Dr. Martin S. Angst

(Reading, Writing, Speaking)

Foundation for Anesthesia Education and Research: Differential rate for development of acute tolerance to opioid induced analgesia, respiratory depression, and sedation, Jul 2002 to Jun 2004.
Stanford University, Department of Anesthesia: Gender and rate differences in acute tolerance and withdrawal to the analgesic, sedative, and respiratory depressant effects of opioids, Apr 2001 to Mar 2002.
Stanford University, Department of Anesthesia: Experimental model of acute opioid-tolerance and withdrawal in man, Apr 2000 to Mar 2001.
Department of Anesthesia, Stanford University School of Medicine: Effects of trans-cranial electro-stimulation on pain perception, cognition and mood in human volunteers, 2006 to 2007.
Organon Pharmaceuticals USA Inc., Roseland, NJ: A multi-center, randomized, phase III trial assessing the PK/PD of Org 25969 in subjects of various ages, 2006 to .
Department of Anesthesia, Stanford University School of Medicine: Effect of Nicotine on Inflammatory & Nociceptive Biomarkers in a Sunburn Model of Hyperalgesia in Healthy Volunteers, 2005 to 2006.
Organon Pharmaceuticals USA Inc., Roseland, NJ: A multi-center, randomized, assessor-blinded, phase II, parallel dose-finding trial to assess the efficacy and safety of Org 25969, 2005 to .
Department of Anesthesia, Stanford University School of Medicine: Human biomarkers of inflammation and nociception: Validation of an in-vivo model, 2004 to 2005.
Physiometrix Inc.: Data Collection Study for PSA 4000 with Hypnos Software Upgrade, 2001 to 2002.
Knoll Pharmaceutical Company: Pharmacokinetics and pharmacodynamics of slow release hydromorphone in humans, 1997 to 2001.
Abbott Inc.: Analgesic action of dexmedetomidine in humans, 1996 to 1997.
Organon Inc.: ORG-9487: A new rapid onset muscle relaxant, 1995 to 1996.
Neurobiological Technologies Inc.: Pharmacokinetics of corticotropin-releasing factor in man, 1995 to 1996.

• Angst MS and Clark JD (2006) Opioid induced hyperalgesia: A qualitative systematic review, Anesthesiology, 104, 570-587
• Koppert W, Filitz J, Troster A, Ihmsen H, Angst MS, Flor H, Schuttler J, Schmelz M (2005) The activation of naloxone sensitive and insensitive inhibitory systems in a human pain model, J Pain, 6, 757-64
• Carroll I, Angst MS, Clark JD (2004) Management of perioperative pain in patients on chronic opioid therapy, Regional Anesthesia and Pain Medicine, 29, 276-91
• Maze M and Angst MS (2004) Defining the role of dexmedetomidine for ICU sedation, Anesthesiology, 101, 1059-61
• Angst MS, Ramaswamy B, Davis F, Maze M (2004) Comparative Analgesic and Mental Effects of Increasing Plasma Concentrations of Dexmedetomidine and Alfentanil in Humans, Anesthesiology, 101, 744-52
• Angst MS (2004) Pancreatic Surgery, Anesthesiologist's Manual of Surgical Procedures, Third Edition, Philadelphia, 483-493 pages (bookchapter)
• Angst MS (2004) Peritoneal Surgery, Anesthesiologist's Manual of Surgical Procedures, Third Edition, Philadelphia, Lippincott Williams & Wilkins, 495-510 pages (bookchapter)
• Ginosar Y, Columb MO, Cohen SE, Mirikatani E, Tingle MS, Ratner EF, Angst MS, Riley ET (November 2003) The site of action of epidural fentanyl infusions in the presence of local anesthetics: a minimum local analgesic concentration infusion study in nulliparous labor, Anesthesia and Analgesia, 97 (5), 1439-45
• Koppert W, Angst M, Alsheimer M, Sittl R, Albrecht S, Schuttler J, Schmelz M (November 2003) Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans, Pain, 106 (1-2), 91-9
• Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M (November 2003) Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal, Pain, 106 (1-2), 49-57
• Ginosar Y, Riley ET, Angst MS (November 2003) The site of action of epidural fentanyl in humans: the difference between infusion and bolus administration, Anesthesia and Analgesia, 97 (5), 1428-38
• Smith DL, Angst MS, Brock-Utne JG, DeBattista C (October 2003) Seizure duration with remifentanil/methohexital vs. methohexital alone in middle-aged patients undergoing electroconvulsive therapy, Acta Anaesthesiologica Scandinavica, 47 (9), 1064-6
• Lotsch J, Angst MS (March 2003) The mu-opioid agonist remifentanil attenuates hyperalgesia evoked by blunt and punctuated stimuli with different potency: a pharmacological evaluation of the freeze lesion in humans, Pain, 102 (1-2), 151-61
• Drover DR, Angst MS, Valle M, Ramaswamy B, Naidu S, Stanski DR, Verotta D (October 2002) Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers, Anesthesiology, 97 (4), 827-36
• Li X, Angst MS, Clark JD (July 2001) Opioid-induced hyperalgesia and incisional pain, Anesthesia and Analgesia, 93 (1), 204-9
• Angst MS, Drover DR, Lotsch J, Ramaswamy B, Naidu S, Wada DR, Stanski DR (Jan 2001) Pharmacodynamics of orally administered sustained- release hydromorphone in humans, Anesthesiology, 94 (1), 63-73
• Li X, Angst MS, Clark JD (Jan 2001) A murine model of opioid-induced hyperalgesia, Brain Research. Molecular Brain Research, 86 (1-2), 56-62
• Lotsch J, Tegeder I, Angst MS, Geisslinger G (May 2000) Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test, Life Sciences, 66 (24), 2393-403
• Angst MS, Buhrer M, Lotsch J (May 2000) Insidious intoxication after morphine treatment in renal failure: delayed onset of morphine-6-glucuronide action, Anesthesiology, 92 (5), 1473-6
• Claure RE, Drover DD, Haddow GR, Esquivel CO, Angst MS (April 2000) Orthotopic liver transplantation for carcinoid tumour metastatic to the liver: anesthetic management, Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 47 (4), 334-7
• Angst MS, Ramaswamy B, Riley ET, Stanski DR (2000) Lumbar epidural morphine in humans and supraspinal analgesia to experimental heat pain [see comments, Anesthesiology, 92 (2), 312-24
• Angst MS, Brose WG, Dyck JB (July 1999) The relationship between the visual analog pain intensity and pain relief scale changes during analgesic drug studies in chronic pain patients, Anesthesiology, 91 (1), 34-41
• Fisher DM, Kahwaji R, Bevan D, Bikhazi G, Fragen RJ, Angst MS, Ornstein E, Matteo RS (April 1999) Factors affecting the pharmacokinetic characteristics of rapacuronium, Anesthesiology, 90 (4), 993-1000
• Angst MS, Dyck JB, Azarnoff DL, Goldblum R, Ho B, Gfroerer T, Linton EA, Glynn BP, Shafer SL (November 1998) Pharmacokinetics, cortisol release, and hemodynamics after intravenous and subcutaneous injection of human corticotropin-releasing factor in humans, Clinical Pharmacology and Therapeutics, 64 (5), 499-510
• Angst MS (April 1998) Dose-response function of epidural fentanyl versus sufentanil, Anesthesia and Analgesia, 86 (4), 918-9
• Angst MS, Mackey SC, Zupfer GH, Tataru CD, Brock-Utne JG (September 1997) Reduction of propofol injection pain with a double lumen i.v. set, Journal of Clinical Anesthesia, 9 (6), 462-6
• Kahwaji R, Bevan DR, Bikhazi G, Shanks CA, Fragen RJ, Dyck JB, Angst MS, Matteo R (May 1997) Dose-ranging study in younger adult and elderly patients of ORG 9487, a new, rapid-onset, short-duration muscle relaxant, Anesthesia and Analgesia, 84 (5), 1011-8
• Saxenhofer H, Angst M, Weidmann P, Shaw SG, Ferrier C (June 1988) Corticosteroid-induced stimulation of atrial natriuretic peptide in man, Acta Endocrinologica, 118 (2), 179-86
• Carvalho B, Angst MS, Fuller A, Lin E, Anbu D, Mathusamy AD, Riley ET, Experimental heat pain delineates pregnancy-induced analgesia in humans, Anesthesiology, Submitted
• Angst MS and Drover DR, The Pharmacology of Drugs Formulated with DepoFoam^TM: A Sustained Release Drug Delivery System for Parenteral Administration Using Multivesicular Liposome Technology, Clinical Pharmacokinetics, Submitted
• Clark JD, Qiao Y, Li X, Xie X, Angst MS, Yeomans D, Regulation of allodynia, edema and incisional cytokine expression by the complement C5a receptor, Anesthesiology, In Press
• Chu LF, Clark JD, Angst MS, Development of tolerance and hyperalgesia in chronic back pain patients after one month of oral morphine, J Pain, 2006, 43-48