Fred Hutchinson Cancer Research Center Infectious Diseases Associate Member University of Washington School of Medicine Medicine Associate Professor |  |
Expertise and Research Interests- Cytomegalovirus: immune reconstitution, virus-host interactions, diagnostic, interaction with HIV, mechanisms of primary CMV infection via blood and stem cell products, impact in immunocompetent subjects, prevention in transplant and HIV-infected subjects
- Respiratory virus infections in immunocompromised hosts (RSV, parainfluenzaviruses, influenza viruses, coronaviruses, rhinoviruses, human metapneumovirus, adenoviruses, and bocaviruses): molecular diagnostic, disease associations, pathogenesis, immune response, treatment, prevention
- Genetic basis of infection complications: whole genome studies and gene expression studies
- VZV: epidemiology and management
- Infections in the immunocompromised host KeywordsCOS Keywords:Blood or Blood Products or Transfusions, HIV, Infectious Diseases or Agents, Organ Transplantation, Stem Cells.Additional Terms:Adenovirus, BK Virus, CMV, Cytomegalovirus, Genetics, Human Metapneumovirus, Immunocompromised, Parainfluenzavirus, RSV, Respiratory Syncytial Virus, Transplant, VZV.Languages(Reading, Writing, Speaking)English: (Fluent, Fluent, Fluent) German: (Fluent, Fluent, Fluent) MembershipsAmerican Society for Blood and Marrow Transplantation American Society for Microbiology American Society of Hematology European Society of Clinical Microbiology and Infectious Diseases German Society for Infectious Diseases Infectious Diseases Society of America International Society for Antiviral Research International Society for Infections in the Immunocompromised Host Publications- Hakki M, Limaye AP, Kim HW, Kirby KA, Corey L, Boeckh M (2007) Invasive Pseudomonas aeruginosa infections: high rate of recurrence and mortality after hematopoietic cell transplantation., Bone Marrow Transplant., 39 (11), 687-93
- Kim YJ, Boeckh M, Englund JA (2007) Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection., Semin Respir Crit Care Med., 28 (2), 222-42
- Upton A, Kirby KA, Carpenter P, Boeckh M, Marr KA (2007) Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality., Clin Infect Dis, 44 (4), 531-40
- Boeckh M, Englund J, Li Y, Miller C, Cross A, Fernandez H, Kuypers J, Kim H, Gnann J, Whitley R, NIAID Collaborative Antiviral Study Group (2007) Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients., Clin Infect Dis, 44 (2), 1377-83
- Baron F, Storer B, Maris MB, Storek J, Piette F, Metcalf M, White K, Sandmaier BM, Maloney DG, Storb R, Boeckh M (2006) Factors Affecting Immunologic Recovery after Nonmyeloablative Conditioning, Biol Blood Marrow Transplant, 12 (11), 1176-87
- Erard V, Guthrie KA, Riddell S, Boeckh M (2006) Impact of HLA A2 and cytomegalovirus serostatus on outcomes in patients with leukemia following matched-sibling myeloablative allogeneic hematopoietic cell transplantation., Haematologica, 91 (10), 1377-83
- Limaye AP, Bakthavatsalam R, Kim HW, Randolph SE, Halldorson JB, Healey PJ, Kuhr CS, Levy AE, Perkins JD, Reyes JD, Boeckh M (2006) Impact of cytomegalovirus in organ transplant recipients in the era of antiviral prophylaxis., Transplantation, 81 (12), 1645-52
- Deeg HJ, Storer BE, Boeckh M, Martin PJ, McCcne JS, Et Al (2006) Reduced incidence of acute and chronic graft-versus-host disease with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimen., Biol Blood Marrow Transplant, 12 (5), 573-84
- Loeffler J, Steffens M, Arlt EM, Toliat MR, Mezger M, Suk A, Wienker TF, Hebart H, Nürnberg P, Boeckh M, Ljungman P, Trenschel R, Einsele H (2006) Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation., J Clin Microbiol, 44 (5), 1847-50
- Erard V, Chien JW, Kim HW, Nichols WG, Flowers ME, Martin PJ, Corey L, Boeckh M (2006) Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses., J Infect Dis., 193 (12), 1619-25
- Englund JA, Boeckh M, Kuypers J, Nichols WG, Hackman RC, Morrow RA, Fredricks DN, Corey L (2006) Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients., Annals of Internal Medicine, 144 (5), 344-9
- Boeckh M, Kim HW, Meyers JD, Bowden RA (Nov 2005) Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation--a randomized double-blind placebo-controlled study., Blood, 107 (5), 1800-5
- Erard V, Kim HW, Corey L, Limaye A, Huang ML, Myerson D, Davis C, Boeckh M (Aug 2005) BK DNA viral load in plasma: evidence for an association with hemorrhagic
cystitis in allogeneic hematopoietic cell transplant
recipients., Blood, 106 (3), 1130-2
 - Sangiolo D, Storer B, Nash R, Corey L, Davis C, Flowers M, Hackman RC, Boeckh M (Jul 2005) Toxicity and efficacy of daily dapsone as Pneumocystis jiroveci
prophylaxis after hematopoietic stem cell transplantation: a case-control
study., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (7), 521-9
 - Parkin RK, Boeckh MJ, Erard V, Huang ML, Myerson D (Apr 2005) Specific delineation of BK polyomavirus in kidney tissue with a
digoxigenin-labeled DNA probe., Molecular and Cellular Probes, 19 (2), 87-92
 - Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M (Apr 2005) Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic
stem cell transplantation., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 40 (7), 932-40
 - Limaye AP, Smith KD, Cook L, Groom DA, Hunt NC, Jerome KR, Boeckh M (Mar 2005) Polyomavirus nephropathy in native kidneys of non-renal transplant
recipients., American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons., 5 (3), 614-20
 - Fries BC, Riddell SR, Kim HW, Corey L, Dahlgren C, Woolfrey A, Boeckh M (Feb 2005) Cytomegalovirus disease before hematopoietic cell transplantation as a
risk for complications after transplantation., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (2), 136-48
 - Erard V, Storer B, Corey L, Nollkamper J, Huang ML, Limaye A, Boeckh M (Dec 2004) BK virus infection in hematopoietic stem cell transplant recipients:
frequency, risk factors, and association with postengraftment hemorrhagic
cystitis., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39 (12), 1861-5
 - Limaye AP, Bakthavatsalam R, Kim HW, Kuhr CS, Halldorson JB, Healey PJ, Boeckh M, Late-onset cytomegalovirus disease in liver transplant recipients despite
antiviral prophylaxis, Transplantation, 78(9), 1390-6, Nov 2004
 - Nichols WG, Guthrie KA, Corey L, Boeckh M (Nov 2004) Influenza infections after hematopoietic stem cell transplantation: risk
factors, mortality, and the effect of antiviral therapy., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39 (9), 1300-6
 - Peck AJ, Corey L, Boeckh M, Pretransplantation respiratory syncytial virus infection: impact of a
strategy to delay transplantation, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39(5), 673-80, Sep 2004
 - Marr KA, Boeckh M, Carter RA, Kim HW, Corey L, Combination antifungal therapy for invasive aspergillosis, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39(6), 797-802, Sep 2004
 - Manley TJ, Luy L, Jones T, Boeckh M, Mutimer H, Riddell SR, Immune evasion proteins of human cytomegalovirus do not prevent a diverse
CD8+ cytotoxic T-cell response in natural infection, Blood, 104(4), 1075-82, Aug 2004
 - Weinstock DM, Boeckh M, Boulad F, Eagan JA, Fraser VJ, Henderson DK, Perl TM, Yokoe D, Sepkowitz KA, Postexposure prophylaxis against varicella-zoster virus infection among
recipients of hematopoietic stem cell transplant: unresolved
issues, Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America., 25(7), 603-8, Jul 2004
 - Fukuda T, Boeckh M, Guthrie KA, Mattson DK, Owens S, Wald A, Sandmaier BM, Corey L, Storb RF, Marr KA, Invasive aspergillosis before allogeneic hematopoietic stem cell
transplantation: 10-year experience at a single transplant
center, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 10(7), 494-503, Jul 2004
 - Boeckh M, Fries B, Nichols WG, Recent advances in the prevention of CMV infection and disease after
hematopoietic stem cell transplantation, Pediatric Transplantation, 8 Suppl 5, 19-27, Jun 2004
 - Bruno B, Zager RA, Boeckh MJ, Gooley TA, Myerson DH, Huang ML, Hackman RC, Adenovirus nephritis in hematopoietic stem-cell transplantation, Transplantation, 77(7), 1049-57, Apr 2004
 - Boeckh M, Nichols WG, The impact of cytomegalovirus serostatus of donor and recipient before
hematopoietic stem cell transplantation in the era of antiviral
prophylaxis and preemptive therapy, Blood, 103(6), 2003-8, Mar 2004
 - Boeckh M, Huang M, Ferrenberg J, Stevens-Ayers T, Stensland L, Nichols WG, Corey L, Optimization of quantitative detection of cytomegalovirus DNA in plasma by
real-time PCR, Journal of Clinical Microbiology, 42(3), 1142-8, Mar 2004
 - Marr KA, Leisenring W, Crippa F, Slattery JT, Corey L, Boeckh M, McDonald GB, Cyclophosphamide metabolism is affected by azole antifungals, Blood, 103(4), 1557-9, Feb 2004
 - Marr KA, Crippa F, Leisenring W, Hoyle M, Boeckh M, Balajee SA, Nichols WG, Musher B, Corey L, Itraconazole versus fluconazole for prevention of fungal infections in
patients receiving allogeneic stem cell transplants, Blood, 103(4), 1527-33, Feb 2004
 - Storek J, Dawson MA, Lim LC, Burman BE, Stevens-Ayers T, Viganego F, Herremans MM, Flowers ME, Witherspoon RP, Maloney DG, Boeckh M, Efficacy of donor vaccination before hematopoietic cell transplantation
and recipient vaccination both before and early after
transplantation, Bone Marrow Transplantation, 33(3), 337-46, Feb 2004
 - Nichols WG, Erdman DD, Han A, Zukerman C, Corey L, Boeckh M, Prolonged outbreak of human parainfluenza virus 3 infection in a stem cell
transplant outpatient department: insights from molecular epidemiologic
analysis, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 10(1), 58-64, Jan 2004
 - Hakki M, Riddell SR, Storek J, Carter RA, Stevens-Ayers T, Sudour P, White K, Corey L, Boeckh M, Immune reconstitution to cytomegalovirus after allogeneic hematopoietic
stem cell transplantation: impact of host factors, drug therapy, and
subclinical reactivation, Blood, 102(8), 3060-7, Oct 2003
 - Maris M, Boeckh M, Storer B, Dawson M, White K, Keng M, Sandmaier B, Maloney D, Storb R, Storek J, Immunologic recovery after hematopoietic cell transplantation with
nonmyeloablative conditioning, Experimental Hematology, 31(10), 941-52, Oct 2003
 - Fukuda T, Hackman RC, Guthrie KA, Sandmaier BM, Boeckh M, Maris MB, Maloney DG, Deeg HJ, Martin PJ, Storb RF, Madtes DK, Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative
and conventional conditioning regimens for allogeneic hematopoietic stem
cell transplantation, Blood, 102(8), 2777-85, Oct 2003
 - Boeckh M, Nichols WG, Papanicolaou G, Rubin R, Wingard JR, Zaia J, Cytomegalovirus in hematopoietic stem cell transplant recipients: Current
status, known challenges, and future strategies, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9(9), 543-58, Sep 2003
 - Chen CS, Boeckh M, Seidel K, Clark JG, Kansu E, Madtes DK, Wagner JL, Witherspoon RP, Anasetti C, Appelbaum FR, Bensinger WI, Deeg HJ, Martin PJ, Sanders JE, Storb R, Storek J, Wade J, Siadak M, Flowers ME, Sullivan KM, Incidence, risk factors, and mortality from pneumonia developing late
after hematopoietic stem cell transplantation, Bone Marrow Transplantation, 32(5), 515-22, Sep 2003
 - Fukuda T, Boeckh M, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Martin PJ, Storb RF, Marr KA, Risks and outcomes of invasive fungal infections in recipients of
allogeneic hematopoietic stem cell transplants after nonmyeloablative
conditioning, Blood, 102(3), 827-33, Aug 2003
 - Boeckh M, Nichols WG, Immunosuppressive effects of beta-herpesviruses, Herpes : the Journal of the Ihmf, 10(1), 12-6, May 2003
 - Nichols WG, Price TH, Gooley T, Corey L, Boeckh M, Transfusion-transmitted cytomegalovirus infection after receipt of
leukoreduced blood products, Blood, 101(10), 4195-200, May 2003
 - Ison MG, Hayden FG, Kaiser L, Corey L, Boeckh M, Rhinovirus infections in hematopoietic stem cell transplant recipients
with pneumonia, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 36(9), 1139-43, May 2003
 - Bruno B, Gooley T, Hackman RC, Davis C, Corey L, Boeckh M, Adenovirus infection in hematopoietic stem cell transplantation: effect of
ganciclovir and impact on survival, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9(5), 341-52, May 2003
 - Storek J, Viganego F, Dawson MA, Herremans MM, Boeckh M, Flowers ME, Storer B, Bensinger WI, Witherspoon RP, Maloney DG, Factors affecting antibody levels after allogeneic hematopoietic cell
transplantation, Blood, 101(8), 3319-24, Apr 2003
 - Nichols WG, Boeckh M, Carter RA, Wald A, Corey L, Transferred herpes simplex virus immunity after stem-cell transplantation:
clinical implications, The Journal of Infectious Diseases, 187(5), 801-8, Mar 2003
 - Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, Stevens-Ayers T, Flowers ME, Cunningham T, Corey L (Jan 2003) Late cytomegalovirus disease and mortality in recipients of allogeneic
hematopoietic stem cell transplants: importance of viral load and T-cell
immunity., Blood, 101 (2), 407-14
 - Marr KA, Carter RA, Boeckh M, Martin P, Corey L, Invasive aspergillosis in allogeneic stem cell transplant recipients:
changes in epidemiology and risk factors, Blood, 100(13), 4358-66, Dec 2002
 - Boeckh M, Nichols WG, Marr KA, Long-term care after hematopoietic-cell transplantation in adults, The New England Journal of Medicine, 347(20), 1625-6; author reply, Nov 2002
 - Hubel K, Carter RA, Liles WC, Dale DC, Price TH, Bowden RA, Rowley SD, Chauncey TR, Bensinger WI, Boeckh M, Granulocyte transfusion therapy for infections in candidates and
recipients of HPC transplantation: a comparative analysis of feasibility
and outcome for community donors versus related do, Transfusion, 42(11), 1414-21, Nov 2002
 - Mutimer HP, Akatsuka Y, Manley T, Chuang EL, Boeckh M, Harrington R, Jones T, Riddell SR, Association between immune recovery uveitis and a diverse intraocular
cytomegalovirus-specific cytotoxic T cell response, The Journal of Infectious Diseases, 186(5), 701-5, Sep 2002
 - Nichols WG, Price T, Boeckh M, Cytomegalovirus infections in cancer patients receiving granulocyte
transfusions, Blood, 99(9), 3483-4, May 2002
 - Junghanss C, Boeckh M, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Chauncey T, McSweeney PA, Little MT, Corey L, Storb R, Incidence and outcome of cytomegalovirus infections following
nonmyeloablative compared with myeloablative allogeneic stem cell
transplantation, a matched control study, Blood, 99(6), 1978-85, Mar 2002
 - Nichols WG, Corey L, Gooley T, Davis C, Boeckh M, High risk of death due to bacterial and fungal infection among
cytomegalovirus (CMV)-seronegative recipients of stem cell transplants
from seropositive donors: evidence for indirect effect, The Journal of Infectious Diseases, 185(3), 273-82, Feb 2002
 - Corey L, Boeckh M, Persistent fever in patients with neutropenia, The New England Journal of Medicine, 346(4), 222-4, Jan 2002
 - Limaye AP, Raghu G, Koelle DM, Ferrenberg J, Huang ML, Boeckh M, High incidence of ganciclovir-resistant cytomegalovirus infection among
lung transplant recipients receiving preemptive therapy, The Journal of Infectious Diseases, 185(1), 20-7, Jan 2002
 - Crippa F, Holmberg L, Carter RA, Hooper H, Marr KA, Bensinger W, Chauncey T, Corey L, Boeckh M, Infectious complications after autologous CD34-selected peripheral blood
stem cell transplantation, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 8(5), 281-9, 2002
 - Li, F, Kenyon, Kirby K, Fishbein D, Boeckh M, Limaye A, Incidence and Clinical Features of Ganciclovir-Resistant Cytomegalovirus in Heart Transplant Recipients., Clin. Infect. Dis, In Press
- Vu D*, Peck A*, Englund J, Nichols W.G, Varley C, Corey L, Boeckh, M, (* Contributed Equally)., Oseltamivir Prophylaxis in Hematopoietic Cell Transplantation Recipients: A Case-Control Study, Clin. Inf. Dis., In Press
- Peck A.J, Englund JA, Kuypers J, Guthrie KA, Corey L, Morrow R, Hackman RC, Cent A, Boeckh M, Respiratory Virus Infection among Hematopoietic Cell Transplantation Recipients: Evidence for Asymptomatic Parainfluenza Virus Infection, Blood, In Press
- Erard V, Guthrie KA, Varley C, Heugel J, Wald A, Flowers ME, Corey L, Boeckh M, One-year acyclovir prophylaxis for preventing varicella-zoster virus (VZV) disease following hematopoietic cell transplantation: no evidence of rebound VZV disease after drug discontinuation, Blood, In Press
- Erard V, Huang ML, Ferrenberg J, Nguy L, Stevens-Ayers TL, Hackman R, Corey L, Boeckh M, Quantitative Real-time PCR for Adenoviruses after T Cell-replete Hematopoietic Cell Transplantation: Viral Load as a Marker for Invasive Disease, Clin. Inf. Dis., In Press
Profile DetailsIndividual Expertise profile of Michael J. Boeckh, Copyright Michael J. Boeckh. © COS Expertise TM, 2008, ProQuest LLC All rights reserved. |