Brenda M. Sandmaier

powered by
COS Expertise®
Fred Hutchinson Cancer Research Center
Clinical Research Division
Transplantation Biology
Member
University of Washington
School of Medicine
Medicine
Oncology
ProfessorAppointed: 1994
Professional Headshot of Brenda M. Sandmaier

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D1-100
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-4961
Fax: (206) 667-6124
bsandmai@fhcrc.org

Qualifications

M.D., University of Alberta, 1983.
B.Sc., University of Alberta, Genetics, 1979.

Expertise and Research Interests

Stem cell engraftment in MHC-matched and mismatched transplants: development of nonmyeloablative conditioning regimens

Our primary goal is to develop conditioning regimens that have minimal toxicity and, thus, allow us to extend the benefit of stem cell transplants to a greater number of patients. Towards that end, we are using a preclinical model and have extended our findings to patients in clinical studies.

The long-term objective of the development of nonmyeloablative conditioning regimens is to extend the application of stem cell transplants to use in older patients and patients with nonmalignant diseases, in addition to patients with malignancies, by developing less toxic conditioning regimens that permit engraftment and prevent graft-versus-host disease (GVHD). To address this goal, nonmyeloablative conditioning regimens for hematopoietic allografts are being studied in a preclinical model. Data indicate that MAbs directed towards CD3/TCR facilitate establishment of donor chimerism in preclinical MHC-identical related transplants in a low dose radiation model. In MHC-haploidentical transplants, data indicate that the anti-CD44 MAb S5 establishes donor engraftment in the low dose radiation model when given with standard immunosuppression.

Attempts to increase the dose of chemoradiotherapy to prevent relapse after transplant have been limited by toxicity to normal organs. Previously, we have carried out studies using emitting isotope-antibody conjugates (including I-131) to target the dose of radiation to the marrow and, thus, spare normal organs. Current studies are investigating the use of the alpha emitting radionuclide bismuth-213 (Bi-213). The alpha emitters have the advantages of a relatively short half-life, high linear energy transfer, and are easier to handle than gamma emitters. We have evaluated a Bi-213 anti-CD45 MAb conjugate for immunosuppression and have shown that this was sufficient conditioning for stable engraftment in the MHC-identical setting. We also have investigated the use of a Bi-213-anti-TCR MAb conjugate to target T cells to eliminate host-versus-graft (HVG) reactions in the MHC-identical setting and have had similar findings. Currently we are investigating this approach in the MHC-nonidentical setting.

Our current regimen for hematopoietic cell transplantation in human patients, developed in our preclinical model, uses a non-myeloablative conditioning regimen consisting of fludarabine and 200 cGy of total body irradiation before and mycophenolate mofetil combined with cyclosporine after transplant. This has now been successfully applied to patients with leukemia, lymphoma, multiple myeloma, and other malignant diseases who were too old or medically infirm to be eligible for conventional myeloablative transplants. Both related and unrelated HLA-identical donors are used. Data, thus far, indicate that successful allografts in patients otherwise ineligible for conventional allografting can be done with minimal toxicities. Complete remissions including molecular remissions, have been seen in a substantial number of the patients, indicating that this approach is feasible and may be curative. We are also extending our findings to using donors that are not HLA-identical. Currently we are investigating the role of donor lymphocyte infusion (DLI) for both improvement of low donor chimerism and for treatment of persistant or relapsed disease.

Keywords

COS Keywords:

Hematology, Oncology, Stem Cells, Transplantation Immunology.

Memberships

American Society of Clinical Oncology
American Society of Hematology
International Society of Experimental Hematology
King County Medical Society

Publications

  • Weiss, AS, Sandmaier BM, Storer B, Storb R, McSweeny PA, Parikh CR (2006) Chronic kidney disease following nonmyeloablative hematopoietic cell transplantation., American Journal of Transplantation, 6, 89-94
  • Scott BL, Sandmaier BM, Storer B, Maris MB, Sorror ML, Maloney DG, Chauncey TR, Storb R, Deeg HJ (2006) Myeloablative vs nonmyeloablative allogeneic transplantation for patients with myelodysplastic syndrome or acute myelogenous leukemia with multilineage dysplasia: a retrospective analysis., Leukemia, 20, 128-35
  • Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG, Storer B (Oct 2005) Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT., Blood, 106 (8), 2912-9 Abstract
  • Bethge WA, Sandmaier BM (Aug 2005) Targeted cancer therapy using radiolabeled monoclonal antibodies., Technology in Cancer Research & Treatment, 4 (4), 393-405 Abstract
  • Kerbauy FR, Storb R, Hegenbart U, Gooley T, Shizuru J, Al-Ali HK, Radich JP, Maloney DG, Agura E, Bruno B, Epner EM, Chauncey TR, Blume KG, Niederwieser D, Sandmaier BM (Jun 2005) Hematopoietic cell transplantation from HLA-identical sibling donors after low-dose radiation-based conditioning for treatment of CML., Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.k., 19 (6), 990-7 Abstract
  • Mielcarek M, Burroughs L, Leisenring W, Diaconescu R, Martin PJ, Sandmaier BM, Maloney DG, Maris MB, Chauncey TR, Shizuru JA, Blume KG, Hegenbart U, Niederwieser D, Forman S, Bruno B, Woolfrey A, Storb R (May 2005) Prognostic relevance of 'early-onset' graft-versus-host disease following non-myeloablative haematopoietic cell transplantation., British Journal of Haematology, 129 (3), 381-91 Abstract
  • Baron F, Maris MB, Storer BE, Sandmaier BM, Panse JP, Chauncey TR, Sorror M, Little MT, Maloney DG, Storb R, Heimfeld S (May 2005) High doses of transplanted CD34+ cells are associated with rapid T-cell engraftment and lessened risk of graft rejection, but not more graft-versus-host disease after nonmyeloablative conditioning and unrelated hematopoietic cell transpl, Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.k., 19 (5), 822-8 Abstract
  • Chien JW, Maris MB, Sandmaier BM, Maloney DG, Storb RF, Clark JG (Apr 2005) Comparison of lung function after myeloablative and 2 Gy of total body irradiation-based regimens for hematopoietic stem cell transplantation., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (4), 288-96 Abstract
  • Baron F, Maris MB, Storer BE, Sandmaier BM, Stuart MJ, McSweeney PA, Radich JP, Pulsipher MA, Agura ED, Chauncey TR, Maloney DG, Shizuru JA, Storb R (Apr 2005) HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with chronic myeloid leukemia., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (4), 272-9 Abstract
  • Baron F, Maris MB, Sandmaier BM, Storer BE, Sorror M, Diaconescu R, Woolfrey AE, Chauncey TR, Flowers ME, Mielcarek M, Maloney DG, Storb R (Mar 2005) Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning., Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology., 23 (9), 1993-2003 Abstract
  • Parikh CR, Schrier RW, Storer B, Diaconescu R, Sorror ML, Maris MB, Maloney DG, McSweeney P, Storb R, Sandmaier BM (Mar 2005) Comparison of ARF after myeloablative and nonmyeloablative hematopoietic cell transplantation., American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation., 45 (3), 502-9 Abstract
  • Panse JP, Heimfeld S, Guthrie KA, Maris MB, Maloney DG, Baril BB, Little MT, Chauncey TR, Storer BE, Storb R, Sandmaier BM (Mar 2005) Allogeneic peripheral blood stem cell graft composition affects early T-cell chimaerism and later clinical outcomes after non-myeloablative conditioning., British Journal of Haematology, 128 (5), 659-67 Abstract
  • Flowers ME, Traina F, Storer B, Maris M, Bethge WA, Carpenter P, Appelbaum F, Storb R, Sandmaier BM, Martin PJ (Feb 2005) Serious graft-versus-host disease after hematopoietic cell transplantation following nonmyeloablative conditioning., Bone Marrow Transplantation, 35 (3), 277-82 Abstract
  • Hegenbart U, Niederwieser D, Sandmaier BM, Maris MB, Shizuru JA, Greinix H, Cordonnier C, Rio B, Gratwohl A, Lange T, Al-Ali H, Storer B, Maloney D, McSweeney P, Chauncey T, Agura E, Epner E, Bruno B, Maziarz RT, Petersen F, Storb R (2005) Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors., Journal of Clinical Oncology, 24, 444-53
  • Giaccone L, McCune JS, Maris MB, Gooley TA, Sandmaier BM, Slattery JT, Cole S, Nash RA, Storb R, Georges GE (2005) Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation., Blood, 106, 4381-8
  • Burroughs L, Mielcarek M, Little MT, Bridger G, MacFarland R, Fricker S, LaBrecque J, Sandmaier BM, Storb R (2005) Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral blood mononuclear cells in a canine transplantation model., Blood, 106, 4002-8
  • Panse JP, Storb R, Storer B, Santos EB, Wentzel C, Sandmaier BM (2005) Prolonged allogeneic marrow engraftment following nonmyeloablative conditioning using 100 cGy total body irradiation and pentostatin before and pharmocological immunosuppression after transplantation., Transplantation, 80, 1518-21
  • Sorror ML, Maris MB, Sandmaier BM, Storer BE, Stuart MJ, Hegenbart U, Agura E, Chauncey TR, Leis J, Pulsipher M, McSweeny P, Radich JP, Bredeson C, Bruno B, Langston A, Loken MR, Al-Ali H, Blume KG, Storb R, Maloney DG (2005) Hematopoietic cell transplantation after nonmyeloablative conditioning for advanced chronic lymphocytic leukemia., Journal of Clinical Oncology, 23, 3819-29
  • Tykodi SS, Warren EH, Thompson JA, Riddell SR, Childs RW, Otterud BE, Leppert MF, Storb R, Sandmaier BM (Dec 2004) Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens., Clinical Cancer Research : an Official Journal of the American Association for Cancer Research., 10 (23), 7799-811 Abstract
  • Maris MB, Sandmaier BM, Storer BE, Chauncey T, Stuart MJ, Maziarz RT, Agura E, Langston AA, Pulsipher M, Storb R, Maloney DG (Dec 2004) Allogeneic hematopoietic cell transplantation after fludarabine and 2 Gy total body irradiation for relapsed and refractory mantle cell lymphoma., Blood, 104 (12), 3535-42 Abstract
  • Baron F, Baker JE, Storb R, Gooley TA, Sandmaier BM, Maris MB, Maloney DG, Heimfeld S, Oparin D, Zellmer E, Radich JP, Grumet FC, Blume KG, Chauncey TR, Little MT (Oct 2004) Kinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning., Blood, 104 (8), 2254-62 Abstract
  • Diaconescu R, Flowers CR, Storer B, Sorror ML, Maris MB, Maloney DG, Sandmaier BM, Storb R (Sep 2004) Morbidity and mortality with nonmyeloablative compared with myeloablative conditioning before hematopoietic cell transplantation from HLA-matched related donors., Blood, 104 (5), 1550-8 Abstract
  • Sorror ML, Maris MB, Storer B, Sandmaier BM, Diaconescu R, Flowers C, Maloney DG, Storb R (Aug 2004) Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative and myeloablative conditioning: influence of pretransplantation comorbidities., Blood, 104 (4), 961-8 Abstract
  • Bethge WA, Wilbur DS, Storb R, Hamlin DK, Santos EB, Brechbiel MW, Sandmaier BM (Aug 2004) Radioimmunotherapy with bismuth-213 as conditioning for nonmyeloablative allogeneic hematopoietic cell transplantation in dogs: a dose deescalation study., Transplantation, 78 (3), 352-9 Abstract
  • Fukuda T, Boeckh M, Guthrie KA, Mattson DK, Owens S, Wald A, Sandmaier BM, Corey L, Storb RF, Marr KA (Jul 2004) Invasive aspergillosis before allogeneic hematopoietic stem cell transplantation: 10-year experience at a single transplant center., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 10 (7), 494-503 Abstract
  • Parikh CR, Sandmaier BM, Storb RF, Blume KG, Sahebi F, Maloney DG, Maris MB, Nieto Y, Edelstein CL, Schrier RW, McSweeney P (Jul 2004) Acute renal failure after nonmyeloablative hematopoietic cell transplantation., Journal of the American Society of Nephrology : Jasn, 15 (7), 1868-76 Abstract
  • Holmberg LA, Sandmaier BM (Jun 2004) Vaccination as a treatment for breast or ovarian cancer., Expert Review of Vaccines, 3 (3), 269-77 Abstract
  • Bethge WA, Hegenbart U, Stuart MJ, Storer BE, Maris MB, Flowers ME, Maloney DG, Chauncey T, Bruno B, Agura E, Forman SJ, Blume KG, Niederwieser D, Storb R, Sandmaier BM (Feb 2004) Adoptive immunotherapy with donor lymphocyte infusions after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning., Blood, 103 (3), 790-5 Abstract
  • Holmberg LA, Sandmaier BM (2004) Vaccination with THERATOPE® (STn-KLH) as treatment for breast cancer., Expert Review Vaccines, 3, 655-63
  • Hogan WJ, Maris M, Storer B, Sandmaier BM, Maloney DG, Schoch HG, Woolfrey AE, Shulman HM, Storb R, McDonald GB (Jan 2004) Hepatic injury after nonmyeloablative conditioning followed by allogeneic hematopoietic cell transplantation: a study of 193 patients., Blood, 103 (1), 78-84 Abstract
  • Deeg HJ, Gooley TA, Flowers ME, Sale GE, Slattery JT, Anasetti C, Chauncey TR, Doney K, Georges GE, Kiem HP, Martin PJ, Petersdorf EW, Radich J, Sanders JE, Sandmaier BM, Warren EH, Witherspoon RP, Storb R, Appelbaum FR (Dec 2003) Allogeneic hematopoietic stem cell transplantation for myelofibrosis., Blood, 102 (12), 3912-8 Abstract
  • Junghanss C, Storb R, Maris MB, Carter RA, Sandmaier BM, Maloney DG, McSweeney PA, Corey L, Boeckh M (Nov 2003) Impact of unrelated donor status on the incidence and outcome of cytomegalovirus infections after non-myeloablative allogeneic stem cell transplantation., British Journal of Haematology, 123 (4), 662-70 Abstract
  • Maloney DG, Molina AJ, Sahebi F, Stockerl-Goldstein KE, Sandmaier BM, Bensinger W, Storer B, Hegenbart U, Somlo G, Chauncey T, Bruno B, Appelbaum FR, Blume KG, Forman SJ, McSweeney P, Storb R (Nov 2003) Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma., Blood, 102 (9), 3447-54 Abstract
  • Fukuda T, Hackman RC, Guthrie KA, Sandmaier BM, Boeckh M, Maris MB, Maloney DG, Deeg HJ, Martin PJ, Storb RF, Madtes DK (Oct 2003) Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplantation., Blood, 102 (8), 2777-85 Abstract
  • Bethge WA, Storer BE, Maris MB, Flowers ME, Maloney DG, Chauncey TR, Woolfrey AE, Storb R, Sandmaier BM (Oct 2003) Relapse or progression after hematopoietic cell transplantation using nonmyeloablative conditioning: effect of interventions on outcome., Experimental Hematology, 31 (10), 974-80 Abstract
  • Maris M, Boeckh M, Storer B, Dawson M, White K, Keng M, Sandmaier B, Maloney D, Storb R, Storek J (Oct 2003) Immunologic recovery after hematopoietic cell transplantation with nonmyeloablative conditioning., Experimental Hematology, 31 (10), 941-52 Abstract
  • Maris MB, Niederwieser D, Sandmaier BM, Storer B, Stuart M, Maloney D, Petersdorf E, McSweeney P, Pulsipher M, Woolfrey A, Chauncey T, Agura E, Heimfeld S, Slattery J, Hegenbart U, Anasetti C, Blume K, Storb R (Sep 2003) HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies., Blood, 102 (6), 2021-30 Abstract
  • Fukuda T, Boeckh M, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Martin PJ, Storb RF, Marr KA (Aug 2003) Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning., Blood, 102 (3), 827-33 Abstract
  • Panse JP, Bastianelli C, Santos EB, Schwarzinger I, Raff RF, Storb R, Sandmaier BM (Aug 2003) Dog leukocyte antigen nonidentical unrelated canine marrow grafts: enhancement of engraftment by CD4 and CD8 T cells., Transplantation, 76 (3), 474-80 Abstract
  • Mielcarek M, Martin PJ, Leisenring W, Flowers ME, Maloney DG, Sandmaier BM, Maris MB, Storb R (Jul 2003) Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation., Blood, 102 (2), 756-62 Abstract
  • Kurre P, Pulsipher M, Woolfrey A, Maris M, Sandmaier B, Kiem HP, Storb R (Jul 2003) Reduced toxicity and prompt engraftment after minimal conditioning of a patient with Fanconi anemia undergoing hematopoietic stem cell transplantation from an HLA-matched unrelated donor., Journal of Pediatric Hematology/oncology : Official Journal of the American Society of Pediatric Hematology/oncology., 25 (7), 581-3 Abstract
  • Bethge WA, Wilbur DS, Storb R, Hamlin DK, Santos EB, Brechbiel MW, Fisher DR, Sandmaier BM (Jun 2003) Selective T-cell ablation with bismuth-213-labeled anti-TCRalphabeta as nonmyeloablative conditioning for allogeneic canine marrow transplantation., Blood, 101 (12), 5068-75 Abstract
  • Feinstein LC, Sandmaier BM, Maloney DG, Maris MB, Gooley TA, Chauncey TR, Hegenbart U, McSweeney PA, Stuart MJ, Forman SJ, Agura EA, Pulsipher MA, Blume KG, Niederwieser DW, Storb RF (Apr 2003) Allografting after nonmyeloablative conditioning as a treatment after a failed conventional hematopoietic cell transplant., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9 (4), 266-72 Abstract
  • Sandmaier BM, Fukuda T, Gooley T, Yu C, Santos EB, Storb R (Feb 2003) Dog leukocyte antigen-haploidentical stem cell allografts after anti-CD44 therapy and reduced-intensity conditioning in a preclinical canine model., Experimental Hematology, 31 (2), 168-75 Abstract
  • Niederwieser D, Maris M, Shizuru JA, Petersdorf E, Hegenbart U, Sandmaier BM, Maloney DG, Storer B, Lange T, Chauncey T, Deininger M, Ponisch W, Anasetti C, Woolfrey A, Little MT, Blume KG, McSweeney PA, Storb RF (Feb 2003) Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MM, Blood, 101 (4), 1620-9 Abstract
  • Holmberg LA, Oparin DV, Gooley T, Sandmaier B (2003) he role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: Experience with the STn-KLH vaccine (Theratope®)., Clinical Breast Cancer, 3 (4), S144-51
  • Feinstein LC, Sandmaier BM, Hegenbart U, McSweeney PA, Maloney DG, Gooley TA, Maris MB, Chauncey TR, Bruno B, Appelbaum FR, Niederwieser DW, Storb RF (Jan 2003) Non-myeloablative allografting from human leucocyte antigen-identical sibling donors for treatment of acute myeloid leukaemia in first complete remission., British Journal of Haematology, 120 (2), 281-8 Abstract
  • Maciej Zaucha J, Mielcarek M, Takatu A, Little MT, Gooley T, Baker J, Maloney DG, Sandmaier BM, Maris M, Chauncey T, Storb R, Torok-Storb B (Dec 2002) Engraftment of early erythroid progenitors is not delayed after non-myeloablative major ABO-incompatible haematopoietic stem cell transplantation., British Journal of Haematology, 119 (3), 740-50 Abstract
  • Sandmaier BM, Bethge WA, Wilbur DS, Hamlin DK, Santos EB, Brechbiel MW, Fisher DR, Storb R, Bismuth 213-labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts, Blood, 100(1), 318-26, July 2002 Abstract
  • Junghanss C, Boeckh M, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Chauncey T, McSweeney PA, Little MT, Corey L, Storb R, Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study, Blood, 99(6), 1978-85, March 2002 Abstract
  • Mielcarek M, Sandmaier BM, Maloney DG, Maris M, McSweeney PA, Woolfrey A, Chauncey T, Feinstein L, Niederwieser D, Blume KG, Forman S, Torok-Storb B, Storb R, Nonmyeloablative hematopoietic cell transplantation: status quo and future perspectives, Journal of Clinical Immunology, 22(2), 70-4, March 2002 Abstract
  • Junghanss C, Marr KA, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Chauncey T, McSweeney PA, Storb R, Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 8(9), 512-20, 2002 Abstract
  • Mielcarek M, Zaucha JM, Sandmaier B, Maloney D, Butrynski J, Maris M, Feinstein L, Torok-Storb B, Storb R, Type of post-grafting immunosuppression after non-myeloablative blood cell transplantation may influence risk of delayed haemolysis due to minor ABO-incompatibility (Letter to the Editor), British Journal of Haematology, 116, 500-501, 2002
  • Appelbaum FR, Sandmaier B, Sensitivity of renal cell cancer to nonmyeloablative allogeneic hematopoietic cell transplantations: unusual or unusually important? (Letter to Editor), Journal of Clinical Oncology, 20, 1965-1967, 2002
  • Jurado M, Deeg HJ, Storer B, Anasetti C, Anderson JE, Bryant E, Chauncey T, Doney K, Flowers MED, Hansen J, Martin PJ, Nash RA, Petersdorf E, Radich J, Sale G, Sandmaier BM, Storb R, Wade J, Witherspoon R, Appelbaum FR, Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome after conditioning with busulfan and fractionated total body irradiation is associated with low relapse rate but considera, BBMT, 8, 161-169, 2002
  • Weissinger F, Sandmaier BM, Maloney DG, Bensinger WI, Gooley T, Storb R, Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings, Blood, 98(13), 3584-8, December 2001 Abstract
  • Georges GE, Storb R, Bruno B, Brodie SJ, Thompson JD, Taranova AG, Zaucha JM, Little MT, Zellmer E, Moore PF, Gooley T, Sale G, Kiem HP, Sandmaier BM, Lyons RM, Nash RA, Engraftment of DLA-haploidentical marrow with ex vivo expanded, retrovirally transduced cytotoxic T lymphocytes, Blood, 98(12), 3447-55, December 2001 Abstract
  • Dimitroff CJ, Lee JY, Schor KS, Sandmaier BM, Sackstein R, differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1, Journal of Biological Chemistry, 276(50), 47623-31, December 2001 Abstract
  • Holmberg LA, Sandmaier BM, Theratope vaccine (STn-KLH), Expert Opinion On Biological Therapy, 1(5), 881-91, September 2001 Abstract
  • Maris M, Woolfrey A, McSweeney PA, Sandmaier BM, Nash RA, Georges G, Maloney DG, Molina A, Chauncey T, Yu C, Zaucha JM, Blume KG, Shizuru J, Niederwieser D, Storb R, Nonmyeloablative hematopoietic stem cell transplantation: transplantation for the 21st century, Frontiers in Bioscience [electronic Resource] : a Journal and Virtual Library, 6, G13-6, August 2001 Abstract
  • McSweeney PA, Niederwieser D, Shizuru JA, Sandmaier BM, Molina AJ, Maloney DG, Chauncey TR, Gooley TA, Hegenbart U, Nash RA, Radich J, Wagner JL, Minor S, Appelbaum FR, Bensinger WI, Bryant E, Flowers ME, Georges GE, Grumet FC, Kiem HP, et al., Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects, Blood, 97(11), 3390-400, June 2001 Abstract
  • Maris M, Sandmaier BM, Maloney DG, McSweeney PA, Woolfrey A, Chauncey T, Shizuru J, Niederwieser D, Blume KG, Forman S, Storb R, Non-myeloablative hematopoietic stem cell transplantation, Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine, 8(3), 231-4, June 2001 Abstract
  • Feinstein L, Sandmaier B, Maloney D, McSweeney PA, Maris M, Flowers C, Radich J, Little M-T, Nash RA, Chauncey T, Woolfrey A, Georges G, Kiem H-P, Zaucha JM, Blume KG, Shizuru J, Niederwieser D, Storb R, Nonmyeloablative hematopoietic cell transplantation: replacing high-dose cytotoxic therapy by the graft-versus-tumor effect, Annals of the New York Academy of Sciences, 938, 328-339, 2001
  • Storb R, McSweeney PA, Sandmaier BM, Nash RA, Georges G, Maloney DG, Molina A, Chauncey T, Yu C, Zaucha JM, Blume KG, Shizuru J, Niederwieser D, Allogeneic hematopoietic stem cell transplantation: from the nuclear age into the twenty-first century, Transplantation Proceedings, 32(7), 2548-9, November 2000 Abstract
  • Mosca JD, Hendricks JK, Buyaner D, Davis-Sproul J, Chuang LC, Majumdar MK, Chopra R, Barry F, Murphy M, Thiede MA, Junker U, Rigg RJ, Forestell SP, Bohnlein E, Storb R, Sandmaier BM, Mesenchymal stem cells as vehicles for gene delivery, Clinical Orthopaedics and Related Research, S71-90, October 2000 Abstract
  • Sandmaier BM, McSweeney P, Yu C, Storb R, Nonmyeloablative transplants: preclinical and clinical results, Seminars in Oncology, 27(2 Suppl 5), 78-81, April 2000 Abstract
  • Stucki A, Hayflick JS, Sandmaier BM, Antibody engagement of intercellular adhesion molecule 3 triggers apoptosis of normal and leukaemic myeloid marrow cells, British Journal of Haematology, 108(1), 157-66, Jan 2000 Abstract
  • Holmberg LA, Oparin DV, Gooley T, Lilleby K, Bensinger W, Reddish MA, MacLean GD, Longenecker BM, Sandmaier BM, Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and Theratope STn-KLH cancer vaccine, Bone Marrow Transplantation, 25, 1233-1241, 2000
  • Storb R, McSweeney PA, Sandmaier BM, Nash RA, Georges G, Maloney DG, Molina A, Maris M, Woolfrey A, Chauncey T, Zaucha M, Blume KG, Shizuru J, Niederwieser D, Nonmyeloablative allogeneic hematopoietic stem cell transplantation, Hematologica, 85(Suppl. 2), 85-87, 2000
  • Molina AJ, Sandmaier BM, Storb R, Nonmyeloablative hematopoietic stem cell allografting, Current Opinion in Organ Transplantation, 5, 366-371, 2000
  • Barsoukov AA, Moore PF, Storb R, Santos EB, Sandmaier BM, The use of an anti-TCRalphabeta monoclonal antibody to control host-versus-graft reactions in canine marrow allograft recipients conditioned with low dose total body irradiation, Transplantation, 67(10), 1329-35, 1999 Abstract
  • Sandmaier BM, Oparin DV, Holmberg LA, Reddish MA, MacLean GD, Longenecker BM, Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with Theratope STn-KLH cancer vaccine, Journal of Immunotherapy, 22(1), 54-66, Jan 1999 Abstract
  • Storb R, Yu C, Sandmaier B, McSweeney P, Georges G, Nash R, Woolfrey A, Mixed hematopoietic chimerism after hematopoietic stem cell allografts, Transplant Proc, 31, 677-678, 1999
  • Storb R, McSweeney PA, Sandmaier BM, Nash RA, Georges G, Maloney DG, Molina A, Chauncey T, Yu C, Zaucha M, Nonmyeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation, Turkish Journal of Haematology(Supplement), 16(3), 3-7, 1999
  • Storb R, Yu C, Sandmaier BM, McSweeney PA, Georges G, Nash RA, Woolfrey A, Mixed hematopoietic chimerism after marrow allografts: transplantation in the ambulatory care setting, Annals of the New York Academy of Sciences, 872, 372-376, 1999
  • Stucki A, Leisenring W, Sandmaier BM, Sanders J, Anasetti C, Storb R, Decreased rejection and improved survival of first and second marrow transplants for severe aplastic anemia (a 26-year retrospective analysis), Blood, 92(8), 2742-9, October 1998 Abstract
  • Tan PH, Sandmaier BM, Stayton PS, Contributions of a highly conserved VH/VL hydrogen bonding interaction to scFv folding stability and refolding efficiency, Biophysical Journal, 75(3), 1473-82, September 1998 Abstract
  • Sandmaier BM, Storb R, Bennett KL, Appelbaum FR, Santos EB, Epitope specificity of CD44 for monoclonal antibody-dependent facilitation of marrow engraftment in a canine model, Blood, 91(9), 3494-502, 1998 Abstract
  • Yu C, Seidel K, Nash RA, Deeg HJ, Sandmaier BM, Barsoukov A, Santos E, Storb R, Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease among lethally irradiated dogs given DLA-nonidentical unrelated marrow grafts, Blood, 91(7), 2581-7, April 1998 Abstract
  • McSweeney PA, Rouleau KA, Wallace PM, Bruno B, Andrews RG, Krizanac-Bengez L, Sandmaier BM, Storb R, Wayner E, Nash RA, Characterization of monoclonal antibodies that recognize canine CD34, Blood, 91(6), 1977-86, March 1998 Abstract
  • Krizanac-Bengez L, Moore PF, Barsoukov A, Sandmaier BM, The expression and differentiation pattern of cell antigens and adhesion molecules on the nonadherent cell population in canine long-term marrow culture: a biphasic development of myeloid, Tissue Antigens, 51(2), 141-55, February 1998 Abstract
  • Sandmaier BM, Storb R, Bennett KL, Appelbaum FR, Santos EB, Epitope specificity of CD44 for monoclonal antibody dependent facilitation of marrow engraftment in a canine model, Blood, 91, 3494-3502, 1998
  • Storb R, Yu C, Deeg HJ, Georges G, Kiem H-P, McSweeney PA, Nash RA, Sandmaier BM, Sullivan KM, Wagner JL, Walters MC, Current and future preparative regimens for bone marrow transplantation in thalassemia, Annals of the New York Academy of Sciences, 885, 276-287, 1998
  • Rossbach HC, Krizanac-Bengez L, Santos EB, Gooley TA, Sandmaier BM, An antibody to CD44 enhances hematopoiesis in long-term marrow cultures, Experimental Hematology, 24(2), 221-7, February 1996 Abstract
  • Sandmaier BM, Storb R, Santos EB, Krizanac-Bengez L, Lian T, McSweeney PA, Yu C, Schuening FG, Deeg HJ, Graham T, Allogeneic transplants of canine peripheral blood stem cells mobilized by recombinant canine hematopoietic growth factors, Blood, 87, 3508-3513, 1996
  • Sandmaier BM, Storb R, Liu Y, Santos EB, Bryant E, Schuening FG, Deeg HJ, Seidel K, Graham T, An anti-CD44 antibody does not enhance engraftment of DLA-identical marrow after low-dose total body irradiation, Transplant Immunology, 4, 271-274, 1996
  • McSweeney PA, Rouleau KA, Storb R, Bolles L, Wallace PM, Beauchamp M, Krizanac-Bengez L, Moore P, Sale G, Sandmaier B, de Revel T, Appelbaum FR, Nash RA, Canine CD34: Cloning of the cDNA and evaluation of an antiserum to recombinant protein, Blood, 88, 1992-2003, 1996
  • Bensinger WI, Clift RA, Anasetti C, Appelbaum FA, Demirer T, Rowley S, Sandmaier BM, Torok-Storb B, Storb R, Buckner CD, Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony stimulating factor, Stem Cells (dayton, Ohio), 14(1), 90-105, January 1996 Abstract
  • Tan PH, Sandmaier BM, Stayton PS, Characterization of an anti-CD44 single-chain FV antibody that stimulates natural killer cell activity and induces TNF alpha release, Immunological Investigations, 24(6), 907-26, November 1995
  • Mathey B, Yu C, Sandmaier BM, Deeg HJ, Graham T, Schuening FG, Nash RA, Stor B, Failure of interleukin-1 and granulocyte-macrophage colony-stimulating factor to enhance allogeneic marrow engraftment and survival in irradiated dogs, Blood, 86(2), 833-4, July 1995 Abstract
  • Jakic-Razumovic J, Sale GE, Beauchamp MD, Storb R, Sandmaier BM, CD8+ activated T lymphocytes produce an in vitro skin graft-versus-host reaction in an organotypic skin culture model, Transplantation, 59(1), 69-78, January 1995 Abstract
  • Yu C, Storb R, Mathey B, Deeg HJ, Schuening FG, Graham TC, Seidel K, Burnett R, Wagner JL, Shulman H, Sandmaier BM, DLA-identical bone marrow grafts after low-dose total body irradiation: Effects of high-dose corticosteroids and cyclosporine on engraftment, Blood, 86, 4376-4381, 1995
  • Tan PH, Liu Y, Santos EB, Sandmaier BM, Mechanisms of enhancement of natural killer activity by an antibody to CD44: Increase in conjugate formation and release of tumor necrosis factor alpha, Cell Immunology, 164, 255-264, 1995
  • Storb R, Deeg HJ, Raff R, Schuening F, Yu C, Sandmaier BM, Graham T, Prevention of graft-versus-host disease: Studies in a canine model (Review), Annals of the New York Academy of Sciences, 770, 149-164, 1995
  • Jakic-Razumovic J, Storb R, Sandmaier BM, Sale GE, An organotypic skin culture model in dogs. A model for transplantation immunopathology in canine systems, Transplantation, 57(2), 285-7, January 1994 Abstract
  • Weaver CH, Petersen FB, Appelbaum FR, Bensinger WI, Press O, Martin P, Sandmaier B, Deeg HJ, Hansen JA, Brunvand M, Rowley S, Benyunes K, Chuancey T, Fefer A, Hackman R, Gooley T, Schiffman K, Storb R, Sullivan KM, Weiden P, Witherspoon R, Buckner CD, High-dose fractionated total-body irradiation, etoposide, and cyclophosphamide followed by autologous stem-cell support in patients with malignant lymphoma, Journal of Clinical Oncology, 12, 2559-2566, 1994
  • Raff RF, Sandmaier BM, Graham T, Loughran TP Jr, Pettinger M, Storb R, 'Resistance' to DLA-nonidentical canine unrelated marrow grafts is unrestricted by the major histocompatibility complex, Experimental Hematology, 22, 893-897, 1994
  • Weaver CH, Bensinger WI, Appelbaum FR, Lilleby K, Sandmaier B, Brunvand M, Rowley S, Petersdorf S, Rivkin S, Gooley T, Weiden P, Zuckerman N, Montgomery P, Trueblood K, Klarnet J, Buckner CD, Phase I study of high-dose busulfan, melphalan and thiotepa with autologous stem cell support in patients with refractory malignancies, Bone Marrow Transplantation, 14, 813-819, 1994
  • Tan PH, Santos EB, Rossbach HC, Sandmaier BM, Enhancement of natural killer activity by an antibody to CD44, Journal of Immunology, 150(3), 812-20, 1993 Abstract
  • Appelbaum FR, Brown PA, Sandmaier BM, Storb R, Fisher DR, Shulman HM, Graham TC, Schuening FG, Deeg HJ, Bianco JA, et al., Specific marrow ablation before marrow transplantation using an aminophosphonic acid conjugate 166Ho-EDTMP, Blood, 80(6), 1608-13, September 1992 Abstract
  • Greinix HT, Ladiges WC, Graham TC, Maslan S, Raff RF, Sandmaier BM, Appelbaum FR, Schuening FG, Deeg HJ, Storb R, Late failure of autologous marrow grafts in lethally irradiated dogs given anti-class II monoclonal antibody, Blood, 78(8), 2131-8, October 1991 Abstract
  • Sandmaier BM, Schuening FG, Bianco JA, Rosenman SJ, Bernstein I, Goehle S, Storb R, Appelbaum FR, Biochemical characterization of a unique canine myeloid antigen, Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.k., 5(2), 125-30, February 1991 Abstract
  • Sandmaier BM, Storb R, Appelbaum FR, Gallatin WM, An antibody that facilitates hematopoietic engraftment recognizes CD44, Blood, 76(3), 630-5, 1990 Abstract
  • Ladiges WC, Storb R, Raff RF, Appelbaum FR, Sandmaier B, Schuening F, Graham T, Failure of anti-MHC antibodies to prevent GVHD in DLA mismatched unrelated canine marrow recipients, Bone Marrow Transplantation, 5, 43-46, 1990
  • Bianco JA, Brown PA, Durack L, Badger C, Bernstein I, Eary J, Durham J, Fisher D, Sandmaier B, Schuening F, Storb R, Appelbaum F, Effects of propylthiouracil on the biodistribution of an iodine-131-labeled anti-myeloid antibody in normal dogs: Dosimetry and clinical implications, Journal of Nuclear Medicine, 31, 1384-1389, 1990
  • Storb R, Appelbaum F, Buckner CD, Clift R, Anasetti C, Beatty P, Bianco J, Doney K, Hansen J, Martin P, Sanders J, Sandmaier B, Schuening F, Sullivan K, Witherspoon R, Thomas ED, HLA-identical marrow transplantation in the leukemias without T-cell depletion, Bone Marrow Transplantation, 6, 80-84, 1990
  • Schuening FG, Storb R, Goehle S, Nash R, Graham TC, Appelbaum FR, Hackman R, Sandmaier BM, Urdal DL, Stimulation of canine hematopoiesis by recombinant human granulocyte-macrophage colony-stimulating factor, Experimental Hematology, 17(8), 889-94, September 1989 Abstract
  • Appelbaum FR, Raff RF, Storb R, Deeg HJ, Graham TC, Sandmaier B, Schuening F, Use of trimetrexate for the prevention of graft-versus-host disease, Bone Marrow Transplantation, 4, 421-424, 1989
  • Appelbaum FR, Brown P, Sandmaier B, Badger C, Schuening F, Graham TC, Storb R, Antibody-radionuclide conjugates as part of a myeloablative preparative regimen for marrow transplantation, Blood, 73, 2202-2208, 1989
  • Storb R, Appelbaum FR, Badger C, Bernstein I, Buckner CD, Petersen FB, Martin P, Hansen J, Anasetti C, Sandmaier B, Bianco J, Schuening F, Thomas ED, for the Seattle Bone Marrow Transplant Team: New conditioning regimens, Bone Marrow Transplantation, 4, 15, 1989
  • Bianco JA, Sandmaier B, Brown P, Badger C, Bernstein I, Eary J, Durak L, Schuening F, Storb R, Appelbaum F, Specific marrow localization of an 131I-labeled anti-myeloid antibody in normal dogs: Effects of a 'cold' antibody pretreatment dose on marrow localization, Experimental Hematology, 17, 929-934, 1989
  • Raff RF, Severns E, Storb R, Martin P, Graham T, Sandmaier B, Schuening F, Sale G, Appelbaum FR, L-leucyl-L-leucine methyl ester treatment of canine marrow and peripheral blood cells. Inhibition of proliferative responses with maintenance of the capacity for autologous marrow engraftm, 46(5), 655-60, November 1988 Abstract
  • Storb R, Raff RF, Appelbaum FR, Schuening FW, Sandmaier BM, Graham TC, Thomas ED, What radiation dose for DLA-identical canine marrow grafts?, 72(4), 1300-4, October 1988 Abstract
  • Storb R, Raff RF, Appelbaum FR, Schuening FW, Sandmaier BM, Graham TC, The influence of transfusions from unrelated DLA-matched or mismatched donors upon marrow grafts between DLA-identical canine littermates, 46(2), 334-6, August 1988 Abstract
  • Appelbaum FR, Graham T, Sandmaier B, Schuening F, Storb R, Sensitivity of newly transplanted marrow to further irradiation, 45(4), 813-4, April 1988 Abstract
  • Storb R, Raff RF, Appelbaum FR, Schuening F, Sandmaier B, Shulman H, Deeg HJ, Graham T, Failure of antithymocyte serum postgrafting to overcome 'resistance' to DLA-nonidentical canine marrow grafts, 45(1), 236-9, January 1988 Abstract
  • Appelbaum FR, Sandmaier B, Brown PA, Kaplan D, Ketring AR, Geockeler WF, Graham T, Schuening F, Storb R, Myelosuppression and mechanism of recovery following administration of 153Samarium-EDTMP, Antibody, Immunoconjugates, and Radiopharmaceuticals, 1, 263-270, 1988
  • Storb R, Deeg HJ, Appelbaum FR, Schuening F, Sandmaier B, Raff RF, Graham T, Failure of anti-la monoclonal antibody to abrogate transfusion-induced sensitization and prevent marrow graft rejection in DLA-identical canine littermates (Brief Communications), Transplantation, 45, 505-506, 1988
  • Deeg, HJ, Storer BE, Boeckh M, Martin PJ, McCune JS, Myerson D, Heimfeld S, Flowers ME, Anasetti C, Doney KC, Hansen JA, Kiem HP, Nash RA, O'Donell PV, Radich JP, Sandmaier BM, Scott BL, Warren EH, Witherspoon RP, Woolfrey A, Appelbaum FR, Storb R, Reduced incidence of acute and chronic GVHD with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimen, Biology of Blood and Marrow Transplant, In Press
  • Burroughs L, Mielcarek M, Leisenring W, Sandmaier BM, Maloney DG, Baron F, Martin PJ, Flowers MED, Forman SJ, Chauncey TR, Bruno B, Storb R, Extending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation., Transplantation, In Press
  • Maris MB, Sandmaier BM, Storer BE, Maloney DG, Shizuru JA, Agura E, Kliem C, Pulsipher M, Maziarz RT, McSweeney PA, Wade J, Langston AA, Chauncey TR, Bruno B, Blume KG, Storb R, Unrelated donor G-CSF mobilized peripheral blood mononuclear cell tranpslantation after nonmyeloablative conditioning: the effect of postgrafting mycophenolate mofetil dosing., Biology of Blood and Marrow, In Press

Profile Details

Last Updated: 5/10/2006

COS Expertise ID #135379
Reference this profile directly: http://myprofile.cos.com/SANDMAIER