Dr. Brian J. Smith

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University of Iowa
College of Public Health
Biostatistics
Assistant ProfessorAppointed: 2002
University of Iowa
Biostatistics Core
Holden Comprehensive Cancer Center
DirectorAppointed: 2006
Professional Headshot of Brian J. Smith

Mailing Address

C22 L GH
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 384-5026
Fax: (319) 384-5018
brian-j-smith@uiowa.edu
http://www.public-health.uiowa.edu/academics/faculty/brian_smith.html

Qualifications

Ph.D., University of Iowa, Biostatistics, 2001.
M.S., University of Texas at Austin, Mathematical Statistics, 1995.
B.A., Saint Louis University, Mathematics, 1993.

Expertise and Research Interests

Bayesian statistics
Computational statistics
Spatial statistics and environmental exposure assessment

Keywords

COS Keywords:

Biometry, Biostatistics, Epidemiology, Spatial Data Or Analysis, Statistics.

Additional Terms:

Bayesian Statistics, Computational Statistics, Spatial Statistics and Environmental Exposure Assessment.

Memberships

American Statistical Association
International Biometric Society
Phi Beta Kappa

Honors and Awards

2006, Children's Environmental Health Recognition Award, US EPA
2006, New Investigator Award, ASA Conference on Radiation and Health
2006, Innovations in Instructional Computing Award, University of Iowa
2005, Steben D. Gray Resident's Research Award, The American Broncho-Esophagological Association
2003, CPH-COM New Investigator Award, College of Public Health, University of Iowa, Bayesian Meta-Analysis
2001, Milford E. Barnes Award for Most Outstanding Graduating Biostatistics Student, College of Public Health, University of Iowa, Biostatistics
2000, John M. Chambers Statistical Software Award, American Statistical Association, The Statistical Computing Section, Bayesian Output Analysis Program
1997, Excellence in Teaching Award for Graduate Teaching Assistants, University of Iowa
1996-1997, Biostatistics Student Group President, University of Iowa
1992, Barry M. Goldwater Grant for Students in the Natural Sciences,

Previous Positions

2005-2006, Co-Director, University of Iowa, Biostatistics Core, Holden Comprehensive Cancer Cener
2001-2002, Visiting Assistant Professor, University of Iowa, College of Public Health, Biostatistics
2000-2001, Graduate Research Assistant, University of Iowa, College of Liberal Arts and Sciences, Statistics and Actuarial Sciences
1999-2000, Graduate Teaching Assistant, University of Iowa, College of Public Health, Biostatistics
1997-1999, Graduate Research Assistant, University of Iowa, College of Public Health, Epidemiology
1995-1997, Graduate Teaching Assistant, University of Iowa, College of Public Health, Biostatistics
1993-1995, Research Scientist, University of Texas at Austin, Advanced Research Laboratories, Advanced Sonar

Funding Received

  • NIEHS: Exposure Intervention in a Rural Asthma Pediatric Cohort, $1,946,270, Sep 30, 2001 to Jul 31, 2006.
  • National Cancer Institute: Cancer Center Support Grant, $850,000, Jul 1, 2000 to 2010.
  • National Cancer Institute: Iowa and Missouri Radon Lung Cancer Studies, $1,072,331, Jan 17, 2001 to Dec 31, 2005.
  • College of Public Health-College of Medicine New Investigator Research Award: Bayesian Models for Meta-Analysis: The Impact of Dietary Fat Intake on Prostate Cancer, $6,000, Jan 1, 2003 to Dec 31, 2003.
  • DOD: Ad5-TRAIL Gene Therapy for Prostate Cancer, $190,000, 2006 to 2008.
  • NIH/NIGMS: Statistics in Microbiology, Infectious Diseases & Bioinformatics, $65,756, 2006 to 2007.
  • Iowa Department of Public Health: Comprehensive Assessment of Rural Health in Iowa, $396,981, 2004 to 2006.
  • American Cancer Society: Cumulative Sun Exposure and Melanoma: A Meta-Analysis, $261,000, 2004 to 2005.
  • Department of Defense: Sexually Transmitted Infections as a Risk Factor for Prostate Cancer among Military Personnel, $553,125, 2004 to 2007.
  • NIH: Evaluation of the Edit Process as Applied to Lung Cases (SEER), $2,788,639, 2003 to 2010.
  • National Cancer Institute: Lymphoma Specialized Program of Research Excellence, $10,978,316, 2002 to 2011.

Publications

  • Luthe G, Garcia Boy R, Jacobus J, Smith BJ, Rahaman A, Robertson LW, Ludewig G (Apr 2008) Xenobiotic Geometry and Media pH Determine Cytotoxicity through Solubility., Chemical research in toxicology Abstract
  • Andrews BT, Smith RB, Hoffman HT, Funk GF (2008) Orocutaneous and pharyngocutaneous fistula closure using a vacuum-assisted closure system, Ann Otol Rhinol Laryngol, 117 (4), 298-302
  • van de Wetering CI, Coleman MC, Spitz DR, Smith BJ, Knudson CM (Apr 2008) Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma., Free radical biology & medicine, 44 (8), 1677-86 Abstract
  • Adam LA, Smith BJ, Calva-Cerqueira D, Howe JR, Lal G (Mar 2008) Role for Limited Neck Exploration in Young Adults with Apparently Sporadic Primary Hyperparathyroidism., World journal of surgery Abstract
  • Khanna G, O'Dorisio MS, Menda Y, Glasier C, Deyoung B, Smith BJ, Graham M, Juweid M (Mar 2008) Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies., Pediatric blood & cancer, 50 (3), 561-6 Abstract
  • Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ (2008) Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth, Free Radic Biol Med, 44 (5), 856-67
  • Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ (Feb 2008) 2-Deoxy-d-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer., Free radical biology & medicine, 44 (3), 322-31 Abstract
  • Smith BJ, Oleson JJ (2008) Geostatistical hierarchial model for temporarlly integrated data measures with error, Journal of Agricultural, Biological, and Environmental Statistics, In Press
  • Cullen JJ, Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR (2008) 2-deoxy-d-glucose causes cytoxicity, oxidative stress, and radiosensitization in pancreatic cancer, Free Radical Biology and Medicine, In Press
  • Oleson JJ, Smith BJ, Kim H (2008) Joint spatio-temporal modeling of low incidence cancers sharing common risk factors, Journal of Data Science, In Press
  • Goodheart M, Jacobson G, Smith BJ, Zhou L (Jan-Feb 2008) Chemoradiation for invasive cervical cancer in elderly patients: Outcomes and morbidity, International Journal of Gynecological Cancer
  • Mazumdar S, Rushton G, Smith BJ, Zimmerman DL, Donham KJ (2008) Geocoding accuracy and the recovery of relationships between environmental exposures and health., International journal of health geographics, 7, 13 Abstract
  • Teoh ML, Sun W, Smith BJ, Oberley LW, Cullen JJ (2007) Modulation of reactive oxygen species in pancreatic cancer, Clin Cancer Res, 13 (24), 7441-50
  • Simons AL, Fath MA, Mattson DM, Smith BJ, Walsh SA, Graham MM, Hichwa RD, Buatti JM, Dornfeld K, Spitz DR (2007) Enhanced Response of Human Head and Neck Cancer Xenograft Tumors to Cisplatin Combined With 2-Deoxy-d-Glucose Correlates With Increased (18)F-FDG Uptake as Determined by PET Imaging, Int J Radiat Oncol Biol Phys, 69 (4), 1222-30
  • Lal G, Padmanabha L, Nicholson R, Smith BJ, Zhang L, Howe JR, Robinson RA, O'Dorisio MS (Nov 2007) ECM1 Expression in Thyroid Tumors-A Comparison of Real-Time RT-PCR and IHC., The Journal of surgical research Abstract
  • Calva-Cerqueira D, Smith BJ, Hostetler ML, Lal G, Menda Y, O'Dorisio TM, Howe JR (2007) Minimally invasive parathyroidectomy and preoperative MIBI scans: correlation of gland weight and preoperative PTH, J Am Coll Surg, 205 (4 Suppl), S38-44
  • Zhang Z, Smith B, Steck DJ, Guo Q, Field RW (2007) Variation in yearly residential radon concentrations in the Upper Midwest, Health Phys, 93 (4), 288-97
  • St Louis EK, Gidal BE, Henry TR, Kaydanova Y, Kromholz A, McCabe PH, Montouris GD, Rosenfeld WE, Smith BJ, Stern JM, Waterhouse EJ, Schulz RM, Garnett WR, Bramley T (2007) Conversions between monotherapies in epilepsy: Expert consensus, 11 (2), 222-34
  • Khanna G, O'Dorisio MS, Menda Y, Glasier c, Deyoung B, Smith BJ, Graham M, Juweid M (2007) Somatostatin receptor scintigraphy in surveillance of pediatric brain malignancies., Pediatr Blood Cancer
  • Smith B, Zhang L, Field WR (2007) Iowa radon leukemia study: A hierarchical population risk model for spatially correlated exposure measured with error, Stat Med
  • Pyeon D, Newton MA, Lambert PF, den Boon JA, Sengupta S, Marsit CJ, Woodworth CD, Connor JP, Haugen TH, Smith EM, Kelsey KT, Turek LP, Ahlquist P (2007) Fundamental Differences in Cell-Cycle Deregulation in Human Papillomavirus-Positive and -Negative Head/Neck and Cervical Cancers, Cancer Res, In Press
  • Smith BJ, Field RW (2007) Effect of housing factors and surfcial uranium on the spatial prediction of residential radon in Iowa, Environmentrics, 18 (5), 481-97
  • Lal G, Padmanabha L, Smith BJ, Nicholson RM, Howe JR, O'Dorisio MS, Domann FE Jr (2006) RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma, Cancer, 107 (12), 2752-9
  • Zhang Y, Smith BJ, Spitz DR, Oberley LW (2006) Enzymatic activity is necessary for the tumor-suppressive effects of MnSOD, Antioxid Redox Signal, 8 (7-8), 1282-93
  • Jacobson G, Betts V, Smith B (2006) Change in volume of lumpectomy cavity during external-beam irradiation of the intact breast, Int J Radiat Oncol Biol Phys, 65 (4), 1161-4
  • Weyer PJ, Smith BJ, Feng ZF, Kantammeni JR, Riley DG (2006) Comparison of nitrate levels in raw water and finished water from historical monitoring data on Iowa municipal drinking water supplies, Environ Monit Assess, 116 (1-3), 81-90
  • Joudi FN, Smith BJ, O'Donnell MA, Konety RG (2006) The impact of age on the response of patients with superficial bladder cancer to intravesical immunotherapy, J Urology, 175 (5), 1634-9 & 1639-40
  • Liu J, Du J, Zhang Y, Sun W, Smith BJ, Oberley LW, Cullen JJ (2006) Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase, Hum Gene Ther, 17 (1), 105-16
  • Slane BG, Aykin-Burns N, Andrekopoulos C, Kalyanaraman B, Smith BJ, Dormann FE, Spitz DR (2006) Mutation of Succinate Dehydrogenase Subunit C Results in Increased O2·-, Oxidative Stress, and Genomic Instability, Cancer Research, 66 (15), 7615-20
  • Konety BR, Veerasathpurush A, Modak S, Smith B, Luft HS (2006) Mortality following major surgery for urologic cancers in specialized urology hospitals: Are they any better?, Journal of Clinical Oncology, 1:24 (13), 2006-12
  • Jacobson GM, Kamath RS, Smith BJ, Goodheart MJ (Feb 2005) Thromboembolic events in patients treated with definitive chemotherapy and radiation therapy for invasive cervical cancer, 96 (2), 470-4
  • Robinson JG, Smith B, Maheshwari N, Schroll H (2005) "Pleiotropic" effects of statins: Benefit beyond cholesterol reduction? A meta-regression analysis, J Am Coll Cardiol, 46, 1855-1862
  • Field RW, Smith BJ, Platz CE, Robinson RA, Neuberger JS, Brus CP, Lynch CF, Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review, Journal of the National Cancer Institute, 96(14), 1105-7, July 2004 Abstract
  • Dennis LK, Snetselaar LG, Smith BJ, Stewart RE, Robbins MEC, Problems with the assessment of dietary fat in prostate cancer studies, Am J Epidemiol, 160(5), 2004
  • Rose SL, Goodheart MJ, DeYoung BR, Smith BJ, Buller RE, p21 expression predicts outcome in p53-null ovarian carcinoma, Clinical Cancer Research : an Official Journal of the American Association for Cancer Research., 9(3), 1028-32, March 2003 Abstract
  • Joudi FN, Smith BJ, O'Donnell MA, Konety B, Contemporary management of superficial bladder cancer in the United States - a pattern of care analysis, Urology, 62, 1083-1088, 2003
  • Rose SL, Robertson AD, Goodheart MJ, Smith BJ, DeYoung BR, Buller RE, The impact of p53 Protein Core Domain Structural Alteration on Ovarian Cancer Survival, Clinical Cancer Research, 9, 4130-4144, 2003
  • Stone PJ, Goodheart MJ, Rose SL, Smith BJ, DeYoung BR, Buller RE, The influence of microvessel density on ovarian carcinogenesis, Gynecologic Oncology, 90, 566-571, 2003
  • Field RW, Smith BJ, Steck DJ, Lynch CF, Residential radon exposure and lung cancer: variation in risk estimates using alternative exposure scenarios, Journal of Exposure Analysis and Environmental Epidemiology, 12(3), 197-203, 2002
  • Smith BJ, Bayesian Output Analysis Program (BOA), Version 0.99.1 for S-PLUS and R [On-line], Available: http://www.public-health.uiowa.edu/BOA, 8 May 2001
  • Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, The Iowa radon lung cancer study--phase I: Residential radon gas exposure and lung cancer, Science of the Total Environment, 272(1-3), 67-72, May 2001 Abstract
  • Smith BJ, Bayesian risk analysis of radon exposure data from the Iowa radon lung cancer study, Paper presented at University of Florida Department of Statistics, Conference on Monte Carlo in the New Millennium, Gainesville FL, 2001
  • Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EL, Neuberger JS, Platz CE, Robinson RA, Woolson RF, Lynch CF, Residential radon gas exposure and lung cancer: the Iowa Radon Lung Cancer Study, American Journal of Epidemiology, 151(11), 1091-102, 2000 Abstract
  • Smith BJ and Cowles MK, Bayesian spatial analysis for data obtained from multiple measurement sources, Paper presented at Eastern North American Region of the International Biometry Society, Chicago IL, 2000
  • Smith BJ and Cowles MK, Bayesian spatial analysis of radon exposure data from the Iowa radon lung cancer study, Paper presented at American Statistical Association, Iowa Chapter, Annual Meeting, Indianola IA, 2000
  • Smith BJ and Cowels MK, Bayesian spatial analysis of radon exposure data from the Iowa radon lung cancer study, Paper presented at American Statistical Association JSM, Indianapolis IN, 2000
  • Cowles MK and Smith BJ, Assessing the proportion of treatment effect captured by two surrogate markers measured longitudinally, Paper presented at the Biostatistics Seminar Series, The University of Iowa, Iowa City IA, 2000
  • Field RW, Smith BJ, and Lynch CF, Response to Straja and Moghissi concerning ecologic studies, Health Physics, 76(3), 318-319, 1999
  • Field RW, Lynch CF, Steck DJ, Smith BJ, Brus CP, Neuberger JS, Woolson RF, Fisher EF, Platz CE and Robinson RA, Iowa radon lung cancer study, Radiation Research, 151, 101-3, 1999
  • Field RW, Smith BJ, and Lynch CF, Cohen's paradox, Health Physics, 77(3), 328-9, 1999
  • Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, What do we know about the risk posed by residential radon? The Iowa radon lung cancer study, Paper presented at Illinois Environmental Health Association, Annual Education Conference, Peoria IL, 1999
  • Field RW (keynote speaker), Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, Beyond BEIR VI - The Iowa radon lung cancer study, Paper presented at University of Illinois at Chicago School of Public Health, Peoria IL, 1999
  • Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, The Iowa radon lung cancer study phase I: improved methods for residential radon exposure assessment, Paper presented at National Institute for Environmental Health Sciences, Interagency Workshop on the Role of Human Exposure Assessment in the Prevention of Environmental Disease; Rockville MD, 1999
  • Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, The Iowa radon lung cancer study phase I: residential radon gas exposure and lung cancer, Paper presented at European Commission, Directorate General for Science, R&D Radiation Research Unit, Radon in the Living Environment, Athens Greece, 1999
  • Fisher EL, Field RW, Smith BJ, Lynch CF, Steck DJ, Neuberger JS, Spatial variation of residential radon concentrations: the Iowa Radon Lung Cancer Study, Health Physics, 75(5), 506-13, November 1998 Abstract
  • Field RW, Smith BJ, Brus CP, Lynch CF, Neuberger JS, Steck DJ, Retrospective temporal and spatial mobility of adult Iowa women, Risk Analysis, 18(5), 575-84, October 1998 Abstract
  • Smith BJ, Field RW, Lynch CF, Residential 222Rn exposure and lung cancer: testing the linear no-threshold theory with ecologic data, Health Physics, 75(1), 11-7, July 1998 Abstract
  • Field RW, Smith BJ, and Lynch CF, Ecologic bias, a rejoinder to Cohen's response to 'Residential Rn-222 exposure and lung cancer: testing the linear no-threshold theory with ecologic data, Health Physics, 75(1), 31-33, 1998
  • Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, Indoor radon and risk of lung cancer: Iowa radon lung cancer study, Paper presented at American Statistical Association, San Diego CA, 1998
  • Smith BJ, Iowa radon lung cancer study: modeling the linear excess risk of lung cancer associated with radon exposure, Presented at Biostatistics Seminar Series, University of Iowa, Iowa City, IA, 1998
  • Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, Preliminary findings of the Iowa radon lung cancer study, Paper presented at Council of Radiation Control Program Directors, US Environmental Protection Agency, Cherry Hill, NJ, 1998
  • Field RW (keynote speaker), Steck DJ, Smith BJ, Brus CP, Fisher EF, Neuberger JS, Lynch CF, Preliminary findings of the Iowa radon lung cancer study, Paper presented at American Association of Radon Scientists and Technologists, Cherry Hill NJ, 1998

Profile Details

Last Updated: 6/23/2008

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