Dr. Alexander K. Murashov | |
East Carolina University Brody School of Medicine Physiology Associate ProfessorAppointed: 2005 |  |
QualificationsPh.D., P.K. Anokhin Institute of Physiology, Physiology, 1987. M.D., N.I. Pirogov 2nd Moscow Medical Institute, Pediatrics, 1982. Expertise and Research InterestsStem Cells and Regeneration in the Nervous System
Regulation of Stem Cells Differentiation Embryonic Stem (ES) Cells in Therapy of: Spinal Cord Injury Traumatic Brain Injury Huntington's Disease
Neuroprotective and regenerative action of estrogens in neural disorders Selective estrogen receptor modulators (SERMs) in treatment of: Peripheral Nerve Injuries Parkinson’s Disease Other ExpertiseBehavioral Neuroscience Reproductive and Developmental Biology
Industrial RelevancesiRNA delivery to the nervous system
KeywordsCOS Keywords:Animal Physiology or Morphology, Cell Biology, Human Physiology, Neuroscience, Physiology, Stem Cells.Additional Terms:Cell Biology, Neuroscience, Physiology, Regeneration, Stem Cells.Languages(Reading, Writing, Speaking)English: (Fluent, Fluent, Fluent) Russian: (Fluent, Fluent, Fluent) MembershipsAmerican Physiological Society New York Academy of Sciences Sigma Xi, The Scientific Research Society Society for Neuroscience Previous Positions1999-2005, Assistant Professor,
East Carolina University,
Brody School of Medicine,
Physiology
1992-1999, Associate Research Scientist,
Columbia University,
Presbyterian Medical Center,
Center for Reproductive Sciences
Publications- Wesley A. Hendricks, Elena S. Pak, J. Paul Owensby, Kristie J. Menta, Margarita Glazova, Justin Moretto, Sarah Hollis, Kori L. Brewer, Alexander K. Murashov (2006) Pre-differentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice, Molecular Medicine, In Press
- Olga Kokiko, Alexander Murashov, Michael R Hoane (2006) Administration of Raloxifene Reduces Sensorimotor and Working Memory Deficits Following Traumatic Brain Injury in the Rat, Behavioural Brain Research, In Press
- Glazova M,, Aho TL,, Palmetshofer A,, Murashov A, K., Scheinin M,, Koskinen PJ. (2005) Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells, Brain Res Mol Brain Res, 138 (2), 116-23
- A. K. Murashov, E. S. Pak, W. A. Hendricks, J.P. Owensby, P. L. Sierpinski, L.M. Tatko, P.L. Fletcher (2005) Directed Differentiation of Embryonic Stem Cells into Dorsal Interneurons, The FASEB Journal, 19 (2), 252-4.
- Murashov A.K., Pak E.S., Katwa L.C. (2005) Parallel Development of Cardiomyocytes and Neurons in Embryonic Stem Cell Culture, Biophysical Research Communications, 332 (3), 653-656
- Murashov A.K., Islamov R.R., McMurray R.J., Pak E.S., Weidner D.A. (2004) Estrogen Increases Retrograde Labeling of Motoneurons: Evidence of a Non-Genomic Mechanism, AJP- Cell Physiology, 287 (2), C320-6
- Islamov R.R., Chintalgattu V., Pak E.S., Katwa L.C., Murashov A.K. (2004) Induction of VEGF and its Flt-1 Receptor after Sciatic Nerve Crush Injury, Neuroreport, 15 (13), 2117-2121
- Murashov A.K., Pak E.S., Hendricks W.A., Tatko L.M. (2004) 17b- Estradiol Enhances Neuronal Differentiation of Mouse Embryonic Stem Cells, FEBS Letters, 569 (1-3), 165-168.
- Hoane M.R., Becerra G.D., Shank J.E., Tatko L., Pak E.S.,, Smith M., Murashov A.K. (2004) Transplantation of Neuronal and Glial Precursors Dramatically Improves Sensorimotor Function but not Cognitive Function in the Traumatically Injured Brain., Journal of Neurotrauma, 21 (2), 163-174
- McMurray R, Islamov R, Murashov AK, Raloxifene analog LY117018 enhances the regeneration of sciatic nerve in
ovariectomized female mice, Brain Research, 980(1), 140-5, August 2003
 - Islamov RR, Hendricks WA, Katwa LC, McMurray RJ, Pak ES, Spanier NS, Murashov AK, Effect of 17 beta-estradiol on gene expression in lumbar spinal cord
following sciatic nerve crush injury in ovariectomized
mice, Brain Research, 966(1), 65-75, March 2003
 - Smith M, Yuan Wang X, Wolgemuth DJ, Murashov AK, Development of the mouse vestibular system in the absence of gravity
perception, Brain Research. Developmental Brain Research, 140(1), 133-5, January 2003
 - Islamov R.R., Chintalgattu V., McMurray R.J, Pak E.S., Murashov A.K., Katwa L.C. (2003) Differential expression of endothelin receptors in regenerating spinal motor neurons in mice., Molecular Brain Research, 116 (1-2), 165-169
- Islamov RR, Hendricks WA, Jones RJ, Lyall GJ, Spanier NS, Murashov AK, 17Beta-estradiol stimulates regeneration of sciatic nerve in female mice, Brain Research, 943(2), 283-6, July 2002
 - Murashov AK, Ul Haq I, Hill C, Park E, Smith M, Wang X, Wang X, Goldberg DJ, Wolgemuth DJ, Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic
nerve injury, Brain Research. Molecular Brain Research, 93(2), 199-208, September 2001
 - Murashov AK, Talebian S, Wolgemuth DJ, Role of heat shock protein Hsp25 in the response of the orofacial nuclei
motor system to physiological stress, Brain Research. Molecular Brain Research, 63(1), 14-24, December 1998
 - Murashov AK, Wolgemuth DJ, Sense and antisense transcripts of the developmentally regulated murine
hsp70.2 gene are expressed in distinct and only partially overlapping
areas in the adult brain, Brain Research. Molecular Brain Research, 37(1-2), 85-95, April 1996
 - Murashov AK, Wolgemuth DJ, Distinct transcripts are recognized by sense and antisense riboprobes for
a member of the murine HSP70 gene family, HSP70.2, in various reproductive
tissues, Molecular Reproduction and Development, 43(1), 17-24, January 1996
 - Wolgemuth DJ, Murashov AK, Models and molecular approaches to assessing the effects of the
microgravity environment on vertebrate development, Asgsb Bulletin : Publication of the American Society for Gravitational and Space Biology., 8(2), 63-72, October 1995
 - Leah JD, Herdegen T, Murashov A, Dragunow M, Bravo R, Expression of immediate early gene proteins following axotomy and
inhibition of axonal transport in the rat central nervous
system, Neuroscience, 57(1), 53-66, November 1993
 - Leah JD, Sandkuhler J, Herdegen T, Murashov A, Zimmermann M, Potentiated expression of FOS protein in the rat spinal cord following
bilateral noxious cutaneous stimulation, Neuroscience, 48(3), 525-32, 1992

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