Miss Rhoda Ashley Morrow

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University of Washington
School of Medicine
Laboratory Medicine
ProfessorAppointed: 1996
Professional Headshot of Rhoda Ashley Morrow

Mailing Address

Box 358080 - LE 500
University of Washington
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 667-5280
Fax: (206) 667-4411
rmorrow@fhcrc.org

Qualifications

Ph.D., University of California, Davis, 1977.

Expertise and Research Interests

The laboratory provides service support for large scale studies to define the natural history of genital herpes and risk factors for transmission of HSV to sex partners and neonates. The test used in these studies (HSV Western blot) was developed in my lab and remains the gold standard test for antibodies to HSV-1 and HSV-2.

Another application of the HSV antibody typing test has been to provide an FDA-accepted comparator test for development of commercial blood tests for HSV antibodies. Six kits have been cleared by the FDA after extensive clinical trials in the virology lab.

Keywords

COS Keywords:

AIDS, Herpes, Infectious Diseases Or Agents, Internal Medicine, Medical Diagnosis, Medical Or Diagnostic Imaging, Sexually Transmitted Diseases, Vaccine, Viral Infections, Virology.

Additional Terms:

Diagnostic Test Development, Infectious Diseases, Lab Medicine.

Memberships

Academy of Clinical Laboratory Physicians and Scientists
American Society for Virology
American Society of Microbiology
Infectious Diseases Society of America
International Society for Antiviral Research
Society for Mucosal Immunity

Honors and Awards

Fellow, Infectious Diseases Society of America

Publications

  • Kuypers J, Martin ET, Heugel J, Wright N, Morrow R, Englund J, Clinical disease in children associated with newly described coronavirus subtypes, Pediatrics, 119(70-76), 2007
  • Drake A, John-Stewart GC, Wald A, Mbori-Ngacha DA, Bosire R, Wamalwa DC, Lohman-Payne BL, Ashley-Morrow R, Corey L, Carey F, Herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission, Obstet Gynecol, 109(403-409), 2007
  • Brown EL, Wald A, Hughes JP, Morrow RA, Krantz E, Mayer K, Buchbinder S, Koblin B, Celum C, High risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the EXPLORE study, Amer J Epidem, 164(733-741), 2006
  • Morrow R, Friedrich D (2006) Performance of a novel test for IgM and IgG antibodies in subjects with culture-documented genital herpes simplex virus (HSV-2) or -2 (HSV-2) infection., CMI, 12 (463-469)
  • Casper C, Carrell D, Pauk JS, Miller K, Judson FD, Morrow RA, Corey L, Wald A, Celum C (2006) HIV serodiscordant sex partners and the prevalence of human herpes virus 8 infection among HIV-negative men who have sex with men IV baseline data from EXPLORE study., STI, 82 (229-235)
  • Wald A, Krantz E, Selke S, Lairson E, Morrow RA, Zeh J (2006) Knowledge of partners' genital herpes protects against HSV-2 acquisition., J Infect Dis, 194 (42-52)
  • Morrow RA, Krantz E, Friedrich D, Wald A (2006) Clinical correlates of index values in the Focus HerpeSelect ELISA for antibodies to herpes simplex virus type 2 (HSV-2)., J Clin Virol, 36 (141-145)
  • Brown EL, Morrow R, Krantz EM, Arvin AM, Prober CG, Yasukawa LL, Corey L, Wald A (2006) Maternal herpes simplex virus antibody avidity and risk of neonatal herpes., J Obst & Gyn, 195 (115-120)
  • Fife KH, Fortenberry JD, Ofner S, Katz BP, Morrow RA, Orr DP (2006) Incidence and prevalence of herpes simplex virus infectins in adolescent wormen., Sex Transm Dis, 33 (441-444)
  • Ameli N, Bacchetti P, Ashley R, Wilkin T, Young M, Cohen M, Kovacs A, Minkoff H, Gange SJ, Greenblatt RM (2006) Herpes Simplex Virus Infections in Women With HIV Infection, Or Who Are At High Risk for It: Epidemiology and Effects of Antiretroviral Therapy on Clinical Manifestations., JID, 20 (1051-1058)
  • Morrow R, Friedrich D, Meier A, Corey L, Use of biokit HSV-2 rapid assay to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA., BMC Infect Dis, 5, 84, 2005
  • Wald A, Langenberg AGM, Krantz E, Douglas J, Handsfield H, DiCarlo RP, Adomora AA, Izu AE, Morrow RA, Corey L, The relationship between condom use and herpes simplex virus acquisition., Annals Intern Med, 143, 707-713, 2005
  • Gardella C, Brown ZA, Wald A, Morrow RA, Selke S, Krantz E, Corey L, Poor correlation between genital lesions and detection of herpes simplex virus in women in labor., Am J Obstet & Gyn, 106(2), 268-274, 2005
  • Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang M-L, Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L, A Population-based Study of Primary Human Herpesvirus 6 Infection., N Engl J Med, 352, 768-776, 2005
  • Kuypers J, Wright N, Corey L, Morrow R, Detection and Quantification of Human Metapheumoviurs in Pediatric Specimens By Real-time RT-PCR., J Clin Virology, 33, 299-305, 2005
  • Morrow RA, Brown ZA, Common Use of Inaccurate Antibody Assays to Identify Infection With Herpes Simplex Virus Type 2., J Amer College of Obs and Gyn, 193, 361-362, 2005
  • Golden MR, Morrow-Ashley R, Swenson P, Hogrefe WR, Hansfield HH, Wald A, HSV-2 Western Blot Confirmatory Testing Among Men Testing Positive for HSV-2 Using the Focus ELISA in An STD Clinic., STD, 32(12), 771-777, 2005
  • Sanchez J, Whittington WLH, Zuckerman PA, Paredes A, Carcamo C, Luchetti AJ, Galvan R, Garcia P, Lama JR, Russell K, Ashley-Morrow R, Celum CL, Incident HIV Infection Associated With Anogenital Ulcer Disease Among Men Who Have Sex With Men in Peru., J AIDS, Submitted, 2005
  • Meyer JL, Crosby RA, Whittington WLH, Carrell D, Ashley-Morrow R, DiClemente R, Wald A, The Psychosocial Impact Ofserological Herpes Simplex Type-2 Testing in An Urban HIV Clinic., Sex Transm Infect, 81, 309-315, 2005
  • Brown ZA, Wald A, Gardella C, Morrow RA, Corey L, Genital Herpes Complicating Pregnancy., J Amer Col Obstet & Gyn, 106, 845-856, 2005
  • Gardella C, Brown ZA, Wald A, Morrow RA, Selke S, Krantz E, Corey L, Poor Correlation Between Genital Lesions and Detection of Herpes Simplex Virus in Women in Labor., Am College of Obs and Gyn, 106(2), 268-274, 2005
  • Ramos S, Lukefahr JL, Morrow RA, Stanberry LR, Rosenthal SL (2006) Prevalence of herpes simplex virus type 1 and 2 among children and adolescents attending a sexul abuse clinic., Peds Infect Dis, 25 (902-905)
  • Casper C, Meier AS, Morrow RA, Corey L, Wald A, Moscicki A-B (2006) Human herpesvirus 8 infectin among American adolescents in the REACH cohort., 160 (937-942)
  • Englund JA, Boeckh M, Kuypers J, Nichols WG, Hackman RC, Morrow R, Fredericks DN, Corey L (2006) Fatal Human Metapneumovirus Infection in Stem Cell Transplant Recipients., JAMA, 144 (344-349)
  • Corey L, Ashley R, Prevention of herpes simplex virus type 2 transmission with antiviral therapy., Herpes, 11(Suppl 3), 170A-174A, 2004
  • Castellsague X, Diaz M, de Sanjose S, Munoz N, Herrero R, Fanceschi S, Peeling RW, Ashley R, Snijders PJF, Meijer CJLM, Bosch X, for the International Agency for Research on Cancer Multicenter Cervical Cancer Study Group, The worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention., J Natl Cancer Instut, In Press, 2004
  • Corey L, Wald A, Patel R, Sacks S, Tyring SK, Warren T, Douglas JM, Paavonen J, Morrow RA, Beutner KR, Stratchounsky LS, Mertz G, Keene ON, Watson HA, Tait D, Vargas-Cortes M, for the Valacyclovir HSV Transmission St, Once-daily Valacyclovir to Reduce the Risk of Transmission of Genital Herpes., New Engl J Med, 350, 11-20, 2004
  • Casper C, Redman M, Huang M-L, Pauk J, Lampinem TM, Hawes SE, Ashley-Morrow R, Corey L, Kiviat N, Wald A, HIV Infection and Human Herpesvirus 8 (HHV-8) Oral Shedding Among Men Who Have Sex With Men., J AIDS, 35, 233-238, 2004
  • Kimball LE, Casper C, Koelle DM, Morrow R, Corey L, Vieira J, Reduced Levels of Neutralizing Antibodies to Kaposi's Sarcoma-associated Herpesvirus in Persons With a History of Kaposi's Sarcoma., J Infect Dis, 189, 2016-2022, 2004
  • Chohan BH, Taylor H, Obrigewitch R, Lavreys L, Richardson BA, Mandaliya KN, Bwayo JJ, Kreiss JK, Morrow R, Human Herpesvirus 8 Seroconversion in Kenyan Women By Enzyme-linked Immunosorbent Assay and Immunofluorescence Assay., J Clin Virol, 30, 137-144, 2004
  • Morrow RA, Nollkamper J, Robinson NJ, Bishop N, Smith J, Performance of Focus ELISA Tests for Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 Antibodies Among Women in Ten Diverse Geographic Locations., Clin Microbiol Infect, 10, 530-536, 2004
  • Taylor MM, Chohan B, Lavreys L, Hassan W, Huang M, Corey L, Morrow RA, Richardson B, Mandaliya K, Ndimya-Achola J, Bwayo J, Kreiss J, Shedding of Human Herpesvirus-8 in Oral and Genital Secretions From Human Immunodeficiency Virus-1 Seropositive and Seronegative Women., J Infect Dis, 190, 484-488, 2004
  • Laeyendecker O, Henson C, Gray RH, Nygun H-N, Horne BJ, Wawer MJ, Serwadda D, Kiwnuka N, Morrow RA, Hogrefe W, Quinn TC, Performance of a Commercial, Type-specific Enzyme-linked Immunosorbent Assay for Detection of Herpes Simplex Virus Type 2-specific Antibodies in Ugandans., J Clin Microbiol, 42, 1794-1796, 2004
  • Morrow RA, Friedrich D, Krantz E, Wald A, Development and Use of a Type-specific Antibody Avidity Test Based on Herpes Simplex Virus Type 2 Glycoprotein G., Sex Trans Dis, 31(8), 508-515, 2004
  • Stanberry LR, Rosenthal SL, Mills L, Succop PA, Biro FM, Morrow Ashley RL, Bernstein DI, Longitudinal Risk of Herpes Simplex Virus (HSV) Type 1, HSV Type 2, and Cytomegalovirus Infections Among Young Adolescent Girls., Clin Infect Dis, 39, 1433-1438, 2004
  • Kuypers J, Wright N, Morrow R, Evaluation of Quantitative and Type-specific Real-time RT-PCR Assays for Detection of Respiratory Syncytial Virus in Respiratory Specimens From Children., J Clin Virol, 31, 123-129, 2004
  • Gardella C, Brown Z, Wald A, Selke S, Morrow R, Risk Factors for Herpes Simplex Virus Transmission to Pregnant Women: a Couples' Study., Amer J Obstet & Gyb, 193, 1891-1899, 2005
  • Anh PTH, Hieu HT, Herrero R, Vaccarella S, Smith JS, Thuy NT, Nga NH, Duc NB, Ashley R, Snijder PJF, Meijer CJLM, Munoz N, Parkin M, Franceschi S, Human papillomavirus infection among women in South and North Vietnam, Intern J Cancer, 104, 213-220, 2003
  • Turgeon DK, Novicki TJ, Quick J, Carlson L, Miller P, Ulness B, Cent A, Ashley R, Larson A, Coyle M, Limaye AP, Cookson BT, Fritsche TR, Six rapid tests for the direct detection of Clostridium difficile and its toxins in fecal samples compared with the fibroblast cytotoxicity assay., J Clin Microbiol, 41, 667-670, 2003
  • Sulvirach S, Smith JS, Tunsakul S, Herrero R, Kesararat W, Opasatian O, Chichareon S, Kaenploy V, Ashley R, Meijer CJLM, Snijders PJF, Munoz N, Franceschi S, Population-based human papillomavirus prevalence in Lampang and Songkla, Thialand., J Infect Dis, 187, 1246-1256, 2003
  • Rodriquez AC, Castle PE, Smith JS, Bratti C, Hildesheim A, Schiffman M, Viscidi R, Burk RD, Ashley RL, Castellsague' X, Herrero R, A population-based study of herpes simplex virus 2 seroprevalence in rural Costa Rica., Sex Transm Infect, 79(6), 460-465, 2003
  • Renzi C, Douglas JM, Foster M, Critchlow CW, Ashley-Morrow R, Buchbinder SP, Koblin BA, McKirnan DJ, Mayer KH, Celum CL, Herpes Simplex Virus Type 2 Infection As a Risk Factor for Human Immunodeficiency Virus Acquisition in Men Who Have Sex With Men., J Infect Dis, 187, 19-25, 2003
  • Brown ZA, Corey L, Ashley R, Zeh J, Selke S, Wald A, Effect of Serologic Status and Cesarean Delivery on Transmission Rates of Herpes Simplex Virus From Mother to Infant., JAMA, 289, 203-209, 2003
  • Lavreys L, Chohan B, Ashley R, Richardson BA, Corey L, Mandaliya K, Ndinya-Achola JO, Kreiss JK, Human Herpesvirus Type 8: Seroprevalence and Correlates in Prostitutes in Mombasa, Kenya., J Infect Dis, 187, 359-363, 2003
  • Cherpes TL, Ashley RL, Meyn LA, Hiller SL, Longitudinal Reliability of Focus Glycoprotein G-based Type-specific Enzyme Immunoassays for Detection of Herpes Simplex Virus Types 1 and 2 in Women., J Clin Microbiol, 41, 671-674, 2003
  • Posavad CM, Wald A, Hosken N, Huang ML, Koelle DM, Ashley RL, Corey L, T Cell Immunity to Herpes Simplex Viruses in Seronegative Subjects: Silent Infection Or Acquired Immunity?, J Immunol, 170, 4380-4388, 2003
  • Ashley-Morrow R, Krantz E, Wald A, Time Course of Seroconversion By HerpeSelect ELISA After Acquisition of Gential Herpes Simplex Virus Type 1 (HSV-1) Or HSV-2., Sex Transm Dis, 30, 310-314, 2003
  • Mbopi-Keou FX, Belec L, Dalessio J, Legoff J, Greenguet G, Mayaud P, Brown DWG, Ashley RL, Cervicovaginal Neutralizing Antibodies T Herpes Simplex Virus (HSV) in Women Seropositive for HSV Type 1 and 2., Clin DIag Lab Immun, 10, 388-393, 2003
  • Morrow RA, Friedrich D, Krantz E, Performance of the Focus and Kalon Enzyme-linked Immunosorbent Assays for Antibodies to Herpes Simplex Virus Type-2 Glycoprotein G in Culture-documented Cases of Genital Herpes., J Clin Microbiol, 41, 5212-5214, 2003
  • Morrow RA, Friedrich D, Inaccuracy of Certain Commercial Enzyme Immunoassays in Diagnosing Genital Infections With Herpes Simplex Virus Typ 1 Or 2., Amer J Clin Pathol, 120, 839-844, 2003
  • Serwadda D, Gray RH, Sewankambo NK, Wabwire-Mangen F, Chen MZ, Quinn TC, Lutalo T, Kiwanuka N, Kigozi G, Nalugoda F, Meehan MP, Morrow RA, Wawer MJ, Human Immunodeficiency Virus Acquisition Associated With Genital Ulcer Disease and Herpes Simplex Virus Type 2; a Nested Case-control Study in Rakai, Uganda., J Infect Dis, 188, 1492-1497, 2003
  • Rea TD, Ashley RL, Russo JE, Buchwald DS, A Systematic Study of Epstein-barr Virus Serologic Assays Following Acute Infection., Am J Clin Pathol, 117, 156-161, 2002
  • McClelland RS, Wang CC, Richardson BA, Corey L, Ashley R, Mandaliya K, Ndinya-Achola J, Bwayo JJ, Kreiss JK, A Prospective Study of Hormonal Contraceptive Use and Cervical Shedding of Herpes Simplex Virus in HIV-1 Seropositive Women., J Infect Dis, 185, 1822-1825, 2002
  • Ashley RL, Performance and Use of HSV Type Specirfic Serology Test Kits., Herpes, 9, 38-45, 2002
  • Leach CT, Ashley R, Baillargeon J, Jenson HB, Performance of Two Commercial Glycoprotein G-based Enzyme Immunoassays for Detecting Antibodies to Herpes Simplex Viruses 1 and 2 in Children and Young Adolescents, Clin Diag Lab Immunol, 9, 1124-1125, 2002
  • Koelle DM, Barcy S, Huang ML, Ashley RL, Corey L, Zeh J, Ashton S, Buchwald D, Markers of Viral Infection in Monozygotic Twins Discordant for Chronic Fatigue Syndrome., Clin Infect Dis, 35(5), 518-525, 2002
  • Casper C, Krantz E, Taylor H, Dalessio J, Carrell D, Wald A, Corey L, Ashley R, Assessment of a Combined Testing Strategy for the Detection of Antibodies to Human Herpesviurs 8 (HHV-8) in Persons With Kaposi's Sarcoma, Persons With Asymptomatic HHV-8 Infection, and Persons At Low Risk for HHV-8 Infection., J Clin Microbiol, 40, 3822-3825, 2002
  • Hogrefe W, Su X, Song J, Ashley R, Kong L, Detection of Herpes Simplex Virus-2 Immunoglobulin G Antibodies in African Sera By Using Recombinant GG2, Western Blotting, and GG2 Inhibition., J Clin Microbiol, 40, 3635-3640, 2002
  • Baeten JM, Chohan BH, Lavreys L, Rakwar JP, Ashley R, Richarson BA, Mandaliya K, Bwayo JJ, Kreiss JK, Correlates of Human Herpesvirus 8 Seropositivity Among Heterosexual Men in Kenya., AIDS, 16, 2073-2078, 2002
  • Wald A, Zeh J, Selke S, Warren T, Ashley R, Corey L, Genital Shedding of Herpes Simplex Virus Among Men., J Infect Dis, 186(Suppl 1), S34-39, 2002
  • Cowan FM, Copas A, Johnson AM, Ashley R, Corey L, Mindel A, Herpes Simplex Virus Type 1 Infection: a Sexually Transmitted Infection of Adolescence?, Sex Transm Infect, 78, 346-348, 2002
  • McCelland RS, Wang CC, Overbaugh J, Richardson BA, Corey L, Ashley R, Mandaliya K, Ndinya-Achola J, Bwayo JJ, Kreiss JK, Association Between Cervical Shedding of Herpes Simplex Virus and HIV-1., AIDS, 16, 1-6, 2002
  • Smith JS, Herrero R, Bosetti C, Munoz N, Eluf-Neto J, Castellsague X, Meijer C, Van den Brule A, Franceschi S, Ashley R, Herpes Simplex Virus-2 As a Human Papillomavirus Cofactor in the Etiology of Invasive Cervical Cancer., J Natl Cancer Inst, 94, 1604-1613, 2002
  • Whittington WLH, Celum C, Cent A, Ashley R, Use of a Glycopretein G-based Type-specific Assay to Detect Antibodies to Herpes Simplex Virus Type 2 Among Persons Attending Sexually Transmitted Disease Clinics, Sex Trans Dis, 28, 99-104, 2001
  • Smith JS, Herrero R, Munoz N, Eluf-Neto J, Ngelangel C, Bosch FX, Ashley RL, Prevalence and Risk Factors for Herpes Simplex Virus Type 2 Infection Among Middle-aged Women in Brazil and the Philippines., Sex Trans Dis, 28, 187-194, 2001
  • Sucato G, Celum C, Dithmer D, Ashley R, Wald A, Demographic Rather Than Behavioral Risk Factors Predict Herpes Simplex Virus Type 2 Infection in Sexually Active Adolescents., Ped Infect Dis, 20, 422-426, 2001
  • Ashley RL, Sorting Out the New HSV Type Specific Antibody Tests., Sex Transm Infect, 77, 232-237, 2001
  • Robinovitch MR, Ashley RL, Iversen JM, Vigoren EM, Oppenheim FG, Lamkin M, Parotid Salivary Basic Proline-rich Proteins Inhibit HIV-1 Infectivity., Oral Dis, 7(2), 86-93, 2001
  • Starr JR, Daling JR, Fitzgibbons ED, Madeleine MM, Ashley R, Galloway DA, Schwartz SM, Serologic Evidence of Herpes Simplex Virus 1 Infection and Oropharyngeal Cancer Risk., Cancer Res, 61, 8459-8464, 2001
  • Wald A, Langenberg AGM, Link K, Izu AE, Ashley R, Warren T, Tyring S, Douglas JM, Corey L, Effect of Condoms on Reducing the Transmission of Herpes Simplex Virus Type 2 From Men to Women., JAMA, 285, 3100-3106, 2001

Profile Details

Last Updated: 6/18/2007

COS Expertise ID #307276
Reference this profile directly: http://myprofile.cos.com/ashleyr76