Debby W. Tsuang

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University of Washington
School of Medicine
Psychiatry and Behavioral Sciences
Associate ProfessorAppointed: 2004
University of Washington
School of Public Health and Community Medicine
Epidemiology
Adjunct Assistant ProfessorAppointed: 2004
VA Puget Sound Health Care System
Mental Illness Research, Education, and Clinical Center
Staff PsychiatristAppointed: 1997

Mailing Address

1660 S. Columbian Way S-116
Seattle, Washington 98108
United States

Contact Information

Phone: (206) 277-1333
Fax: (206) 277-4731
dwt1@u.washington.edu

Qualifications

M.Sc., University of Iowa, 1992.
M.D., University of Iowa, 1988.

Keywords

COS Keywords:

Behavioral or Social Studies, Epidemiology, Geriatric Mental Health, Mental Health, Psychiatry.

Memberships

American Association for Geriatric Psychiatry
American Medical Association
American Psychiatric Association
American Society of Human Genetics
Society of Biological Psychiatry

Honors and Awards

2001-2002, Investigator, Browning Foundation
1992-1992, Resident Research Award, APA/Dista Product
1992-1992, Resident Research Award, Winokur

Previous Positions

1999-2004, Assistant Professor, University of Washington, School of Medicine, Psychiatry and Behavioral Sciences
1995-1997, Staff Psychiatrist, VA Puget Sound Health Care System, Mental Health Service
1995-1999, Acting Assistant Professor, University of Washington, School of Medicine, Psychiatry and Behavioral Sciences
1995-2004, Adjunct Assistant Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1993-1995, Acting Instructor, University of Washington, School of Medicine, Psychiatry and Behavioral Sciences

Funding Received

  • VA Merit Review: Genomic Analysis of Schizophrenia, , 2006 to 2011.
  • National Institutes of Health (NIH): University of Washington Alzheimer's Disease Research Center, , 2005 to 2010.
  • National Institutes of Health (NIH): Clinical, Pathologic, and Genetic Characteristics of DLB: A Multicenter Collaborative Study, , 2003 to 2007.
  • National Institutes of Health (NIH): Consortium on the Genetics of Endophenotypes and Schizophrenia, , 2003 to 2008.
  • National Institutes of Health (NIH): Characterization of DLB: A Collaborative Study, , 2003 to 2008.
  • NARSAD: Genetics of Neurocognition in Families with Schizophrenia, , 2001 to 2003.
  • National Institutes of Health (NIH): Psychopathology of Alzheimer's: APOE and the HPA Axis, , 2001 to 2006.
  • VA Merit Review: Parkinson's-related Neurodegenerative Dementia in a Community Sample, , 2001 to 2004.
  • NACC: CSF Cortisol and APOE Genotype: A Multicenter Collaborative Study, , 2001 to 2003.
  • NIMH: Interdisciplinary Clinical Research Skills Training, , 2001 to 2002.
  • UW ADRC One-Year Pilot: A Family Study of dementia with Lewy bodies, , 2000 to 2001.
  • National Institutes of Health (NIH): Alzheimer's in Long-Term Care: Propranolol for Agitation, , 2000 to 2004.
  • NIA: Psychopathology and Age of Onset in Huntington's Disease, , 1995 to 1998.

Publications

  • Zaja-Milatovic S, Keene D, Montine KS, Leverenz J, Tsuang DW, Montine T (2006) Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies, Neurology, 66 (10), 1591-1593
  • Leverenz JB, et al (2006) Lewy body pathology in familial AD: evidence for disease and mutation specific pathologic phenotype, Arch Neurology, 63 (3), 370-376
  • Tsuang DW, Et Al. (2006) Predicting Lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease., J Geriatr Psychiatry Neurol, In Press
  • Radant A et al (2006) Successful multi-site measurement of antisaccade performance deficits in schizophrenia., Schizophr Res, In Press
  • Calkins M, et al (2006) The Consortium on the Genetics of Endophenotypes in Schizophrenia (COGS): Model Recruitment, Assessment, and Endophenotyping Methods for a Multi-Site Collaboration., Schizophr Bull, In Press
  • Li G, et al (2006) Salivary cortisol and memory function in human aging, Neurobiol Aging, 27 (11), 1705-1714
  • Tsuang DW (2006) Lewy body pathology in late-onset familial Alzheimer's disease: A clinicopathological case series, J Alzheimer's Dis, 9 (3), 235 - 242
  • Zabetian C, Lauricella C, Tsuang DW, Leverenz J, Schellenberg G, Payami H (2006) Analysis of the LRRK2 G2019S mutation in Alzheimer's disease, Arch Neurol, 63 (1), 156-157
  • Li G, Shofer JB, Kukull WA, Peskind ER, Tsuang DW, Breitner JC, McCormick W, Bowen JD, Teri L, Schellenberg GD, Larson EB (Oct 2005) Serum cholesterol and risk of Alzheimer disease: a community-based cohort study, Neurology, 65 (7), 1045-50 Abstract
  • Tsuang DW, Wilson RK, Lopez OL, Luedecking-Zimmer EK, Leverenz JB, DeKosky ST, Kamboh MI, Hamilton RL (Feb 2005) Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease, Neurology, 64 (3), 509-13 Abstract
  • Peskind ER, Tsuang DW, Bonner LT, Pascualy M, Riekse RG, Snowden MB, Thomas R, Raskind MA (Jan-Mar 2005) Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study, Alzheimer Dis Assoc Disord, 19 (1), 23-8 Abstract
  • Tsuang D, Simpson KL, Li G, Barnhart RL, Edland SD, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB (Apr-Jun 2005) Evaluation of selection bias in an incident-based dementia autopsy case series, Alzheimer Dis Assoc Disord, 19 (2), 67-73 Abstract
  • Kraybill M, et al (2005) Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both, Neurology, 64, 2069-73
  • Skol A, et al (2005) An algorithm to construct genetically similar subsets of families with the use of self-reported ethnicity information, Am J Hum Genet, 77, 346-54
  • Faraone SV (2005) Genome scan of schizophrenia families in a large Veterans Affairs Cooperative Study sample: Evidence for linkage to 18p11.32 and for racial heterogeneity on chromosomes 6 and 14, Am J Med Genet (Neuropsychiatric Section), 139B, 91-100
  • Sasha Erickson (2005) Dementia with Lewy bodies, Spectrum Psychotic Disorders, In Press (bookchapter)
  • Tsuang D, Simpson KL, Li G, Barnhart RL, Edland SD, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB (Apr-Jun 2005) Evaluation of selection bias in an incident-based dementia autopsy case series., Alzheimer Disease and Associated Disorders, 19 (2), 67-73 Abstract
  • Peskind ER, Tsuang DW, Bonner LT, Pascualy M, Riekse RG, Snowden MB, Thomas R, Raskind MA (Jan-Mar 2005) Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study., Alzheimer Disease and Associated Disorders, 19 (1), 23-8 Abstract
  • Li G, Higdon R, Kukull WA, Peskind E, Van Valen Moore K, Tsuang D, van Belle G, McCormick W, Bowen JD, Teri L, Schellenberg GD, Larson EB (Nov 2004) Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study, Neurology, 63 (9), 1624-8 Abstract
  • Riekse RG, Leverenz JB, McCormick W, Bowen JD, Teri L, Nochlin D, Simpson K, Eugenio C, Larson EB, Tsuang D (Sep 2004) Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study, J Am Geriatr Soc, 52 (9), 1442-8 Abstract
  • Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, Bird TD, Leverenz JB, Tsuji S, La Spada AR (Sep 2004) Beta-synuclein gene alterations in dementia with Lewy bodies, Neurology, 63 (5), 805-11 Abstract
  • Tsuang DW, DiGiacomo L, Bird TD (Mar-Apr 2004) Familial occurrence of dementia with Lewy bodies, Am J Geriatr Psychiatry, 12 (2), 179-88 Abstract
  • Debby Tsuang (2004) The role of genetic counseling, Early Clinical Intervention and Prevention in Schizophrenia, Totowa, Humana Press (bookchapter)
  • Debby W. Tsuang (2004) Genetics of Dementia, Comprehensive Textbook of Geriatric Psychiatry, Third edition, New York, W.W. Norton and Company (bookchapter)
  • Skol AD, Young KA, Tsuang DW, Faraone SV, Haverstock SL, Bingham S, Prabhudesai S, Mena F, Menon AS, Yu CE, Rundell P, Pepple J, Sauter F, Baldwin C, Weiss D, Collins J, Keith T, Boehnke M, Schellenberg GD, Tsuang MT (Apr 2003) Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample, Am J Med Genet (Neuropsychiatric Section), 118B (1), 8-15 Abstract
  • Bonner LT, Tsuang DW, Cherrier MM, Eugenio CJ, Du Jennifer Q, Steinbart EJ, Limprasert P, La Spada AR, Seltzer B, Bird TD, Leverenz JB (Mar 2003) Familial dementia with Lewy bodies with an atypical clinical presentation, J Geriatr Psychiatry Neurol, 16 (1), 59-64 Abstract
  • Tsuang DW, Dalan AM, Eugenio CJ, Poorkaj P, Limprasert P, La Spada AR, Steinbart EJ, Bird TD, Leverenz JB (Oct 2002) Familial dementia with lewy bodies: a clinical and neuropathological study of 2 families, Arch Neurol, 59 (10), 1622-30 Abstract
  • Faraone SV, Skol AD, Tsuang DW, Bingham S, Young KA, Prabhudesai S, Haverstock SL, Mena F, Menon AS, Bisset D, Pepple J, Sautter F, Baldwin C, Weiss D, Collins J, Keith T, Boehnke M, Tsuang MT, Schellenberg GD (Aug 2002) Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample, Am J Med Genet (Neuropsychiatric Section), 114 (6), 598-604 Abstract
  • Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland SD, Nochlin D, DiGiacomo L, Bowen JD, McCormick WC, Teri L, Raskind MA, Kukull WA, Larson EB (Jul 2002) Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study, Arch Neurol, 59 (7), 1099-106 Abstract
  • Tsuang DW, Bird TD (May 2002) Genetics of dementia, Med Clin North Am, 86 (3), 591-614 Abstract
  • Tsuang D, et al (2002) Implications of psychiatric genetics and the use of genetic counseling, Dir Psychiatry, 22, 155-164
  • Steven V. Faraone (2002) Methods in psychiatric genetics, Textbook in Psychiatric Epidemiology, Second Edition, New York, John Wiley & Sons (bookchapter)
  • Tsuang DW, Skol AD, Faraone SV, Bingham S, Young KA, Prabhudesai S, Haverstock SL, Mena F, Menon AS, Bisset D, Pepple J, Sauter F, Baldwin C, Weiss D, Collins J, Boehnke M, Schellenberg GD, Tsuang MT, Veterans Affairs Cooperative Study (Dec 2001) Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample, Am J Med Genet (Neuropsychiatric Section), 105 (8), 662-8 Abstract
  • Poorkaj P, Tsuang D, Wijsman E, Steinbart E, Garruto RM, Craig UK, Chapman NH, Anderson L, Bird TD, Plato CC, Perl DP, Weiderholt W, Galasko D, Schellenberg GD (Nov 2001) TAU as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam, Arch Neurol, 58 (11), 1871-8 Abstract
  • Radant A, Tsuang D, Peskind ER, McFall M, Raskind W (Jul 2001) Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder, Psychiatry Res, 102 (3), 203-15 Abstract
  • Tsuang DW, Faraone SV, Tsuang MT (Apr 2001) Genetic counseling for psychiatric disorders, Curr Psychiatry Rep, 3 (2), 138-43 Abstract
  • Tsuang D, Almqvist EW, Lipe H, Strgar F, DiGiacomo L, Hoff D, Eugenio C, Hayden MR, Bird TD (Dec 2000) Familial aggregation of psychotic symptoms in Huntington's disease, Am J Psychiatry, 157 (12), 1955-9 Abstract
  • Debby Tsuang (2000) Psychiatric genetic counseling, Psychopharmacology: The Fourth Generation of Progress/CD ROM, American College of Neuropsychopharmacology (bookchapter)
  • Tsuang D, Larson EB, Bowen J, McCormick W, Teri L, Nochlin D, Leverenz JB, Peskind ER, Lim A, Raskind MA, Thompson ML, Mirra SS, Gearing M, Schellenberg GD, Kukull W (Dec 1999) The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series, Arch Neurol, 56 (12), 1489-95 Abstract
  • Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W, Bowen J, Teri L, Thompson J, Peskind ER, Raskind M, Larson EB (May 1999) Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series, J Am Geriatr Soc, 47 (5), 564-9 Abstract
  • Stephen V. Faraone (1999) Genetics of mental disorders: What practitioners and students need to know, New York, Guilford Press
  • Peskind ER, Jensen CF, Pascualy M, Tsuang D, Cowley D, Martin DC, Wilkinson CW, Raskind MA (Nov 1998) Sodium lactate and hypertonic sodium chloride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder, Biol Psychiatry, 44 (10), 1007-16 Abstract
  • Levy-Lahad E, Tsuang D, Bird TD (Summer 1998) Recent advances in the genetics of Alzheimer's disease, J Geriatr Psychiatry Neurol, 11 (2), 42-54 Abstract
  • Tsuang D, DiGiacomo L, Lipe H, Bird TD (Jul 1998) Familial aggregation of schizophrenia-like symptoms in Huntington's disease, Am J Med Genet (Neuropsychiatry Section), 81 (4), 323-7 Abstract
  • Pascualy M, Tsuang D, Shores M, Agustin C, Krause E, Spain W, Bird T, Peskind E (Oct 1997) Frontal-complex partial status epilepticus misdiagnosed as bipolar affective disorder in a 75-year-old man, J Geriatr Psychiatry Neurol, 10 (4), 158-60 Abstract
  • Tsuang D, Raskind MA, Leverenz J, Peskind ER, Schellenberg G, Bird TD (Jan 1997) The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles, Biol Psychiatry, 41 (2), 191-5 Abstract
  • Edland SD, Silverman JM, Peskind ER, Tsuang D, Wijsman E, Morris JC (Jul 1996) Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance, Neurology, 47 (1), 254-6 Abstract
  • Tsuang D, Kukull W, Sheppard L, Barnhart RL, Peskind E, Edland SD, Schellenberg G, Raskind M, Larson EB (Jun 1996) Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease samples, J Am Geriatr Soc, 44 (6), 704-7 Abstract
  • Tsuang D, et al (1996) Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease samples, J Am Geriatr Soc, 44, 704-707
  • Tsuang D, Cowley D, Ries R, Dunner DL, Roy-Byrne PP (Dec 1995) The effects of substance use disorder on the clinical presentation of anxiety and depression in an outpatient psychiatric clinic, J Clin Psychiatry, 56 (12), 549-55 Abstract
  • Tsuang D, Coryell W (Aug 1993) An 8-year follow-up of patients with DSM-III-R psychotic depression, schizoaffective disorder, and schizophrenia, Am J Psychiatry, 150 (8), 1182-8 Abstract
  • Tsuang D et al (1993) Late-onset depression: is it a distinct disorder?, Neurology, Psychiatry, Brain Res, 1, 145-149
  • Coryell W, Tsuang D (Aug 1992) Hypothalamic-pituitary-adrenal axis hyperactivity and psychosis: recovery during an 8-year follow-up, Am J Psychiatry, 149 (8), 1033-9 Abstract
  • Tsuang DW, Winokur G (Jul 1992) Testing the validity of the neurotic depression concept, J Nerv Ment Dis, 180 (7), 446-50 Abstract
  • Tsuang D, et al (1992) Testing the validity of the neurotic depression concept, J Nerv Ment Dis, 180, 446-450
  • Alvine G, Black DW, Tsuang D, Case of delirium secondary to phenelzine/L-tryptophan combination., The Journal of Clinical Psychiatry, 51(7), 311, Jul 1990 Abstract
  • McSherry E, et al (1987) Spiritual resources in older hospitalized men, Soc Compass, 34, 515-537

Profile Details

Last Updated: 9/15/2006

COS Expertise ID #802930
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