Cyrus P. Zabetian

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University of Washington
School of Medicine
Neurology
Neurogenetics
Assistant Professor
VA Puget Sound Health Care System
Geriatric Research, Education, and Clinical Center
Staff Neurologist

Mailing Address

GRECC (S-182)
VA Puget Sound Health Care System
1660 S. Columbian Way
Seattle, Washington 98108
United States

Contact Information

Phone: (206) 764-2021
Fax: (206) 764-2802
zabetian@u.washington.edu

Qualifications

M.D., University of Miami, 1994.
M.S., University of Washington, 1988.
B.S., University of California, Los Angeles, 1986.

Keywords

COS Keywords:

Catecholamines, Dopamine, Genetic Markers, Genetics, Geriatrics, Human Population and Genetics, Medical Genetics, Molecular Genetics, Neurology, Neuroscience, Parkinson's Disease.

Additional Terms:

Dopamine Beta-Hydroxylase, Haplotype, Linkage Disequilibrium, Noradrenergic, Parkinson's Disease.

Memberships

American Academy of Neurology
American Society of Human Genetics
Society for Neuroscience

Funding Received

  • Department of Veterans Affairs: Analysis of Nurr1 Variants in Familial and Sporadic Parkinson's Disease, 2005 to 2009.
  • Department of Veterans Affairs: Adrenergic Mechanisms and Treatment for PTSD and Secondary Drug Abuse, 2005 to 2010.
  • American Parkinson Disease Association: A Comprehensive Screen of the LRRK2 Gene in Familial Parkinson's Disease and Dementia with Lewy Bodies, 2005 to 2006.
  • Parkinson's Disease Foundation: Iron Regulatory Genes as Modifiers of Susceptibility and Age of Onset in Parkinson's Disease, 2004 to 2005.
  • Michael J. Fox Foundation for Parkinson's Research: Gene-environment Interaction in Parkinson's Disease, 2004 to 2006.
  • NIH K08 NS44138: DBH as a Modifying Gene in Neurodegenerative Diseases, 2002 to 2007.

Publications

  • Mata IF, Cosentino C, Marca V, Torres L, Mazzetti P, Ortega O, Raggio V, Aljanati R, Buzó R, Yearout D, Dieguez E, Zabetian CP (Jun 2009) LRRK2 mutations in patients with Parkinson's disease from Peru and Uruguay., Parkinsonism & related disorders, 15 (5), 370-3 Abstract
  • Zabetian CP, Yamamoto M, Lopez AN, Ujike H, Mata IF, Izumi Y, Kaji R, Maruyama H, Morino H, Oda M, Hutter CM, Edwards KL, Schellenberg GD, Tsuang DW, Yearout D, Larson EB, Kawakami H (Apr 2009) LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease., Movement disorders : official journal of the Movement Disorder Society Abstract
  • Hwang H, Zhang J, Chung KA, Leverenz JB, Zabetian CP, Peskind ER, Jankovic J, Su Z, Hancock AM, Pan C, Montine TJ, Pan S, Nutt J, Albin R, Gearing M, Beyer RP, Shi M (Apr 2009) Glycoproteomics in neurodegenerative diseases., Mass spectrometry reviews Abstract
  • Bar-Shira A, Hutter CM, Giladi N, Zabetian CP, Orr-Urtreger A (Mar 2009) Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries., Neurogenetics Abstract
  • Mata IF, Hutter CM, González-Fernández MC, de Pancorbo MM, Lezcano E, Huerta C, Blazquez M, Ribacoba R, Guisasola LM, Salvador C, Gómez-Esteban JC, Zarranz JJ, Infante J, Jankovic J, Deng H, Edwards KL, Alvarez V, Zabetian CP (Mar 2009) Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain., Neurogenetics Abstract
  • Stüve O, Korth C, Gabatto P, Cameron EM, Hu W, Eagar TN, Monson NL, Frohman EM, Racke MK, Zabetian CP, Oksenberg JR (Feb 2009) Genetic polymorphism at codon 129 of the prion protein gene is not associated with multiple sclerosis., Archives of neurology, 66 (2), 280-1 Abstract
  • Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ (Oct 2008) Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism., Parkinsonism & related disorders Abstract
  • Kay DM, Factor SA, Samii A, Higgins DS, Griffith A, Roberts JW, Leis BC, Nutt JG, Montimurro JS, Keefe RG, Atkins AJ, Yearout D, Zabetian CP, Payami H (Oct 2008) Genetic association between alpha-synuclein and idiopathic Parkinson's disease., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B (7), 1222-30 Abstract
  • Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW (Jul 2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study., Lancet neurology, 7 (7), 583-90 Abstract
  • Haugarvoll K, Rademakers R, Kachergus JM, Nuytemans K, Ross OA, Gibson JM, Tan EK, Gaig C, Tolosa E, Goldwurm S, Guidi M, Riboldazzi G, Brown L, Walter U, Benecke R, Berg D, Gasser T, Theuns J, Pals P, Cras P, De Deyn PP, Engelborghs S, Pickut B, Uitti RJ, Foroud T, Nichols WC, Hagenah J, Klein C, Samii A, Zabetian CP, Bonifati V, Van Broeckhoven C, Farrer MJ, Wszolek ZK (Apr 2008) Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease., Neurology, 70 (16 Pt 2), 1456-60 Abstract
  • McCulloch CC, Kay DM, Factor SA, Samii A, Nutt JG, Higgins DS, Griffith A, Roberts JW, Leis BC, Montimurro JS, Zabetian CP, Payami H (Apr 2008) Exploring gene-environment interactions in Parkinson's disease., Human genetics, 123 (3), 257-65 Abstract
  • Mata IF, Samii A, Schneer SH, Roberts JW, Griffith A, Leis BC, Schellenberg GD, Sidransky E, Bird TD, Leverenz JB, Tsuang D, Zabetian CP (Mar 2008) Glucocerebrosidase gene mutations: a risk factor for lewy body disorders., Archives of neurology, 65 (3), 379-82 Abstract
  • Pan S, Rush J, Peskind ER, Galasko D, Chung K, Quinn J, Jankovic J, Leverenz JB, Zabetian C, Pan C, Wang Y, Oh JH, Gao J, Zhang J, Montine T (Feb 2008) Application of Targeted Quantitative Proteomics Analysis in Human Cerebrospinal Fluid Using a Liquid Chromatography Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Tandem Mass Spectrometer (LC MALDI TOF/TOF) Platform., Journal of proteome research, 7 (2), 720-30 Abstract
  • Hutter CM, Samii A, Factor SA, Nutt JG, Higgins DS, Bird TD, Griffith A, Roberts JW, Leis BC, Montimurro JS, Kay DM, Edwards KL, Payami H, Zabetian CP (Feb 2008) Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease., European journal of neurology : the official journal of the European Federation of Neurological Societies, 15 (2), 134-9 Abstract
  • Powers KM, Kay DM, Factor SA, Zabetian CP, Higgins DS, Samii A, Nutt JG, Griffith A, Leis B, Roberts JW, Martinez ED, Montimurro JS, Checkoway H, Payami H (Jan 2008) Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk., Movement disorders : official journal of the Movement Disorder Society, 23 (1), 88-95 Abstract
  • Tang YL, Epstein MP, Anderson GM, Zabetian CP, Cubells JF (Aug 2007) Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans., European journal of human genetics : EJHG, 15 (8), 878-83 Abstract
  • Zabetian CP, Hutter CM, Factor SA, Nutt JG, Higgins DS, Griffith A, Roberts JW, Leis BC, Kay DM, Yearout D, Montimurro JS, Edwards KL, Samii A, Payami H (Aug 2007) Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease., Annals of neurology, 62 (2), 137-44 Abstract
  • Chun LS, Samii A, Hutter CM, Griffith A, Roberts JW, Leis BC, Mosley AD, Wander PL, Edwards KL, Payami H, Zabetian CP (Jul 2007) DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease., Annals of neurology, 62 (1), 99-101 Abstract
  • Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD (May 2007) A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology., Brain : a journal of neurology, 130 (Pt 5), 1360-74 Abstract
  • Kay DM, Moran D, Moses L, Poorkaj P, Zabetian CP, Nutt J, Factor SA, Yu CE, Montimurro JS, Keefe RG, Schellenberg GD, Payami H (Jan 2007) Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients., Annals of neurology, 61 (1), 47-54 Abstract
  • Tang Y, Buxbaum SG, Waldman I, Anderson GM, Zabetian CP, Köhnke MD, Cubells JF (Nov 2006) A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide pol, Biological psychiatry, 60 (10), 1034-8 Abstract
  • Elbaz A, Nelson LM, Payami H, Ioannidis JP, Fiske BK, Annesi G, Carmine Belin A, Factor SA, Ferrarese C, Hadjigeorgiou GM, Higgins DS, Kawakami H, Krüger R, Marder KS, Mayeux RP, Mellick GD, Nutt JG, Ritz B, Samii A, Tanner CM, Van Broeckhoven C, Van Den Eeden SK, Wirdefeldt K, Zabetian CP, Dehem M, Montimurro JS, Southwick A, Myers RM, Trikalinos TA (Nov 2006) Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study., Lancet neurology, 5 (11), 917-23 Abstract
  • Zabetian CP, Hutter CM, Yearout D, Lopez AN, Factor SA, Griffith A, Leis BC, Bird TD, Nutt JG, Higgins DS, Roberts JW, Kay DM, Edwards KL, Samii A, Payami H (Oct 2006) LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago., American journal of human genetics, 79 (4), 752-8 Abstract
  • Ishihara L, Warren L, Gibson R, Amouri R, Lesage S, Dürr A, Tazir M, Wszolek ZK, Uitti RJ, Nichols WC, Griffith A, Hattori N, Leppert D, Watts R, Zabetian CP, Foroud TM, Farrer MJ, Brice A, Middleton L, Hentati F (Sep 2006) Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations., Archives of neurology, 63 (9), 1250-4 Abstract
  • Zabetian CP, Morino H, Ujike H, Yamamoto M, Oda M, Maruyama H, Izumi Y, Kaji R, Griffith A, Leis BC, Roberts JW, Yearout D, Samii A, Kawakami H (Aug 2006) Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease., Neurology, 67 (4), 697-9 Abstract
  • Abdi F, Quinn JF, Jankovic J, McIntosh M, Leverenz JB, Peskind E, Nixon R, Nutt J, Chung K, Zabetian C, Samii A, Lin M, Hattan S, Pan C, Wang Y, Jin J, Zhu D, Li GJ, Liu Y, Waichunas D, Montine TJ, Zhang J (Aug 2006) Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders., Journal of Alzheimer's disease : JAD, 9 (3), 293-348 Abstract
  • Kay DM, Zabetian CP, Factor SA, Nutt JG, Samii A, Griffith A, Bird TD, Kramer P, Higgins DS, Payami H (Apr 2006) Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics., Movement disorders : official journal of the Movement Disorder Society, 21 (4), 519-23 Abstract
  • Zabetian CP, Lauricella CJ, Tsuang DW, Leverenz JB, Schellenberg GD, Payami H (Jan 2006) Analysis of the LRRK2 G2019S mutation in Alzheimer Disease., Archives of neurology, 63 (1), 156-7 Abstract
  • Kay DM, Bird TD, Zabetian CP, Factor SA, Samii A, Higgins DS, Nutt J, Roberts JW, Griffith A, Leis BC, Montimurro JS, Philpott S, Payami H (2006) Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease., Genetic testing, 10 (3), 221-7 Abstract
  • Tang Y, Anderson GM, Zabetian CP, Köhnke MD, Cubells JF (Nov 2005) Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 139 (1), 88-90 Abstract
  • Zabetian CP, Samii A, Mosley AD, Roberts JW, Leis BC, Yearout D, Raskind WH, Griffith A, A Clinic-based Study of the LRRK2 Gene in Parkinson Disease Yields New Mutations., Neurology, 65(5), 741-4, Sep 2005 Abstract
  • Kay DM, Kramer P, Higgins D, Zabetian CP, Payami H, Escaping Parkinson's Disease: a Neurologically Healthy Octogenarian With the LRRK2 G2019S Mutation., Movement Disorders : Official Journal of the Movement Disorder Society, 20(8), 1077-8, Aug 2005 Abstract
  • Olson VG, Zabetian CP, Bolanos CA, Edwards S, Barrot M, Eisch AJ, Hughes T, Self DW, Neve RL, Nestler EJ, Regulation of Drug Reward By CAMP Response Element-binding Protein: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area., The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 25(23), 5553-62, Jun 2005 Abstract
  • Cubells JF, Zabetian CP, Human Genetics of Plasma Dopamine Beta-hydroxylase Activity: Applications to Research in Psychiatry and Neurology., Psychopharmacology, 174(4), 463-76, Aug 2004 Abstract
  • Zabetian CP, Romero R, Robertson D, Sharma S, Padbury JF, Kuivaniemi H, Kim KS, Kim CH, Kohnke MD, Kranzler HR, Gelernter J, Cubells JF, A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T --> C in African- and European-Americans, American Journal of Medical Genetics, 123A(2), 190-2, December 2003 Abstract
  • Cho S, Kim CH, Cubells JF, Zabetian CP, Hwang DY, Kim JW, Cohen BM, Biaggioni I, Robertson D, Kim KS, Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy, American Journal of Medical Genetics, 120A(2), 234-6, July 2003 Abstract
  • Zabetian CP, Buxbaum SG, Elston RC, Kohnke MD, Anderson GM, Gelernter J, Cubells JF, The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity, American Journal of Human Genetics, 72(6), 1389-400, June 2003 Abstract
  • Kohnke MD, Zabetian CP, Anderson GM, Kolb W, Gaertner I, Buchkremer G, Vonthein R, Schick S, Lutz U, Kohnke AM, Cubells JF, A genotype-controlled analysis of plasma dopamine beta-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function, Biological Psychiatry, 52(12), 1151-8, December 2002 Abstract
  • Kim CH, Zabetian CP, Cubells JF, Cho S, Biaggioni I, Cohen BM, Robertson D, Kim KS, Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency, American Journal of Medical Genetics, 108(2), 140-7, March 2002 Abstract
  • Cubells JF, Price LH, Meyers BS, Anderson GM, Zabetian CP, Alexopoulos GS, Nelson JC, Sanacora G, Kirwin P, Carpenter L, Malison RT, Gelernter J, Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression, Biological Psychiatry, 51(5), 358-64, March 2002 Abstract
  • Zabetian CP, Anderson GM, Buxbaum SG, Elston RC, Ichinose H, Nagatsu T, Kim KS, Kim CH, Malison RT, Gelernter J, Cubells JF, A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus, American Journal of Human Genetics, 68(2), 515-22, February 2001 Abstract
  • Zabetian CP, Gelernter J, Cubells JF, Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence, American Journal of Medical Genetics, 96(5), 638-45, October 2000 Abstract

Profile Details

Last Updated: 5/25/2009

COS Expertise ID #1107262
Reference this profile directly: http://myprofile.cos.com/Zabetian