Dr. Andy J. Chien

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University of Washington
School of Medicine
Medicine
Dermatology
Assistant ProfessorAppointed: 2005

Mailing Address

Box 356524
Health Sciences Bldg.
University of Washington School of Medicine
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-5290
andchien@u.washington.edu

Qualifications

Board Certified, American Board of Medical Specialties, 2005.
Chief Resident, University of Washington, Dermatology, 2004.
Residency, University of Washington, Dermatology, 2001.
M.D., Northwestern University, Medicine, 1999.
Ph.D., Northwestern University, Molecular Pharmacology and Biochemistry, 1999.
Residency, University of Washington, Internal Medicine, 1999.
B.A. (with Honors), Johns Hopkins University, Biology, 1991.

Expertise and Research Interests

My current research interest is directed at translational therapies for metastatic melanoma, with an emphasis on cancer stem cells.

I also have a side interest in dermatologic diseases attributed to genes of unclear function. Examples of these types of diseases would be epidermodysplasia verruciformis and Birt-Hogge-Dube syndrome.

Other Expertise

80's music, foosball, Stratego, protein purification

Keywords

COS Keywords:

Cell Biology, Dermatology, Metastasis, Signal Transduction.

Additional Terms:

Cell Motility, Dermatology, Melanoma Metastasis, Signal Transduction, Wnt Signaling.

Memberships

American Academy of Dermatology
American Medical Association
American Society for Cell Biology
Seattle Dermatological Society
Society for Investigative Dermatology
University of Washington Institute of Stem Cell and Regenerative Medicine

Honors and Awards

2004-2005, Chief Resident, Division of Dermatology, University of Washington
2002-2004, Medical Center Basketball Champions, University of Washington
1996-1997, Intramural Basketball Champions for Under Six Foot League, Office of Intramural Athletics, Northwestern University
1991-1999, Medical Scientist Training Program, National Institutes of Health (NIH), Northwestern University
1991-1991, William McElroy Award, Department of Biology, Johns Hopkins University

Funding Received

  • National Institutes of Health (NIH): K08 Mentored Career Development Award, 2007 to 2011.
  • American Skin Association: Research Scholar Award, 2006 to 2007.
  • Dermatology Foundation: Physician Scientist Career Development Award, 2006 to 2009.
  • Dermatology Foundation: Investigator Research Fellowship, 2005 to 2006.
  • National Institutes of Health (NIH): NRSA Pre-doctoral Fellowship, 1995 to 1998.
  • Howard Hughes Research Institute: Undergraduate Research Fellowship, 1990 to 1990.

Publications

  • Chien AJ, Conrad WH, Moon RT (Jan 2009) A Wnt Survival Guide: From Flies to Human Disease., The Journal of investigative dermatology Abstract
  • Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT (Jan 2009) Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model., Proceedings of the National Academy of Sciences of the United States of America, 106 (4), 1193-8 Abstract
  • Shah KV, Chien AJ, Yee C, Moon RT (Dec 2008) CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors., The Journal of investigative dermatology, 128 (12), 2870-9 Abstract
  • Stetsenko GY, McFarlane RJ, Chien AJ, Fleckman P, Swanson P, George E, Argenyi ZB (Dec 2008) Subungual Bowen disease in a patient with epidermodysplasia verruciformis presenting clinically as longitudinal melanonychia., The American Journal of dermatopathology, 30 (6), 582-5 Abstract
  • Chien AJ, Kalus AA (2008) The legend of recurrent zoster, and other tales of varicella zoster virus, US Infectious Disease, 4 (1), 36-8
  • O'Connor KM, Chien AJ (Feb 2008) Management of melanocytic lesions in the primary care setting., Mayo Clinic proceedings. Mayo Clinic, 83 (2), 208-14 Abstract
  • Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, Chung N, Ferrer M, Yi X, Stoick-Cooper CL, von Haller PD, Kategaya L, Chien A, Angers S, MacCoss M, Cleary MA, Arthur WT, Moon RT (2008) New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening., Science signaling, 1 (45), ra12 Abstract
  • Chien AJ, Moon RT (2007) WNTS and WNT receptors as therapeutic tools and targets in human disease processes., Frontiers in bioscience : a journal and virtual library, 12, 448-57 Abstract
  • Chien AJ, Olerud JE (2007) Why do so many clinicians believe that recurrent zoster is common?, Dermatology online journal, 13 (2), 2 Abstract
  • Horner KL, Chien AJ, Edenholm M, Hornung RL (2007) Winnie the Pooh and psoriasis too: an isomorphic response of guttate psoriasis in a tattoo., Pediatric dermatology, 24 (5), E70-2 Abstract
  • Kalus AA, Chien AJ, Olerud JE (2007) Dermatologic Manifestations of Endocrine Disease, Fitzpatrick's Dermatology in General Medicine, 7th Edition, McGraw-Hill Professional, ISBN=0071466908 (bookchapter)
  • Simon S, Kalina RE, Chien AJ (Sep 2006) Pigmented lesions of the iris: common in patients, uncommon in dermatology textbooks., Archives of dermatology, 142 (9), 1243-4 Abstract
  • Chien AJ, Asgari M, Argenyi ZB (Jun 2006) Eccrine angiomatous hamartoma with elements of an arterio-venous malformation: a newly recognized variant., Journal of cutaneous pathology, 33 (6), 433-6 Abstract
  • Chien AJ, Valentine MC, Sybert VP (Feb 2006) Hereditary woolly hair and keratosis pilaris., Journal of the American Academy of Dermatology, 54 (2 Suppl), S35-9 Abstract
  • Chien AJ, Argenyi ZB, Colven RM, Kirby P (Nov 2004) Acute lymphoblastic leukemia presenting with urticarial plaques and hypereosinophilia in a child., Journal of the American Academy of Dermatology, 51 (5 Suppl), S151-5 Abstract
  • Chien AJ, Presland RB, Kuechle MK (Aug 2002) Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation., Biochemical and biophysical research communications, 296 (4), 911-7 Abstract
  • Gerhardstein BL, Puri TS, Chien AJ, Hosey MM (Aug 1999) Identification of the sites phosphorylated by cyclic AMP-dependent protein kinase on the beta 2 subunit of L-type voltage-dependent calcium channels., Biochemistry, 38 (32), 10361-70 Abstract
  • Gao T, Chien AJ, Hosey MM (Jan 1999) Complexes of the alpha1C and beta subunits generate the necessary signal for membrane targeting of class C L-type calcium channels., The Journal of biological chemistry, 274 (4), 2137-44 Abstract
  • Chien AJ, Gao T, Perez-Reyes E, Hosey MM (Sep 1998) Membrane targeting of L-type calcium channels. Role of palmitoylation in the subcellular localization of the beta2a subunit., The Journal of biological chemistry, 273 (36), 23590-7 Abstract
  • Chien AJ, Hosey MM (Aug 1998) Post-translational modifications of beta subunits of voltage-dependent calcium channels., Journal of bioenergetics and biomembranes, 30 (4), 377-86 Abstract
  • Meyers MB, Puri TS, Chien AJ, Gao T, Hsu PH, Hosey MM, Fishman GI (Jul 1998) Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels., The Journal of biological chemistry, 273 (30), 18930-5 Abstract
  • Gao T, Puri TS, Gerhardstein BL, Chien AJ, Green RD, Hosey MM (Aug 1997) Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes., The Journal of biological chemistry, 272 (31), 19401-7 Abstract
  • Chien AJ, Carr KM, Shirokov RE, Rios E, Hosey MM (Oct 1996) Identification of palmitoylation sites within the L-type calcium channel beta2a subunit and effects on channel function., The Journal of biological chemistry, 271 (43), 26465-8 Abstract
  • Hosey MM, Chien AJ, Puri TS (1996) Structure and Regulation of L-type Calcium Channels, Trends in Cardiovascular Medicine, 6, 265-273
  • Chien AJ, Zhao X, Shirokov RE, Puri TS, Chang CF, Sun D, Rios E, Hosey MM (Dec 1995) Roles of a membrane-localized beta subunit in the formation and targeting of functional L-type Ca2+ channels., The Journal of biological chemistry, 270 (50), 30036-44 Abstract
  • Hoover KK, Chien AJ, Corces VG (Oct 1993) Effects of transposable elements on the expression of the forked gene of Drosophila melanogaster., Genetics, 135 (2), 507-26 Abstract
  • Hoover KK, Gerasimova TI, Chien AJ, Corces VG (Nov 1992) Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster., Genetics, 132 (3), 691-7 Abstract
  • Geyer PK, Chien AJ, Corces VG, Green MM (Aug 1991) Mutations in the su(s) gene affect RNA processing in Drosophila melanogaster., Proceedings of the National Academy of Sciences of the United States of America, 88 (16), 7116-20 Abstract

Profile Details

Last Updated: 2/18/2009

COS Expertise ID #1204530
Reference this profile directly: http://myprofile.cos.com/andchien