Dr. Miguel Reyes-Múgica

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Yale University
School of Medicine
Pediatrics
Pediatric Pathologist
Yale University
School of Medicine
Pathology
Assistant Professor

Mailing Address

310 Cedar Street, Rm LB20
Yale University
New Haven, Connecticut 06520-8023
United States

Contact Information

Phone: (203) 737-5097
Fax: (203) 785-3348
miguel.reyes-mugica@yale.edu
http://info.med.yale.edu/pathol/faculty/mrm/mrm.htm

Qualifications

M.D., Children's Memorial Hospital, Northwestern University, 1983.
Residency, Children's Memorial Hospital, Northwestern University.
Fellowship, Children's Memorial Hospital, Northwestern University.

Expertise and Research Interests

Research summary:
I am currently involved in studies of childhood tumors and defects of neural crest cell migration. In the first group, we are studying neuroblastoma, a neural crest derived neoplasm with heterogenous biology and clinical behavior, in which the therapeutic advances have developed with difficulty. We have shown that lack of deleted in colorectal cancer [DCC] expression by neuroblastoma correlates with advanced clinical stage and metastatic status. According to our results, DCC plays an independent role in the behavior of this tumor, probably separate from that of MYCN and histologic parameters, which opens another potential avenue for understanding the biology of neuroblastoma.

In the area of neural crest cell migration, Hirschsprungdisease (congenital megacolon) represents a condition in which ganglion cells are absent in the colonic nerve plexi, leading to chronic constipation. Studies to improve our diagnostic approach based on histologic examination being conducted.

Another rare condition involving abnormal neural crest cell migration and proliferation is Neurocutaneous Melanosis. Patients present with large (giant) congenital nevi and meningeal/brain melanocytic proliferations. Studies of the clonality, chromosomal aberrations, allelic loss and mutation of melanoma-related genes in these lesions are in progress.

I am also involved in the study of all pediatric surgical specimens and autopsies, the elaboration of appropriate clinico-pathological correlations in these cases, and providing support to clinical projects in the Department of Pediatrics.

Other Expertise

I wish to be contacted by interested students (medical, graduate or undergraduates) as a potential research mentor/thesis advisor.

Keywords

COS Keywords:

Pathology, Pediatrics, Tumors.

Additional Terms:

Hirschsprung Disease, Neural Crest Disorders, Neuroblastoma, Pediatric Pathology, Pediatric Tumors, Pediatrics.

Languages

(Reading, Writing, Speaking)

Spanish: (Fluent, Fluent, Fluent)

Memberships

Society for Pediatric Pathology
United States and Canadian Academy of Pathology

Publications

  • Boles RG, Buck EA, Blitzer MG, Platt MS, Cowan TM, Martin SK, Yoon H, Madsen JA, Reyes-Múgica M, Rinaldo P., Retrospective biochemical screening of fatty acid oxidation disorders in postmortem liver of 418 cases of sudden death in the first year of life., Journal of Pediatrics, 132, 924-933, 1998
  • Reyes-Múgica M, Lin Pei, Yakota J, Reale MA., DCC loss of expression and neuroblastoma metastasis., Laboratory Investigation, 78, 669-675, 1998
  • Adida C, Berrebi D, Peuchmaur M, Reyes-Múgica M, Altieri DC., Identification of prognostically unfavorable neuroblastoma by expression of the novel cancer anti-apoptosis gene, survivin., Lancet, 351, 882-883, 1998
  • Abu-Alfa A, Kuan SF, West AB, Reyes-Múgica M., Cathepsin D: a Potential Aid for Diagnosis of Suspected Hirschsprung's Disease, American Journal of Surgical Pathology, 21, 201-205, 1997
  • Reyes-Múgica M, Rieger-Christ K, Ohgaki H, Helie M, Kleinman G, Bogler O, Yahanda A, Fearon E, Kleihues P, Reale MA., DCC Loss of Expression in Glioma Progression, Cancer Research, 57, 382-386, 1997
  • Reale MA, Reyes-Múgica M, Pierceall W, Look AT, Rubinstein MC, Hedrick L, Cohn S, Brodeur GM, Fearon ER., Absence of the Deleted in Colorectal Cancer (DCC) Protein in Neuroblastoma - Correlation with Disseminated Disease., Clinical Cancer Research, 2, 1097-1102, 1996
  • Gill J, Reyes-Múgica M, Iyengar S. Kidd KK, Touloukian R, Smith C, Keller MS, Genel M., Early Presentation of Metastatic Medullary carcinoma in Multiple Endocrine Neoplasia (MEN2A): implications for therapy, Journal of Pediatrics, 129, 459-464, 1996
  • Hisama FM, Reyes-Múgica M, Wargowski DS, Mahoney MJ., Renal tunular dysgenesis, absent nipples and multiple malformations in three brothers: a new lethal syndrome., American Journal of Medical Genetics, In press
  • Odaib AL, Shneider BL, Bennett MJ, Pober BN, Reyes-Múgica M, Friedman AL, Suchy FJ, Rinaldo P., A defect of Long-chain fatty acid transport in a patient with recurrent fulminant liver failure., New England Journal of Medicine, (in press)

Profile Details

Last Updated: 8/20/1998

COS Expertise ID #397258
Reference this profile directly: http://myprofile.cos.com/Reyes