Dr. Melissa A. Austin

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University of Washington
School of Public Health and Community Medicine
Epidemiology
Institute for Public Health Genetics
DirectorAppointed: 1997
University of Washington
Graduate School
Office of Academic Programs
Associate DeanAppointed: 2005
Fred Hutchinson Cancer Research Center
Public Health Sciences
Cancer Prevention Research Program
Joint Member
University of Washington
School of Public Health and Community Medicine
Epidemiology
Professor

Mailing Address

Box 357236
Department of Epidemiology and Institute for Public Health Genetics
University of Washington
Seattle, Washington 98195-7236
United States

Contact Information

maustin@u.washington.edu

Qualifications

Ph.D., University of California, Berkeley, Epidemology, 1985.
M.S., University of California, Los Angeles, Biostatistics, 1975.

Expertise and Research Interests

My expertise is in the following areas:
Genetic epidemiology of chronic diseases
Lipoprotein metabolism
Genetic epidemiology
Cardiovascular disease epidemiology
Epidemiology of pancreatic cancer
Public health genetics

Keywords

COS Keywords:

Biostatistics, Cancer Or Carcinogenesis, Cardiovascular Diseases, Epidemiology, Genetics, Lipoproteins, Protein Metabolism, Public Health.

Additional Terms:

Cardiovascular Disease Epidemiology, Genetic Epidemiology, Lipoprotein Metabolism, Public Health Genetics.

Publications

  • Austin MA, Edwards KL, McNeely MJ, Chandler WL, Leonetti DL, Talmud PJ, Humphries SE, Fujimoto WY, Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans, Diabetes, 53(4), 1166-9, April 2004 Abstract
  • Hutter C, Austin MA, Humphries SE, Familial Hypercholesterolemia, Peripheral Arterial Disease and Stroke: A Human Genome Epidemiology Mini-review, American Journal of Epidemiology, 2004
  • Austin MA, Hutter C, Zimmern RL, Humphries SE, Familial Hypercholesterolemia and Coronary Heart Disease: A Human Genome Epidemiology Association Review, American Journal of Epidemiology, 2004
  • Austin MA, Hutter C, Zimmern RL, Humphries SE, Genetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia : A Human Genome Epidemiology Prevalence Review, American Journal of Epidemiology, 2004
  • Austin MA, Talmud PJ, Farin FM, Nickerson DA, Edwards KL, Leonetti D, McNeely MJ, Viernes HM, Humphries SE, Fujimoto WY, Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans, Biochimica Et Biophysica Acta, 1688(1), 1-9, January 2004 Abstract
  • Austin MA, Zhang C, Humphries SE, Chandler W, Talmud PJ, Edwards KL, Leonetti DL, McNeely MJ, Fujimoto WY., Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans, Annals of Human Genetics, 2004
  • Austin MA, Harding SE, McElroy CE, Monitoring ethical, legal and social issues in developing population genetic databases, Genetics in Medicine, 2003
  • Austin MA, Edwards KL, Monks SA, Koprowicz K, Brunzell JD, Motulsky AG, Hixson JE, Genomewide Scan for Quantitative Trait Loci Influencing Low-density Lipoprotein Size and Plasma Triglyceride in Familial Hypertriglyceridemia, Journal of Lipid Research, 2003
  • Rulyak SJ, Brentnall TA, Lynch HT, Austin MA, Characterization of the neoplastic phenotype in the familial atypical multiple mole melanoma-pancreatic cancer syndrome, Cancer, 2003
  • Austin MA, Harding S, McElroy C, Genebanks: A comparison of eight proposed international genetic databases, Community Genetics, 2003
  • Austin MA, Zimmern RL, Humphries SE, High 'population attributable fraction' for coronary heart disease among relatives in monogenic familial hypercholesterolemia, Genetics in Medicine, 2002
  • Austin MA, Ethical issues in human genome epidemiology: A case study of based on the Japanese American Family Study in Seattle, American Journal of Epidemiology, 2002
  • Austin MA, Arnett D, Beaty T, Durfy S, Fineman R, Gettig E, Lochner Doyle D, Peyser P, Sorenson J, Thompson JD, Watts C, Opportunities for public health genetics trainees: Results from an employer/workplace survey, Community Genetics, 2002
  • Puhlajamaki J, Austin MA, Edwards KL, Laakso M., Major gene effect on fasting insulin and insulin resistance in familial combined hyperlipidemia, Diabetes, 2002
  • Kamigaki AS, Siscovick DS, Schwartz SM, Psaty BM, Edwards KL, Raghunathan TE, Austin MA, Low density lipoprotein particle size and risk of early-onset myocardial infarction in women, American Journal of Epidemiology, 153(10), 939-45, 2001 Abstract
  • Kim H, Marcovina SM, Edwards KL, McKnight B, Bradley CM, McNeely MJ, Psaty BM, Brunzell JD, Motulsky AG, Austin MA, Lipoprotein(a) as a risk factor for maternal cardiovascular disease death, Clinical Genetics, 60, 188-197, 2001
  • McNeely MJ, Edwards KL, Wallace K, Brunzell JD, Motulsky AG, Austin MA, Refining lipoprotein disorders in familial combined hyperlipidemia: a 20-year prospective study, Atherosclerosis, 159, 471-481, 2001
  • Friedlander Y, Talmud PJ, Edwards KL, Humphries SE, Austin MA, Sib-pair linkage analysis of longitudinal changes in lipoprotein risk factors and lipase genes in women twins, Journal of Lipid Research, 41(8), 1302-9, August 2000 Abstract
  • Austin MA, Rodriguez BL, McKnight B, McNeely MJ, Edwards KL, Curb JD, Sharp DS, Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men, American Journal of Cardiology, 86(4), 412-6, August 2000 Abstract
  • Austin MA, McKnight B, Edwards KL, Bradley CM, McNeely MJ, Psaty BM, Brunzell JD, Motulsky AG, Cardiovascular disease mortality in familial forms of hypertriglyceridemia: A 20-year prospective study, Circulation, 101(24), 2777-82, June 2000 Abstract
  • Talmud PJ, Edwards KL, Turner CM, Newman B, Palmen JM, Humphries SE, Austin MA, Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter, Circulation, 101(21), 2461-6, May 2000 Abstract
  • Edwards KL, Mahaney MC, Motulsky AG, Austin MA, Pleiotropic genetic effects on LDL size, plasma triglyceride, and HDL cholesterol in families, Arteriosclerosis, Thrombosis, and Vascular Biology, 19(10), 2456-64, October 1999 Abstract
  • Hokanson JE, Brunzell JD, Jarvik GP, Wijsman EM, Austin MA, Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency., American Journal of Human Genetics, 64(2), 608-18, February 1999 Abstract
  • Friedlander Y, Kark JD, Sinnreich R, Edwards KL, Austin MA, Inheritance of LDL peak particle diameter: results from a segregation analysis in Israeli families., Genetic Epidemiology, 16(4), 382-96, 1999 Abstract
  • Austin MA, Stephens K, Walden CE, Wijsman E, Linkage analysis of candidate genes and the small, dense low-density lipoprotein phenotype, Atherosclerosis, 142(1), 79-87, Jan 1999 Abstract
  • Austin M A, Plasma triglyceride as a risk factor for cardiovascular disease., Canadian Journal of Cardiology, 14 Suppl B, 14B-17B, May 1998 Abstract
  • Edwards K L, Burchfiel C M, Sharp D S, Curb J D, Rodriguez B L, Fujimoto W Y, LaCroix A Z, Vitiello M V, Austin M A, Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men, American Journal of Epidemiology, 147(5), 441-7, 1 Mar 1998 Abstract
  • Edwards KL, Burchfiel CM, Sharp DS, Curb JD, Rodriguez BL, Fujimoto WY, LaCroix AZ, Vitiello MV, Austin MA, Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men., American Journal of Epidemiology, 147(5), 441-7, 1 1998 Abstract
  • Austin M A, Hokanson J E, Edwards K L, Hypertriglyceridemia as a cardiovascular risk factor, American Journal of Cardiology, 81(4A), 7B-12B, 26 Feb 1998 Abstract
  • Austin MA, Hokanson JE, Edwards KL, Hypertriglyceridemia as a cardiovascular risk factor., American Journal of Cardiology, 81(4A), 7B-12B, 26 1998 Abstract
  • Austin M A, Talmud P J, Luong L A, Haddad L, Day I N, Newman B, Edwards K L, Krauss R M, Humphries S E, Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins, American Journal of Human Genetics, 62(2), 406-19, February 1998 Abstract
  • Wijsman E M, Brunzell J D, Jarvik G P, Austin M A, Motulsky A G, Deeb S S, Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex, Arteriosclerosis, Thrombosis, and Vascular Biology, 18(2), 215-26, February 1998 Abstract
  • Austin MA, Talmud PJ, Luong LA, Haddad L, Day IN, Newman B, Edwards KL, Krauss RM, Humphries SE, Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins., American Journal of Human Genetics, 62(2), 406-19, 1998 Abstract
  • Friedlander Y, Siscovick DS, Weinmann S, Austin MA, Psaty BM, Lemaitre RN, Arbogast P, Raghunathan TE, Cobb LA, Family history as a risk factor for primary cardiac arrest., Circulation, 97(2), 155-60, 20 1998 Abstract
  • Knopp R H, Retzlaff B M, Walden C E, Dowdy A A, Tsunehara C H, Austin M A, Nguyen T, A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet, Journal of The American College of Nutrition, 16(6), 551-61, December 1997 Abstract
  • Austin M A, Friedlander Y, Newman B, Edwards K, Mayer-Davis E J, King M C, Genetic influences on changes in body mass index: a longitudinal analysis of women twins, Obesity Research, 5(4), 326-31, July 1997 Abstract
  • Austin M A, Triacylglycerol and coronary heart disease, Proceedings of The Nutrition Society, 56(2), 667-70, July 1997 Abstract
  • Jarvik G P, Goode E L, Austin M A, Auwerx J, Deeb S, Schellenberg G D, Reed T, Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis, American Journal of Human Genetics, 61(1), 171-81, July 1997 Abstract
  • Friedlander Y, Austin M A, Newman B, Edwards K, Mayer-Davis E I, King M C, Heritability of longitudinal changes in coronary-heart-disease risk factors in women twins, American Journal of Human Genetics, 60(6), 1502-12, June 1997 Abstract
  • Edwards K L, Newman B, Mayer E, Selby J V, Krauss R M, Austin M A, Heritability of factors of the insulin resistance syndrome in women twins, Genetic Epidemiology, 14(3), 241-53, 1997 Abstract
  • Austin M A, Genetic epidemiology of dyslipidaemia and atherosclerosis, Annals of Medicine, 28(5), 459-63, October 1996 Abstract
  • Austin M A, Ordovas J M, Eckfeldt J H, Tracy R, Boerwinkle E, Lalouel J M, Printz M, Guidelines of the National Heart, Lung, and Blood Institute Working Group on Blood Drawing, Processing, and Storage for Genetic Studies [published erratum appears in Am J Epidemiol 1997 Mar 15;145(6):, American Journal of Epidemiology, 144(5), 437-41, 1 Sep 1996 Abstract
  • Capell W H, Zambon A, Austin M A, Brunzell J D, Hokanson J E, Compositional differences of LDL particles in normal subjects with LDL subclass phenotype A and LDL subclass phenotype B, Arteriosclerosis, Thrombosis, and Vascular Biology, 16(8), 1040-6, August 1996 Abstract
  • Austin M A, Edwards K L, Small, dense low density lipoproteins, the insulin resistance syndrome and noninsulin-dependent diabetes, Current Opinion In Lipidology, 7(3), 167-71, June 1996 Abstract
  • Hokanson J E, Austin M A, Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies, Journal of Cardiovascular Risk, 3(2), 213-9, April 1996 Abstract
  • Mayer E J, Newman B, Austin M A, Zhang D, Quesenberry C P Jr, Edwards K, Selby J V, Genetic and environmental influences on insulin levels and the insulin resistance syndrome: an analysis of women twins, American Journal of Epidemiology, 143(4), 323-32, 15 Feb 1996 Abstract
  • Austin M A, Mykkanen L, Kuusisto J, Edwards K L, Nelson C, Haffner S M, Pyorala K, Laakso M, Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women, Circulation, 92(7), 1770-8, 1 Oct 1995 Abstract
  • Austin M A, Selby J V, LDL subclass phenotypes and the risk factors of the insulin resistance syndrome, International Journal of Obesity and Related Metabolic Disorders, 19 Suppl 1, S22-6, May 1995 Abstract
  • Edwards K L, Austin M A, Jarvik G P, Evidence for genetic influences on smoking in adult women twins, Clinical Genetics, 47(5), 236-44, May 1995 Abstract
  • Hokanson J E, Krauss R M, Albers J J, Austin M A, Brunzell J D, LDL physical and chemical properties in familial combined hyperlipidemia, Arteriosclerosis, Thrombosis, and Vascular Biology, 15(4), 452-9, April 1995 Abstract
  • Austin M A, Krauss R M, LDL density and atherosclerosis, Jama, 273(2), 115, 11 Jan 1995 Abstract
  • Austin M A, Hokanson J E, Brunzell J D, Characterization of low-density lipoprotein subclasses: methodologic approaches and clinical relevance, Current Opinion In Lipidology, 5(6), 395-403, December 1994 Abstract
  • Edwards K L, Austin M A, Newman B, Mayer E, Krauss R M, Selby J V, Multivariate analysis of the insulin resistance syndrome in women, Arteriosclerosis and Thrombosis, 14(12), 1940-5, December 1994 Abstract
  • Jarvik G P, Brunzell J D, Austin M A, Krauss R M, Motulsky A G, Wijsman E, Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype, Arteriosclerosis and Thrombosis, 14(11), 1687-94, November 1994 Abstract
  • Austin M A, Genetic and environmental influences on LDL subclass phenotypes, Clinical Genetics, 46(1 Spec No), 64-70, July 1994 Abstract
  • Selby J V, Austin M A, Sandholzer C, Quesenberry C P Jr, Zhang D, Mayer E, Utermann G, Environmental and behavioral influences on plasma lipoprotein(a) concentration in women twins, Preventive Medicine, 23(3), 345-53, May 1994 Abstract
  • Jarvik G P, Austin M A, Fabsitz R R, Auwerx J, Reed T, Christian J C, Deeb S, Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects, Genetic Epidemiology, 11(4), 375-84, 1994 Abstract
  • Austin M A, Small, dense low-density lipoprotein as a risk factor for coronary heart disease, International Journal of Clinical and Laboratory Research, 24(4), 187-92, 1994 Abstract
  • Austin M A, Hokanson J E, Epidemiology of triglycerides, small dense low-density lipoprotein, and lipoprotein(a) as risk factors for coronary heart disease, Medical Clinics of North America, 78(1), 99-115, January 1994 Abstract
  • Hokanson J E, Austin M A, Treatment of and screening for hyperlipidemia, New England Journal of Medicine, 329(15), 1126; discussion 112, 7 Oct 1993 Abstract
  • Selby J V, Austin M A, Newman B, Zhang D, Quesenberry C P Jr, Mayer E J, Krauss R M, LDL subclass phenotypes and the insulin resistance syndrome in women, Circulation, 88(2), 381-7, August 1993 Abstract
  • Cheung M C, Austin M A, Moulin P, Wolf A C, Cryer D, Knopp R H, Effects of pravastatin on apolipoprotein-specific high density lipoprotein subpopulations and low density lipoprotein subclass phenotypes in patients with primary hypercholesterolemia, Atherosclerosis, 102(1), 107-19, August 1993 Abstract
  • Austin M A, Newman B, Selby J V, Edwards K, Mayer E J, Krauss R M, Genetics of LDL subclass phenotypes in women twins. Concordance, heritability, and commingling analysis, Arteriosclerosis and Thrombosis, 13(5), 687-95, May 1993 Abstract
  • Hokanson J E, Austin M A, Zambon A, Brunzell J D, Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia, Arteriosclerosis and Thrombosis, 13(3), 427-34, March 1993 Abstract
  • Austin M A, Newman B, Genetic influence on smoking, New England Journal of Medicine, 328(5), 353; discussion 354, 4 Feb 1993 Abstract
  • Zambon A, Austin M A, Brown B G, Hokanson J E, Brunzell J D, Effect of hepatic lipase on LDL in normal men and those with coronary artery disease, Arteriosclerosis and Thrombosis, 13(2), 147-53, February 1993 Abstract
  • Austin M A, The Kaiser-Permanente Women Twins Study data set, Genetic Epidemiology, 10(6), 519-22, 1993 Abstract
  • Krauss R M, Williams P T, Blanche P J, Cavanaugh A, Holl L G, Austin M A, Lipoprotein subclasses in genetic studies: the Berkeley data set, Genetic Epidemiology, 10(6), 523-8, 1993 Abstract
  • Austin M A, Jarvik G P, Hokanson J E, Edwards K, Complex segregation analysis of LDL peak particle diameter, Genetic Epidemiology, 10(6), 599-604, 1993 Abstract
  • Austin M A, Genetic epidemiology of low-density lipoprotein subclass phenotypes, Annals of Medicine, 24(6), 477-81, December 1992 Abstract
  • Austin M A, Sandholzer C, Selby J V, Newman B, Krauss R M, Utermann G, Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes, American Journal of Human Genetics, 51(4), 829-40, October 1992 Abstract
  • Austin M A, Joint lipid risk factors and coronary heart disease, Circulation, 85(1), 365-7, January 1992 Abstract
  • Austin M A, Horowitz H, Wijsman E, Krauss R M, Brunzell J, Bimodality of plasma apolipoprotein B levels in familial combined hyperlipidemia, Atherosclerosis, 92(1), 67-77, January 1992 Abstract
  • Austin M A, Low-density lipoprotein subclass phenotypes and familial combined hyperlipidemia, diabetes/metabolism Reviews, 7(3), 173-7, September 1991 Abstract
  • Austin M A, Goto Y, Lenfant C, Tyroler H A, The hypertriglyceridemias: Risk and management. Epidemiology, American Journal of Cardiology, 68(3), 22A-25A, 24 Jul 1991 Abstract
  • Rosenblatt K A, Thomas D B, McTiernan A, Austin M A, Stalsberg H, Stemhagen A, Thompson W D, Curnen M G, Satariano W, Austin D F, et al, Breast cancer in men: aspects of familial aggregation, Journal of The National Cancer Institute, 83(12), 849-54, 19 Jun 1991 Abstract
  • Selby J V, Newman B, Quiroga J, Christian J C, Austin M A, Fabsitz R R, Concordance for dyslipidemic hypertension in male twins, Jama, 265(16), 2079-84, 24 Apr 1991 Abstract
  • LaBelle M, Austin M A, Rubin E, Krauss R M, Linkage analysis of low-density lipoprotein subclass phenotypes and the apolipoprotein B gene, Genetic Epidemiology, 8(4), 269-75, 1991 Abstract
  • Austin M A, Wijsman E, Guo S W, Krauss R M, Brunzell J D, Deeb S, Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia, Genetic Epidemiology, 8(5), 287-97, 1991 Abstract
  • Austin M A, Plasma triglyceride and coronary heart disease, Arteriosclerosis and Thrombosis, 11(1), 2-14, Winter 1991 Abstract
  • Austin M A, King M C, Vranizan K M, Krauss R M, Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk, Circulation, 82(2), 495-506, August 1990 Abstract
  • Austin M A, Brunzell J D, Fitch W L, Krauss R M, Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia, Arteriosclerosis, 10(4), 520-30, Summer 1990 Abstract
  • Dreon D M, Vranizan K M, Krauss R M, Austin M A, Wood P D, The effects of polyunsaturated fat vs monounsaturated fat on plasma lipoproteins, Jama, 263(18), 2462-6, 9 May 1990 Abstract
  • Brunzell J D, Austin M A, Individuality, hyperlipidemia, and premature coronary artery disease, World Review of Nutrition and Dietetics, 63, 72-83, 1990 Abstract
  • Forte T M, Genzel-Boroviczeny O, Austin M A, Kao L C, Scott C, Albers J J, D'Harlingue A E, Effect of total parenteral nutrition with intravenous fat on lipids and high density lipoprotein heterogeneity in neonates, jpen. Journal of Parenteral and Enteral Nutrition, 13(5), 490-500, Autumn 1989 Abstract
  • Austin M A, Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond, American Journal of Epidemiology, 129(2), 249-59, February 1989 Abstract

Profile Details

Last Updated: 6/15/2007

COS Expertise ID #373905
Reference this profile directly: http://myprofile.cos.com/austinm05