Edward F. Bell

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University of Iowa
Carver College of Medicine
Pediatrics
Neonatology
ProfessorAppointed: 1988
Professional Headshot of Edward F. Bell

Mailing Address

Department of Pediatrics
University of Iowa
200 Hawkins Drive
8811 JPP
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 356-4006
Fax: (319) 356-4685
edward-bell@uiowa.edu
http://www.uihealthcare.com/depts/med/pediatrics/pedsmds/bell.html

Qualifications

M.D., Columbia University, 1973.
B.A., Washington and Jefferson College, Mathematics, 1969.

Expertise and Research Interests

My research involves studies of nutrition, growth, energy metabolism, and body temperature regulation of newborn infants. Recent projects include studies of methods of measuring body energy expenditure and the effect of diet on energy utilization and body composition during growth. Current research involves study of oxygen delivery and utilization in anemia of prematurity. Other aims include improving decisions about transfusing anemic preterm infants, reducing the need for transfusion, and identifying safer techniques of transfusion. I am also interested in multicenter clinical trials and lead our group's participation in several such studies.

Other Expertise

- American Academy of Pediatrics Committee on Nutrition, 1987-1993
- American Academy of Pediatrics Committee on Fetus and Newborn, 2001-2007
- American Board of Pediatrics, Member of Subboard of Neonatal-Perinatal Medicine, 1995-2000
- Midwest Society for Pediatric Research, President, 1991-1992
- Society for Pediatric Research, Council, 1990-1993

Future Research

I will continue to examine issues of importance in the early clinical management of prematurely born infants.

Industrial Relevance

My research has only indirect relevance to industry.

Keywords

COS Keywords:

Anemia, Blood or Blood Products or Transfusions, Body Composition, Energy Metabolism, Energy Utilization, Infants, Internal Medicine, International Health, Lactation, Medical Decision Making, Neonatal Disorders, Neonatology, Nutrition Or Dietetics, Pediatrics, Perinatal Health, Thermoregulation.

Additional Terms:

Anemia, Anemic Preterm Infant, Body Composition, Body Energy Expenditure, Body Temperature Regulation, Energy Metabolism, Energy Utilization, Infants, International Health, Lactation, Neonatal Disorder, Newborn Infant, Nutrition, Oxygen Delivery, Pediatrics, Perinatal Health, Prematurity, Transfusion.

Languages

(Reading, Writing, Speaking)

German: (Functional, Basic, Functional)

Memberships

American Pediatric Society
American Society for Clinical Nutrition
Midwest Society for Pediatric Research
Perinatal Research Society
Society for Pediatric Research

Honors and Awards

2002, Humanism in Medicine Award, Association of American Medical Colleges
2001, Humanism in Medicine Award, Healthcare Foundation of New Jersey
1981, Young Investigator Award, American Academy of Pediatrics, Section on Perinatal Pediatrics

Previous Positions

1983-1988, Associate Professor, University of Iowa, Carver College of Medicine, Pediatrics
1979-1983, Assistant Professor, University of Iowa, Carver College of Medicine, Pediatrics
1977-1979, Fellow, Brown University, Neonatology
1976-1977, Fellow, McMaster University, Neonatology

Funding Received

  • National Institutes of Health (NIH): NICHD Cooperative Multicenter Neonatal Research Network, , 2006 to 2011.
  • National Institutes of Health (NIH): Neonatal anemia: pathophysiology and treatment (PPG: project PI GY01-05, coinvestigator GY 06-15), , 1992 to 2011.
  • March of Dimes Birth Defects Foundation: Energy expenditure of prematurely born infants, 1985 to 1987.
  • National Institutes of Health (NIH): Energy expenditure of infants (PPG: project PI), 1984 to 1990.
  • National Institutes of Health (NIH): Energy balance and growth of small premature infants, 1982 to 1988.
  • March of Dimes Birth Defects Foundation: Thermal care of the premature infant, 1980 to 1985.

Publications

  • Murphy CR, Bell EF, Sato Y, Klein JM (2007) Periventricular leukomalacia and prenatal methamphetamine exposure: a case report, American Journal of Perinatology, 24, 123-6
  • Bell EF (2006) Transfusion thresholds for preterm infants: how low should we go?, Journal of Pediatrics, 149, 287-9
  • Bell EF, Strauss RG, Widness JA, Mahoney LT, Mock DM, Seward VJ, Cress GA, Johnson KJ, Kromer IJ, Zimmerman MB (2005) Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants, Pediatrics, 115, 1685-91 Abstract
  • Brion LP, Bell EF, Raghuveer TS (2005) Variability in the dose of intravenous vitamin E given to very low birth weight infants, Journal of Perinatology, 25, 139-42 Abstract
  • Bell EF (2005) Preventing necrotizing enterocolitis: what works and how safe?, Pediatrics, 115, 173-4 Abstract
  • Brion LP, Bell EF, Raghuveer TS, Soghier L, What is the appropriate intravenous dose of vitamin E for very-low-birth-weight infants?, Journal of Perinatology, 24, 205-7, 2004 Abstract
  • Mock DM, Bell EF, Lankford GL, Widness JA, Hematocrit correlates well with circulating red blood cell volume in very low birth weight infants, Pediatric Research, 50, 525-31, 2001 Abstract
  • Schrand LM, Elliott JM, Ross MB, Bell EF, Mutnick AH (2001) A cost-benefit analysis of RSV prophylaxis in high-risk infants, Annals of Pharmacotherapy, 35, 1186-93, 2001 Abstract
  • Hay WW Jr, Bell EF, Oxygen therapy, oxygen toxicity, and the STOP-ROP trial [comment], Pediatrics, 105, 424-425, 2000 Abstract
  • Bell EF, Acarregui MJ, Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants, Cochrane Library (complete collection published quarterly on CD-ROM), Update Software Ltd, Oxford, 2000 Abstract
  • Widness JA, Lowe LS, Bell EF, Burmeister LF, Mock DM, Kistard JA, Bard H, Adaptive responses during anemia and its correction in lambs, Journal of Applied Physiology, 88, 1397-1406, 2000 Abstract
  • Adams AK, Nelson RA, Bell EF, Egoavil CA, Use of infrared thermographic calorimetry to determine energy expenditure in preterm infants, American Journal of Clinical Nutrition, 71, 969-977, 2000 Abstract
  • Ek JR, Bell EF, Nelson RA, Radhi MA, Infrared thermographic calorimetry applied to preterm infants under radiant warmers, Journal of Thermal Biology, 24, 97-103, 1999
  • Klein JM, Thompson MW, Snyder JM, George TN, Whitsett JA, Bell EF, McCray PB Jr, Nogee LM, Transient surfactant protein B deficiency in a term infant with severe respiratory failure, Journal of Pediatrics, 132, 244-248, 1998 Abstract
  • Segar JL, Chemtob S, Bell EF, Changes in body water compartments with diuretic therapy in infants with chronic lung disease, Early Human Development, 48, 99-107, 1997 Abstract
  • Strauss RG, Burmeister LF, Johnson K, James T, Miller J, Cordle DG, Bell EF, Ludwig GA, AS-1 red cells for neonatal transfusions: a randomized trial assessing donor exposure and safety, Transfusion, 36, 873-878, 1996 Abstract
  • Zbar RI, Chen AH, Behrendt DM, Bell EF, Smith RJ, Incidence of vocal fold paralysis in infants undergoing ligation of patent ductus arteriosus, Annals of Thoracic Surgery, 61, 814-816, 1996 Abstract
  • Kao SC, Bell EF, Brown BP, Smith WL, Duplex Doppler sonography of changes in portal vein flow in healthy term newborn infants after feeding, Journal of Ultrasound in Medicine, 15, 121-125, 1996 Abstract
  • Widness JA, Seward VJ, Kromer IJ, Burmeister LF, Bell EF, Strauss RG, Changing patterns of red blood cell transfusion in very low birth weight infants, Journal of Pediatrics, 129, 680-687, 1996 Abstract
  • Bell EF, Diet and body composition of preterm infants, Acta Paediatrica. Supplement, 405, 25-28, 1994 Abstract
  • Meis SJ, Dove EL, Bell EF, Thompson CM, Glatzl-Hawlik MA, Gants AL, Kim WK, A gradient-layer calorimeter for measurement of energy expenditure of infants, American Journal of Physiology, 266, R1052-R1060, 1994 Abstract
  • Rivera A Jr, Bell EF, Bier DM, Effect of intravenous amino acids on protein metabolism of preterm infants during the first three days of life, Pediatric Research, 33, 106-111, 1993 Abstract
  • Segar JL, Robillard JE, Johnson KJ, Bell EF, Chemtob S, Addition of metolazone to overcome tolerance to furosemide in infants with bronchopulmonary dysplasia, Journal of Pediatrics, 120, 966-973, 1992 Abstract
  • Johnson KJ, Bhatia P, Bell EF, Infrared thermometry of newborn infants, Pediatrics, 87, 34-38, 1991 Abstract
  • Stegink LD, Filer LJ Jr, Brummel MC, Baker GL, Krause WL, Bell EF, Ziegler EE, Plasma amino acid concentrations and amino acid ratios in normal adults and adults heterozygous for phenylketonuria ingesting a hamburger and milk shake meal, American Journal of Clinical Nutrition, 53, 670-675, 1991 Abstract
  • Bhatia P, Johnson KJ, Bell EF, Variability of abdominal circumference of premature infants, Journal of Pediatric Surgery, 25, 543-544, 1990 Abstract
  • Stegink LD, Filer LJ Jr, Bell EF, Ziegler EE, Tephly TR, Krause WL, Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria, Metabolism, 39, 1076-1081, 1990 Abstract
  • Stegink LD, Brummel MC, Persoon TJ, Filer LJ Jr, Bell EF, Ziegler EE, Effect of sucrose on the metabolic disposition of aspartame, American Journal of Clinical Nutrition, 52, 335-341, 1990 Abstract
  • Wolf-Novak LC, Stegink LD, Brummel MC, Persoon TJ, Filer LJ Jr, Bell EF, Ziegler EE, Krause WL, Aspartame ingestion with and without carbohydrate in phenylketonuric and normal subjects: effect on plasma concentrations of amino acids, glucose, and insulin, Metabolism, 39, 391-396, 1990 Abstract
  • Bell EF, Upper limit of vitamin E in infant formulas, Journal of Nutrition, 119, 1829-1831, 1989 Abstract
  • Rivera A Jr, Bell EF, Stegink LD, Ziegler EE, Plasma amino acid profiles during the first three days of life in infants with respiratory distress syndrome: effect of parenteral amino acid supplementation, Journal of Pediatrics, 115, 465-468, 1989 Abstract
  • O'Donovan BH, Bell EF, Effects of furosemide on body water compartments in infants with bronchopulmonary dysplasia, Pediatric Research, 26, 121-124, 1989 Abstract
  • Brans YW, Shaffer SG, Bell EF, Schwartz CA, Martin LA, Antipyrine interferes with chemical determination of bromide in simultaneous estimation of total body water and extracellular water, Clinical Chemistry, 35, 1367-1370, 1989 Abstract
  • Trapp SA, Bell EF, An improved spectrophotometric bromide assay for the estimation of extracellular water volume, Clin Chim Acta, 181, 207-211, 1989 Abstract
  • Stegink LD, Filer LJ Jr, Bell EF, Ziegler EE, Tephly TR, Effect of repeated ingestion of aspartame-sweetened beverage on plasma amino acid, blood methanol, and blood formate concentrations in normal adults, Metabolism, 38, 357-363, 1989 Abstract
  • Stegink LD, Filer LJ Jr, Baker GL, Bell EF, Ziegler EE, Brummel MC, Krause WL, Repeated ingestion of aspartame-sweetened beverage: effect on plasma amino acid concentrations in individuals heterozygous for phenylketonuria, Metabolism, 38, 78-84, 1989 Abstract
  • Stegink LD, Wolf-Novak LC, Filer LJ Jr, Bell EF, Ziegler EE, Krause WL, Brummel MC, Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria, Journal of Nutrition, 117, 1989-1995, 1987 Abstract
  • Eckburg JJ, Bell EF, Rios GR, Wilmoth PK, Effects of formula temperature on postprandial thermogenesis and body temperature of premature infants, Journal of Pediatrics, 111, 588-592, 1987 Abstract
  • Bell EF, History of vitamin E in infant nutrition, American Journal of Clinical Nutrition, 46, 183-186, 1987 Abstract
  • Stegink LD, Filer LJ Jr, Bell EF, Ziegler EE, Plasma amino acid concentrations in normal adults administered aspartame in capsules or solution: lack of bioequivalence, Metabolism, 36, 507-512, 1987 Abstract
  • Zipursky A, Brown EJ, Watts J, Milner R, Rand C, Blanchette VS, Bell EF, Paes B, Ling E, Oral vitamin E supplementation for the prevention of anemia in premature infants: a controlled trial, Pediatrics, 79, 61-68, 1987 Abstract
  • Templeman MC, Bell EF, Head insulation for premature infants in servocontrolled incubators and radiant warmers, American Journal of Dis Child, 140, 940-942, 1986 Abstract
  • Bell EF, Rios GR, Wilmoth PK, Estimation of 24-hour energy expenditure from shorter measurement periods in premature infants, Pediatric Research, 20, 646-649, 1986 Abstract
  • Stegink LD, Bell EF, Filer LJ Jr, Ziegler EE, Andersen DW, Seligson FH, Effects of equimolar doses of L-methionine, D-methionine and L-methionine-dl-sulfoxide on plasma and urinary amino acid levels in normal adult humans, Journal of Nutrition, 116, 1185-1192, 1986 Abstract
  • Strauss RG, Bell EF, Snyder EL, Elbert C, Crawford G, Floss A, Wilmoth PK, Rios GR, Koontz FP, Effects of environmental warming on blood components dispensed in syringes for neonatal transfusions, Journal of Pediatrics, 109, 109-113, 1986 Abstract
  • Stegink LD, Filer LJ Jr, Baker GL, Bell EF, Effect of sucrose ingestion on plasma glutamate concentrations in humans administered monosodium L-glutamate, American Journal of Clinical Nutrition, 43, 510-515, 1986 Abstract
  • Stegink LD, Filer LJ Jr, Baker GL, Bell EF, Plasma glutamate concentrations in 1-year-old infants and adults ingesting monosodium L-glutamate in consomme, Pediatric Research, 20, 53-58, 1986 Abstract
  • Weinstein MR, Bell EF, Oh W, Energy intake, norepinephrine excretion, and oxygen consumption in low birthweight infants, Journal of Pediatric Gastroenterology and Nutrition, 4, 774-777, 1985 Abstract
  • Wispe JR, Bell EF, Roberts RJ, Assessment of lipid peroxidation in newborn infants and rabbits by measurements of expired ethane and pentane: influence of parenteral lipid infusion, Pediatric Research, 19, 374-379, 1985 Abstract
  • Bell EF, Ziegler EE, Forbes GB, Corrected bromide space [letter], Pediatric Research, 18, 392-393, 1984 Abstract
  • Mayfield SR, Nakamura KT, Bhatia J, Rios GR, Bell EF, Tympanic membrane temperature of term and preterm neonates, Early Human Development, 9, 241-247, 1984 Abstract
  • Nakamura KT, Beal DW, Koontz FP, Bell EF, Fulminant neonatal septicemia due to Hemophilus parainfluenzae, American Journal of Clinical Pathology, 81, 388-389, 1984 Abstract
  • Mayfield SR, Bhatia J, Nakamura KT, Rios GR, Bell EF, Temperature measurement in term and preterm neonates, Journal of Pediatrics, 104, 271-275, 1984 Abstract
  • Bell EF, Filer LJ Jr, Stegink LD, Plasma glutamate and aspartate concentrations in young infants on Neopham, Acta Chirurgica Scandinavica. Supplementum, 517, 29-37, 1983 Abstract
  • Bell EF, Rios GR, Air versus skin temperature servocontrol of infant incubators, Journal of Pediatrics, 103, 954-959, 1983 Abstract
  • Bell EF, Infant incubators and radiant warmers, Early Human Development, 8, 351-375, 1983 Abstract
  • Bell EF, Rios GR, Performance characteristics of two double-walled infant incubators, Critical Care Medicine, 11, 663-667, 1983 Abstract
  • Stonestreet BS, Bell EF, Warburton D, Oh W, Renal response in low-birth-weight neonates. Results of prolonged intake of two different amounts of fluid and sodium, American Journal of Dis Child, 137, 215-219, 1983 Abstract
  • Bell EF, Rios GR, A double-walled incubator alters the partition of body heat loss of premature infants, Pediatric Research, 17, 135-140, 1983 Abstract
  • Bell EF, Filer LJ Jr, Wong AP, Stegink LD, Effects of a parenteral nutrition regimen containing dicarboxylic amino acids on plasma, erythrocyte, and urinary amino acid concentrations of young infants, American Journal of Clinical Nutrition, 37, 99-107, 1983 Abstract
  • Bell EF, Oh W, Water requirement of premature newborn infants, Acta Paediatrica Scandinavica. Supplement, 305, 21-26, 1983 Abstract
  • Bell EF, Weinstein MR, Oh W, Effects of intravenously administered safflower oil emulsion on respiratory gas exchange of low-birth-weight infants, Journal of Pediatric Gastroenterology and Nutrition, 2, 517-520, 1983 Abstract
  • Warburton D, Bell EF, Stonestreet BS, Oh W, Echocardiographic effects of high and low volumes of maintenance fluid administration in low-birth-weight infants, Developmental Pharmacology and Therapeutics, 6, 45-54, 1983 Abstract
  • Vohr BR, Bell EF, Oh W, Infants with bronchopulmonary dysplasia. Growth pattern and neurologic and developmental outcome, American Journal of Dis Child, 136, 443-447, 1982 Abstract
  • Bell EF, Contrast echocardiography in diagnosis of PDA [letter], Journal of Pediatrics, 99, 668-669, 1981 Abstract
  • Bell EF, Filer LJ Jr, The role of vitamin E in the nutrition of premature infants, American Journal of Clinical Nutrition, 34, 414-422, 1981 Abstract
  • Bell EF, Naloxone reversal of diazepam effects [letter], Anesthesiology, 53, 264, 1980 Abstract
  • Bell EF, Weinstein MR, Oh W, Heat balance in premature infants: comparative effects of convectively heated incubator and radiant warmer, with without plastic heat shield, Journal of Pediatrics, 96, 460-465, 1980 Abstract
  • Bell EF, Warburton D, Stonestreet BS, Oh W, Effect of fluid administration on the development of symptomatic patent ductus arteriosus and congestive heart failure in premature infants, New England Journal of Medicine, 302, 598-604, 1980 Abstract
  • Bell EF, Gray JC, Weinstein MR, Oh W, The effects of thermal environment on heat balance and insensible water loss in low-birth-weight infants, Journal of Pediatrics, 96, 452-459, 1980 Abstract
  • Warburton D, Bell EF, Oh W, Pharmacokinetics and echocardiographic effects of digoxin in low birth weight infants with left-to-right shunting due to patent ductus arteriosus, Developmental Pharmacology and Therapeutics, 1, 189-200, 1980 Abstract
  • Warburton D, Singer D, Bell EF, Corwin R, Oh W, Anatomic confirmation of echocardiographic measurements in neonatal hearts, Pediatrics, 64, 468-471, 1979 Abstract
  • Stonestreet BS, Bell EF, Oh W, Validity of endogenous creatinine clearance in low birthweight infants, Pediatric Research, 13, 1012-1014, 1979 Abstract
  • Bell EF, Warburton D, Stonestreet BS, Oh W, High-volume fluid intake predisposes premature infants to necrotising enterocolitis [letter], Lancet, 2, 90, 1979 Abstract
  • Bell EF, Neidich GA, Cashore WJ, Oh W, Combined effect of radiant warmer and phototherapy on insensible water loss in low-birth-weight infants, Journal of Pediatrics, 94, 810-813, 1979 Abstract
  • Bell EF, Brown EJ, Milner R, Sinclair JC, Zipursky A, Vitamin E absorption in small premature infants, Pediatrics, 63, 830-832, 1979 Abstract
  • Bell EF, Oh W, Fluid and electrolyte balance in very low birth weight infants, Clinical Perinatology, 6, 139-150, 1979 Abstract
  • Bell EF, Warburton D, Two reciprocal translocations associated with microcephaly and retardation, Journal of Medical Genetics, 14, 141-142, 1977 Abstract
  • Bell EF, The use of naloxone in the treatment of diazepam poisoning, Journal of Pediatrics, 87, 803-804, 1975 Abstract
  • Lenard HG, Bell EF, Clinical note. Bioelectric brain development in hypothyroidism. A quantitative analysis with EEG power spectra, Electroencephalography and Clinical Neurophysiology, 35, 545-549, 1973 Abstract
  • Schulte FJ, Kaiser HJ, Engelbart S, Bell EF, Castell R, Lenard HG, Sleep patterns in hyperphenylalaninemia: a lesson on serotonin to be learned from phenylketonuria, Pediatric Research, 7, 588-599, 1973 Abstract
  • Schulte FJ, Bell EF, Bioelectric brain development. An atlas of EEG power spectra in infants and young children, Neuropediatrics, 4, 30-45, 1973 Abstract

Profile Details

Last Updated: 5/30/2007

COS Expertise ID #215123
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