Antonio Bedalov

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Fred Hutchinson Cancer Research Center
Clinical Research
Assistant MemberAppointed: 2004
University of Washington
School of Medicine
Medicine
Assistant ProfessorAppointed: 2004
Professional Headshot of Antonio Bedalov

Mailing Address

1100 Fairview Ave. N., Mailstop D2-190
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-4863
Fax: (206) 667-6519
abedalov@fhcrc.org

Qualifications

Ph.D., University of Zagreb, Medical Sciences, 1998.
M.D., University of Zagreb, 1989.

Keywords

COS Keywords:

Cancer or Carcinogenesis, Clinical Research Or Studies, Gerontology.

Additional Terms:

Aging, Cancer.

Memberships

American Board of Internal Medicine
American Board of Medical Oncology

Honors and Awards

1998, Mentored Clinical Scientist Development Award (KO8), National Heart Lung and Blood Institute, Fred Hutchinson Cancer Research Center
1992, American Heart Association Fellowship Award, American Heart Association (AHA), Fred Hutchinson Cancer Research Center

Previous Positions

1999-2004, Acting Instructor, University of Washington, School of Medicine, Medicine
1999-2004, Associate, Fred Hutchinson Cancer Research Center, Clinical Research
1997-1999, Senior Fellow, Fred Hutchinson Cancer Research Center, Clinical Research
1996-1997, Hematology/Oncology Fellow, Clinical Rotations, University of Washington, School of Medicine
1993-1996, Resident, The Texas A&M Health Science Center, Baylor College of Medicine, Internal Medicine
1990-1993, Postdoctoral Fellow, University of Connecticut, Health Center

Publications

  • Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O (Feb 2009) Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner., Nature medicine, 15 (2), 206-10 Abstract
  • Chevillet JR, Park GJ, Bedalov A, Simon JA, Vasioukhin VI (Oct 2008) Identification and characterization of small-molecule inhibitors of hepsin., Molecular cancer therapeutics, 7 (10), 3343-51 Abstract
  • Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Merrill RA, Lory S, Stagljar I (Feb 2008) Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen., PLoS genetics, 4 (2), e1000005 Abstract
  • Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A (Dec 2007) Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56., The Journal of biological chemistry, 282 (52), 37805-14 Abstract
  • Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L (Nov 2007) Genetic basis of proteome variation in yeast., Nature genetics, 39 (11), 1369-75 Abstract
  • Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME, Sandmaier BM, Witherspoon RP, Nash RA, Sanders JE, Bedalov A, Hansen JA, Clurman BE, Storb R, Appelbaum FR, Deeg HJ (Aug 2007) Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic d, Blood, 110 (4), 1379-87 Abstract
  • Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A (Apr 2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes., Cancer research, 66 (8), 4368-77 Abstract
  • Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A (Mar 2006) Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast., PLoS genetics, 2 (3), e35 Abstract
  • Foss E, Bedalov A (Mar 2006) Pharmacogenetics: yeast lead the way., Chemistry & biology, 13 (3), 236-8 Abstract
  • Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK (Apr 2005) Substrate-specific activation of sirtuins by resveratrol., The Journal of biological chemistry, 280 (17), 17038-45 Abstract
  • Bedalov A, Simon JA, Neuroscience. NAD to the rescue, Science, 305(5686), 954-5, August 2004 Abstract
  • Simon JA, Bedalov A, Yeast as a model system for anticancer drug discovery, Nature Reviews. Cancer, 4(6), 481-92, June 2004 Abstract
  • Posakony J, Hirao M, Stevens S, Simon JA, Bedalov A, Inhibitors of Sir2: evaluation of splitomicin analogues, Journal of Medicinal Chemistry, 47(10), 2635-44, May 2004 Abstract
  • Posakony J, Hirao M and A Bedalov, Identification and Chracterizaton of Sir2 Inhibitors Through Phenotypic Assays in Yeast, Comb Chem High Throughput Screen, 7, 661-668, 2004
  • Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A, Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast, Journal of Bioligical Chemistry, 278(52), 52773-82, 2003 Abstract
  • Bedalov A, Hirao M, Posakony J, Nelson M, Simon JA, NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae, Molecular and Cellular Biology, 23(19), 7044-54, 2003 Abstract
  • Bedalov A, Simon JA, Sir2 flexes its muscle, Developmental Cell, 5(2), 188-9, 2003 Abstract
  • Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA, Identification of a small molecule inhibitor of Sir2p, Proceedings of the National Academy of Sciences (USA), 98(26), 15113-8, December 2001 Abstract
  • Bedalov A, Salvatori R, Dodig M, Kapural B, Pavlin D, Kream BE, Clark SH, Woody CO, Rowe DW, Lichtler AC, 1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice, Biochimica Et Biophysica Acta, 1398(3), 285-93, July 1998 Abstract
  • Bedalov A, Balasubramanyam A, Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the acute treatment of preterm labor. A case report, Diabetes Care, 20(6), 922-4, June 1997 Abstract
  • Dodig M, Kronenberg MS, Bedalov A, Kream BE, Gronowicz G, Clark SH, Mack K, Liu YH, Maxon R, Pan ZZ, Upholt WB, Rowe DW, Lichtler AC, Identification of a TAAT-containing motif required for high level expression of the COL1A1 promoter in differentiated osteoblasts of transgenic mice, Journal of Biological Chemistry, 271(27), 16422-9, July 1996 Abstract
  • Bedalov A, Salvatori R, Dodig M, Kronenberg MS, Kapural B, Bogdanovic Z, Kream BE, Woody CO, Clark SH, Mack K, et al., Regulation of COL1A1 expression in type I collagen producing tissues: identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice, Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research., 10(10), 1443-51, October 1995 Abstract
  • Bedalov A, Differences in regulation of alpha 1(I) collagen promoter in vascular smooth muscle cells in transfection studies and transgenic mice, Biochemistry and Molecular Biology International, 37(1), 159-66, September 1995 Abstract
  • Thomas HF, Feldman JA, Bedalov A, Woody CO, Clark SH, Mack K, Lichtler AC, Identification of regulatory elements necessary for the expression of the COL1A1 promoter in murine odontoblasts, Connective Tissue Research, 33(1-3), 81-5, 1995 Abstract
  • Pavlin D, Bedalov A, Kronenberg MS, Kream BE, Rowe DW, Smith CL, Pike JW, Lichtler AC, Analysis of regulatory regions in the COL1A1 gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression in osteoblastic cells, Journal of Cellular Biochemistry, 56(4), 490-501, December 1994 Abstract
  • Bogdanovic Z, Bedalov A, Krebsbach PH, Pavlin D, Woody CO, Clark SH, Thomas HF, Rowe DW, Kream BE, Lichtler AC, Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice, Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research., 9(2), 285-92, February 1994 Abstract
  • Bedalov A, Breault DT, Sokolov BP, Lichtler AC, Bedalov I, Clark SH, Mack K, Khillan JS, Woody CO, Kream BE, et al., Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells, Journal of Biological Chemistry, 269(7), 4903-9, February 1994 Abstract
  • Pavlin D, Lichtler AC, Bedalov A, Kream BE, Harrison JR, Thomas HF, Gronowicz GA, Clark SH, Woody CO, Rowe DW, Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells, Journal of Cell Biology, 116(1), 227-36, January 1992 Abstract

Profile Details

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