Dr. Antoine Bechara |
|
University of Iowa Carver College of Medicine Neurology Adjunt Associate ProfessorAppointed: 1997 |
Mailing AddressDepartment of Neurology University of Iowa Hospitals and Clinics Iowa City, Iowa 52242United States | Contact Information |
Qualifications
Ph.D., University of Toronto, Medicine and Neuroscience, 1991.
B.Sc., University of Toronto, Pharmacology, 1983.
Expertise and Research Interests
1) Neurobiology of Decision-Making: Anatomical, Psychophysiological, and Behavioral Aspects
2) Role of Emotion in Cognitive Functions: Anatomical, Psychophysiological, and Behavioral Aspects
3) Neurobiology of Addiction: Anatomical, Pharmacological, and Behavioral Aspects
2) Role of Emotion in Cognitive Functions: Anatomical, Psychophysiological, and Behavioral Aspects
3) Neurobiology of Addiction: Anatomical, Pharmacological, and Behavioral Aspects
Other Expertise
I. TEACHING ACTIVITIES (past 5 years)
1) Medical Neuroscience:
a) Lectures (spring term):
Blood Supply of the brain (1 hour) (years: 1999)
Cerebral Cortex (2 hours) (years: 1999)
Motor Systems (1 hour) (Years: 1999)
b) Small Group Discussions (spring term):
4 sessions (2 hours each) for discussing clinical cases with a group of medical students (years: 1994-1999).
c) Laboratory Instructions in Human Brain Dissection (spring term):
Medical students, 10 laboratory sessions (2 hours each) for dissecting the entire human brain and spinal cord (years:1994-1999)
Neurology residents, 3 laboratory sessions (1 hour each) for dissecting the human brain (years: 1999)
Nurse Aneasthetists, 2 laboratory sessions (3 hours each) for dissecting the human brain and spinal cord (years: 1997)
d) Board Reviews (USMLE part I):
2 sessions (3 hours total) to prepare medical students for the USMLE part I, anatomy and neuroanatomy (years: 1998, 1999)
2) Human Gross Anatomy:
a) Lectures (fall term):
Head and neck (2 hours) (years: 1996, 1997)
Infratemporal fossa (1 hour) (years: 1996, 1997)
Orbital region (1 hour) (Years: 1996, 1997)
Mouth, palate, pharynx, ear, nose, and sinuses (2 hours) (years: 1996, 1997)
Abdomen (2 hours) (years: 1996, 1997)
b) Laboratory Instructions in Human Body Dissection (fall term):
Medical students, 60 laboratory sessions (2.5 hours each) for dissecting the entire human body (years:1994-1999)
II. INVITED LECTURESHIP (national and international)
1) 'Viewing addiction as a problem in decision-making: parallels between the human frontal lobe syndrome and addictive behaviors.' NIDA, Baltimore, MD, Jan 17, 1997. Audience: professional.
2) 'The frontal lobe and decision-making: clues from brain-damaged patients about thecognitive mechanisms underlying drug abuse.' A Satellite Symposium organized by NIDA and American Psychological Society entitled: Cognition and Emotion: Applications to Drug Abuse. Washington, DC, May 21, 1998. Audience: professional.
3) 'Emotion anddecision-making after frontal lobe damage: Implications for understanding certain disorders from psychiatry' A Satellite Symposium organized by Lilly Deutschland entitled: Emotionen: Regulation and Fehlregulation. Baden-Baden, Germany, June 6, 1998. Audience: professional.
4) 'Decision-making and emotion in patients with brain lesions: Apllications to substance abuse' Department of Psychology Colloquium Series 1998/1999, Concordia University, Montreal, Canada, October 29, 1998. Audience: professional.
5) 'Memory and emotion: relationships between emotion, memory, and decision-making, and their relevance to substance abuse' Center for Studies on Drug Dependence, Concordia University, Montreal, Canada, October 30, 1998. Audience: professional.
6) 'The role of gut feelings in making decisions' McDonnell-Pew Program in Cognitive Neuroscience Annual Meeting, San Diego, California, June 19, 1999. Audience: professional.
7) 'Role of cerebral cortex on LHPA axis in humans' A symposium organized by NIDA entitled: LHPA Axis in Psychiatric Disorders. Bethesda, MD, September 22, 1999. Audience: professional.
8) 'Neural mechanisms underlying the behavior of patients with ventromedial prefrontal cortex lesions' A symposium organized by European Brain and Behavior Society entitled: Behavioral disinhibition and its relation to affective disorders. Rome, Italy, October 1, 1999. Audience: professional.
III. MEMBERSHIPS ON EDUCATION-RELATED COMMITTEES
1. Director of Medical Neuroscience course, 1999-present.
2. Graduate Student Admissions Committee, School of Graduate Studies, Neuroscience Program, University of Iowa, 1997-present.
3. Medical Student Admissions Committee, College of Medicine, University of Iowa, 1999-present.
IV. AWARDS FOR TEACHING
1. Nomination for M1 Teacher of the Year Award, Medical Students, University of Iowa, 1996.
2. M1 Teacher of the Year Award, Medical Students, University of Iowa, 1997.
1) Medical Neuroscience:
a) Lectures (spring term):
Blood Supply of the brain (1 hour) (years: 1999)
Cerebral Cortex (2 hours) (years: 1999)
Motor Systems (1 hour) (Years: 1999)
b) Small Group Discussions (spring term):
4 sessions (2 hours each) for discussing clinical cases with a group of medical students (years: 1994-1999).
c) Laboratory Instructions in Human Brain Dissection (spring term):
Medical students, 10 laboratory sessions (2 hours each) for dissecting the entire human brain and spinal cord (years:1994-1999)
Neurology residents, 3 laboratory sessions (1 hour each) for dissecting the human brain (years: 1999)
Nurse Aneasthetists, 2 laboratory sessions (3 hours each) for dissecting the human brain and spinal cord (years: 1997)
d) Board Reviews (USMLE part I):
2 sessions (3 hours total) to prepare medical students for the USMLE part I, anatomy and neuroanatomy (years: 1998, 1999)
2) Human Gross Anatomy:
a) Lectures (fall term):
Head and neck (2 hours) (years: 1996, 1997)
Infratemporal fossa (1 hour) (years: 1996, 1997)
Orbital region (1 hour) (Years: 1996, 1997)
Mouth, palate, pharynx, ear, nose, and sinuses (2 hours) (years: 1996, 1997)
Abdomen (2 hours) (years: 1996, 1997)
b) Laboratory Instructions in Human Body Dissection (fall term):
Medical students, 60 laboratory sessions (2.5 hours each) for dissecting the entire human body (years:1994-1999)
II. INVITED LECTURESHIP (national and international)
1) 'Viewing addiction as a problem in decision-making: parallels between the human frontal lobe syndrome and addictive behaviors.' NIDA, Baltimore, MD, Jan 17, 1997. Audience: professional.
2) 'The frontal lobe and decision-making: clues from brain-damaged patients about thecognitive mechanisms underlying drug abuse.' A Satellite Symposium organized by NIDA and American Psychological Society entitled: Cognition and Emotion: Applications to Drug Abuse. Washington, DC, May 21, 1998. Audience: professional.
3) 'Emotion anddecision-making after frontal lobe damage: Implications for understanding certain disorders from psychiatry' A Satellite Symposium organized by Lilly Deutschland entitled: Emotionen: Regulation and Fehlregulation. Baden-Baden, Germany, June 6, 1998. Audience: professional.
4) 'Decision-making and emotion in patients with brain lesions: Apllications to substance abuse' Department of Psychology Colloquium Series 1998/1999, Concordia University, Montreal, Canada, October 29, 1998. Audience: professional.
5) 'Memory and emotion: relationships between emotion, memory, and decision-making, and their relevance to substance abuse' Center for Studies on Drug Dependence, Concordia University, Montreal, Canada, October 30, 1998. Audience: professional.
6) 'The role of gut feelings in making decisions' McDonnell-Pew Program in Cognitive Neuroscience Annual Meeting, San Diego, California, June 19, 1999. Audience: professional.
7) 'Role of cerebral cortex on LHPA axis in humans' A symposium organized by NIDA entitled: LHPA Axis in Psychiatric Disorders. Bethesda, MD, September 22, 1999. Audience: professional.
8) 'Neural mechanisms underlying the behavior of patients with ventromedial prefrontal cortex lesions' A symposium organized by European Brain and Behavior Society entitled: Behavioral disinhibition and its relation to affective disorders. Rome, Italy, October 1, 1999. Audience: professional.
III. MEMBERSHIPS ON EDUCATION-RELATED COMMITTEES
1. Director of Medical Neuroscience course, 1999-present.
2. Graduate Student Admissions Committee, School of Graduate Studies, Neuroscience Program, University of Iowa, 1997-present.
3. Medical Student Admissions Committee, College of Medicine, University of Iowa, 1999-present.
IV. AWARDS FOR TEACHING
1. Nomination for M1 Teacher of the Year Award, Medical Students, University of Iowa, 1996.
2. M1 Teacher of the Year Award, Medical Students, University of Iowa, 1997.
Future Research
Extension and application of current research on emotion, memory, and decision-making to neuropsychiatric disorders including addiction, schizophrenia, and depression, and to neurodegenerative disorders including Alzheimer and Parkinson.
Industrial Relevance
Current research involves exploration of the pharmacological substrates of decision-making. This work has a potential for developing pharmacotherapies for disorders such as addiction, and for frontal lobe decline in aging.
Keywords
COS Keywords:
Neurobiology, Neurology.Languages
(Reading, Writing, Speaking)
Arabic: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)
French: (Functional, Functional, Functional)
Memberships
American Academy of Neurology
Society for Neuroscience
Previous Positions
1995-1997, Associate,
University of Iowa,
Carver College of Medicine,
Anatomy and Cell Biology
1991-1995, Postdoctoral Fellow,
University of Iowa,
Carver College of Medicine,
Behavioral Neurology
Funding Received
- National Institutes of Health (NIH): The Pharmacological Basis of Decision-Making, $446,718, Jul 1, 1999 to Jun 30, 2003.
- The Mathers Foundation (a co-investigator on this grant; Damasio, A.R. is PI): The Neurobiology of Human Emotion, $1,184,214, Jul 1, 1999 to Jun 30, 2002.
- National Institutes of Health (NIH) (A co-investigator on this grant; Damasio, A.R is PI): Anatomical Substrates of Complex Behavior, $3,463,335, Jul 1, 1996 to Jun 30, 2001.
- National Institutes of Health (NIH): Cognitive and Neural Mechanisms of Substance Abuse, $423,867, Apr 1, 1998 to Mar 31, 2001.
Publications
- Bechara A, Damasio H, Damasio AR, Emotion, decision-making, and the orbitofrontal cortex, Cerebral Cortex, December 1999
- Bechara A, Damasio H, Damasio A.R, Lee GP, Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making, Journal of Neuroscience, 19(13), 5473-81, July 1999
- Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR, Impairment of social and moral behavior related to early damage in the human prefrontal cortex, Nature Neuroscience, 1999
- Damasio AR, Grabowski TG, Bechara A, Damasio H, Ponto LLB, Parvizi J, Hichaw RD, Distinctive patterns of subcortical and cortical brain activation associated with self-generated emotions and feelings, Neuron, 1999
- Lee GP, Bechara A, Adolphs R, Arena J, Meador KJ, Loring DW, Smith JR, Clinical and physiological effects of stereotaxic bilateral amygdalotomy for intractable aggression, Journal of Neuropsychiatry and Clinical Neurosciences, 10(4), 413-20, 1998
- Bechara A, Nader K, van der Kooy D, A two-separate-motivational-systems hypothesis of opioid addiction., Pharmacology, Biochemistry and Behavior, 59(1), 1-17, Jan 1998
- Bechara A, Damasio H, Tranel D, Anderson S W, Dissociation of working memory from decision making within the human prefrontal cortex., Journal of Neuroscience, 18(1), 428-37, 1 Jan 1998
- Bechara A, Damasio H, Tranel D, Damasio A R, Deciding advantageously before knowing the advantageous strategy, Science, 275(5304), 1293-5, 28 Feb 1997
- Nader K, Bechara A, van der Kooy D, Neurobiological constraints on behavioral models of motivation., Annual Review of Psychology, 48, 85-114, 1997
- Nader K, Bechara A, van der Kooy D, Lesions of the lateral parabrachial nucleus block the aversive motivational effects of both morphine and morphine withdrawal but spare morphine's discriminative properties., Behavioral Neuroscience, 110(6), 1496-502, December 1996
- Bechara A, Tranel D, Damasio H, Damasio A R, Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex., Cerebral Cortex, 6(2), 215-25, March 1996
- Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, Damasio A R, Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans., Science, 269(5227), 1115-8, 25 Aug 1995
- Bechara A, Nader K, van der Kooy D, Neurobiology of withdrawal motivation: evidence for two separate aversive effects produced in morphine-naive versus morphine-dependent rats by both naloxone and spontaneous withdrawal., Behavioral Neuroscience, 109(1), 91-105, February 1995
- Nader K, Bechara A, Roberts D C, van der Kooy D, Neuroleptics block high- but not low-dose heroin place preferences: further evidence for a two-system model of motivation., Behavioral Neuroscience, 108(6), 1128-38, December 1994
- Skinner D M, Martin G M, Harley C, Kolb B, Pridgar A, Bechara A, van der Kooy D, Acquisition of conditional discriminations in hippocampal lesioned and decorticated rats: evidence for learning that is separate from both simple classical conditioning and configural learning., Behavioral Neuroscience, 108(5), 911-26, October 1994
- Bechara A, Damasio A R, Damasio H, Anderson S W, Insensitivity to future consequences following damage to human prefrontal cortex., Cognition, 50(1-3), 7-15, April 1994
- Bechara A, Martin G M, Pridgar A, van der Kooy D, The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of morphine., Behavioral Neuroscience, 107(1), 147-60, February 1993
- Bechara A, Harrington F, Nader K, van der Kooy D, Neurobiology of motivation: double dissociation of two motivational mechanisms mediating opiate reward in drug-naive versus drug-dependent animals., Behavioral Neuroscience, 106(5), 798-807, October 1992
- Bechara A, van der Kooy D, Lesions of the tegmental pedunculopontine nucleus: effects on the locomotor activity induced by morphine and amphetamine., Pharmacology, Biochemistry and Behavior, 42(1), 9-18, May 1992
- Bechara A, van der Kooy D, Chronic exposure to morphine does not alter the neural tissues subserving its acute rewarding properties: apparent tolerance is overshadowing., Behavioral Neuroscience, 106(2), 364-73, April 1992
- Bechara A, van der Kooy D, A single brain stem substrate mediates the motivational effects of both opiates and food in nondeprived rats but not in deprived rats., Behavioral Neuroscience, 106(2), 351-63, April 1992
- Bechara A, van der Kooy D, The tegmental pedunculopontine nucleus: a brain-stem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine, Journal of Neuroscience, 9(10), 3400-9, October 1989
- Martin GM, Bechara A, van der Kooy D, Morphine preexposure attenuates the aversive properties of opiates without preexposure to the aversive properties, Pharmacology, Biochemistry and Behavior, 30(3), 687-92, July 1988
- Zito KA, Bechara A, Greenwood C, van der Kooy D, The dopamine innervation of the visceral cortex mediates the aversive effects of opiates, Pharmacology, Biochemistry and Behavior, 30(3), 693-9, July 1988
- Bechara A, van der Kooy D, Kappa receptors mediate the peripheral aversive effects of opiates, Pharmacology, Biochemistry and Behavior, 28(2), 227-33, October 1987
- Bechara A, Zito K.A, van der Kooy D, Peripheral receptors mediate the aversive conditioning effects of morphine in the rat, Pharmacology, Biochemistry and Behavior, 28(2), 219-25, October 1987
- Bechara A, van der Kooy D, Opposite motivational effects of endogenous opioids in brain and periphery, Nature, 314(6011), 533-4, April 1985
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