Dr. Ajay K. Gopal

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University of Washington
School of Medicine
Medicine
Oncology
Associate ProfessorAppointed: 2007
Fred Hutchinson Cancer Research Center
Clinical Research Division
Clinical Research
Associate MemberAppointed: 2007
Professional Headshot of Ajay K. Gopal

Mailing Address

Seattle Cancer Care Alliance
825 Eastlake Ave. East
Rm. 6802
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 288-2035
Fax: (206) 288-1130
agopal@u.washington.edu

Qualifications

M.D., Emory University, Medicine, 1993.
B.S., Duke University, Zoology, 1989.

Keywords

COS Keywords:

Cancer or Carcinogenesis, Clinical Research or Studies, Hematology, Oncology, Zoology.

Additional Terms:

Biological Therapy, Lymphoid Malignancies, Medical Oncology.

Memberships

American Association for Cancer Research
American Society for Clinical Oncology
American Society of Hematology

Previous Positions

2003-2007, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division
2003-2007, Assistant Professor, University of Washington, School of Medicine, Medicine, Oncology
1997-2000, Fellow in Medical Oncology, University of Washington, School of Medicine, Medicine, Oncology
1993-1996, Resident in Internal Medicine, Duke University, Duke University Medical Center, Medicine

Publications

  • Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA, Qian X, James SE, Raubitschek A, Forman SJ, Gopal AK, Pagel JM, Lindgren CG, Greenberg PD, Riddell SR, Press OW (May 2008) Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells., Blood Abstract
  • Gopal AK, Press OW, Wilbur SM, Maloney DG, Pagel JM (May 2008) Rituximab blocks binding of radiolabeled anti-CD20 antibodies (Ab) but not radiolabeled anti-CD45-Ab., Blood Abstract
  • Rajendran JG, Gopal AK, Fisher DR, Durack LD, Gooley TA, Press OW (May 2008) Myeloablative 131I-tositumomab radioimmunotherapy in treating non-Hodgkin's lymphoma: comparison of dosimetry based on whole-body retention and dose to critical organ receiving the highest dose., Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49 (5), 837-44 Abstract
  • Nemecek ER, Green DJ, Fisher DR, Pagel JM, Lin Y, Gopal AK, Durack LD, Rajendran JG, Wilbur DS, Nilsson R, Sandberg B, Press OW (Apr 2008) Extracorporeal adsorption therapy: a method to improve targeted radiation delivered by radiometal-labeled monoclonal antibodies., Cancer biotherapy & radiopharmaceuticals, 23 (2), 181-91 Abstract
  • Zhang MM, Gopal AK (Apr 2008) Radioimmunotherapy-based conditioning regimens for stem cell transplantation., Seminars in hematology, 45 (2), 118-25 Abstract
  • Pham RN, Gooley TA, Keeney GE, Press OW, Pagel JM, Greisman HA, Bensinger WI, Holmberg LA, Petersdorf SH, Maloney DG, Gopal AK (Dec 2007) The impact of histologic grade on the outcome of high-dose therapy and autologous stem cell transplantation for follicular lymphoma., Bone marrow transplantation, 40 (11), 1039-44 Abstract
  • Pagel JM, Lionberger J, Gopal AK, Sabath DE, Loeb K (Dec 2007) Therapeutic use of Rituximab for sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)., American journal of hematology, 82 (12), 1121-2 Abstract
  • Pagel JM, Hedin N, Drouet L, Wood BL, Pantelias A, Lin Y, Hamlin DK, Wilbur DS, Gopal AK, Green D, Appelbaum FR, Press OW (Nov 2007) Eradication of disseminated leukemia in a syngeneic murine leukemia model using pretargeted anti-CD45 radioimmunotherapy. Abstract
  • Keeney GE, Gooley TA, Pham RN, Press OW, Pagel JM, Petersdorf SH, Maloney DG, Bensinger W, Holmberg L, Gopal AK (Oct 2007) The pretransplant Follicular Lymphoma International Prognostic Index is associated with survival of follicular lymphoma patients undergoing autologous hematopoietic stem cell transplantation., Leukemia & lymphoma, 48 (10), 1961-7 Abstract
  • Green DJ, Pagel JM, Pantelias A, Hedin N, Lin Y, Wilbur DS, Gopal A, Hamlin DK, Press OW (Sep 2007) Pretargeted radioimmunotherapy for B-cell lymphomas., Clinical cancer research : an official journal of the American Association for Cancer Research, 13 (18 Pt 2), 5598s-5603s Abstract
  • Pagel JM, Pantelias A, Hedin N, Wilbur S, Saganic L, Lin Y, Axworthy D, Hamlin DK, Wilbur DS, Gopal AK, Press OW (Jun 2007) Evaluation of CD20, CD22, and HLA-DR targeting for radioimmunotherapy of B-cell lymphomas., Cancer research, 67 (12), 5921-8 Abstract
  • Pantelias A, Pagel JM, Hedin N, Saganic L, Wilbur S, Hamlin DK, Wilbur DS, Lin Y, Stone D, Axworthy D, Gopal AK, Press OW (Jun 2007) Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas., Blood, 109 (11), 4980-7 Abstract
  • Ying SX, Seal S, Abbassi N, Hockenbery DM, Kiem HP, Li X, Pagel JM, Gopal AK, Deeg HJ (May 2007) Differential effects of bexarotene on intrinsic and extrinsic pathways in TRAIL-induced apoptosis in two myeloid leukemia cell lines., Leukemia & lymphoma, 48 (5), 1003-14 Abstract
  • Gopal AK, Rajendran JG, Gooley TA, Pagel JM, Fisher DR, Petersdorf SH, Maloney DG, Eary JF, Appelbaum FR, Press OW (Apr 2007) High-dose [131I]tositumomab (anti-CD20) radioimmunotherapy and autologous hematopoietic stem-cell transplantation for adults > or = 60 years old with relapsed or refractory B-cell lymphoma., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 25 (11), 1396-402 Abstract
  • Gopal AK, Pagel JM, Rajendran JG, Maloney DG, Appelbaum FR, Sorror ML, Sandmaier BM, Storb R, Press OW (Jul 2006) Improving the efficacy of reduced intensity allogeneic transplantation for lymphoma using radioimmunotherapy., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 (7), 697-702 Abstract
  • Pagel JM, Appelbaum FR, Eary JF, Rajendran J, Fisher DR, Gooley T, Ruffner K, Nemecek E, Sickle E, Durack L, Carreras J, Horowitz MM, Press OW, Gopal AK, Martin PJ, Bernstein ID, Matthews DC (Mar 2006) 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission., Blood, 107 (5), 2184-91 Abstract
  • Wallen H, Gooley TA, Deeg HJ, Pagel JM, Press OW, Appelbaum FR, Storb R, Gopal AK (May 2005) Ablative Allogeneic Hematopoietic Cell Transplantation in Adults 60 Years of Age and Older, Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 23 (15), 3439-46
  • Rajendran J, Gopal A, Durack L, Fisher D, Press O, Eary J, Comparison of Radiation Dose Estimation for Myeloablative Radioimmunotherapy for Relapsed Or Recurrent Mantle Cell Lymphoma Using (131)I Tositumomab to That of Other Types of Non-Hodgkin's Lymphoma, Cancer Biotherapy & Radiopharmaceuticals, 19(6), 738-45, Dec 2004
  • Rajendran JG, Fisher DR, Gopal AK, Durack LD, Press OW, Eary JF (Jun 2004) High-dose (131)I-tositumomab (anti-CD20) radioimmunotherapy for non-Hodgkin's lymphoma: adjusting radiation absorbed dose to actual organ volumes, Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 45 (6), 1059-64
  • Gopal AK, Pagel JM, Hedin N, Press OW, Fenretinide enhances rituximab-induced cytotoxicity against B-cell lymphoma xenografts through a caspase-dependent mechanism, Blood, 103(9), 3516-20, 2004
  • Gopal AK, Gooley TA, Maloney DG, Petersdorf SH, Eary JF, Rajendran JG, Bush SA, Durack LD, Golden J, Martin PJ, Matthews DC, Appelbaum FR, Bernstein ID, Press OW, High-dose radioimmunotherapy versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin lymphoma: a multivariable coho, Blood, 102(7), 2351-7, October 2003
  • Gopal AK, Rajendran JG, Petersdorf SH, Maloney DG, Eary JF, Wood BL, Gooley TA, Bush SA, Durack LD, Martin PJ, Matthews DC, Appelbaum FR, Bernstein ID, Press OW, High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma, Blood, 99(9), 3158-62, May 2002
  • Shan D, Gopal AK, Press OW (August 2001) Synergistic effects of the fenretinide (4-HPR) and anti-CD20 monoclonal antibodies on apoptosis induction of malignant human B cells, Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 7 (8), 2490-5
  • Gopal AK, Gooley TA, Golden JB, Maloney DG, Bensinger WI, Petersdorf SH, Appelbaum FR, Press OW, Efficacy of high-dose therapy and autologous hematopoietic stem cell transplantation for non-Hodgkin's lymphoma in adults 60 years of age and older, Bone Marrow Transplantation, 27(6), 593-9, March 2001
  • Press OW, Eary JF, Gooley T, Gopal AK, Liu S, Rajendran JG, Maloney DG, Petersdorf S, Bush SA, Durack LD, Martin PJ, Fisher DR, Wood B, Borrow JW, Porter B, Smith JP, Matthews DC, Appelbaum FR, Bernstein ID, A phase I/II trial of iodine-131-tositumomab (anti-CD20), etoposide, cyclophosphamide, and autologous stem cell transplantation for relapsed B-cell lymphomas, Blood, 96(9), 2934-42, November 2000
  • Gopal AK, Fowler VG Jr, Shah M, Gesty-Palmer D, Marr KA, McClelland RS, Kong LK, Gottlieb GS, Lanclos K, Li J, Sexton DJ, Corey GR (March 2000) Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy, Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 18 (5), 1110-5
  • Gottlieb GS, Fowler VG Jr, Kong LK, McClelland RS, Gopal AK, Marr KA, Li J, Sexton DJ, Glower D, Corey GR (Jan 2000) Staphylococcus aureus bacteremia in the surgical patient: a prospective analysis of 73 postoperative patients who developed Staphylococcus aureus bacteremia at a tertiary care facility, Journal of the American College of Surgeons, 190 (1), 50-7
  • Gopal AK, Whitehouse JD, Simel DL, Corey GR, Cranial computed tomography before lumbar puncture: a prospective clinical evaluation, Archives of Internal Medicine, 159(22), 2681-5, December 1999
  • Gopal AK, Press OW (November 1999) Clinical applications of anti-CD20 antibodies, Journal of Laboratory and Clinical Medicine, 134 (5), 445-50
  • Gopal AK, Schuetze SM, Maloney DG, Weiden PL, Large cell non-Hodgkin's lymphoma and Hodgkin's disease arising synchronously in a patient with chronic lymphocytic leukemia: importance of immunocytochemistry, Blood, 94(7), 2537, October 1999
  • Gopal AK, Thorning DR, Back AL, Fatal outcome due to cyclosporine neurotoxicity with associated pathological findings, Bone Marrow Transplantation, 23(2), 191-3, Jan 1999
  • Fowler VG Jr, Sanders LL, Sexton DJ, Kong L, Marr KA, Gopal AK, Gottlieb G, McClelland RS, Corey GR, Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 27(3), 478-86, September 1998
  • Fowler VG Jr, Li J, Corey GR, Boley J, Marr KA, Gopal AK, Kong LK, Gottlieb G, Donovan CL, Sexton DJ, Ryan T (October 1997) Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients, Journal of the American College of Cardiology, 30 (4), 1072-8
  • Gopal AK, Roe MT, Calcified cardiac lesion, Chest, 110(4), 1097-8, October 1996
  • Chalasani NP, Valdecanas MA, Gopal AK, McGowan JE Jr, Jurado RL, Clinical utility of blood cultures in adult patients with community-acquired pneumonia without defined underlying risks, Chest, 108(4), 932-6, October 1995
  • Gulati SC, Gopal R, Prowda JB, Spanik S, Jain M, Gopal A, Growth factors and hematopoietic recovery, Medical Oncology (northwood, London, England), 11(1), 1-6, 1994
  • Gulati S, Bennett C, Toia M, Gopal A, Gopal R, Role of granulocyte-macrophage colony stimulating factor (GM-CSF) after autologous bone marrow transplantation for Hodgkin's disease, Anti-cancer Drugs, 4 Suppl 1, 13-6, May 1993

Profile Details

Last Updated: 6/24/2008

COS Expertise ID #1124847
Reference this profile directly: http://myprofile.cos.com/agopal