Dr. Alexander K. Murashov

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East Carolina University
Brody School of Medicine
Physiology
Associate ProfessorAppointed: 2005
Professional Headshot of Alexander K. Murashov

Mailing Address

Brody Bldg. #6N-98
600 Moye Blvd.
Greenville, North Carolina 27834
United States

Contact Information

Phone: (252) 744-3111
Fax: (252) 744-3460
murashoval@ecu.edu
http://www.ecu.edu/physio/labakm/

Qualifications

Ph.D., P.K. Anokhin Institute of Physiology, Physiology, 1987.
M.D., N.I. Pirogov 2nd Moscow Medical Institute, Pediatrics, 1982.

Expertise and Research Interests

Stem Cells and Regeneration in the Nervous System

Regulation of Stem Cells Differentiation
Embryonic Stem (ES) Cells in Therapy of:
Spinal Cord Injury
Traumatic Brain Injury
Huntington's Disease

Neuroprotective and regenerative action of estrogens in neural disorders
Selective estrogen receptor modulators (SERMs) in treatment of:
Peripheral Nerve Injuries
Parkinson’s Disease

Other Expertise

Behavioral Neuroscience
Reproductive and Developmental Biology

Future Research

Cell Therapy

Industrial Relevance

siRNA delivery to the nervous system

Keywords

COS Keywords:

Animal Physiology or Morphology, Cell Biology, Human Physiology, Neuroscience, Physiology, Stem Cells.

Additional Terms:

Cell Biology, Neuroscience, Physiology, Regeneration, Stem Cells.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
Russian: (Fluent, Fluent, Fluent)

Memberships

American Physiological Society
New York Academy of Sciences
Sigma Xi, The Scientific Research Society
Society for Neuroscience

Previous Positions

1999-2005, Assistant Professor, East Carolina University, Brody School of Medicine, Physiology
1992-1999, Associate Research Scientist, Columbia University, Presbyterian Medical Center, Center for Reproductive Sciences

Publications

  • Olga Kokiko, Alexander Murashov, Michael R Hoane (2006) Administration of Raloxifene Reduces Sensorimotor and Working Memory Deficits Following Traumatic Brain Injury in the Rat, Behavioural Brain Research, In Press
  • Wesley A. Hendricks, Elena S. Pak, J. Paul Owensby, Kristie J. Menta, Margarita Glazova, Justin Moretto, Sarah Hollis, Kori L. Brewer, Alexander K. Murashov (2006) Pre-differentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice, Molecular Medicine, In Press
  • Glazova M,, Aho TL,, Palmetshofer A,, Murashov A, K., Scheinin M,, Koskinen PJ. (2005) Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells, Brain Res Mol Brain Res, 138 (2), 116-23
  • A. K. Murashov, E. S. Pak, W. A. Hendricks, J.P. Owensby, P. L. Sierpinski, L.M. Tatko, P.L. Fletcher (2005) Directed Differentiation of Embryonic Stem Cells into Dorsal Interneurons, The FASEB Journal, 19 (2), 252-4.
  • Murashov A.K., Pak E.S., Katwa L.C. (2005) Parallel Development of Cardiomyocytes and Neurons in Embryonic Stem Cell Culture, Biophysical Research Communications, 332 (3), 653-656
  • Murashov A.K., Islamov R.R., McMurray R.J., Pak E.S., Weidner D.A. (2004) Estrogen Increases Retrograde Labeling of Motoneurons: Evidence of a Non-Genomic Mechanism, AJP- Cell Physiology, 287 (2), C320-6
  • Hoane M.R., Becerra G.D., Shank J.E., Tatko L., Pak E.S.,, Smith M., Murashov A.K. (2004) Transplantation of Neuronal and Glial Precursors Dramatically Improves Sensorimotor Function but not Cognitive Function in the Traumatically Injured Brain., Journal of Neurotrauma, 21 (2), 163-174
  • Murashov A.K., Pak E.S., Hendricks W.A., Tatko L.M. (2004) 17b- Estradiol Enhances Neuronal Differentiation of Mouse Embryonic Stem Cells, FEBS Letters, 569 (1-3), 165-168.
  • Islamov R.R., Chintalgattu V., Pak E.S., Katwa L.C., Murashov A.K. (2004) Induction of VEGF and its Flt-1 Receptor after Sciatic Nerve Crush Injury, Neuroreport, 15 (13), 2117-2121
  • McMurray R, Islamov R, Murashov AK, Raloxifene analog LY117018 enhances the regeneration of sciatic nerve in ovariectomized female mice, Brain Research, 980(1), 140-5, August 2003 Abstract
  • Islamov RR, Hendricks WA, Katwa LC, McMurray RJ, Pak ES, Spanier NS, Murashov AK, Effect of 17 beta-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice, Brain Research, 966(1), 65-75, March 2003 Abstract
  • Smith M, Yuan Wang X, Wolgemuth DJ, Murashov AK, Development of the mouse vestibular system in the absence of gravity perception, Brain Research. Developmental Brain Research, 140(1), 133-5, January 2003 Abstract
  • Islamov R.R., Chintalgattu V., McMurray R.J, Pak E.S., Murashov A.K., Katwa L.C. (2003) Differential expression of endothelin receptors in regenerating spinal motor neurons in mice., Molecular Brain Research, 116 (1-2), 165-169
  • Islamov RR, Hendricks WA, Jones RJ, Lyall GJ, Spanier NS, Murashov AK, 17Beta-estradiol stimulates regeneration of sciatic nerve in female mice, Brain Research, 943(2), 283-6, July 2002 Abstract
  • Murashov AK, Ul Haq I, Hill C, Park E, Smith M, Wang X, Wang X, Goldberg DJ, Wolgemuth DJ, Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury, Brain Research. Molecular Brain Research, 93(2), 199-208, September 2001 Abstract
  • Murashov AK, Talebian S, Wolgemuth DJ, Role of heat shock protein Hsp25 in the response of the orofacial nuclei motor system to physiological stress, Brain Research. Molecular Brain Research, 63(1), 14-24, December 1998 Abstract
  • Murashov AK, Wolgemuth DJ, Sense and antisense transcripts of the developmentally regulated murine hsp70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain, Brain Research. Molecular Brain Research, 37(1-2), 85-95, April 1996 Abstract
  • Murashov AK, Wolgemuth DJ, Distinct transcripts are recognized by sense and antisense riboprobes for a member of the murine HSP70 gene family, HSP70.2, in various reproductive tissues, Molecular Reproduction and Development, 43(1), 17-24, January 1996 Abstract
  • Wolgemuth DJ, Murashov AK, Models and molecular approaches to assessing the effects of the microgravity environment on vertebrate development, Asgsb Bulletin : Publication of the American Society for Gravitational and Space Biology., 8(2), 63-72, October 1995 Abstract
  • Leah JD, Herdegen T, Murashov A, Dragunow M, Bravo R, Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system, Neuroscience, 57(1), 53-66, November 1993 Abstract
  • Leah JD, Sandkuhler J, Herdegen T, Murashov A, Zimmermann M, Potentiated expression of FOS protein in the rat spinal cord following bilateral noxious cutaneous stimulation, Neuroscience, 48(3), 525-32, 1992 Abstract

Profile Details

Last Updated: 5/5/2006

COS Expertise ID #351083
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