Dr. Amalia Meier Magaret

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University of Washington
School of Medicine
Laboratory Medicine
Virology
Research Assistant ProfessorAppointed: 2004
Fred Hutchinson Cancer Research Center
Biostatistics
Joint Assistant MemberAppointed: 2004

Mailing Address

Virology Research Clinic
600 Broadway, Suite 400
Seattle, Washington 98122
United States

Contact Information

Phone: (206) 520-4316
Fax: (206) 720-4371
amag@u.washington.edu

Qualifications

Ph.D., University of Washington, Biostatistics, 2001.
M.S., Western Michigan University, Applied Statistics, 1997.

Expertise and Research Interests

Dr. Magaret provides statistical support to clinical research on HSV1 and HSV2 and other herpesvirus infections: the natural history, immunology, risk factors for acquisition, treatments and vaccines. She also supports investigations regarding the clinical association between herpes and HIV.

Areas of statistical methods work include misclassification in time-to-event outcomes, laboratory assay validation, and methods for quantifying and examining risk factors for viral shedding.

Keywords

COS Keywords:

Biometry, Biostatistics, Clinical Research Or Studies, Herpes, HIV, Immunology, Survival Probability, Vaccine, Virology.

Additional Terms:

Diagnostic Methods, Herpes and HIV, Survival Analysis.

Memberships

American Statistical Association
International Biometric Society

Publications

  • Baeten JM, Strick LB, Lucchetti A, Whittington WL, Sanchez J, Coombs RW, Magaret A, Wald A, Corey L, Celum C (Dec 2008) Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial., The Journal of infectious diseases, 198 (12), 1804-8 Abstract
  • Nduba VN, Mwachari CW, Magaret AS, Park DR, Kigo A, Hooton TM, Cohen CR (Nov 2008) Placebo found equivalent to amoxicillin for treatment of acute bronchitis in Nairobi, Kenya: a triple blind, randomised, equivalence trial., Thorax, 63 (11), 999-1005 Abstract
  • Magaret AS (Nov 2008) Incorporating validation subsets into discrete proportional hazards models for mismeasured outcomes., Statistics in medicine, 27 (26), 5456-70 Abstract
  • Mark KE, Wald A, Magaret AS, Selke S, Olin L, Huang ML, Corey L (Oct 2008) Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults., The Journal of infectious diseases, 198 (8), 1141-9 Abstract
  • Gardella C, Goltra LB, Laschansky E, Drolette L, Magaret A, Chadwick HS, Eschenbach D (Sep 2008) High-concentration supplemental perioperative oxygen to reduce the incidence of postcesarean surgical site infection: a randomized controlled trial., Obstetrics and gynecology, 112 (3), 545-52 Abstract
  • Johnston C, Magaret A, Selke S, Remington M, Corey L, Wald A (Jul 2008) Herpes simplex virus viremia during primary genital infection., The Journal of infectious diseases, 198 (1), 31-4 Abstract
  • Koelle DM, Magaret A, McClurkan CL, Remington ML, Warren T, Teofilovici F, Wald A (May 2008) Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naīve and HSV-2-infected subjects., Clinical and vaccine immunology : CVI, 15 (5), 773-82 Abstract
  • Nguyen HQ, Magaret AS, Kitahata MM, Van Rompaey SE, Wald A, Casper C (May 2008) Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response., AIDS (London, England), 22 (8), 937-45 Abstract
  • Lingappa JR, Lambdin B, Bukusi EA, Ngure K, Kavuma L, Inambao M, Kanweka W, Allen S, Kiarie JN, Makhema J, Were E, Manongi R, Coetzee D, de Bruyn G, Delany-Moretlwe S, Magaret A, Mugo N, Mujugira A, Ndase P, Celum C (2008) Regional differences in prevalence of HIV-1 discordance in Africa and enrollment of HIV-1 discordant couples into an HIV-1 prevention trial., PLoS ONE, 3 (1), e1411 Abstract
  • Abu-Raddad LJ, Magaret AS, Celum C, Wald A, Longini IM, Self SG, Corey L (2008) Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa., PLoS ONE, 3 (5), e2230 Abstract
  • Gardella C, Barnes J, Magaret AS, Richards J, Drolette L, Wald A (Dec 2007) Prenatal herpes simplex virus serologic screening beliefs and practices among obstetricians., Obstetrics and gynecology, 110 (6), 1364-70 Abstract
  • Zuckerman RA, Lucchetti A, Whittington WL, Sanchez J, Coombs RW, Zuņiga R, Magaret AS, Wald A, Corey L, Celum C (Nov 2007) Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial., The Journal of infectious diseases, 196 (10), 1500-8 Abstract
  • Richards J, Scholes D, Caka S, Drolette L, Magaret AM, Yarbro P, Lafferty W, Crosby R, Diclemente R, Wald A (Sep 2007) HSV-2 serologic testing in an HMO population: uptake and psychosocial sequelae., Sexually transmitted diseases, 34 (9), 718-25 Abstract
  • Bochud PY, Magaret AS, Koelle DM, Aderem A, Wald A (Aug 2007) Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection., The Journal of infectious diseases, 196 (4), 505-9 Abstract
  • Rhoads MP, Magaret AS, Zerr DM (Jun 2007) Family saliva sharing behaviors and age of human herpesvirus-6B infection., The Journal of infection, 54 (6), 623-6 Abstract
  • Cohen CR, Nosek M, Meier A, Astete SG, Iverson-Cabral S, Mugo NR, Totten PA (May 2007) Mycoplasma genitalium infection and persistence in a cohort of female sex workers in Nairobi, Kenya., Sexually transmitted diseases, 34 (5), 274-9 Abstract
  • Magaret AS, Wald A, Huang ML, Selke S, Corey L (May 2007) Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa., Journal of clinical microbiology, 45 (5), 1618-20 Abstract
  • Mark KE, Corey L, Meng TC, Magaret AS, Huang ML, Selke S, Slade HB, Tyring SK, Warren T, Sacks SL, Leone P, Bergland VA, Wald A (May 2007) Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial., The Journal of infectious diseases, 195 (9), 1324-31 Abstract
  • Meier AS, Bukusi EA, Cohen CR, Holmes KK (Sep 2006) Independent association of hygiene, socioeconomic status, and circumcision with reduced risk of HIV infection among Kenyan men., Journal of acquired immune deficiency syndromes (1999), 43 (1), 117-8 Abstract
  • Casper C, Meier AS, Wald A, Morrow RA, Corey L, Moscicki AB (Sep 2006) Human herpesvirus 8 infection among adolescents in the REACH cohort., Archives of pediatrics & adolescent medicine, 160 (9), 937-42 Abstract
  • Kim HN, Meier A, Huang ML, Kuntz S, Selke S, Celum C, Corey L, Wald A (Aug 2006) Oral herpes simplex virus type 2 reactivation in HIV-positive and -negative men., The Journal of infectious diseases, 194 (4), 420-7 Abstract
  • Bukusi EA, Cohen CR, Meier AS, Waiyaki PG, Nguti R, Njeri JN, Holmes KK (Jun 2006) Bacterial vaginosis: risk factors among Kenyan women and their male partners., Sexually transmitted diseases, 33 (6), 361-7 Abstract
  • Hosken N, McGowan P, Meier A, Koelle DM, Sleath P, Wagener F, Elliott M, Grabstein K, Posavad C, Corey L (Jun 2006) Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes., Journal of virology, 80 (11), 5509-15 Abstract
  • Casper C, Carrell D, Miller KG, Judson FD, Meier AS, Pauk JS, Morrow RA, Corey L, Wald A, Celum C (Jun 2006) HIV serodiscordant sex partners and the prevalence of human herpesvirus 8 infection among HIV negative men who have sex with men: baseline data from the EXPLORE Study., Sexually transmitted infections, 82 (3), 229-35 Abstract
  • Mwachari CW, Nduba VN, Park DR, Meier AS, Kariuki JN, Muyodi JA, Karimi F, Kigo A, Holmes KK, Cohen CR (May 2006) Clinical presentation among HIV-infected and non-infected adults with community acquired pneumonia in Nairobi., The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 10 (5), 516-22 Abstract
  • Mugo NR, Kiehlbauch JA, Nguti R, Meier A, Gichuhi JW, Stamm WE, Cohen CR (Apr 2006) Effect of human immunodeficiency virus-1 infection on treatment outcome of acute salpingitis., Obstetrics and gynecology, 107 (4), 807-12 Abstract
  • Fredricks DN, Smith C, Meier A (Oct 2005) Comparison of six DNA extraction methods for recovery of fungal DNA as assessed by quantitative PCR, Journal of Clinical Microbiology, 43 (10), 5122-8
  • Cohen CR, Koochesfahani KM, Meier AS, Shen C, Karunakaran K, Ondondo B, Kinyari T, Mugo NR, Nguti R, Brunham RC (Aug 2005) Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma, The Journal of Infectious Diseases, 192 (4), 591-9
  • Meyer JL, Crosby RA, Whittington WL, Carrell D, Ashley-Morrow R, Meier AS, Harrington RD, DiClemente R, Wald A (Aug 2005) The psychosocial impact of serological herpes simplex type 2 testing in an urban HIV clinic, Sexually Transmitted Infections, 81 (4), 309-15
  • Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L (Feb 2005) A population-based study of primary human herpesvirus 6 infection, The New England Journal of Medicine, 352 (8), 768-76
  • Meier AS, Gilbert PB (2005) Accuracy and precision of estimating intervention efficacy when the timing of observed events differ by treatment arm, Contemporary Clinical Trials, 26, 598-610
  • Criniti A, Mwachari CW, Meier AS, Nduba V, Sanguli L, Ngumo JK, Cohen CR (Dec 2003) Association of hormonal contraception and HIV-seroprevalence in Nairobi, Kenya, Aids (london, England), 17 (18), 2667-9
  • Meier AS, Richardson BA, Hughes JP (Dec 2003) Discrete proportional hazards models for mismeasured outcomes, Biometrics, 59 (4), 947-54
  • Mwachari CW, Meier AS, Muyodi J, Gatei W, Waiyaki P, Cohen CR (Sep 2003) Chronic diarrhoea in HIV-1-infected adults in Nairobi, Kenya: evaluation of risk factors and the WHO treatment algorithm, Aids (london, England), 17 (14), 2124-6
  • Penner J, Meier AS, Mwachari C, Ayuka F, Muchina B, Odhiambo J, Cohen CR (Feb 2003) Risk factors for pneumonia in urban-dwelling HIV-infected women: a case-control study in Nairobi, Kenya, Journal of Acquired Immune Deficiency Syndromes (1999), 32 (2), 223-8
  • Mwachari CW, Cohen CR, Meier AS, Nganga LW, Kimari JN, Odhiambo JA (Aug 2001) Respiratory tract infection in HIV-1-infected adults in Nairobi, Kenya: evaluation of risk factors and the world health organization treatment algorithm, Journal of Acquired Immune Deficiency Syndromes (1999), 27 (4), 365-71
  • Van Kessel K, Reed S, Newton K, Meier A, Lentz G (Jun 2001) The second stage of labor and stress urinary incontinence, American Journal of Obstetrics and Gynecology, 184 (7), 1571-5
  • Eschenbach DA, Patton DL, Hooton TM, Meier AS, Stapleton A, Aura J, Agnew K (Mar 2001) Effects of vaginal intercourse with and without a condom on vaginal flora and vaginal epithelium, The Journal of Infectious Diseases, 183 (6), 913-8
  • Patton DL, Thwin SS, Meier A, Hooton TM, Stapleton AE, Eschenbach DA (Oct 2000) Epithelial cell layer thickness and immune cell populations in the normal human vagina at different stages of the menstrual cycle, American Journal of Obstetrics and Gynecology, 183 (4), 967-73
  • Eschenbach DA, Patton DL, Meier A, Thwin SS, Aura J, Stapleton A, Hooton TM (Sep 2000) Effects of oral contraceptive pill use on vaginal flora and vaginal epithelium, Contraception, 62 (3), 107-12
  • Miller L, Patton DL, Meier A, Thwin SS, Hooton TM, Eschenbach DA (Sep 2000) Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium, Obstetrics and Gynecology, 96 (3), 431-9
  • Eschenbach DA, Thwin SS, Patton DL, Hooton TM, Stapleton AE, Agnew K, Winter C, Meier A, Stamm WE (Jun 2000) Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 30 (6), 901-7

Profile Details

Last Updated: 1/8/2009

COS Expertise ID #1230777
Reference this profile directly: http://myprofile.cos.com/amag