Dr. Khurshida Begum

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UT Health Science Center
Rheumatology & Clinical Immunogenetics
Research Associate
Professional Headshot of Khurshida Begum

Mailing Address

The University of Texas Medical School at Houston
6431 Fannin St
MSB5.270
Houston, Texas 77030
United States

Contact Information

Phone: (979) 703-2928
Khurshida.Begum@uth.tmc.edu
http://www.begumk.freewebspace.com

Qualifications

Ph.D., Okayama University, Biopharmaceutical Sciences, 2003.
M.Sc., University of Dhaka, Parasitology (Zoology), 1992.
B.Sc. Hons., University of Dhaka, Zoology, 1990.

Expertise and Research Interests

Molecular Biology/Genetics & Biotechnology,
Toxicology,Parasitology,Drug Development
and Malaria,etc.

Presently working on the projects:

*Use of genetically modified bacteria to deliver compounds that reduce fire ant fitness.

*Research aiming at improving the genetic transformation system for the yellow fever mosquito, Aedes aegypti.

Other Expertise

Biomolecular techiniques learned/used in my research/experiences:
1. Cell Culture
a. Plasmodium falciparum (malaria parasite)
b. FM3A cell (Mouse Tumor cell)
c. S2,Kc167, BG2C6 Cell lines
2. SDS-PAGE
3. PFGE (Pulsed Field Gel Electrophoresis)
4. In Situ Hybridization
5. Flourescence in situ hybridization (FISH)
6. Southern blotting
7. Northen blotting
8. Western blotting
9. Immunohistochemistry, immunocytochemistry
10. Cloning/ligation/transfection/restriction enzyme digestion etc.
11. PCR, RT-PCR, Real time PCR etc.
12. Screening of drug for sensitivity (IC50, IC90)
13. Drug combinations and interactions
14. Action mechanism of antimalarial drug:
Hemoglobin degradation pathways
Hem detoxification pathways
15. Analysis of multi-drug resistant (mdr) mechanism
16. Microscopy
17. Synchronization of parasite
18. MPN method
19. Analyses of parasite recrudescence after drug treatment
20. BAC and cDNA library screening etc.
21. RNAi
22. ELISA
23. Micro-injection
24. Rearing of Mosquito,Drosophila, Red flour beetle, etc

Over 40 abstract published/presented in various national and international conferences on parasite, drug development and molecular sciences. (1993-2006)

Future Research

Interested to continue Drug Development, Malaria, Parasitology, Zoology, Molecular Biology, Toxicology, etc.

Industrial Relevance

Biomedical Sciences, Pharmaceutical, Biotechnology, etc.

Keywords

COS Keywords:

Drug Design, Entomology, Malaria, Parasitology, Physiology, Toxicology, Zoology.

Memberships

Bangladesh Environmental Society
Bangladesh Zoological Society
Entomological Society of America
International Leptospirosis Society

Honors and Awards

2001-2003, Rotary Yoneyama Memorial Foundation Fellowship, Rotary Club (Japan)
1984-1988, Eden College Scholarship, Eden College, Bangladesh
Who's Who in America (62nd and 63rd Editions, 2008-09), Marquis Who'sWho, USA
Who's Who of American Women (27th Edition, 2008-09), Marquis Who'sWho, USA

Previous Positions

2008-2009, Postdoctoral Research Associate, Texas A&M University-College Station, Texas AgriLife Research, Molecular Genetics & Biotechnology Laboratory
2003-2008, Postdoctoral Research Associate, Kansas State University, Deaprtment of Entomology
2001-2003, Rotary Yoneyama Memorial Foundation Fellow, Okayama University
1999-2000, Researcher, Okayama University, Faculty of Pharmaceutical Sciences
1995-1998, Lecturer, Rajuk Uttara Model College, Dhaka, Bangladesh, Zoology
1994-1995, Class Teacher, Shikkangon Pre-Cadet and High School, Dhaka, Bangladesh, Biology
1990-1992, Research Fellow, University of Dhaka, Eden College, Bangladesh

Publications

  • Begum K, Li B , Beeman RW and Y Park (2009) Functions of Ion Transport Peptide and Ion Transport Peptide-like in the red flour beetle Tribolium castaneum, Insect Biochemistry and Molecular Biology, 39, 717-725
  • Arakane Y, Dixit R, Begum K, Park P, Specht CA, Merzendorfer H, Kramer KJ, Beeman RW, (2009) Muthukrishnan S. Analysis of functions of the chitin deacetylase gene family in Tribolium castaneum., Insect Biochemistry and Molecular Biology., 39 (5-6), 355-365
  • Mutti NS, Louis J, Pappan LK, Pappan K, Begum K, Chen MS,Park Y, Dittmer N, Marshall J, Reese JC, and GR Reeck (2008) A protein from the salivary glands of the pea aphid, Acyrthosiphon pisum, is essential in feeding on a host plant., Proc Natl Acad Sci U S A ., 105 (29), 9965-9969
  • Aikins MJ, Schooley D, Begum K, Dupriez V, Beeman R, and Park Y. (2008) Vasopressin like peptide and its receptor function in indirect diuretic signaling pathway in red flour beetle., Insect Biochemistry and Molecular Biology, 38 (7), 740- 748
  • Jasrapuria, S.; Arakane, Y., Begum, K., Muthukrishnan, S., Kramer, K. J., Beeman, R. W., Park, Y. (2008) Characterization, Gene Organization, Expression and Functional Analysis of Peritrophins in Tribolium castaneum, (In preparation)
  • Anderson TD, Jin-Clark Y, Begum K, Zhu KY. (2008) Gene expression profiling reveals decreased expression of two hemoglobin genes associated with increased consumption of oxygen in Chironomus tentans exposed to atrazine: A possible mechanism for adapting to oxygen deficiency., Aquatic Toxicology, 86, 148-156
  • Begum K, Li B, Beeman and Park Y. (2008) Characterization of ion transport peptide in Tribolium castaneum (Herbst). In preparation.
  • Begum K, Kim H, Adam M and Park Y, (2008) A novel function of ion transport peptide in Drosophila ecdysis. In preparation.
  • Li B, Begum K, and Park Y. (2006) Molecular identification of the genes and coding two AKH peptides and N AKH receptor in Tribolium castanium., The 54th Annual Meeting Of the Entomological Society of America, Indianapolis, IN
  • Begum K, and Park Y. (2006) Characterization of ion transport peptide in Drosophila and Anophelis mosquito., The 54th Annual Meeting Of the Entomological Society of America, Indianapolis, IN
  • Hirai S, Kikuchi H, Kim HS, Begum K, Wataya Y, Tasaka H, Miyazawa Y, Yamamoto K, Oshima Y (Sep 2003) Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite, Journal of Medicinal Chemistry, 46 (20), 4351-9
  • Tokuyasu T, Kunikawa S, Abe M, Masuyama A, Nojima M, Kim HS, Begum K, Wataya Y (Sep 2003) Synthesis of antimalarial yingzhaosu A analogues by the peroxidation of dienes with Co(II)/O2/Et3SiH, The Journal of Organic Chemistry, 68 (19), 7361-7
  • Tran QL, Tezuka Y, Ueda JY, Nguyen NT, Maruyama Y, Begum K, Kim HS, Wataya Y, Tran QK, Kadota S (2003) In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine., Journal of Ethnopharmacology, 86 (2-3), 249-252
  • Begum K, Kim HS, Kumar V, Stojiljkovic I, Wataya Y (Jun 2003) In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum, Parasitology Research, 90 (3), 221-4
  • Kim HS, Begum K, Ogura N, Wataya Y, Nonami Y, Ito T, Masuyama A, Nojima M, McCullough KJ (May 2003) Antimalarial activity of novel 1,2,5,6-tetraoxacycloalkanes and 1,2,5-trioxacycloalkanes, Journal of Medicinal Chemistry, 46 (10), 1957-61
  • Begum K, Investigations of new and potent anti-malarial drugs against malaria parasite, Plasmodium falciparum, PhD Thesis., Japan, Okayama University, Mar 2003
  • Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim HS, Begum K, Wataya Y, Kobayashi M (Feb 2003) New semisynthetic quassinoids with in vivo antimalarial activity, Journal of Medicinal Chemistry, 46 (4), 638-41
  • Kim HS, Begum K, Ogura N, Wataya Y, Tokuyasu T, Masuyama A, Nojima M, McCullough KJ (Oct 2002) Antimalarial activity of yingzhaosu A analogues, Journal of Medicinal Chemistry, 45 (21), 4732-6
  • Begum K, Kim HS, Okuda Y, Wataya Y, Kimura M, Huruta T (2002) Genomic analysis of mefloquine-resistant Plasmodium falciparum, Nucleic Acids Research. Supplement (2001) (2), 223-4
  • Kim HS, Nagai Y, Ono K, Begum K, Wataya Y, Hamada Y, Tsuchiya K, Masuyama A, Nojima M, McCullough KJ (Jul 2001) Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes, Journal of Medicinal Chemistry, 44 (14), 2357-61
  • Kim HS, Okuda Y, Begum K, Nagai Y, Wataya Y, Kimura M, Huruta T (2001) Analysis of Pfmdr 1 gene in mefloquine-resistant Plasmodium falciparum, Nucleic Acids Research. Supplement (2001) (1), 231-2
  • Begum K, Studies on the parasito-fauna of elasmobranch fishes in the Bay of Bengal, M.Sc. Thesis, Bangladesh, Eden College/University of Dhaka., Dec 1992

Profile Details

Last Updated: 2/4/2010

COS Expertise ID #1223786
Reference this profile directly: http://myprofile.cos.com/begumk