Dr. Ashkan Farhadi

(Reading, Writing, Speaking)

American College of Gastroenterology: Does Stress cause IBD exacerbation through Stress, $10,000, Dec 1, 2000 to Nov 30, 2001.
National Institutes of Health (NIH): Alcoholic Liver Disease, $1,500,000, 2001 to 2006.

• Ashkan farhadi, MD, MS FACG (2007) I Have IBS. Now What?!!!, Third Edition, IHaveIBS.com, Booksurg Publishing, ISBN=1-4196-7182-0
• Farhadi A, Fields JZ, Keshavarzian A. (2007) Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation., World J. Gastroenterology, 13 (22), 3027-30
• Farhadi A, Forsyth C, Banan A, Shaikh M, Engen P, Fields JZ, Keshavarzian A. (2007) Evidence for non-chemical, non-electrical intercellular signaling in intestinal epithelial cells, Bioelectrochemistry
• Ranjbaran Z, Keefer L, Stepanski E, Farhadi A, Keshavarzian A (2006) The impact of sleep disturbances in inflammatory bowel disease., J. Gastroenterology and Hepatology, In Press
• Haddish NB, Nyquist C, Haghighi K, Corvalan C, Campanella o, Rickus J, Farhadi A (2006) Biological variability and targeted delivery of therapeutics for Inflammatory Bowel Diseases: an in silico approach., INFLAMMATION & ALLERGY DRUG TARGETS
• Craven M, Chandler ML, Steiner J, Farhadi A, Welsh E, Pratschke K (2006) Monitoring the effect of Caprofen and Meloxicam on canine gastrointestinal absorptive capacity, J Veterinary Internal Medicine, In Press
• Farhadi A, Keshavarzian A, Shaikh M, banan A, Fields JZ (2007) Reduced immunostaining for c-kit receptors in mucosal mast cells in Inflammatory Bowel Diseases., J Gastroenterology and hepatology
• Farhadi a, Keshavarzian A, Holmes E, Fields JZ, Shaikh M, Banan A (2006) Commonly used sugar interfere with the testing of intestinal permeability, J Chromatography, 836, 63-68
• Ranjbaran Z, Keefer L, Stepenski E, Farhadi A, keshavarzian A (2006) The relevance of sleep to chronic inflammatory conditions., Inflammation Research, 56, 1-7
• Farhadi A, Banan A, Forsyth C, Keshavarzian A (2006) Protein oxidation, intestinal barrier and Alcoholic Liver Disease., Protein Oxidation and Disease. Recent Research Developments in Pathological Biochemistry, Dresden, Germany, Rossendorf Research Center (bookchapter)
• Farhadi A, Banan A, Forsyth C, Keshavarzian A (2006) Protein oxidation, intestinal barrier and Inflammatory Bowel Disease, Protein Oxidation and Disease. Recent Research Developments in Pathological Biochemistry, Dresden, Germany, Rossendorf Research Center (bookchapter)
• Farhadi A, Keshavarzian A, Van de Kar LD, Jakate S, Domm A, Zhang L, Shaikh M, Banan A, Fields JZ (Aug 2005) Heightened responses to stressors in patients with inflammatory bowel disease., The American Journal of Gastroenterology, 100 (8), 1796-804
• Banan A, Zhang LJ, Shaikh M, Fields JZ, Choudhary S, Forsyth CB, Farhadi A, Keshavarzian A, Theta Isoform of Protein Kinase C Alters Barrier Function in Intestinal Epithelium Through Modulation of Distinct Claudin Isotypes: a Novel Mechanism for Regulation of Permeability, The Journal of Pharmacology and Experimental Therapeutics, 313(3), 962-82, Jun 2005
• Banan A, Zhang LJ, Shaikh M, Fields JZ, Choudhary S, Forsyth CB, Farhadi A, Keshavarzian A (Jun 2005) theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability., The Journal of Pharmacology and Experimental Therapeutics, 313 (3), 962-82
• Banan A, Zhang LJ, Farhadi A, Fields JZ, Shaikh M, Forsyth CB, Choudhary S, Keshavarzian A, Critical Role of the Atypical {lambda} Isoform of Protein Kinase C (PKC-{lambda}) in Oxidant-induced Disruption of the Microtubule Cytoskeleton and Barrier Function of Intestinal Epithelium., The Journal of Pharmacology and Experimental Therapeutics, 312(2), 458-71, Feb 2005
• Banan A, Zhang LJ, Farhadi A, Fields JZ, Shaikh M, Forsyth CB, Choudhary S, Keshavarzian A (Feb 2005) Critical role of the atypical {lambda} isoform of protein kinase C (PKC-{lambda}) in oxidant-induced disruption of the microtubule cytoskeleton and barrier function of intestinal epithelium., The Journal of Pharmacology and Experimental Therapeutics, 312 (2), 458-71
• Hadish Berhan N, Nyguist C, Haghighi K, Corvalan C, Keshavarzian A, Farhadi A (2005) A multi-scale stochastic drug release model for colon targeted drug delivery systems., J Controled Release, 110, 314-322
• Farhadi A, Keshavarzian A, Ranjbaran Z, Fields JZ, Banan A (2005) Role of PKC isoforms in modulation of injury and repair of intestinal barrier function., J Pharmacol Exp Ther, 316, 1-7
• Banan A, Zhang LJ, Shaikh M, Fields JZ, Farhadi A, Keshavarzian A, Novel effect of NF-kappaB activation: carbonylation and nitration injury to cytoskeleton and disruption of monolayer barrier in intestinal epithelium, American Journal of Physiology. Cell Physiology, 287(4), C1139-51, Oct 2004
• Banan A, Zhang LJ, Shaikh M, Fields JZ, Farhadi A, Keshavarzian A, Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: a novel function for PKC-theta, American Journal of Physiology. Cell Physiology, 287(1), C218-34, Jul 2004
• Banan A, Zhang LJ, Shaikh M, Fields JZ, Farhadi A, Keshavarzian A, Inhibition of oxidant-induced nuclear factor-kappaB activation and inhibitory-kappaBalpha degradation and instability of F-actin cytoskeletal dynamics and barrier function by epidermal gro, The Journal of Pharmacology and Experimental Therapeutics, 309(1), 356-68, Apr 2004
• Banan A, Zhang LJ, Farhadi A, Fields JZ, Shaikh M, Keshavarzian A, PKC-beta1 Isoform Activation Is Required for EGF-induced NF-kappaB Inactivation and IkappaBalpha Stabilization and Protection of F-actin Assembly and Barrier Function in Enterocyte Monolayers, American Journal of Physiology. Cell Physiology, 286(3), C723-38, Mar 2004
• Banan A, Zhang LJ, Shaikh M, Fields JZ, Farhadi A, Keshavarzian A, Key role of PLC-gamma in EGF protection of epithelial barrier against iNOS upregulation and F-actin nitration and disassembly, American Journal of Physiology. Cell Physiology, 285(4), C977-93, October 2003
• Banan A, Fields JZ, Zhang LJ, Shaikh M, Farhadi A, Keshavarzian A, Zeta Isoform of Protein Kinase C Prevents Oxidant-induced Nuclear Factor-kappaB Activation and I-kappaBalpha Degradation: a Fundamental Mechanism for Epidermal Growth Factor Protection of the Microtubule Cytoskeleton and Intestinal Barr, The Journal of Pharmacology and Experimental Therapeutics, 307(1), 53-66, Oct 2003
• Banan A, Farhadi A, Fields JZ, Mutlu E, Zhang L, Keshavarzian A, Evidence That Nuclear Factor-kappa B Activation Is Critical In Oxidant-induced Disruption of the Microtubule Cytoskeleton and Barrier Integrity and That Its Inactivation Is Essential in Epidermal Growth Factor-mediated Protection of the, The Journal of Pharmacology and Experimental Therapeutics, 306(1), 13-28, Jul 2003
• Farhadi A, Mutlu E, Keshavarzian A, An Overview of future therapeutic options for IBD, Hospital Pharmacy Europe, 10(5), 1-5, June 2003
• Keshavarzian A, Banan A, Farhadi A, Komanduri S, Mutlu E, Zhang Y, Fields JZ, Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease, Gut, 52(5), 720-8, May 2003
• Farhadi A, Banan A, Fields J, Keshavarzian A, Intestinal barrier: an interface between health and disease, Journal of Gastroenterology and Hepatology, 18(5), 479-97, May 2003
• Banan A, Farhadi A, Fields JZ, Zhang LJ, Shaikh M, Keshavarzian A, The delta-isoform of protein kinase C causes inducible nitric-oxide synthase and nitric oxide up-regulation: key mechanism for oxidant-induced carbonylation, nitration, and disassembly of the microtub, Journal of Pharmacology and Experimental Therapeutics, 305(2), 482-94, May 2003
• Farhadi A, Banan A, Keshavarzian A, Role of Cytoskeletal Structure in Modulation of Intestinal Permeability, AIMJ, 6(1), 2003
• Farhadi A, Keshavarzian A, Holmes EW, Fields J, Zhang L, Banan A, Gas chromatographic method for detection of urinary sucralose: application to the assessment of intestinal permeability, Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences., 784(1), 145-54, January 2003
• Farhadi A, Banan A, Fields JZ, Keshavarzian A (2003) Alcohol and intestinal permeability. Implication for human toxicity, Reviews in Food and Nutrition Toxicity, London, UK, Taylor and Francis (bookchapter)
• Banan A, Zhang L, Fields JZ, Farhadi A, Talmage DA, Keshavarzian A, PKC-zeta prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity, American Journal of Physiology. Gastrointestinal and Liver Physiology, 283(4), G909-22, October 2002
• Banan A, Fields JZ, Farhadi A, Talmage DA, Zhang L, Keshavarzian A, Activation of delta-isoform of protein kinase C is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epithelia, Journal of Pharmacology and Experimental Therapeutics, 303(1), 17-28, October 2002
• Farhadi A, Keshavarzian A, Fitzpatrick LR, Mutlu E, Zhang Y, Banan A, Modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on neutrophil reactive oxygen species production in presence of a novel antioxidant, rebamipide, Digestive Diseases and Sciences, 47(6), 1342-8, June 2002
• Banan A, Fields JZ, Farhadi A, Talmage DA, Zhang L, Keshavarzian A, The beta 1 isoform of protein kinase C mediates the protective effects of epidermal growth factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis i, Journal of Pharmacology and Experimental Therapeutics, 301(3), 852-66, June 2002
• Mutlu EA, Farhadi A, Keshavarzian A, New developments in the treatment of inflammatory bowel disease, Expert Opinion on Investigational Drugs, 11(3), 365-85, March 2002
• Farhadi A, Fields J, Banan A, Keshavarzian A, Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus, and the latter's progression toward esophageal cancer?, The American Journal of Gastroenterology, 97(1), 22-6, January 2002
• Farhadi A, Fields J, Bozorgnia SH, Assessment of esophagogastroduodenoscopy tolerance: A prospective study of 300 cases, Diagnostic & Therapeutic Endoscopy, 7(3), 11, 2002
• Prendiville SS, Hagle T, Farhadi A, Brand M, Saclarides T, Keshavarzian A, Aggressive Use of Examination Under Anesthesia in Symptomatic Perianal CrohnÂ’s Disease Reduces the Infectious Perianal Complications of Remicade, The American Journal of Gastroenterology, 97(9), S268, 2002
• Farhadi A, Keshavarzian A, Holms E, Zhang L, Banan A, A novel gas chromatographic method for detection of urinary Sucralose: Application to the assessment of intestinal permeability, The American Journal of Gastroenterology, 97(9), S79, 2002
• Domm A, Farhadi A, Jakate S, Bakaites M, Banan A, Keshavarzian A., Intestinal Mast Cell Activation and Degranulation Following Physiological Stress in IBD; Electron Microscopy Study, The American Journal of Gastroenterology, 97(9), S255, 2002
• Banan A, Fields JZ, Farhadi A, Zhang L, Keshavarzian A, isoform of Protein Kinase C (PKC-zeta) is a novel modulator of intestinal barrier integrity and cytoskeletal assembly and key in cellular protection, Gastroenterology, 122(4), M1132, 2002
• Farhadi A, Keshavarzian A, Holms E, Zhang L, Banan A, A novel gas chromatographic method for detection of urinary Sucralose: Application to the assessment of intestinal permeability, The American Journal of Gastroenterology, 97(9), S79, 2002
• Aneziokoro AE, Zhang L, Banan A, Farhadi A, Cotler S, Jakate S, Keshavarzian A, Endotoxemia and increased TNF in alcoholic liver disease are essential factor for the initiating alcohol-induced liver disease, The American Journal of Gastroenterology, 97(9), S91, 2002
• Banan A, Farhadi A, Fields JZ, Zhang L, Keshavarzian A, Role of phospholipase C signaling in EGF Protection of intestinal barrier integrity & F-Actin Dynamic assembly: Requirement for Tyrosine phosphorylation & activation of the gama isoform of PLC, Gastroenterology, 122(4), T863, 2002
• Banan A, Fields JZ, Farhadi A, Zhang L, Keshavarzian A, EGF Protects intestinal barrier integrity by stabilizing microtubule assembly: role of PKC-zeta isoform signaling & iNOS down-regulation, Gastroenterology, 122(4), M1156, 2002
• Banan A, Fields JZ, Farhadi A, Zhang L, Keshavarzian A, PKC-delta could explain how oxidants disrupt the microtubule cytoskeleton and injure monolayers of intestinal epithelia, Gastroenterology, 122(4), 771, 2002
• Aneziokoro AE, Farhadi A, Bakaites M, Banan A, Zeidi S, Cotler S, Keshavarzian A, Susceptibility of the small and large bowel to leakiness is a factor in alcoholics with liver disease, Gastroenterology, 122(4), M1358, 2002
• Farhadi A, Jakate S, Zhang L, Bakaites M, Banan A, Keshavarzian A, Differing response of mucosal mast cells to stress in IBD and controls, The American Journal of Gastroenterology, 97(9), S253, 2002
• Banan A, Farhadi A, Fields JZ, Zhang L, Keshavarzian A, EGF Protects intestinal barrier integrity by stabilizing F-Actin Dynamics: role of PKC-beta 1 isoform signal activation and Ca homeostasis, Gastroenterology, 122(4), S833, 2002
• Farhadi A, Bruninga K, Fields J, Keshavarzian A, Irritable bowel syndrome: an update on therapeutic modalities, Expert Opinion on Investigational Drugs, 10(7), 1211-22, July 2001
• Farhadi A, Fields J, Assessment of esophagogastroduodenoscopy tolerance: A prospective study of 300 cases, Gastroenterology, 120(5), 1304, 2001
• Farhadi A, Keshavarzian A, Banan A, Zhang Y, Fitzpatrick LF, The modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on OPC antioxidant, The American Journal of Gastroenterology, 96(9), S290, 2001
• Kaplan M, Banan A, Mutlu E, Mallavarapu R, Zhang L, Farhadi A, Keshavarzian A, Protection by commonly used herbs against oxidant-induced cell injury in a human colonic cell line, The American Journal of Gastroenterology, 96(9), S296, 2001
• Farhadi A, Parhizgar A, Rahman S, Haghshenas M, Tuberculosis: The most common cause of fever of undetermined origin in Shiraz, Med J IR Iran, 2, 173, 1999
• Farhadi A, Haghshenas M, Pseudotumor cerebri as the major manifestation of SLE in a case of FUO, Med J IR Iran, 11, 259, 1997
• Farhadi A (1997) I have Peptic Ulcer, Sari, Iran, Shafagh
• Zali MR, Mohammad K, Farhadi A, Masjedi MR, Zargar A, Noroozi A, Epidemiology of hepatitis B in Islamic Republic of Iran, Eastern Mediterranean Health J, 2, 290, 1996
• Farhadi A (1996) I have Irritable Bowel Syndrom, Sari, Iran, Shafagh
• Omrani GH, Farhadi A, Parhizgar A, Ardehali S, Haghshenas M, Visceral Leishmaniasis as fever of undetermined origin, Med J IR Iran, 8, 97, 1994
• Farhadi A, Omrani GH, Parhizgar A, Haghshenas M, Bone marrow culture versus Widal test in the diagnosis of typhoid fever as a cause of fever of undetermined origin, Iran J Med SCI, 16, 132, 1991
• Ashkan farhadi, "I Have IBS... Now What" Monthy Bulletin, IHaveIBS.com, SanitizAir