William D. Atchison

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Michigan State University
College of Veterinary Medicine
Pharmacology and Toxicology
ProfessorAppointed: 1982
Michigan State University
Life Science

Mailing Address

B331 Life Sciences Bldg.
Michigan State University
East Lansing, Michigan 48824
United States

Contact Information

atchiso1@msu.edu

Qualifications

Ph.D., University of Wisconsin, Pharmacology and Toxicology, 1980.

Expertise and Research Interests

Neuroscience, neuropharmacology especially relating to neuromuscular systems. Neurotoxicology especially relating to neurotoxicity of environmental chemicals. Neurophysiology especially related to calcium-dependent mechanisms of synaptic function.

Keywords

COS Keywords:

Chromatography, Disease Model, Electrophysiology, Microscopy, Nervous System, Neurological Disorders, Pharmacology, Stroke, Toxicology.

Additional Terms:

Acetylcholine, Antigen Antibody Reaction, Autoantibody, Autoimmune Disorder, Calcium Channel, Calcium Flux, Chemical Model, Cholinergic Receptor, Clone Cell, Disease Model, Electrophysiology, Fluorescence Microscopy, Fluorescent Dye Probe, Gel Electrophoresis, Human Tissue, Immunoaffinity Chromatography, Immunoglobulin G, Laboratory Mouse, Laboratory Rat, Membrane Channel, Microelectrode, Mixed Tissue Cell Culture, Neuromuscular Disorder, Neuromuscular Junction, Neuromuscular Transmission, Neuronal Transport, Neurotoxin, Neurotransmitter Transport, Patch Clamp, Pc, Protein Purification, Synapse, Synaptosome, Thiourea, Voltage Gated Channel, Western Blotting.

Memberships

American Society of Pharmacology & Experimental Therapeutics
Biophysical Society
Society for Neuroscience
Society of Toxicology

Honors and Awards

Astra-Zeneca Traveling Lectureship, Society of Toxicology
Board of Publications Award, 1995 for Best Paper in Societal Journal, Society of Toxicology

Funding Received

  • National Institutes of Health (NIH): Potential Contribution of Environmental Metals to ALS, 2006 to 2008.
  • National Institutes of Health (NIH): MECHANISMS OF Pb-INDUCED HYPERTENSION: ROLE OF ALTERED CALCIUM HOMEOSTASIS, 2005 to 2008.
  • National Institutes of Health (NIH): Murine Models of Presynaptic Neuromuscular Disease, 2005 to 2009.
  • Myasthenia Gravis Foundation: OSSERMAN POSTDOCTORAL FELLOWSHIP AWARD APPLICATION FOR DR NICOLE E PARDO, 2004 to 2005.
  • Center for Alternatives to Animal Testing: ORGANOTYPIC CULTURE OF CEREBELLAR SLICE FOR STUDIES OF METHYLMERCURY DEVELOPMENTAL NEUROTOXICITY, 2003 to 2004.
  • Muscular Dystrophy Association of America: UNMASKING OF L TYPE Ca2+ CHANNELS IN LAMBERT EATON SYNDROME, 2003 to 2005.
  • National Institutes of Health (NIH): CEREBELLAR GABA-A RECEPTORS AS TARGETS OF NEUROTOXIC MERCURIALS, 2002 to 2006.
  • MICHIGAN ECONOMIC DEVELOPMENT CORP: CONFOCAL MICROSCOPY FOR NEUROSCIENCE AND TOXICOLOGY, 2001 to 2002.
  • National Institutes of Health (NIH): EFFECTS OF ORGANOTINS ON HIPPOCAMPAL NEURONAL DEVELOPMENT, 2000 to 2002.
  • National Institutes of Health (NIH): PROTEIN TARGETS IN LAMBERT-EATON MYASTHENIC SYNDROME, 1996 to 1999.
  • National Institutes of Health (NIH): CALCIUM CHANNELS: CRITICAL TARGETS OF TOXICANTS & DISEASES, 1995 to 2005.
  • National Institutes of Health (NIH): CHEMICAL MODELS OF PRESYNAPTIC NEUROMUSCULAR DISEASES, 1987 to 1999.
  • National Institutes of Health (NIH): NEUROTOXIC MECHANISM OF METHYLMERCURY POISONING, 1983 to 2005.

Publications

  • Mancini, J.D., Atchison, W.D. (2007) The NR2B subunit in NMDA receptors is functionally important during cerebellar granule cell migration., Neurosci. Lett., 429 (2-3), 87-90
  • Herden, C.J., Pardo, N.E., Hajela, R.K., Yuan, Y., Atchison, W.D. (2007) Differential effects of methylmercury on gamma-aminobutyric acid type A receptor currents in rat cerebellar granule and cerebral cortical neurons in culture., J Pharmacol Exp Ther., 324 (2), 517-528
  • Pardo, N.E., Hajela, R.K., Atchison, W.D. (2006) ACETYLCHOLINE RELEASE AT NEUROMUSCULAR JUNCTIONS OF ADULT TOTTERING MICE IS CONTROLLED BY N- (Cav2.2) AND R- (Cav2.3), BUT NOT L-TYPE (Cav1.2) Ca2+ CHANNELS, J. Pharmacol. Exp. Ther., 319 (3), 1009-1020
  • Atchison, W.D. (2005) Is chemical neurotransmission altered specifically during methylmercury-induced cerebellar dysfunction?, Trends Pharmacol. Sci., 26 (11), 549-557
  • Peng SQ, Hajela RK, Atchison WD, Fluid Flow-induced Increase in Inward Ba2+ Current Expressed in HEK293 Cells Transiently Transfected With Human Neuronal L-type Ca2+ Channels, Brain Res., 1045, 116-123, 31 May 2005
  • Yuan Y, Atchison WD, Methylmercury Induces a Spontaneous, Transient Slow Inward Chloride Current in Purkinje Cells of Rat Cerebellar Slices., The Journal of Pharmacology and Experimental Therapeutics, 313(2), 751-64, May 2005 Abstract
  • Yuan, Y., Otero-Montanez, J.K., Yao, A.-Z., Herden, C.J., Sirois, J.E., Atchison, W.D. (2005) Inwardly rectifying and voltage-gated outward potassium channels exhibit low sensitivity to methylmercury., Neurotoxicology, 26 (3), 439-454
  • Edwards, J.R., Marty, M.S., Atchison, W.D. (2005) Comparative sensitivity of rat cerebellar neurons to dysregulation of divalent cation homeostasis and cytotoxicity caused by methylmercury., Toxicol Appl Pharmacol., 208 (3), 222-232
  • Limke TL, Heidemann SR, Atchison WD, Disruption of Intraneuronal Divalent Cation Regulation By Methylmercury: Are Specific Targets Involved in Altered Neuronal Development And Cytotoxicity in Methylmercury Poisoning?, Neurotoxicology, 25(5), 741-60, Sep 2004 Abstract
  • Limke TL, Bearss JJ, Atchison WD, Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells Through An M3 Muscarinic Receptor-linked Pathway., Toxicological Sciences : An Official Journal of the Society of Toxicology, 80(1), 60-8, Jul 2004 Abstract
  • Atchison WD, Neurotoxicants and Synaptic Function: Session VII-B Summary and Research Needs., Neurotoxicology, 25(4), 515-9, Jun 2004 Abstract
  • Rheuben MB, Autio DM, Xu YF, Atchison WD, Morphometric Characterization of the Neuromuscular Junction of Rodents Intoxicated With 2,4-dithiobiuret: Evidence That Nerve Terminal Recycling Processes Contribute to Muscle Weakness., Toxicology and Applied Pharmacology, 196(2), 266-86, Apr 2004 Abstract
  • Atchison WD, Effects of Toxic Environmental Contaminants on Voltage-gated Calcium Channel Function: From Past to Present., Journal of Bioenergetics and Biomembranes, 35(6), 507-32, Dec 2003 Abstract
  • Flink MT, Atchison WD, Ca2+ Channels As Targets of Neurological Disease: Lambert-Eaton Syndrome and Other Ca2+ Channelopathies., Journal of Bioenergetics and Biomembranes, 35(6), 697-718, Dec 2003 Abstract
  • Hajela RK, Peng SQ, Atchison WD, Comparative Effects of Methylmercury and Hg(2+) on Human Neuronal N- And R-type High-voltage Activated Calcium Channels Transiently Expressed In Human Embryonic Kidney 293 Cells., The Journal of Pharmacology and Experimental Therapeutics, 306(3), 1129-36, Sep 2003 Abstract
  • Yuan Y, Atchison WD, Methylmercury Differentially Affects GABA(A) Receptor-mediated Spontaneous IPSCs in Purkinje and Granule Cells of Rat Cerebellar Slices., The Journal of Physiology, 550(Pt 1), 191-204, Jul 2003 Abstract
  • Flink MT, Atchison WD, Iberiotoxin-induced Block of Ca2+-activated K+ Channels Induces Dihydropyridine Sensitivity of ACh Release From Mammalian Motor Nerve Terminals., The Journal of Pharmacology and Experimental Therapeutics, 305(2), 646-52, May 2003 Abstract
  • Limke TL, Otero-Montanez JK, Atchison WD, Evidence for Interactions Between Intracellular Calcium Stores During Methylmercury-induced Intracellular Calcium Dysregulation in Rat Cerebellar Granule Neurons., The Journal of Pharmacology and Experimental Therapeutics, 304(3), 949-58, Mar 2003 Abstract
  • Peng S, Hajela RK, Atchison WD, Characteristics of Block By Pb2+ of Function of Human Neuronal L-, N-, And R-type Ca2+ Channels Transiently Expressed in Human Embryonic Kidney 293 Cells., Molecular Pharmacology, 62(6), 1418-30, Dec 2002 Abstract
  • Xu YF, Autio D, Rheuben MB, Atchison WD, Impairment of Synaptic Vesicle Exocytosis and Recycling During Neuromuscular Weakness Produced in Mice By 2,4-dithiobiuret., Journal of Neurophysiology, 88(6), 3243-58, Dec 2002 Abstract
  • Flink MT, Atchison WD, Passive Transfer of Lambert-Eaton Syndrome to Mice Induces Dihydropyridine Sensitivity of Neuromuscular Transmission., The Journal of Physiology, 543(Pt 2), 567-76, Sep 2002 Abstract
  • Peng S, Hajela RK, Atchison WD, Effects of Methylmercury on Human Neuronal L-type Calcium Channels Transiently Expressed in Human Embryonic Kidney Cells (HEK-293)., The Journal of Pharmacology and Experimental Therapeutics, 302(2), 424-32, Aug 2002 Abstract
  • Limke TL, Atchison WD, Acute Exposure to Methylmercury Opens the Mitochondrial Permeability Transition Pore in Rat Cerebellar Granule Cells., Toxicology and Applied Pharmacology, 178(1), 52-61, Jan 2002 Abstract
  • Heidemann SR, Lamoureux P, Atchison WD, Inhibition of Axonal Morphogenesis By Nonlethal, Submicromolar Concentrations of Methylmercury., Toxicology and Applied Pharmacology, 174(1), 49-59, Jul 2001 Abstract
  • Audesirk G, Armstrong D, van den Maagdenberg AM, Atchison W, Shafer T, Fletcher C, Calcium Channels: Critical Targets of Toxicants and Diseases., Environmental Health Perspectives, 108(12), 1215-8, Dec 2000 Abstract
  • Mulvey SF, Atchison WG, Grimwade JC, Renou PM, Shekleton PA, Wallace EM, The Utilisation of Nuchal Translucency As a Prenatal Marker of Down Syndrome, 1993-1999., The Australian & New Zealand Journal of Obstetrics & Gynaecology, 40(4), 423-6, Nov 2000 Abstract
  • Sirois JE, Atchison WD, Methylmercury Affects Multiple Subtypes of Calcium Channels in Rat Cerebellar Granule Cells., Toxicology and Applied Pharmacology, 167(1), 1-11, Aug 2000 Abstract
  • Yuan Y, Atchison WD, Comparative Effects of Methylmercury on Parallel-fiber and Climbing-fiber Responses of Rat Cerebellar Slices., The Journal of Pharmacology and Experimental Therapeutics, 288(3), 1015-25, Mar 1999 Abstract
  • Xu YF, Hewett SJ, Atchison WD, Passive Transfer of Lambert-Eaton Myasthenic Syndrome Induces Dihydropyridine Sensitivity of ICa in Mouse Motor Nerve Terminals., Journal of Neurophysiology, 80(3), 1056-69, Sep 1998 Abstract
  • Narahashi T, Treistman SN, Suszkiw JB, Miletic V, Atchison WD, Symposium Overview: Chemical Modulation of Neuroreceptors and Channels Via Intracellular Components., Toxicological Sciences : An Official Journal of the Society of Toxicology, 45(1), 9-25, Sep 1998 Abstract
  • Hajela RK, Atchison WD, Isolation of Ca2+ Channel Alpha 1A, Alpha 2, and Beta Subunit Segments From Human Spinal Cord RNA., Annals of the New York Academy of Sciences, 841, 115-8, May 1998 Abstract
  • Marty MS, Atchison WD, Elevations of Intracellular Ca2+ As a Probable Contributor to Decreased Viability in Cerebellar Granule Cells Following Acute Exposure To Methylmercury., Toxicology and Applied Pharmacology, 150(1), 98-105, May 1998 Abstract
  • Marty MS, Atchison WD, Pathways Mediating Ca2+ Entry in Rat Cerebellar Granule Cells Following In Vitro Exposure to Methyl Mercury., Toxicology and Applied Pharmacology, 147(2), 319-30, Dec 1997 Abstract
  • Yuan Y, Atchison WD, Action of Methylmercury on GABA(A) Receptor-mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its Early Stimulatory Effects On Hippocampal CA1 Excitatory Synaptic Transmission., The Journal of Pharmacology and Experimental Therapeutics, 282(1), 64-73, Jul 1997 Abstract
  • Rheuben MB, Autio DM, Yao AZ, Atchison WD, Effects of the Paralytic Agent 2,4-dithiobiuret on Viability And Morphology of Rat Pheochromocytoma (PC12) Cells., Neurotoxicology, 18(1), 105-22, 1997 Abstract
  • Xu YF, Atchison WD, Effects of Omega-agatoxin-IVA and Omega-conotoxin-MVIIC on Perineurial Ca++ and Ca(++)-activated K+ Currents of Mouse Motor Nerve Terminals., The Journal of Pharmacology and Experimental Therapeutics, 279(3), 1229-36, Dec 1996 Abstract
  • Bickmeyer U, Hare MF, Atchison WD, Tetrandrine Blocks Voltage-dependent Calcium Entry and Inhibits The Bradykinin-induced Elevation of Intracellular Calcium in NG108-15 Cells., Neurotoxicology, 17(2), 335-41, Summer 1996 Abstract
  • Denny MF, Atchison WD, Mercurial-induced Alterations in Neuronal Divalent Cation Homeostasis., Neurotoxicology, 17(1), 47-61, Spring 1996 Abstract
  • Sirois JE, Atchison WD, Effects of Mercurials on Ligand- and Voltage-gated Ion Channels: a Review., Neurotoxicology, 17(1), 63-84, Spring 1996 Abstract
  • Ireland LM, Yan CH, Nelson LM, Atchison WD, Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma \(PC12\) cells., Journal of Pharmacology and Experimental Therapeutics, 275(3), 1453-62, December 1995 Abstract
  • Yuan Y, Atchison WD, Methylmercury Acts At Multiple Sites to Block Hippocampal Synaptic Transmission., The Journal of Pharmacology and Experimental Therapeutics, 275(3), 1308-16, Dec 1995 Abstract
  • Hare MF, Atchison WD, Nifedipine and Tetrodotoxin Delay the Onset of Methylmercury-induced Increase in [Ca2+]i in NG108-15 Cells., Toxicology and Applied Pharmacology, 135(2), 299-307, Dec 1995 Abstract
  • Smith DO, Conklin MW, Jensen PJ, Atchison WD, Decreased Calcium Currents in Motor Nerve Terminals of Mice With Lambert-Eaton Myasthenic Syndrome., The Journal of Physiology, 487 ( Pt 1), 115-23, Aug 1995 Abstract
  • Hare MF, Atchison WD, Methylmercury Mobilizes Ca++ From Intracellular Stores Sensitive To Inositol 1,4,5-trisphosphate in NG108-15 Cells., The Journal of Pharmacology and Experimental Therapeutics, 272(3), 1016-23, Mar 1995 Abstract
  • Hajela RK, Atchison WD, The Proteins Synaptotagmin and Syntaxin Are Not General Targets Of Lambert-Eaton Myasthenic Syndrome Autoantibody., Journal of Neurochemistry, 64(3), 1245-51, Mar 1995 Abstract
  • Spitsbergen JM, Atchison WD, The Paralytic Agent 2,4-dithiobiuret Decreases Open Time of Murine Skeletal Muscle Acetylcholine Receptor Channels., The Journal of Pharmacology and Experimental Therapeutics, 272(2), 645-51, Feb 1995 Abstract
  • Yuan Y, Atchison WD, Comparative Effects of Inorganic Divalent Mercury, Methylmercury And Phenylmercury on Membrane Excitability and Synaptic Transmission of CA1 Neurons in Hippocampal Slices of the Rat., Neurotoxicology, 15(2), 403-11, Summer 1994 Abstract
  • Denny MF, Atchison WD, Methylmercury-induced Elevations in Intrasynaptosomal Zinc Concentrations: An 19F-NMR Study., Journal of Neurochemistry, 63(1), 383-6, Jul 1994 Abstract
  • Atchison WD, Hare MF, Mechanisms of Methylmercury-induced Neurotoxicity., The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology., 8(9), 622-9, Jun 1994 Abstract
  • Royal SA, Cloud GA, Atchison WM, Malpractice in Pediatric Radiology: a Survey in the United States And Canada., Pediatric Radiology, 24(7), 519-22, 1994 Abstract
  • Denny MF, Hare MF, Atchison WD, Methylmercury Alters Intrasynaptosomal Concentrations of Endogenous Polyvalent Cations., Toxicology and Applied Pharmacology, 122(2), 222-32, Oct 1993 Abstract
  • Hare MF, McGinnis KM, Atchison WD, Methylmercury Increases Intracellular Concentrations of Ca++ and Heavy Metals in NG108-15 Cells., The Journal of Pharmacology and Experimental Therapeutics, 266(3), 1626-35, Sep 1993 Abstract
  • Yuan Y, Atchison WD, Disruption By Methylmercury of Membrane Excitability and Synaptic Transmission of CA1 Neurons in Hippocampal Slices of The Rat., Toxicology and Applied Pharmacology, 120(2), 203-15, Jun 1993 Abstract
  • Hewett SJ, Atchison WD, Disruption of Synaptosomal Calcium Channel Function By Lambert-Eaton Myasthenic Immunoglobulin Is Serum-dependent., Brain Research, 599(2), 317-23, Dec 1992 Abstract
  • Hewett SJ, Atchison WD, Specificity of Lambert-Eaton Myasthenic Syndrome Immunoglobulin for Nerve Terminal Calcium Channels., Brain Research, 599(2), 324-32, Dec 1992 Abstract
  • Shafer TJ, Atchison WD, Effects of Methylmercury on Perineurial Na+ and Ca(2+)-dependent Potentials At Neuromuscular Junctions of the Mouse., Brain Research, 595(2), 215-9, Nov 1992 Abstract
  • Levesque PC, Hare MF, Atchison WD, Inhibition of Mitochondrial Ca2+ Release Diminishes the Effectiveness Of Methyl Mercury to Release Acetylcholine From Synaptosomes., Toxicology and Applied Pharmacology, 115(1), 11-20, Jul 1992 Abstract
  • Williams KD, Peterson RE, Atchison WD, High Dose Refractoriness to the Neuromuscular Toxicity of Dithiobiuret In Rats., Neurotoxicology, 13(2), 331-45, Summer 1992 Abstract
  • Hare MF, Atchison WD, Comparative Action of Methylmercury and Divalent Inorganic Mercury On Nerve Terminal and Intraterminal Mitochondrial Membrane Potentials., The Journal of Pharmacology and Experimental Therapeutics, 261(1), 166-72, Apr 1992 Abstract
  • Hewett SJ, Atchison WD, Effects of Charge and Lipophilicity on Mercurial-induced Reduction Of 45Ca2+ Uptake in Isolated Nerve Terminals of the Rat., Toxicology and Applied Pharmacology, 113(2), 267-73, Apr 1992 Abstract
  • Hare MF, Atchison WD, Differentiation Between Alterations in Plasma and Mitochondrial Membrane Potentials in Synaptosomes Using a Carbocyanine Dye., Journal of Neurochemistry, 58(4), 1321-9, Apr 1992 Abstract
  • Atchison WD, Geary TG, Manning B, VandeWaa EA, Thompson DP, Comparative Neuromuscular Blocking Actions of Levamisole and Pyrantel-type Anthelmintics on Rat and Gastrointestinal Nematode Somatic Muscle., Toxicology and Applied Pharmacology, 112(1), 133-43, Jan 1992 Abstract
  • Hewett SJ, Atchison WD, Serum and Plasma From Patients With Lambert-Eaton Myasthenic Syndrome Reduce Depolarization-dependent Uptake of 45Ca2+ Into Rat Cortical Synaptosomes., Brain Research, 566(1-2), 320-4, Dec 1991 Abstract
  • Shafer TJ, Atchison WD, Transmitter, Ion Channel and Receptor Properties of Pheochromocytoma (PC12) Cells: a Model for Neurotoxicological Studies., Neurotoxicology, 12(3), 473-92, Fall 1991 Abstract
  • Shafer TJ, Atchison WD, Methylmercury Blocks N- and L-type Ca++ Channels in Nerve Growth Factor-differentiated Pheochromocytoma (PC12) Cells., The Journal of Pharmacology and Experimental Therapeutics, 258(1), 149-57, Jul 1991 Abstract
  • Spitsbergen JM, Atchison WD, Voltage Clamp Analysis Reveals Multiple Populations of Quanta Released At Neuromuscular Junctions of Rats Treated With 2,4-dithiobiuret., The Journal of Pharmacology and Experimental Therapeutics, 256(1), 159-63, Jan 1991 Abstract
  • Levesque PC, Atchison WD, Disruption of Brain Mitochondrial Calcium Sequestration By Methylmercury., The Journal of Pharmacology and Experimental Therapeutics, 256(1), 236-42, Jan 1991 Abstract
  • Atchison WD, Reduced Safety Factor for Neuromuscular Transmission and Abnormal Quantal Secretion Precede Neuromuscular Weakness Induced By Dithiobiuret., Toxicology and Applied Pharmacology, 106(2), 234-44, Nov 1990 Abstract
  • Shafer TJ, Contreras ML, Atchison WD, Characterization of Interactions of Methylmercury With Ca2+ Channels In Synaptosomes and Pheochromocytoma Cells: Radiotracer Flux and Binding Studies., Molecular Pharmacology, 38(1), 102-13, Jul 1990 Abstract
  • Spitsbergen JM, Atchison WD, Acute Alterations in Murine Neuromuscular Transmission Following Exposure to a Nonparalytic Dose of Dithiobiuret., Toxicology and Applied Pharmacology, 102(1), 68-79, Jan 1990 Abstract
  • Atchison WD, Dihydropyridine-sensitive and -insensitive Components of Acetylcholine Release From Rat Motor Nerve Terminals., The Journal of Pharmacology and Experimental Therapeutics, 251(2), 672-8, Nov 1989 Abstract
  • Atchison WD, Alterations of Spontaneous and Evoked Release of Acetylcholine During Dithiobiuret-induced Neuromuscular Weakness., The Journal of Pharmacology and Experimental Therapeutics, 249(3), 735-43, Jun 1989 Abstract
  • Shafer TJ, Atchison WD, Block of 45Ca Uptake Into Synaptosomes By Methylmercury: Ca++- And Na+-dependence., The Journal of Pharmacology and Experimental Therapeutics, 248(2), 696-702, Feb 1989 Abstract
  • Levesque PC, Atchison WD, Effect of Alteration of Nerve Terminal Ca2+ Regulation on Increased Spontaneous Quantal Release of Acetylcholine By Methyl Mercury., Toxicology and Applied Pharmacology, 94(1), 55-65, Jun 1988 Abstract
  • Atchison WD, Adgate L, Beaman CM, Effects of Antibiotics on Uptake of Calcium Into Isolated Nerve Terminals., The Journal of Pharmacology and Experimental Therapeutics, 245(2), 394-401, May 1988 Abstract
  • Atchison WD, Effects of Neurotoxicants on Synaptic Transmission: Lessons Learned From Electrophysiological Studies., Neurotoxicology and Teratology, 10(5), 393-416, Sep-Oct 1988 Abstract
  • Atchison WD, O'Leary SM, BAY K 8644 Increases Release of Acetylcholine At the Murine Neuromuscular Junction., Brain Research, 419(1-2), 315-9, Sep 1987 Abstract
  • Traxinger DL, Atchison WD, Reversal of Methylmercury-induced Block of Nerve-evoked Release Of Acetylcholine At the Neuromuscular Junction., Toxicology and Applied Pharmacology, 90(1), 23-33, Aug 1987 Abstract
  • Atchison WD, Effects of Activation of Sodium and Calcium Entry on Spontaneous Release of Acetylcholine Induced By Methylmercury., The Journal of Pharmacology and Experimental Therapeutics, 241(1), 131-9, Apr 1987 Abstract
  • Traxinger DL, Atchison WD, Comparative Effects of Divalent Cations on the Methylmercury-induced Alterations of Acetylcholine Release., The Journal of Pharmacology and Experimental Therapeutics, 240(2), 451-9, Feb 1987 Abstract
  • Levesque PC, Atchison WD, Interactions of Mitochondrial Inhibitors With Methylmercury on Spontaneous Quantal Release of Acetylcholine., Toxicology and Applied Pharmacology, 87(2), 315-24, Feb 1987 Abstract
  • Atchison WD, Luke VS, Narahashi T, Vogel SM, Nerve Membrane Sodium Channels As the Target Site of Brevetoxins At Neuromuscular Junctions., British Journal of Pharmacology, 89(4), 731-8, Dec 1986 Abstract
  • Atchison WD, Joshi U, Thornburg JE, Irreversible Suppression of Calcium Entry Into Nerve Terminals By Methylmercury., The Journal of Pharmacology and Experimental Therapeutics, 238(2), 618-24, Aug 1986 Abstract
  • Atchison WD, Extracellular Calcium-dependent and -independent Effects of Methylmercury on Spontaneous and Potassium-evoked Release of Acetylcholine At The Neuromuscular Junction., The Journal of Pharmacology and Experimental Therapeutics, 237(2), 672-80, May 1986 Abstract
  • Williams KD, Lopachin RM, Atchison WD, Peterson RE, Antagonism of Dithiobiuret Toxicity in Rats., Neurotoxicology, 7(1), 33-49, Spring 1986 Abstract
  • Wu CH, Huang JM, Vogel SM, Luke VS, Atchison WD, Narahashi T, Actions of Ptychodiscus Brevis Toxins on Nerve and Muscle Membranes., Toxicon : Official Journal of the International Society on Toxinology, 23(3), 481-7, 1985 Abstract
  • Atchison WD, Narahashi T, Mechanism of Action of Lead on Neuromuscular Junctions., Neurotoxicology, 5(3), 267-82, Fall 1984 Abstract
  • Atchison WD, Peterson RE, Excretion of Porphyrins and Porphyrin Precursors During Neuromuscular Paralysis Produced By Dithiobiuret., Experimental Neurology, 85(1), 63-8, Jul 1984 Abstract
  • Atchison WD, Narahashi T, Vogel SM, Endplate Blocking Actions of Lophotoxin., British Journal of Pharmacology, 82(3), 667-72, Jul 1984 Abstract
  • Porter WR, Dickins J, Atchison WD, Peterson RE, Effects of Dose and Dosing Regimen on Tissue Distribution and Elimination Kinetics of [14C] Dithiobiuret in Rats., Neurotoxicology, 4(4), 57-68, Winter 1983 Abstract
  • Atchison WD, Dickins J, Peterson RE, Age Dependence of Dithiobiuret Neurotoxicity in Male and Female Rats., Neurotoxicology, 3(4), 233-41, Dec 1982 Abstract
  • Atchison WD, Narahashi T, Methylmercury-induced Depression of Neuromuscular Transmission in the Rat., Neurotoxicology, 3(3), 37-50, Nov 1982 Abstract
  • Atchison WD, Mellon WS, Lalley PM, Peterson RE, Dithiobiuret-induced Muscle Weakness in Rats: Evidence for a Prejunctional Effect., Neurotoxicology, 3(1), 44-54, Jul 1982 Abstract
  • Atchison WD, Yang KH, Peterson RE, Dithiobiuret Toxicity in the Rat: Evidence for Latency and Cumulative Dose Thresholds., Toxicology and Applied Pharmacology, 61(2), 166-71, Nov 1981 Abstract
  • Atchison WD, Lalley PM, Cassens RG, Peterson RE, Depression of Neuromuscular Function in the Rat By Chronic 2, 4-dithiobiuret Treatment., Neurotoxicology, 2(2), 329-46, Oct 1981 Abstract
  • Atchison WD, Peterson RE, Potential Neuromuscular Toxicity of 2,4-dithiobiuret in the Rat., Toxicology and Applied Pharmacology, 57(1), 63-8, Jan 1981 Abstract
  • Atchison WD, Stewart JJ, Bass P, A Unique Distribution of Laxative-induced Spike Potentials From the Small Intestine of the Dog., The American Journal of Digestive Diseases, 23(6), 513-20, Jun 1978 Abstract

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