Dr. Michael P. Andre

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University of California, San Diego
School of Medicine
Radiology
Physics & Engineering
Division ChiefAppointed: 1992
Moores UCSD Cancer Center
Medicine
Translational Sciences
Imaging Services
MemberAppointed: 2006
San Diego Veterans Medical Research Foundation
Research ScientistAppointed: 1999
San Diego Veterans Affairs Healthcare System
Radiology Service
Chief PhysicistAppointed: 1981
University of California, San Diego
School of Medicine
Radiology
Physics & Engineering
ProfessorAppointed: 1981
Professional Headshot of Michael P. Andre

Mailing Address

University of California, San Diego
SD VA Healthcare System (114)
3350 La Jolla Village Drive
San Diego, California 92161
United States

Contact Information

Phone: (858) 552-8585, ext. 7792
Fax: (858) 642-6280
mandre@ucsd.edu

Qualifications

Professional Certification, American Board of Radiology, Diagnostic Radiologic Physics, 1999.
Ph.D., University of California, Los Angeles, Medical Physics, 1980.
M.Sc., University of California, Los Angeles, Medical Physics, 1975.

Expertise and Research Interests

Research activities focus on novel imaging techniques for breast cancer detection and diagnosis, and on methods to enhance tissue differences on ultrasound using contrast agents. We are currently interested in three different approaches to breast cancer imaging: ultrasound computed tomography, digital x-ray mammography and ultrasound computer-aided diagnosis. We developed a diffraction tomography system using large-scale (20 cm diameter) toroidal arrays of 512 and 1024 transducer elements that measure the entire scatter field around the breast. Research is focused on development of reconstruction algorithms and quantitative maps of breast tissue properties. Our work in ultrasound contrast agents includes the development of materials and measurement techniques to enhance sensitivity to blood flow, to target breast cancer and to detect perfusion abnormalities. We are involved in design and development of a number of special solid state sensors for direct high-resolution x-ray imaging for mammography, general radiography and fluoroscopy. We produced the first full-field (18x24 cm) digital x-ray mammograms which have resolution of 60 microns. This effort includes work on image quality requirements, x-ray beam filtering and optimization, breast dosimetry, and image display. Acoustical holography is a technique involving production of acoustic interference patterns using transmission ultrasound and reconstructing a real-time image using optical processing. It provides dynamic transmission images with very large fields of view that may be useful for biopsy guidance, tumor ablation and musculoskeletal imaging.

Other Expertise

Editor, Acoustical Imaging 28
Guest Editor, International Journal of Imaging Systems & Technology
Scientific Consultant, Swedish Research Council for Engineering Sciences
Review Panel Chair, U.S. Army Breast Cancer Research Program
Review Panel Chair, National Institutes of Health, National Cancer Institute
Review Panel, U.S. Army Prostate Cancer Research Program
Consultant, Singapore National Academy of Sciences
Review Panel, Susan Komen Breast Cancer Foundation
Scientific Advisory Board, International Symposium on Acoustical Imaging
Consultant, Karmanos Cancer Foundation

Future Research

Automated scoring of breast ultrasound level of suspicion

Industrial Relevance

Scientific Advisory Board, Oldelft Corporation, Netherlands
Scientific Advisory Board, Techniscan Medical Systems, Salt Lake City, Utah
Scientific Advisory Board, Advanced Diagnostic Imaging, Richland WA
Scientific Advisory Board, Radco Corporation, San Diego CA
Chief Medical Officer, Almen Laboratories, Inc., Vista CA

Keywords

COS Keywords:

Applied Ultrasonics, Breast Cancer, Computed Tomography, Holography, Medical Diagnosis, Medical Or Diagnostic Imaging, Medical Physics, Ultrasonic Technology, Ultrasonography.

Additional Terms:

Breast Imaging, Computer Aided Diagnosis, Digital Radiography, Digital X-ray Sensors, Holography, Image Analysis, Inverse Scattering, Medical Physics, Ultrasound, Ultrasound Contrast Agents, ultrasound computed tomography.

Memberships

Acoustical Society of America
American Association of Physicists in Medicine
American College of Radiology
American Institute of Ultrasound in Medicine
Society of Photo-Optical Instrumentation Engineers

Previous Positions

1979-1984, Senior Radiation Physicist, Cedars-Sinai Medical Center, Los Angeles, Radiology
1977-1981, Medical Physicist, University of California, Los Angeles, Olive View Medical Center, Radiological Sciences
1977-1981, Radiation Safety Officer, University of California, Los Angeles, Olive View Medical Center, Radiological Sciences
1973-1974, Member of Technical Staff, Hughes Aircraft Company, Systems Engineering

Funding Received

  • US Army Breast Cancer Research Program: Evaluation of Optical Sonography for Real-Time Breast Imaging and Biopsy Guidance, $284,386, Jul 19, 1999 to Jul 18, 2002.
  • NCI SBIR Fast Track: Clinical Feasibility Study: Inverse Scatter Breast Scan, $1.5M, 2007 to 2010.
  • NCI SBIR Fast Track: Computer-Aided Tool for Diagnostic Breast Ultrasound, $998,000, 2006 to 2009.
  • National Institutes of Health (NIH): Computer-Aided Tool For Diagnostic Breast Ultrasound, $99,995, 2004 to 2005.
  • Gustavus and Louise Pfeiffer Research Foundation: Improving the Accuracy of Diagnostic Breast Ultrasound, $225,000, 2002 to 2004.

Publications

  • Galperin M (2008) Reproducibility of image analysis for breast ultrasound computer-aided diagnosis, Acoustical Imaging, 29, In Press
  • Andre MP (2008) Pre-clinical experience with full-wave inverse-scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging, 29, In Press
  • MP Andre (2007) Optimization of a breast mass classifier for computer-aided ultrasound analysis, Acoustical Imaging, 28, 341-348
  • MP Andre (2007) Diagnostic performance of a computer-aided image analysis system for breast ultrasound, Acoustical Imaging, 28, 267-277
  • Michael P. Andre (2007) Acoustical Imaging, Vol. 28, Dordrecht, The Netherlands, Springer, 477 pages, ISBN=1-4020-5720-2
  • Andre MP (2003) ROC analysis of lesion descriptors in breast ultrasound images, SPIE Medical Imaging, SPIE, 453-461 pages
  • Garlick TF (2002) Useful metrics for evaluation of diffractive energy imaging, Acoustical Imaging, 26, 281-288
  • Andre MP (2002) Improving the accuracy of diagnostic breast ultrasound, Acoustical Imaging, 26, 453-460
  • Theodorou DJ, Theodorou SJ, André MP, Kubota D, Weigert JM, Sartoris DJ, Quantitative computed tomography of the spine: Comparison of three-dimensional to two-dimensional imaging approach in clinical practice, Journal of Clinical Densitometry, 4(1), 57-62, 2001
  • Andre MP, Galperin M, Olson LK, Payrovi S, Richman K, Blickenstaff DE, Preliminary investigation of a method to assess breast ultrasound level of suspicion, SPIE Medical Imaging, 4322(In Press), 2001
  • Rose SC, Andre MP, Roberts AD, Kinney TB, et al, Integral role of interventional radiology in the development of a pediatric liver transplantation program, Journal of Pediatric Transplantation, 2001
  • C Sexton, L Olson, M Andre, A Olson, S Horton, S Lin, L Sverdrup, Preliminary clinical evaluation of a digital diagnostic imaging system using a-Se on CMOS, Digital Mammography Workshop, 2000
  • Lehman CD, André MP, Fecht BA, Johansen JM, Shelby RL, Through transmission US applied to breast imaging, Academic Radiology, 7(2), 100-107, 2000
  • MP Andre, CD Lehman, V Neely, BA Fecht, JO Shelby, T Nguyen, Recent experience with acoustical holography for breast imaging, Acoustical Imaging, 25, 309-316, 2000
  • André MP, Janée HS, Otto GP, Martin PJ, Ysrael MZ, Diffraction tomography breast imaging system: Patient image reconstruction and analysis, Acoustical Imaging, 24, 325-334, 2000
  • Liu CC, Theodorou DJ, Theodorou SJ, André MP, Sartoris DJ, Szollar SM, Martin EM, Deftos LJ, Quantitative Computed tomography in the evaluation of spinal osteoporosis following spinal cord injury, Osteoporosis International, 11(10), 889-96, 2000
  • André MP, Janée HS, Olson LK, Lehman CD, Fecht BA, Novel breast imaging techniques using transmitted ultrasound, Journal of the Acoustical Society of America, 106(4), 2134, October 1999
  • Lehman CD, André MP, Fecht BA, Johansen JM, Shelby RL, Shelby JO, Evaluation of real-time acoustical holography for breast imaging and biopsy guidance, SPIE Medical Imaging, 3659, 236-243, 1999
  • Fecht BA, André MP, Garlick GF, Shelby RL, Shelby JO, Lehman CD, Investigation of an acoustical holography system for real-time imaging, SPIE Medical Imaging, 3336, 106-112, 1998
  • André MP, Spivey B, Martin P, Morsell L, Atlas E, Pellegrino T, An integrated CMOS-selenium x-ray detector for digital mammography, SPIE Medical Imaging, 3336, 204-209, 1998
  • André MP, Janee HS, Martin PJ, Otto GP, Spivey BA, Palmer DA, High-speed data acquisition in a diffraction tomography system employing large-scale toroidal arrays, International Journal of Imaging Systems and Technology, 8(1), 137-147, 1997
  • André MP, Janee HS, Barrett TK, Spivey BA, Martin PJ, Simultaneous spatial and velocity vector mapping with diffraction tomography, Acoustical Imaging, 23, 583-588, 1997
  • André MP, Spivey BA, Optimization of tungsten x-ray spectra for digital mammography: Comparison of model to experiment, SPIE Medical Imaging, 3032, 411-418, 1997
  • André MP, Janée HS, Ysrael MZ, Olson LK, Leopold GR, Hodler J, Schulz RA, Three-dimensional holographic display of ultrasound computed tomograms, SPIE Medical Imaging, 3031, 314-320, 1997
  • Janée HS, Jones JP, André MP, Analysis of scatter fields in diffraction tomography experiments, Acoustical Imaging, 22, 21-26, 1996
  • André MP, Janée HS, Otto GP, Martin PJ, Reduction of phase aberration in a diffraction tomography system for breast imaging, Acoustical Imaging, 22, 151-157, 1996
  • André MP, Martin PJ, Otto GP, Olson LK, Barrett TK, Spivey BA, A new consideration of diffraction computed tomography for breast, Acoustical Imaging, 21, 379-390, 1995
  • André MP, Mammography tomorrow: Approaches to future breast imaging technology, Mammography Today, 1(3), 18-22, 1994
  • Martin PJ, André MP, Spivey BA, Palmer DA, Hackelöer BJ, Madjar H, Taubner J, Sonic computed tomography for breast imaging, Breast Ultrasound Update, 52-58, 1994
  • André MP, Steinbach GC, Mattrey RF, Enhancement of the echogenicity of flowing blood by perflubron contrast agent, Investigative Radiology, 28(6), 478-484, 1993
  • André MP, Nelson TR, Mattrey RF, Physical and acoustical properties of perfluorooctylbromide, an ultrasound contrast agent, Investigative Radiology, 25(9), 983-987, 1990

Profile Details

Last Updated: 11/4/2008

COS Expertise ID #137527
Reference this profile directly: http://myprofile.cos.com/andre27