaard A, Beese I, Grandjean P, Learning disabilities in children: significance of low-level lead-exposure and confounding factors, Acta Paediatrica Scandinavica, 79(3), 352-60, March 1990
 - Nielsen GD, Jepsen LV, Jorgensen PJ, Grandjean P, Brandrup F, Nickel-sensitive patients with vesicular hand eczema: oral challenge with a diet naturally high in nickel, British Journal of Dermatology, 122(3), 299-308, March 1990
 - Lyngbye T, Hansen ON, Grandjean P, Predictors of tooth-lead level with special reference to traffic. A study of lead-exposure in children, International Archives of Occupational and Environmental Health, 62(6), 417-22, 1990
 - Grandjean P, Horder M, Thomassen Y, Fluoride, aluminum, and phosphate kinetics in cryolite workers, Journal of Occupational Medicine, 32(1), 58-63, January 1990
 - Grandjean P, Kristensen K, Jorgensen PJ, Nielsen GD, Andersen O, Trace element status in alcoholism before and during disulfiram treatment, Annals of Clinical and Laboratory Science, 20(1), 28-35, 1990
 - Bonde I, Beck HI, Jorgensen PJ, Grandjean P, Brandrup F, Nickel in intercellular fluid. Comparison between nickel-allergic patients and controls, Acta Dermato-venereologica, 70(4), 300-3, 1990
 - Grandjean P, Jensen BM, Sando SH, Jogensen PJ, Antonsen S, Delayed blood regeneration in lead exposure: an effect on reserve capacity, American Journal of Public Health, 79(10), 1385-8, October 1989
 - Hansen ON, Trillingsgaard A, Beese I, Lyngbye T, Grandjean P, A neuropsychological study of children with elevated dentine lead level: assessment of the effect of lead in different socio-economic groups, Neurotoxicology and Teratology, 11(3), 205-13, 1989
 - Grandjean P, Hollnagel H, Hedegaard L, Christensen JM, Larsen S, Blood lead-blood pressure relations: alcohol intake and hemoglobin as confounders, American Journal of Epidemiology, 129(4), 732-9, April 1989
 - Andersen O, Grandjean P, Effects of tetraethylthiuram disulfide on the toxicokinetics of cadmium in mice, Pharmacology and Toxicology, 64(2), 210-5, February 1989
 - Lyngbye T, Hansen ON, Grandjean P, Neurological deficits in children: medical risk factors and lead exposure, Neurotoxicology and Teratology, 10(6), 531-7, 1988
 - Madsen HH, Skjodt T, Jorgensen PJ, Grandjean P, Blood lead levels in patients with lead shot retained in the appendix, Acta Radiologica, 29(6), 745-6, 1988
 - Lyngbye T, Hansen O, Grandjean P, Trillingsgaard A, Beese I, Traffic a source of lead exposure in childhood, Science of the Total Environment, 71(3), 461-7, June 1988
 - Christoffersen J, Christoffersen MR, Larsen R, Rostrup E, Tingsgaard P, Andersen O, Grandjean P, Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases, Calcified Tissue International, 42(5), 331-9, May 1988
 - Grandjean P, Ancient skeletons as silent witnesses of lead exposures in the past, Critical Reviews in Toxicology, 19(1), 11-21, 1988
 - Lyngbye T, Hansen ON, Grandjean P, Bias from non-participation: a study of low-level lead exposure in children, Scandinavian Journal of Social Medicine, 16(4), 209-15, 1988
 - Grandjean P, Andersen O, Nielsen GD, Carcinogenicity of occupational nickel exposures: an evaluation of the epidemiological evidence, American Journal of Industrial Medicine, 13(2), 193-209, 1988
 - Grandjean P, Berlin A, Gilbert M, Penning W, Preventing percutaneous absorption of industrial chemicals: the 'skin' denotation, American Journal of Industrial Medicine, 14(1), 97-107, 1988
 - Grandjean P, Bach E, Indirect exposures: the significance of bystanders at work and at home, American Industrial Hygiene Association Journal, 47(12), 819-24, December 1986
 - Grandjean P, Reference intervals for toxic metals: problems and prospects. Abraham J. Gitlitz memorial lecture, Annals of Clinical and Laboratory Science, 16(1), 67-74, 1986
 - Grandjean P, Lyngbye T, Hansen ON, Lead concentration in deciduous teeth: variation related to tooth type and analytical technique, Journal of Toxicology and Environmental Health, 19(3), 437-44, 1986
 - Grandjean P, Juel K, Jensen OM, Mortality and cancer morbidity after heavy occupational fluoride exposure, American Journal of Epidemiology, 121(1), 57-64, January 1985
 - Grandjean P, Hansen ON, Lyngbye K, Analysis of lead in circumpulpal dentin of deciduous teeth, Annals of Clinical and Laboratory Science, 14(4), 270-5, 1984
 - Grandjean P, Lead poisoning: hair analysis shows the calendar of events, Human Toxicology, 3(3), 223-8, June 1984
 - Eskildsen J, Grandjean P, Lead exposure from lead pellets: age-related accumulation in mute swans, Toxicology Letters, 21(2), 225-9, May 1984
 - Grandjean P, Human exposure to nickel, Iarc Scientific Publications, 469-85, 1984
 - Grandjean P, Thomsen G, Reversibility of skeletal fluorosis, British Journal of Industrial Medicine, 40(4), 456-61, November 1983
 - Grandjean P, Wulf HC, Niebuhr E, Sister chromatid exchange in response to variations in occupational lead exposure, Environmental Research, 32(1), 199-204, October 1983
 - Grandjean P, Storage depots in the body: passive retention or time bomb? [editorial], American Journal of Industrial Medicine, 4(6), 689-90, 1983
 - Grandjean P, Andersen O, Toxicity of lead additives [letter], Lancet, 2(8293), 333-4, August 1982
 - Grandjean P, Occupational fluorosis through 50 years: clinical and epidemiological experiences, American Journal of Industrial Medicine, 3(2), 227-36, 1982
 - Grandjean P, Hollnagel H, Olsen NB, Occupationally related lead exposure in the general population. A population study of 40-year-old men, Scandinavian Journal of Work, Environment and Health, 7(4), 298-301, December 1981
 - Olsen NB, Hollnagel H, Grandjean P, Indicators of lead exposure in an adult Danish suburban population, Danish Medical Bulletin, 28(4), 168-76, September 1981
 - Grandjean P, Blood lead concentrations reconsidered [news], Nature, 291(5812), 188, May 1981
 - Hertz MM, Bolwig TG, Grandjean P, Westergaard E, Lead poisoning and the blood-brain barrier, Acta Neurologica Scandinavica, 63(5), 286-96, May 1981
 - Grandjean P, Kon SH, Lead exposure of welders and bystanders in a ship repair yard, American Journal of Industrial Medicine, 2(1), 65-70, 1981
 - Grandjean P, Olsen NB, Hollnagel H, Influence of smoking and alcohol consumption on blood lead levels, International Archives of Occupational and Environmental Health, 48(4), 391-7, 1981
 - Arnvig E, Grandjean P, Beckmann J, Neurotoxic effects of heavy lead exposure determined with psychological tests, Toxicology Letters, 5(6), 399-404, May 1980
 - Grandjean P, Selikoff IJ, Shen SK, Sunderman FW Jr, Nickel concentrations in plasma and urine of shipyard workers, American Journal of Industrial Medicine, 1(2), 181-9, 1980
 - Grandjean P, Occupational lead exposure in Denmark: screening with the haematofluorometer, British Journal of Industrial Medicine, 36(1), 52-8, February 1979
 - Grandjean P, Nielsen T, Organolead compounds: environmental health aspects, Residue Reviews, 72, 97-148, 1979
 - Grandjean P, Nielsen OV, Shapiro IM, Lead retention in ancient Nubian and contemporary populations, Journal of Environmental Pathology and Toxicology, 2(3), 781-7, 1979
 - Grandjean P, Arnvig E, Beckmann J, Psychological dysfunctions in lead-exposed workers. Relation to biological parameters of exposure, Scandinavian Journal of Work, Environment and Health, 4(4), 295-303, December 1978
 - Grandjean P, Lead concentration in single hairs as a monitor of occupational lead exposure, International Archives of Occupational and Environmental Health, 42(2), 69-81, November 1978
 - Grandjean P, Lintrup J, Erythrocyte-Zn-protoporphyrin as an indicator of lead exposure, Scandinavian Journal of Clinical and Laboratory Investigation, 38(7), 669-75, November 1978
 - Grandjean P, Widening perspectives of lead toxicity. A review of health effects of lead exposure in adults, Environmental Research, 17(2), 303-21, October 1978
 - Nielsen T, Jensen KA, Grandjean P, Organic lead in normal human brains, Nature, 274(5671), 602-3, August 1978
 - Grandjean P, Possible effect of lead on egg-shell thickness in kestrels 1874-1974, Bulletin of Environmental Contamination and Toxicology, 16(1), 101-6, July 1976
 - Grandjean P, Lead in danes. Historical and toxicological studies, Environmental Quality and Safety. Supplement, 2, 6-75, 1975
 - Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P, Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years., Neurotoxicology and teratology, 28 (3), 363-75
 - Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P, Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years., Neurotoxicology and teratology, 28 (5), 536-47
 - Landrigan P, Nordberg M, Lucchini R, Nordberg G, Grandjean P, Iregren A, Alessio L, The Declaration of Brescia on Prevention of the Neurotoxicity of Metals Brescia, Italia 17-18 June 2006., La Medicina del lavoro, 97 (6), 811-4
 - Grandjean P, Methylmercury toxicity and functional programming., Reproductive toxicology (Elmsford, N.Y.), 23 (3), 414-20

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