Dr. Ann E. Stapleton

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University of Washington
School of Medicine
Medicine
Allergy and Infectious Diseases
Associate Professor

Mailing Address

Box 356523
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 616-4121
Fax: (206) 616-4898
stapl@u.washington.edu

Qualifications

M.D., Albert Einstein College of Medicine, 1984.
A.B., Harvard University, Biology, 1980.

Expertise and Research Interests

Urinary tract infection; bacterial-host interactions; vaginal physiology in health and disease; glycoconjugates and infection; commensal bacterial flora.

Other Expertise

Board Certification:
1987 Diplomate, American Board of Internal Medicine
1990 Diplomate, Subspecialty of Infectious Disease
2006 Re-certified, Subspecialty of Infectious Disease

Keywords

COS Keywords:

Epidemiology, Infectious Diseases or Agents.

Additional Terms:

Epidemiology, Glycosphingolipid, Infectious Diseases, Nephrology/tract/urinary Biology: Urinary Tract.

Languages

(Reading, Writing, Speaking)

French: (Basic, None, None)

Honors and Awards

1999-1999, Masaaki Ohkoshi Award, International Congress of Chemotherapy, Given for best clinical study on the subject of urinary tract infections during a two-year period
1992, Edwin Beer Research Fellowship in Urology and Urology-Related Fields, New York Academy of Medicine
1984, Alpha Omega Alpha, Alpha Omega Alpha, Albert Einstein College of Medicine

Previous Positions

1987-1991, Fellow, University of Washington, School of Medicine, Medicine, Allergy and Infectious Diseases
1984-1987, Resident, University of California, San Francisco, School of Medicine, Internal Medicine

Patents

Compositions for treating Escherichia coli urinary tract infections, Patent Number: 6432681, 1999, United States of America.
Method for determining susceptibility to Escherichia coli urinary tract infections and method for diagnosing secretors and nonsecretors, and method and medicament for preventing Escherichia coli urinary tract infections, Patent Number: 6130205, 1995, United States of America.
Method for determining susceptibility to Escherichia coli urinary tract infections and method for diagnosing secretors and nonsecretors, Patent Number: 5374532, 1992, United States of America.

Publications

  • Korotkova N, Yarova-Yarovaya Y, Tchesnokova V, Yazvenko N, Carl MA, Stapleton AE, Moseley SL (Jun 2008) E. coli DraE adhesin - associated bacterial internalization by epithelial cells is independently promoted by decay accelerating factor and CEACAM binding, and does not require the DraD "invasin", Infection and immunity Abstract
  • Gupta K, Chou MY, Howell A, Wobbe C, Grady R, Stapleton AE (2007) Cranberry products inhibit adherence of P-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells, J Urol, 177 (6), 2357-2360
  • Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A, Abraham SN (2007) A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells, PLoS Pathog, 3 (4), e60
  • Czaja CA, Stapleton AE, Yarova-Yarovaya Y, Stamm WE (2007) Phase I trial of a Lactobacillus crispatus vaginal suppository for prevention of recurrent urinary tract infection in women., Infectious diseases in obstetrics and gynecology, 2007, 35387 Abstract
  • Stapleton AE (2006) Urinary tract infections in women: new pathogenic considerations, Curr Infect Dis Rep, 8 (6), 465-472
  • Kwok L, Stapleton A, Stamm WE, Hillier SL, Wobbe CL, Gupta K (2006) Adherence of Lactobacillus crispatus to vaginal epithelial cells from women with and without a history of recurrent UTI, J Urol, 176 (5), 2050-2054
  • Weissman SJ, Chattopadhyay S, Aprikian P, Obata-Yasuoka M, Yarova-Yarovaya Y, Stapleton A, Ba-Thein W, Dykhuizen D, Johnson JR, Sokurenko EV (2006) Clonal analysis reveals high rate of structural mutations in fimbrial adhesins of extraintestinal pathogenic Escherichia coli, Mol Micro, 59 (3), 975-988
  • Stapleton A (2005) Novel mechanism of P fimbriated Escherichia coli virulence in pyelonephritis, J Am Soc Nephrol, 16 (12), 3458-3460
  • Hooton TM, Scholes D, Gupta K, Stapleton AE, Roberts PL, Stamm WE (Feb 2005) Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial., Jama : the Journal of the American Medical Association, 293 (8), 949-55 Abstract
  • Scholes D, Hooton TM, Roberts PL, Gupta K, Stapleton AE, Stamm WE (Jan 2005) Risk factors associated with acute pyelonephritis in healthy women., Annals of Internal Medicine, 142 (1), 20-7 Abstract
  • Brown JS, Wessells H, Chancellor MB, Howards SS, Stamm WE, Stapleton AE, Steers WD, Van Den Eeden SK, McVary KT (Jan 2005) Urologic complications of diabetes., Diabetes Care, 28 (1), 177-85 Abstract
  • Stapleton A (2004) A new candidate vaccine for Escherichia coli pyelonephritis, J Urol, 171 (4), 1686-1687
  • Schlager TA, Whittam TS, Hendley JO, Bhang JL, Wobbe CL, Stapleton A (Oct 2003) Variation in frequency of the virulence-factor gene in Escherichia coli clones colonizing the stools and urinary tracts of healthy prepubertal girls., The Journal of Infectious Diseases, 188 (7), 1059-64 Abstract
  • Stapleton A (Jun 2003) Novel approaches to prevention of urinary tract infections., Infectious Disease Clinics of North America, 17 (2), 457-71 Abstract
  • Nicolle LE, Hooton TM, Jones WK, Fisher C, Fourcroy JL, Gupta K, Hooton TM, Johnson JR, Krieger JN, Martens MG, Moore A, Nicolle LE, Ronald A, Schlager TA, Sheeler RD, Stapleton AE, Managing acute uncomplicated cystitis in the era of antibiotic resistance, Clinical Courier, Califon, NJ, Office on Women's Health, USDHHS and IMED Publications, 21, 1-16, 2003
  • Stapleton A (Jul 2002) Urinary tract infections in patients with diabetes., The American Journal of Medicine, 113 Suppl 1A, 80S-84S Abstract
  • Johnson JR, Jerome C, Boster DR, Stapleton AE, Tarr PI (Jun 2002) Analysis of urinary Escherichia coli isolates for ability to produce Shiga toxin., Journal of Clinical Microbiology, 40 (6), 2247-8 Abstract
  • Stapleton AE, Fennell CL, Coder DM, Wobbe CL, Roberts PL, Stamm WE (Feb 2002) Precise and rapid assessment of Escherichia coli adherence to vaginal epithelial cells by flow cytometry., Cytometry, 50 (1), 31-7 Abstract
  • Jelacic S, Wobbe CL, Boster DR, Ciol MA, Watkins SL, Tarr PI, Stapleton AE (Jan 2002) ABO and P1 blood group antigen expression and stx genotype and outcome of childhood Escherichia coli O157:H7 infections., The Journal of Infectious Diseases, 185 (2), 214-9 Abstract
  • Stamm WE, Stapleton A (2002) Urinary tract infection In Gorbach SL, Bartlett JG, Blacklow NR (eds), Infectious Diseases, 2nd Edition, Philadelphia, PA, WD Saunders (bookchapter)
  • Johnson JR, O'Bryan TT, Delavari P, Kuskowski M, Stapleton A, Carlino U, Russo TA (May 2001) Clonal relationships and extended virulence genotypes among Escherichia coli isolates from women with a first or recurrent episode of cystitis., The Journal of Infectious Diseases, 183 (10), 1508-17 Abstract
  • Eschenbach DA, Patton DL, Hooton TM, Meier AS, Stapleton A, Aura J, Agnew K (Mar 2001) Effects of vaginal intercourse with and without a condom on vaginal flora and vaginal epithelium., The Journal of Infectious Diseases, 183 (6), 913-8 Abstract
  • Scholes D, Hooton TM, Roberts PL, Stapleton AE, Gupta K, Stamm WE (Oct 2000) Risk factors for recurrent urinary tract infection in young women., The Journal of Infectious Diseases, 182 (4), 1177-82 Abstract
  • Patton DL, Thwin SS, Meier A, Hooton TM, Stapleton AE, Eschenbach DA (Oct 2000) Epithelial cell layer thickness and immune cell populations in the normal human vagina at different stages of the menstrual cycle., American Journal of Obstetrics and Gynecology, 183 (4), 967-73 Abstract
  • Hooton TM, Scholes D, Stapleton AE, Roberts PL, Winter C, Gupta K, Samadpour M, Stamm WE (Oct 2000) A prospective study of asymptomatic bacteriuria in sexually active young women., The New England Journal of Medicine, 343 (14), 992-7 Abstract
  • Eschenbach DA, Patton DL, Meier A, Thwin SS, Aura J, Stapleton A, Hooton TM (Sep 2000) Effects of oral contraceptive pill use on vaginal flora and vaginal epithelium., Contraception, 62 (3), 107-12 Abstract
  • Eschenbach DA, Thwin SS, Patton DL, Hooton TM, Stapleton AE, Agnew K, Winter C, Meier A, Stamm WE (Jun 2000) Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 30 (6), 901-7 Abstract
  • Schlager TA, Whittam TS, Hendley JO, Wilson RA, Bhang J, Grady R, Stapleton A (Jan 2000) Expression of virulence factors among Escherichia coli isolated from the periurethra and urine of children with neurogenic bladder on intermittent catheterization., The Pediatric Infectious Disease Journal, 19 (1), 37-41 Abstract
  • Hooton TM, Stapleton AE, Roberts PL, Winter C, Scholes D, Bavendam T, Stamm WE (Dec 1999) Perineal anatomy and urine-voiding characteristics of young women with and without recurrent urinary tract infections., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 29 (6), 1600-1 Abstract
  • Stapleton A (1999) Host factors in susceptibility to urinary tract infections., Advances in Experimental Medicine and Biology, 462, 351-8 Abstract
  • Stapleton A (Jan 1999) Prevention of recurrent urinary-tract infections in women., Lancet, 353 (9146), 7-8 Abstract
  • Ummenhofer WC, Stapleton AE, Bernards CM (Jan-Feb 1999) Effect of Staphylococcus aureus bacteria and bacterial toxins on meningeal permeability in vitro., Regional Anesthesia and Pain Medicine, 24 (1), 24-9 Abstract
  • Stroud MR, Stapleton AE, Levery SB (Dec 1998) The P histo-blood group-related glycosphingolipid sialosyl galactosyl globoside as a preferred binding receptor for uropathogenic Escherichia coli: isolation and structural characterization from human kidney., Biochemistry, 37 (50), 17420-8 Abstract
  • Gupta K, Stapleton A E, Hooton T M, Roberts P L, Fennell C L, Stamm W E, Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections., Journal of Infectious Diseases, 178(2), 446-50, August 1998 Abstract
  • Stapleton AE, Stroud MR, Hakomori SI, Stamm WE (Aug 1998) The globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor In vitro for uropathogenic Escherichia coli expressing pap-encoded adhesins., Infection and Immunity, 66 (8), 3856-61 Abstract
  • Island MD, Cui X, Foxman B, Marrs CF, Stamm WE, Stapleton AE, Warren JW (Jul 1998) Cytotoxicity of hemolytic, cytotoxic necrotizing factor 1-positive and -negative Escherichia coli to human T24 bladder cells., Infection and Immunity, 66 (7), 3384-9 Abstract
  • Johnson DE, Lockatell CV, Russell RG, Hebel JR, Island MD, Stapleton A, Stamm WE, Warren JW (Jul 1998) Comparison of Escherichia coli strains recovered from human cystitis and pyelonephritis infections in transurethrally challenged mice., Infection and Immunity, 66 (7), 3059-65 Abstract
  • Johnson JR, Russo TA, Brown JJ, Stapleton A (Jan 1998) papG alleles of Escherichia coli strains causing first-episode or recurrent acute cystitis in adult women., The Journal of Infectious Diseases, 177 (1), 97-101 Abstract
  • Stapleton A, Stamm WE (Sep 1997) Prevention of urinary tract infection., Infectious Disease Clinics of North America, 11 (3), 719-33 Abstract
  • Andreu A, Stapleton AE, Fennell C, Lockman HA, Xercavins M, Fernandez F, Stamm WE (Aug 1997) Urovirulence determinants in Escherichia coli strains causing prostatitis., The Journal of Infectious Diseases, 176 (2), 464-9 Abstract
  • Smith HS, Hughes JP, Hooton TM, Roberts P, Scholes D, Stergachis A, Stapleton A, Stamm WE (Jul 1997) Antecedent antimicrobial use increases the risk of uncomplicated cystitis in young women., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 25 (1), 63-8 Abstract
  • Johnson JR, Stapleton AE, Russo TA, Scheutz F, Brown JJ, Maslow JN (Jun 1997) Characteristics and prevalence within serogroup O4 of a J96-like clonal group of uropathogenic Escherichia coli O4:H5 containing the class I and class III alleles of papG., Infection and Immunity, 65 (6), 2153-9 Abstract
  • Tarr PI, Fouser LS, Stapleton AE, Wilson RA, Kim HH, Vary JC Jr, Clausen CR (Aug 1996) Hemolytic-uremic syndrome in a six-year-old girl after a urinary tract infection with Shiga-toxin-producing Escherichia coli O103:H2., The New England Journal of Medicine, 335 (9), 635-8 Abstract
  • Hooton TM, Scholes D, Hughes JP, Winter C, Roberts PL, Stapleton AE, Stergachis A, Stamm WE (Aug 1996) A prospective study of risk factors for symptomatic urinary tract infection in young women., The New England Journal of Medicine, 335 (7), 468-74 Abstract
  • Schlager TA, Whittam TS, Hendley JO, Hollis RJ, Pfaller MA, Wilson RA, Stapleton A (Sep 1995) Comparison of expression of virulence factors by Escherichia coli causing cystitis and E. coli colonizing the periurethra of healthy girls., The Journal of Infectious Diseases, 172 (3), 772-7 Abstract
  • Russo TA, Stapleton A, Wenderoth S, Hooton TM, Stamm WE (Aug 1995) Chromosomal restriction fragment length polymorphism analysis of Escherichia coli strains causing recurrent urinary tract infections in young women., The Journal of Infectious Diseases, 172 (2), 440-5 Abstract
  • Andreu A, Stapleton AE, Fennell CL, Hillier SL, Stamm WE (May 1995) Hemagglutination, adherence, and surface properties of vaginal Lactobacillus species., The Journal of Infectious Diseases, 171 (5), 1237-43 Abstract
  • Stapleton A, Hooton TM, Fennell C, Roberts PL, Stamm WE (Mar 1995) Effect of secretor status on vaginal and rectal colonization with fimbriated Escherichia coli in women with and without recurrent urinary tract infection., The Journal of Infectious Diseases, 171 (3), 717-20 Abstract
  • Stapleton A, Nudelman E, Clausen H, Hakomori S, Stamm WE (Sep 1992) Binding of uropathogenic Escherichia coli R45 to glycolipids extracted from vaginal epithelial cells is dependent on histo-blood group secretor status., The Journal of Clinical Investigation, 90 (3), 965-72 Abstract
  • Spach DH, Stapleton AE, Stamm WE (Feb 1992) Lack of circumcision increases the risk of urinary tract infection in young men., Jama : the Journal of the American Medical Association, 267 (5), 679-81 Abstract
  • Stapleton A, Moseley S, Stamm WE (Apr 1991) Urovirulence determinants in Escherichia coli isolates causing first-episode and recurrent cystitis in women., The Journal of Infectious Diseases, 163 (4), 773-9 Abstract
  • Stapleton A, Latham RH, Johnson C, Stamm WE (Aug 1990) Postcoital antimicrobial prophylaxis for recurrent urinary tract infection. A randomized, double-blind, placebo-controlled trial., Jama : the Journal of the American Medical Association, 264 (6), 703-6 Abstract
  • Stamm WE, Hooton TM, Johnson JR, Johnson C, Stapleton A, Roberts PL, Moseley SL, Fihn SD (Mar 1989) Urinary tract infections: from pathogenesis to treatment., The Journal of Infectious Diseases, 159 (3), 400-6 Abstract
  • Stapleton A, Fine R (1988) Hypertension management In Skach W, Daley C, Forsmark C (eds), Handbook of Medical Treatment, 18th Edition, Greenbrae, CA, Jones Medical Publications, 123-135 pages (bookchapter)
  • Schwartz JH, Bernier L, Castellucci VF, Palazzolo M, Saitoh T, Stapleton A, Kandel ER (1983) What molecular steps determine the time course of the memory for short-term sensitization in Aplysia?, Cold Spring Harbor Symposia On Quantitative Biology, 48 Pt 2, 811-9 Abstract

Profile Details

Last Updated: 8/11/2008

COS Expertise ID #135135
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