Dr. Michael J. Bevan

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University of Washington
School of Medicine
Immunology
InvestigatorAppointed: 1990
University of Washington
School of Medicine
Immunology
ProfessorAppointed: 1990
Professional Headshot of Michael J. Bevan

Mailing Address

Box 357370
University of Washington
Howard Hughes Medical Institute
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 685-3610
Fax: (206) 685-3612
mbevan@u.washington.edu

Qualifications

Ph.D., Mill Hill, London, Immunology, 1972.

Expertise and Research Interests

Dr. Bevan's research interests are in two main areas: 1) The development of T cells in the thymus and in particular how the forces of positive selection and negative selection (central tolerance) shape the repertoire of antigen receptors, and 2) The response to foreign antigen by mature T lymphocytes in the periphery.

We believe that most T cells with receptors bearing high affinity receptors for self antigen are efficiently removed by the processes of central tolerance and peripheral tolerance, the latter serving as a backup mechanism. This is true even for tissue restricted self antigens expressed in only one or a few peripheral tissues such as the pancreas or melanocytes. However, tolerance spares low avidity T cells specific for self. Since most tumor target antigens for T cells are non-mutated self antigens, the efficacy of T cell immunotherapy is limited. Our goal is to adapt an in vitro system that can already generate large numbers of immature T cells from blood or marrow stem cells so that differentiation of mature T cells occurs. This generation of mature T cells will happen in the absence of tissue restricted target antigens and we hope to devise means to skew the positively selected T cell repertoire to high affinity reactivity with potential tumor antigen targets.

We have shown that CD4 help is required for the generation of long-lived, functional CD8 memory T cells. One component of what CD4 T cells provide is IL-2. CD8 T cells lacking CD25 (and therefore the high affinity IL-2 receptor), generate memory cells which are unable to mount a robust response to second encounter with antigen. We have found that IL-2 signals can be provided to these cells by the use of potent IL-2/anti-IL-2 mab complexes. Our future goals are to elucidate the role CD4 T cells play in the CD8 T cell response, and to explore the timing of IL-2 signals.

Keywords

COS Keywords:

Allergy, Bacteria, Bacterial Infections, Biochemistry, Blood or Blood Products or Transfusions, Bone Marrow, Bone Marrow Transplantation, Cell Biology, Cytology, Gene Expression, Gene Regulation, Genes, Genetics, Immunobiology, Immunology, Infectious Diseases or Agents, Inflammation, Lymphocytes, Microbiology, Viral Infections, Virology.

Additional Terms:

Allergy, Bacteria, Bacterial Disease, Blood, Blood Cells, Bone Marrow Environment, Bone Marrow Transplantation, Gene Expression, Gene Regulation, Genes, Hematopoiesis, Immunobiology, Immunology, Infectious Diseases, Inflammation, Lymphocytes, Lymphoid Organs, Lymphopoie, Macrophages 9, Microbiology, T-Cell, Thymus, Viral Disease, Viruses.

Memberships

American Association of Immunologists
Royal Society of London

Publications

  • Prlic M, Williams MA, Bevan MJ (2007) Requirements for CD8 T cell priming, memory generation and maintenance, Current Opinion in Immunology, In Press
  • Zehn D, Bevan MJ (2007) More promiscuity resulting in more tolerance, Nature Immunology, 8, 120-122
  • Williams MA, Bevan MJ (2007) Effector and memory CTL differentiation, Annual Reviews of Immunology, 25, 171-192
  • Prlic M, Hernandez-Hoyos G, Bevan MJ (2006) Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response, Journal of Experimental Medicine, 203, 2135-2143
  • Sun JC, Lehar SM, Bevan MJ (2006) Augmented IL-7 signaling during viral infection drives greater expansion of effector T cells but does not enhance memory, Journal of Immunology, 177, 4458-4463
  • Gallegos AM, Bevan MJ (2006) Central tolerance: good but perfect, Immunological Reviews, 209, 290-96
  • Williams MA, Bevan MJ (2006) Immunology: Exhausted T cells perk up, Nature, 439, 669-670
  • Bevan MJ (2006) Cross-priming, Nature Immunology, 7, 363-65
  • Prlic M, Bevan MJ (2006) An antibody paradox, resolved, Science, 311, 1875-76
  • Williams MA, Holmes BJ, Sun JC, Bevan MJ (2006) Developing and maintaining protective CD8+ memory T cells, Immunological Reviews, 211, 146-153
  • Williams MA, Tyznik AJ, Bevan MJ (2006) IL-2 signals during priming are required for secondary expansion of CD8+ memory T cells, Nature, 441, 890-893
  • Williams MA, Bevan MJ, T cell memory: fixed or flexible?, Nature Immunology, 6(8), 752-4, Aug 2005 Abstract
  • Williams MA, Bevan MJ (Aug 2005) Cutting edge: A single MHC class Ia is sufficient for CD8 memory T cell differentiation, Journal of Immunology (baltimore, Md. : 1950), 175 (4), 2066-9
  • Belz GT, Shortman K, Bevan MJ, Heath WR (Jul 2005) CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo, Journal of Immunology (baltimore, Md. : 1950), 175 (1), 196-200
  • Lehar SM, Dooley J, Farr AG, Bevan MJ (Feb 2005) Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors, Blood, 105 (4), 1440-7
  • Williams MA, Bevan MJ (Dec 2004) Shortening the infectious period does not alter expansion of CD8 T cells but diminishes their capacity to differentiate into memory cells, Journal of Immunology (baltimore, Md. : 1950), 173 (11), 6694-702
  • Gallegos AM and Bevan MJ, Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation, Journal of Experimental Medicine, 200, 18 Oct 2004
  • Bevan MJ, Altered self, altered world, Journal of Immunology, 173, 2897-8, September 2004
  • Sun JC, Williams MA, Bevan MJ, CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection, Nature Immunology, 5(9), 927-33, Sep 2004 Abstract
  • Ottenhoff THM and Bevan MJ, Host-pathogen interactions, Curr. Opin. Immunol., 16, 439-442, August 2004
  • Bevan MJ, Helping the CD8(+) T-cell response, Nature Reviews. Immunology, 4(8), 595-602, August 2004 Abstract
  • Yankee TM, Yun TJ, Draves KE, Ganesh K, Bevan MJ, Murali-Krishna K, Clark EA, The Gads (GrpL) adaptor protein regulates T cell homeostasis, Journal of Immunology (baltimore, Md. : 1950), 173(3), 1711-20, Aug 2004 Abstract
  • Lehar SM, Bevan MJ, Immunology: polarizing a T-cell response, Nature, 430(6996), 150-1, July 2004 Abstract
  • Xu R, Johnson AJ, Liggitt D, Bevan MJ, Cellular and humoral immunity against vaccinia virus infection of mice, Journal of Immunology (baltimore, Md. : 1950), 172(10), 6265-71, May 2004 Abstract
  • Gallegos AM, Bevan MJ, Driven to autoimmunity: the nod mouse, Cell, 117(2), 149-51, April 2004 Abstract
  • Sun JC, Bevan MJ, Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells, Journal of Immunology (baltimore, Md. : 1950), 172(6), 3385-9, March 2004 Abstract
  • Tyznik AJ, Sun JC, Bevan MJ, The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells, Journal of Experimental Medicine, 199(4), 559-65, February 2004 Abstract
  • He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ, The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens, Nature Immunology, 5(1), 88-97, January 2004 Abstract
  • Bevan, M.J., Helping the CD8+ T-cell response, Nat. Revs. Immunol., 4, 595-602, 2004
  • Ploss A, Lauvau G, Contos B, Kerksiek KM, Guirnalda PD, Leiner I, Lenz LL, Bevan MJ, Pamer EG, Promiscuity of MHC class Ib-restricted T cell responses, Journal of Immunology (baltimore, Md. : 1950), 171(11), 5948-55, December 2003 Abstract
  • Huang EY, Gallegos AM, Richards SM, Lehar SM, Bevan MJ, Surface expression of notch1 on thymocytes: correlation with the double-negative to double-positive transition, Journal of Immunology (baltimore, Md. : 1950), 171(5), 2296-304, September 2003 Abstract
  • Yun TJ, Bevan MJ, Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development, Journal of Immunology (baltimore, Md. : 1950), 170(12), 5834-41, June 2003 Abstract
  • Sun JC, Bevan MJ, Defective CD8 T cell memory following acute infection without CD4 T cell help, Science, 300(5617), 339-42, April 2003 Abstract
  • Norment AM, Bogatzki LY, Klinger M, Ojala EW, Bevan MJ, Kay RJ, Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes, Journal of Immunology (baltimore, Md. : 1950), 170(3), 1141-9, February 2003 Abstract
  • Urdahl KB, Liggitt D, Bevan MJ, CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection, Journal of Immunology (baltimore, Md. : 1950), 170(4), 1987-94, February 2003 Abstract
  • Lehar SM, Bevan MJ, T cell development in culture, Immunity, 17(6), 689-92, December 2002 Abstract
  • Bevan MJ, Immunology: remembrance of things past, Nature, 420(6917), 748-9, December 2002 Abstract
  • den Haan JM, Bevan MJ, Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo, Journal of Experimental Medicine, 196(6), 817-27, September 2002 Abstract
  • Urdahl KB, Sun JC, Bevan MJ, Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells, Nature Immunology, 3(8), 772-9, Aug 2002 Abstract
  • Goldrath AW, Sivakumar PV, Glaccum M, Kennedy MK, Bevan MJ, Benoist C, Mathis D, Butz EA, Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells, Journal of Experimental Medicine, 195(12), 1515-22, June 2002 Abstract
  • Kirchner J, Forbush KA, Bevan MJ, Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity, Molecular and Cellular Biology, 21(24), 8592-604, December 2001 Abstract
  • Krebs LT, Deftos ML, Bevan MJ, Gridley T, The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway, Developmental Biology, 238(1), 110-9, October 2001 Abstract
  • den Haan JM, Bevan MJ, Antigen presentation to CD8+ T cells: cross-priming in infectious diseases, Current Opinion in Immunology, 13(4), 437-41, August 2001 Abstract
  • Bevan MJ, Fink PJ, The CD8 response on autopilot, Nature Immunology, 2(5), 381-2, May 2001 Abstract
  • Yun TJ, Bevan MJ, The Goldilocks conditions applied to T cell development, Nature Immunology, 2(1), 13-4, Jan 2001 Abstract
  • den Haan JM, Lehar SM, Bevan MJ, CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo, Journal of Experimental Medicine, 192(12), 1685-96, December 2000 Abstract
  • den Haan JM, Bevan MJ, A novel helper role for CD4 T cells, Proceedings of the National Academy of Sciences (USA), 97(24), 12950-2, November 2000 Abstract
  • Lenz LL, Butz EA, Bevan MJ, Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens, Journal of Experimental Medicine, 192(8), 1135-42, October 2000 Abstract
  • Norment AM, Bevan MJ, Role of chemokines in thymocyte development, Seminars in Immunology, 12(5), 445-55, October 2000 Abstract
  • Goldrath AW, Bogatzki LY, Bevan MJ, Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation, Journal of Experimental Medicine, 192(4), 557-64, August 2000 Abstract
  • Deftos ML, Huang E, Ojala EW, Forbush KA, Bevan MJ, Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes, Immunity, 13(1), 73-84, July 2000 Abstract
  • He YW, Beers C, Deftos ML, Ojala EW, Forbush KA, Bevan MJ, Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation, Journal of Immunology (baltimore, Md. : 1950), 164(11), 5668-74, June 2000 Abstract
  • Bevan MJ, Goldrath AW, T-cell memory: You must remember this .., Current Biology, 10(9), R338-40, 2000 Abstract
  • Deftos ML, Bevan MJ, Notch signaling in T cell development, Current Opinion in Immunology, 12(2), 166-72, April 2000 Abstract
  • Norment AM, Bogatzki LY, Gantner BN, Bevan MJ, Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling, Journal of Immunology, 164(2), 639-48, 2000 Abstract
  • Goldrath AW, Bevan MJ, Selecting and maintaining a diverse T-cell repertoire, Nature, 402(6759), 255-62, 1999 Abstract
  • Goldrath AW, Bevan MJ, Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts, Immunity, 11(2), 183-90, August 1999 Abstract
  • Kirchner J, Bevan MJ, ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes, Journal of Experimental Medicine, 190(2), 217-28, July 1999 Abstract
  • Harty JT, Bevan MJ, Responses of CD8(+) T cells to intracellular bacteria, Current Opinion in Immunology, 11(1), 89-93, February 1999 Abstract
  • Deftos ML, He YW, Ojala EW, Bevan MJ, Correlating notch signaling with thymocyte maturation, Immunity, 9(6), 777-86, December 1998 Abstract
  • He YW, Deftos ML, Ojala EW, Bevan MJ, RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells, Immunity, 9(6), 797-806, December 1998 Abstract
  • Lampe MF, Wilson CB, Bevan MJ, Starnbach MN, Gamma interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection, Infection and Immunity, 66(11), 5457-61, November 1998 Abstract
  • Martin S, Bevan MJ, Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation, European Journal of Immunology, 28(10), 2991-3002, October 1998 Abstract
  • Princiotta MF, Lenz LL, Bevan MJ, Staerz UD, H2-M3 restricted presentation of a Listeria-derived leader peptide, Journal of Experimental Medicine, 187(10), 1711-9, May 1998 Abstract
  • Jameson S C, Bevan M J, T-cell selection., Current Opinion In Immunology, 10(2), 214-9, April 1998 Abstract
  • Butz EA, Bevan MJ, Massive expansion of antigen-specific CD8+ T cells during an acute virus infection, Immunity, 8(2), 167-75, February 1998 Abstract
  • Gavin M A, Bevan M J, Major histocompatibility complex allele-specific peptide libraries and identification of T-cell mimotopes., Methods In Molecular Biology, 87, 235-48, 1998 Abstract
  • Butz E, Bevan MJ, Dynamics of the CD8+ T cell response during acute LCMV infection, Advances in Experimental Medicine and Biology, 452, 111-22, 1998 Abstract
  • Butz EA, Bevan MJ, Differential presentation of the same MHC class I epitopes by fibroblasts and dendritic cells, Journal of Immunology, 160(5), 2139-44, 1998 Abstract
  • Martin S, Bevan M J, Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection., European Journal of Immunology, 27(10), 2726-36, October 1997 Abstract
  • Brossart P, Bevan MJ, Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines, Blood, 90(4), 1594-9, 1997 Abstract
  • Bevan M J, In thymic selection, peptide diversity gives and takes away., Immunity, 7(2), 175-8, August 1997 Abstract
  • Lenz LL, Bevan MJ, CTL responses to H2-M3-restricted Listeria epitopes, Immunological Reviews, 158, 115-21, August 1997 Abstract
  • Goldrath A W, Hogquist K A, Bevan M J, CD8 lineage commitment in the absence of CD8., Immunity, 6(5), 633-42, May 1997 Abstract
  • Cookson BT, Bevan MJ, Identification of a natural T cell epitope presented by Salmonella-infected macrophages and recognized by T cells from orally immunized mice, Journal of Immunology (baltimore, Md. : 1950), 158(9), 4310-9, May 1997 Abstract
  • Brossart P, Goldrath A W, Butz E A, Martin S, Bevan M J, Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL., Journal of Immunology, 158(7), 3270-6, 1 Apr 1997 Abstract
  • Harty JT, Bevan MJ, CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes, Infection and Immunity, 64(9), 3632-40, September 1996 Abstract
  • Harty JT, Lenz LL, Bevan MJ, Primary and secondary immune responses to Listeria monocytogenes, Current Opinion in Immunology, 8(4), 526-30, August 1996 Abstract
  • Alberola-Ila J, Hogquist K A, Swan K A, Bevan M J, Perlmutter R M, Positive and negative selection invoke distinct signaling pathways., Journal of Experimental Medicine, 184(1), 9-18, 1 Jul 1996 Abstract
  • Lenz LL, Dere B, Bevan MJ, Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3, Immunity, 5(1), 63-72, July 1996 Abstract
  • Brossart P, Bevan MJ, Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide, Journal of Experimental Medicine, 183(6), 2449-58, June 1996 Abstract
  • Lenz LL, Bevan MJ, H2-M3 restricted presentation of Listeria monocytogenes antigens, Immunological Reviews, 151, 107-21, June 1996 Abstract
  • Hogquist K A, Bevan M J, The nature of the peptide/MHC ligand involved in positive selection., Seminars In Immunology, 8(2), 63-8, April 1996 Abstract
  • Gavin M A, Bevan M J, Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire., Immunity, 3(6), 793-800, December 1995 Abstract
  • Bevan MJ, Antigen presentation to cytotoxic T lymphocytes in vivo, Journal of Experimental Medicine, 182(3), 639-41, September 1995 Abstract
  • Starnbach MN, Bevan MJ, Lampe MF, Murine cytotoxic T lymphocytes induced following Chlamydia trachomatis intraperitoneal or genital tract infection respond to cells infected with multiple serovars, Infection and Immunity, 63(9), 3527-30, September 1995 Abstract
  • Harty J T, Bevan M J, Specific immunity to Listeria monocytogenes in the absence of IFNγ, Immunity, 3(1), 109-17, July 1995
  • Hogquist KA, Jameson SC, Bevan MJ, Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells, Immunity, 3(1), 79-86, July 1995 Abstract
  • Bevan M J, Braciale T J, Why can't cytotoxic T cells handle HIV?, Proceedings of the National Academy of Sciences (USA), 92(13), 5765-7, 20 Jun 1995 Abstract
  • Jameson S C, Hogquist K A, Bevan M J, Positive selection of thymocytes., Annual Review of Immunology, 13, 93-126, 1995 Abstract
  • Jameson S C, Bevan M J, T cell receptor antagonists and partial agonists., Immunity, 2(1), 1-11, January 1995 Abstract
  • Fink PJ, Bevan MJ, Positive selection of thymocytes., Advances in Immunology, 59, 99-133, 1995 Abstract
  • Starnbach MN, Bevan MJ, Lampe MF, Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis, Journal of Immunology (baltimore, Md. : 1950), 153(11), 5183-9, December 1994 Abstract
  • Gavin M A, Dere B, Grandea A G 3rd, Hogquist K A, Bevan M J, Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope., European Journal of Immunology, 24(9), 2124-33, September 1994 Abstract
  • Starnbach MN, Bevan MJ, Cells infected with Yersinia present an epitope to class I MHC-restricted CTL, Journal of Immunology (baltimore, Md. : 1950), 153(4), 1603-12, August 1994 Abstract
  • Jameson S C, Hogquist K A, Bevan M J, Specificity and flexibility in thymic selection., Nature, 369(6483), 750-2, 30 Jun 1994 Abstract
  • Bevan M J, Hogquist K A, Jameson S C, Selecting the T cell receptor repertoire., Science, 264(5160), 796-7, 6 May 1994 Abstract
  • Vukmanovic S, Stella G, King P D, Dyall R, Hogquist K A, Harty J T, Nikolic-Zugic J, Bevan M J, A positively selecting thymic epithelial cell line lacks costimulatory activity., Journal of Immunology, 152(8), 3814-23, 15 Apr 1994 Abstract
  • Hogquist K A, Jameson S C, Bevan M J, The ligand for positive selection of T lymphocytes in the thymus., Current Opinion In Immunology, 6(2), 273-8, April 1994 Abstract
  • Dick LR, Aldrich C, Jameson SC, Moomaw CR, Pramanik BC, Doyle CK, DeMartino GN, Bevan MJ, Forman JM, Slaughter CA, Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides, Journal of Immunology (baltimore, Md. : 1950), 152(8), 3884-94, April 1994 Abstract
  • Vukmanovic S, Jameson S C, Bevan M J, A thymic epithelial cell line induces both positive and negative selection in the thymus., International Immunology, 6(2), 239-46, February 1994 Abstract
  • Hogquist K A, Jameson S C, Heath W R, Howard J L, Bevan M J, Carbone F R, T cell receptor antagonist peptides induce positive selection., Cell, 76(1), 17-27, 14 Jan 1994 Abstract
  • Hogquist K A, Grandea A G 3d, Bevan M J, Peptide variants reveal how antibodies recognize major histocompatibility complex class I., European Journal of Immunology, 23(11), 3028-36, November 1993 Abstract
  • Gavin M A, Gilbert M J, Riddell S R, Greenberg P D, Bevan M J, Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes., Journal of Immunology, 151(8), 3971-80, 15 Oct 1993 Abstract
  • Grandea A G 3d, Bevan M J, A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides., Journal of Immunology, 151(8), 3981-7, 15 Oct 1993 Abstract
  • Vukmanovic S, Bevan M J, Hogquist K A, The specificity of positive selection: MHC and peptides., Immunological Reviews, 135, 51-66, October 1993 Abstract
  • Wipke B T, Jameson S C, Bevan M J, Pamer E G, Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule., European Journal of Immunology, 23(8), 2005-10, August 1993 Abstract
  • Jameson S C, Carbone F R, Bevan M J, Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells., Journal of Experimental Medicine, 177(6), 1541-50, 1 Jun 1993 Abstract
  • Hogquist KA, Gavin MA, Bevan MJ, Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture, Journal of Experimental Medicine, 177(5), 1469-73, May 1993 Abstract
  • Pamer E G, Bevan M J, Lindahl K F, Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?, Trends In Microbiology, 1(1), 35-8, April 1993 Abstract
  • Harty JT, Schreiber RD, Bevan MJ, CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion, Proceedings of the National Academy of Sciences of the United States of America., 89(23), 11612-6, December 1992 Abstract
  • Vukmanovic S, Grandea A G 3d, Faas S J, Knowles B B, Bevan M J, Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line., Nature, 359(6397), 729-32, 22 Oct 1992 Abstract
  • Jameson S C, Bevan M J, Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs., European Journal of Immunology, 22(10), 2663-7, October 1992 Abstract
  • Pamer EG, Wang CR, Flaherty L, Lindahl KF, Bevan MJ, H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes, Cell, 70(2), 215-23, July 1992 Abstract
  • Harty JT, Bevan MJ, CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo, Journal of Experimental Medicine, 175(6), 1531-8, June 1992 Abstract
  • Grandea A G 3d, Bevan M J, Single-residue changes in class I major histocompatibility complex molecules stimulate responses to self peptides., Proceedings of the National Academy of Sciences (USA), 89(7), 2794-8, 1 Apr 1992 Abstract
  • Hosken N A, Bevan M J, An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S., Journal of Experimental Medicine, 175(3), 719-29, 1 Mar 1992 Abstract
  • Attaya M, Jameson S, Martinez C K, Hermel E, Aldrich C, Forman J, Lindahl K F, Bevan M J, Monaco J J, Ham-2 corrects the class I antigen-processing defect in RMA-S cells., Nature, 355(6361), 647-9, 13 Feb 1992 Abstract
  • Pamer EG, Harty JT, Bevan MJ, Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes, Nature, 353(6347), 852-5, October 1991 Abstract
  • Hosken N A, Bevan M J, Defective presentation of endogenous antigen by a cell line expressing class I molecules., Science, 248(4953), 367-70, 20 Apr 1990 Abstract
  • Nikolic-Zugic J, Bevan M J, Role of self-peptides in positively selecting the T-cell repertoire, Nature, 344(6261), 65-7, 1 Mar 1990 Abstract
  • Carbone FR, Bevan MJ, Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo, Journal of Experimental Medicine, 171(2), 377-87, February 1990 Abstract
  • Nikolic-Zugic J, Bevan M J, Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus., International Immunology, 2(2), 135-41, 1990 Abstract
  • Moore MW, Crispe IN, Bevan MJ, Analysis of T cell receptor gamma chains from adult CD4- CD8- thymocytes, European Journal of Immunology, 19(8), 1501-4, August 1989 Abstract
  • Nikolic-Zugic J, Moore MW, Bevan MJ, Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation, European Journal of Immunology, 19(4), 649-53, April 1989 Abstract
  • Staerz U D, Rammensee H G, Benedetto J D, Bevan M J, Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor., Journal of Immunology, 134(6), 3994-4000, June 1985 Abstract
  • Lefrancois L, Bevan M J, Functional modifications of cytotoxic T-lymphocyte T200 glycoprotein recognized by monoclonal antibodies., Nature, 314(6010), 449-52, 4 Apr 1985 Abstract
  • Hedrick SM, Germain RN, Bevan MJ, Dorf M, Engel I, Fink P, Gascoigne N, Heber-Katz E, Kapp J, Kaufmann Y, et al., Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets, Proceedings of the National Academy of Sciences of the United States of America., 82(2), 531-5, January 1985 Abstract
  • Zehn D, Bevan MJ, R cells with low avidity for a tissue restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity, Immunity, 25, 261-270

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Last Updated: 6/1/2009

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