Dr. Alison K. Bauer

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Michigan State University
College of Veterinary Medicine
Pathobiology and Diagnostic Investigation
Assistant ProfessorAppointed: 2006
Michigan State University
College of Veterinary Medicine
Centers for Integrative Toxicology
Assistant ProfessorAppointed: 2006

Mailing Address

B43 Food Safety and Toxicology Bldg.
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 884-2075
Fax: (517) 432-2310
akbauer@msu.edu

Qualifications

Ph.D., University of Colorado Health Sciences Center, Pharmacology, 2000.
B.S., Pennsylvania State University, Biochemistry, 1994.

Expertise and Research Interests

My research interests are in the role of the innate immune system in mouse and human pulmonary inflammation and tumorigenesis; the mechanisms of environmental lung carcinogenesis; chemoprevention of lung carcinogenesis; and the mechanisms downstream of TLR4 ozone-induced lung injury/inflammation.

Keywords

COS Keywords:

Environmental Toxicology, Toxicology.

Additional Terms:

Antioxidant, Carcinogenesis, Environmental, Inflammation, Innate Immune System, NRF2, Ozone, Pulmonary, TLR4.

Memberships

American Thoracic Society
Great Lakes Cancer Institute
Society of Toxicology

Previous Positions

2002-2006, Postdoctoral Fellow, National Institute for Environmental Health Sciences, Laboratory of Respiratory Biology
2000-2002, Postdoctoral Fellow, CIIT Centers for Health Research, Cancer Biology

Funding Received

  • National Institute for Environmental Health Sciences: National Institute of Environmental Health Sciences Transition to Independent Position K22 grant (2006): The role of toll-like receptor 4 in O3-induced lung inflammation and injury., $100,000 per yr for, 2006 to 2009.
  • National Institute for Environmental Health Sciences: The role of NQO1 in benzene-induced hematotoxicity., NRSA post-doctoral, 2001 to 2002.

Publications

  • Hye-Youn Cho, Daniel Morgan, Alison K Bauer, Steven R. Kleeberger (2007) Signal Transduction Pathways of Tumor Necrosis Factor-Mediated Lung Injury Induced by Ozone, Am. J. Resp. Crit. Care Med, 175 (8), 829-839
  • Alison. K. Bauer (2007) The role of inflammation in lung neoplasia, ACVP and ASCVP Conference, American College of Veterinary Pathologists, International Veterinary Information Service
  • Morten Dahl, Alison K Bauer, Mohamed Arredouani, Steve R. Kleeberger, Raija Soininen, Karl Trygvasson, Lester Kobzik (2007) Protection of the lung against inhaled oxidants through scavenging of oxidized lipids by macrophage class A scavenger receptors MARCO and SRAI/II., JCI, 117 (3), 757-764
  • Alison. K. Bauer et al. (2007) Genetic susceptibility to ozone-induced inflammation: Role of MHC Class II Genes, Am. J. Resp. Crit. Care Med, Submitted
  • Alison K. Bauer et al. (2005) A protective role for toll-like receptor (TLR)-4 in butylated hydroxytoluene (BHT)-induced mouse pulmonary inflammation and tumorigenesis., JNCI, 97, 1778-1781
  • Dwyer-Nield LD, Srebernak MC, Barrett BS, Ahn J, Cosper P, Meyer AM, Kisley LR, Bauer AK, Thompson DC, Malkinson AM (Jul 2005) Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines., Carcinogenesis, 26 (7), 1196-206 Abstract
  • Bauer AK, Malkinson AM, Kleeberger SR (Oct 2004) Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities., American Journal of Physiology. Lung Cellular and Molecular Physiology, 287 (4), L685-703 Abstract
  • Faiola B, Bauer AK, Fuller ES, Wong VA, Pluta LJ, Abernethy DJ, Mangum JB, Everitt JI, Recio L (Oct 2003) Variations in Prkdc and susceptibility to benzene-induced toxicity in mice., Toxicological Sciences : an Official Journal of the Society of Toxicology, 75 (2), 321-32 Abstract
  • Bauer AK, Faiola B, Abernethy DJ, Marchan R, Pluta LJ, Wong VA, Gonzalez FJ, Butterworth BE, Borghoff SJ, Everitt JI, Recio L (Apr 2003) Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity., Toxicological Sciences : an Official Journal of the Society of Toxicology, 72 (2), 201-9 Abstract
  • Bauer AK, Faiola B, Abernethy DJ, Marchan R, Pluta LJ, Wong VA, Roberts K, Jaiswal AK, Gonzalez FJ, Butterworth BE, Borghoff S, Parkinson H, Everitt J, Recio L (Mar 2003) Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1., Cancer Research, 63 (5), 929-35 Abstract
  • Kisley LR, Barrett BS, Bauer AK, Dwyer-Nield LD, Barthel B, Meyer AM, Thompson DC, Malkinson AM (Dec 2002) Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis., Cancer Research, 62 (23), 6850-6 Abstract
  • Kisley LR, Barrett BS, Dwyer-Nield LD, Bauer AK, Thompson DC, Malkinson AM (Oct 2002) Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice., Carcinogenesis, 23 (10), 1653-60 Abstract
  • Malkinson AM, Radcliffe RA, Bauer AK (Mar 2002) Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice., Carcinogenesis, 23 (3), 411-7 Abstract
  • Bauer AK, Dwyer-Nield LD, Hankin JA, Murphy RC, Malkinson AM (Dec 2001) The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice., Toxicology, 169 (1), 1-15 Abstract
  • Bauer AK, Dwyer-Nield LD, Keil K, Koski K, Malkinson AM (Apr-May 2001) Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion., Experimental Lung Research, 27 (3), 197-216 Abstract
  • Blaxall BC, Dwyer-Nield LD, Bauer AK, Bohlmeyer TJ, Malkinson AM, Port JD (Jun 2000) Differential expression and localization of the mRNA binding proteins, AU-rich element mRNA binding protein (AUF1) and Hu antigen R (HuR), in neoplastic lung tissue., Molecular Carcinogenesis, 28 (2), 76-83 Abstract
  • Bauer AK, Dwyer-Nield LD, Malkinson AM (Apr 2000) High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors., Carcinogenesis, 21 (4), 543-50 Abstract
  • Bauer AK, Dwyer-Nield LD, Malkinson AM (Apr 2000) High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors., Carcinogenesis, 21 (4), 543-50 Abstract
  • Girod CE, Shin DH, Geraci MW, Warren HB, Dobbs LG, Gao B, Rainer JS, Bauer AK, Ikegami M, Shannon JM, Miller YE (Jul 1999) Surfactant protein C promoter-driven expression of T1-alpha induces lung, Chest, 116 (1 Suppl), 61S Abstract
  • Thompson DC, Porter SE, Bauer AK, Das KC, Ou B, Dwyer-Nield L, White CW, Malkinson AM (Jun 1998) Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines., The American Journal of Physiology, 274 (6 Pt 1), L922-32 Abstract

Profile Details

Last Updated: 3/26/2008

COS Expertise ID #1241958
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