Michael J. Boeckh

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Fred Hutchinson Cancer Research Center
Infectious Diseases
Associate Member
University of Washington
School of Medicine
Medicine
Associate Professor
Professional Headshot of Michael J. Boeckh

Mailing Address

1100 Fairview Avenue N.
D3-100
Seattle, Washington 98109
United States

Contact Information

Phone: (206) 667-6702
Fax: (206) 667-4411
mboeckh@fhcrc.org

Qualifications

M.D..

Expertise and Research Interests

- Cytomegalovirus: immune reconstitution, virus-host interactions, diagnostic, interaction with HIV, mechanisms of primary CMV infection via blood and stem cell products, impact in immunocompetent subjects, prevention in transplant and HIV-infected subjects
- Respiratory virus infections in immunocompromised hosts (RSV, parainfluenzaviruses, influenza viruses, coronaviruses, rhinoviruses, human metapneumovirus, adenoviruses, and bocaviruses): molecular diagnostic, disease associations, pathogenesis, immune response, treatment, prevention
- Genetic basis of infection complications: whole genome studies and gene expression studies
- VZV: epidemiology and management
- Infections in the immunocompromised host

Keywords

COS Keywords:

Blood or Blood Products or Transfusions, HIV, Infectious Diseases or Agents, Organ Transplantation, Stem Cells.

Additional Terms:

Adenovirus, BK Virus, CMV, Cytomegalovirus, Genetics, Human Metapneumovirus, Immunocompromised, Parainfluenzavirus, RSV, Respiratory Syncytial Virus, Transplant, VZV.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)

Memberships

American Society for Blood and Marrow Transplantation
American Society for Microbiology
American Society of Hematology
European Society of Clinical Microbiology and Infectious Diseases
German Society for Infectious Diseases
Infectious Diseases Society of America
International Society for Antiviral Research
International Society for Infections in the Immunocompromised Host

Honors and Awards

Ph.D. in Medicine,

Publications

  • Hakki M, Limaye AP, Kim HW, Kirby KA, Corey L, Boeckh M (2007) Invasive Pseudomonas aeruginosa infections: high rate of recurrence and mortality after hematopoietic cell transplantation., Bone Marrow Transplant., 39 (11), 687-93
  • Kim YJ, Boeckh M, Englund JA (2007) Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection., Semin Respir Crit Care Med., 28 (2), 222-42
  • Upton A, Kirby KA, Carpenter P, Boeckh M, Marr KA (2007) Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality., Clin Infect Dis, 44 (4), 531-40
  • Boeckh M, Englund J, Li Y, Miller C, Cross A, Fernandez H, Kuypers J, Kim H, Gnann J, Whitley R, NIAID Collaborative Antiviral Study Group (2007) Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients., Clin Infect Dis, 44 (2), 1377-83
  • Baron F, Storer B, Maris MB, Storek J, Piette F, Metcalf M, White K, Sandmaier BM, Maloney DG, Storb R, Boeckh M (2006) Factors Affecting Immunologic Recovery after Nonmyeloablative Conditioning, Biol Blood Marrow Transplant, 12 (11), 1176-87
  • Erard V, Guthrie KA, Riddell S, Boeckh M (2006) Impact of HLA A2 and cytomegalovirus serostatus on outcomes in patients with leukemia following matched-sibling myeloablative allogeneic hematopoietic cell transplantation., Haematologica, 91 (10), 1377-83
  • Limaye AP, Bakthavatsalam R, Kim HW, Randolph SE, Halldorson JB, Healey PJ, Kuhr CS, Levy AE, Perkins JD, Reyes JD, Boeckh M (2006) Impact of cytomegalovirus in organ transplant recipients in the era of antiviral prophylaxis., Transplantation, 81 (12), 1645-52
  • Deeg HJ, Storer BE, Boeckh M, Martin PJ, McCcne JS, Et Al (2006) Reduced incidence of acute and chronic graft-versus-host disease with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimen., Biol Blood Marrow Transplant, 12 (5), 573-84
  • Loeffler J, Steffens M, Arlt EM, Toliat MR, Mezger M, Suk A, Wienker TF, Hebart H, Nürnberg P, Boeckh M, Ljungman P, Trenschel R, Einsele H (2006) Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation., J Clin Microbiol, 44 (5), 1847-50
  • Erard V, Chien JW, Kim HW, Nichols WG, Flowers ME, Martin PJ, Corey L, Boeckh M (2006) Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses., J Infect Dis., 193 (12), 1619-25
  • Englund JA, Boeckh M, Kuypers J, Nichols WG, Hackman RC, Morrow RA, Fredricks DN, Corey L (2006) Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients., Annals of Internal Medicine, 144 (5), 344-9
  • Boeckh M, Kim HW, Meyers JD, Bowden RA (Nov 2005) Long-term acyclovir for prevention of varicella zoster virus disease after allogeneic hematopoietic cell transplantation--a randomized double-blind placebo-controlled study., Blood, 107 (5), 1800-5
  • Erard V, Kim HW, Corey L, Limaye A, Huang ML, Myerson D, Davis C, Boeckh M (Aug 2005) BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients., Blood, 106 (3), 1130-2 Abstract
  • Sangiolo D, Storer B, Nash R, Corey L, Davis C, Flowers M, Hackman RC, Boeckh M (Jul 2005) Toxicity and efficacy of daily dapsone as Pneumocystis jiroveci prophylaxis after hematopoietic stem cell transplantation: a case-control study., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (7), 521-9 Abstract
  • Parkin RK, Boeckh MJ, Erard V, Huang ML, Myerson D (Apr 2005) Specific delineation of BK polyomavirus in kidney tissue with a digoxigenin-labeled DNA probe., Molecular and Cellular Probes, 19 (2), 87-92 Abstract
  • Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M (Apr 2005) Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 40 (7), 932-40 Abstract
  • Limaye AP, Smith KD, Cook L, Groom DA, Hunt NC, Jerome KR, Boeckh M (Mar 2005) Polyomavirus nephropathy in native kidneys of non-renal transplant recipients., American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons., 5 (3), 614-20 Abstract
  • Fries BC, Riddell SR, Kim HW, Corey L, Dahlgren C, Woolfrey A, Boeckh M (Feb 2005) Cytomegalovirus disease before hematopoietic cell transplantation as a risk for complications after transplantation., Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 11 (2), 136-48 Abstract
  • Erard V, Storer B, Corey L, Nollkamper J, Huang ML, Limaye A, Boeckh M (Dec 2004) BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39 (12), 1861-5 Abstract
  • Limaye AP, Bakthavatsalam R, Kim HW, Kuhr CS, Halldorson JB, Healey PJ, Boeckh M, Late-onset cytomegalovirus disease in liver transplant recipients despite antiviral prophylaxis, Transplantation, 78(9), 1390-6, Nov 2004 Abstract
  • Nichols WG, Guthrie KA, Corey L, Boeckh M (Nov 2004) Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy., Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39 (9), 1300-6 Abstract
  • Peck AJ, Corey L, Boeckh M, Pretransplantation respiratory syncytial virus infection: impact of a strategy to delay transplantation, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39(5), 673-80, Sep 2004 Abstract
  • Marr KA, Boeckh M, Carter RA, Kim HW, Corey L, Combination antifungal therapy for invasive aspergillosis, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 39(6), 797-802, Sep 2004 Abstract
  • Manley TJ, Luy L, Jones T, Boeckh M, Mutimer H, Riddell SR, Immune evasion proteins of human cytomegalovirus do not prevent a diverse CD8+ cytotoxic T-cell response in natural infection, Blood, 104(4), 1075-82, Aug 2004 Abstract
  • Weinstock DM, Boeckh M, Boulad F, Eagan JA, Fraser VJ, Henderson DK, Perl TM, Yokoe D, Sepkowitz KA, Postexposure prophylaxis against varicella-zoster virus infection among recipients of hematopoietic stem cell transplant: unresolved issues, Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America., 25(7), 603-8, Jul 2004 Abstract
  • Fukuda T, Boeckh M, Guthrie KA, Mattson DK, Owens S, Wald A, Sandmaier BM, Corey L, Storb RF, Marr KA, Invasive aspergillosis before allogeneic hematopoietic stem cell transplantation: 10-year experience at a single transplant center, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 10(7), 494-503, Jul 2004 Abstract
  • Boeckh M, Fries B, Nichols WG, Recent advances in the prevention of CMV infection and disease after hematopoietic stem cell transplantation, Pediatric Transplantation, 8 Suppl 5, 19-27, Jun 2004 Abstract
  • Bruno B, Zager RA, Boeckh MJ, Gooley TA, Myerson DH, Huang ML, Hackman RC, Adenovirus nephritis in hematopoietic stem-cell transplantation, Transplantation, 77(7), 1049-57, Apr 2004 Abstract
  • Boeckh M, Nichols WG, The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy, Blood, 103(6), 2003-8, Mar 2004 Abstract
  • Boeckh M, Huang M, Ferrenberg J, Stevens-Ayers T, Stensland L, Nichols WG, Corey L, Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR, Journal of Clinical Microbiology, 42(3), 1142-8, Mar 2004 Abstract
  • Marr KA, Leisenring W, Crippa F, Slattery JT, Corey L, Boeckh M, McDonald GB, Cyclophosphamide metabolism is affected by azole antifungals, Blood, 103(4), 1557-9, Feb 2004 Abstract
  • Marr KA, Crippa F, Leisenring W, Hoyle M, Boeckh M, Balajee SA, Nichols WG, Musher B, Corey L, Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants, Blood, 103(4), 1527-33, Feb 2004 Abstract
  • Storek J, Dawson MA, Lim LC, Burman BE, Stevens-Ayers T, Viganego F, Herremans MM, Flowers ME, Witherspoon RP, Maloney DG, Boeckh M, Efficacy of donor vaccination before hematopoietic cell transplantation and recipient vaccination both before and early after transplantation, Bone Marrow Transplantation, 33(3), 337-46, Feb 2004 Abstract
  • Nichols WG, Erdman DD, Han A, Zukerman C, Corey L, Boeckh M, Prolonged outbreak of human parainfluenza virus 3 infection in a stem cell transplant outpatient department: insights from molecular epidemiologic analysis, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 10(1), 58-64, Jan 2004 Abstract
  • Hakki M, Riddell SR, Storek J, Carter RA, Stevens-Ayers T, Sudour P, White K, Corey L, Boeckh M, Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation, Blood, 102(8), 3060-7, Oct 2003 Abstract
  • Maris M, Boeckh M, Storer B, Dawson M, White K, Keng M, Sandmaier B, Maloney D, Storb R, Storek J, Immunologic recovery after hematopoietic cell transplantation with nonmyeloablative conditioning, Experimental Hematology, 31(10), 941-52, Oct 2003 Abstract
  • Fukuda T, Hackman RC, Guthrie KA, Sandmaier BM, Boeckh M, Maris MB, Maloney DG, Deeg HJ, Martin PJ, Storb RF, Madtes DK, Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplantation, Blood, 102(8), 2777-85, Oct 2003 Abstract
  • Boeckh M, Nichols WG, Papanicolaou G, Rubin R, Wingard JR, Zaia J, Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9(9), 543-58, Sep 2003 Abstract
  • Chen CS, Boeckh M, Seidel K, Clark JG, Kansu E, Madtes DK, Wagner JL, Witherspoon RP, Anasetti C, Appelbaum FR, Bensinger WI, Deeg HJ, Martin PJ, Sanders JE, Storb R, Storek J, Wade J, Siadak M, Flowers ME, Sullivan KM, Incidence, risk factors, and mortality from pneumonia developing late after hematopoietic stem cell transplantation, Bone Marrow Transplantation, 32(5), 515-22, Sep 2003 Abstract
  • Fukuda T, Boeckh M, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Martin PJ, Storb RF, Marr KA, Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning, Blood, 102(3), 827-33, Aug 2003 Abstract
  • Boeckh M, Nichols WG, Immunosuppressive effects of beta-herpesviruses, Herpes : the Journal of the Ihmf, 10(1), 12-6, May 2003 Abstract
  • Nichols WG, Price TH, Gooley T, Corey L, Boeckh M, Transfusion-transmitted cytomegalovirus infection after receipt of leukoreduced blood products, Blood, 101(10), 4195-200, May 2003 Abstract
  • Ison MG, Hayden FG, Kaiser L, Corey L, Boeckh M, Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia, Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America., 36(9), 1139-43, May 2003 Abstract
  • Bruno B, Gooley T, Hackman RC, Davis C, Corey L, Boeckh M, Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 9(5), 341-52, May 2003 Abstract
  • Storek J, Viganego F, Dawson MA, Herremans MM, Boeckh M, Flowers ME, Storer B, Bensinger WI, Witherspoon RP, Maloney DG, Factors affecting antibody levels after allogeneic hematopoietic cell transplantation, Blood, 101(8), 3319-24, Apr 2003 Abstract
  • Nichols WG, Boeckh M, Carter RA, Wald A, Corey L, Transferred herpes simplex virus immunity after stem-cell transplantation: clinical implications, The Journal of Infectious Diseases, 187(5), 801-8, Mar 2003 Abstract
  • Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, Stevens-Ayers T, Flowers ME, Cunningham T, Corey L (Jan 2003) Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity., Blood, 101 (2), 407-14 Abstract
  • Marr KA, Carter RA, Boeckh M, Martin P, Corey L, Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors, Blood, 100(13), 4358-66, Dec 2002 Abstract
  • Boeckh M, Nichols WG, Marr KA, Long-term care after hematopoietic-cell transplantation in adults, The New England Journal of Medicine, 347(20), 1625-6; author reply, Nov 2002 Abstract
  • Hubel K, Carter RA, Liles WC, Dale DC, Price TH, Bowden RA, Rowley SD, Chauncey TR, Bensinger WI, Boeckh M, Granulocyte transfusion therapy for infections in candidates and recipients of HPC transplantation: a comparative analysis of feasibility and outcome for community donors versus related do, Transfusion, 42(11), 1414-21, Nov 2002 Abstract
  • Mutimer HP, Akatsuka Y, Manley T, Chuang EL, Boeckh M, Harrington R, Jones T, Riddell SR, Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response, The Journal of Infectious Diseases, 186(5), 701-5, Sep 2002 Abstract
  • Nichols WG, Price T, Boeckh M, Cytomegalovirus infections in cancer patients receiving granulocyte transfusions, Blood, 99(9), 3483-4, May 2002 Abstract
  • Junghanss C, Boeckh M, Carter RA, Sandmaier BM, Maris MB, Maloney DG, Chauncey T, McSweeney PA, Little MT, Corey L, Storb R, Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study, Blood, 99(6), 1978-85, Mar 2002 Abstract
  • Nichols WG, Corey L, Gooley T, Davis C, Boeckh M, High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effect, The Journal of Infectious Diseases, 185(3), 273-82, Feb 2002 Abstract
  • Corey L, Boeckh M, Persistent fever in patients with neutropenia, The New England Journal of Medicine, 346(4), 222-4, Jan 2002 Abstract
  • Limaye AP, Raghu G, Koelle DM, Ferrenberg J, Huang ML, Boeckh M, High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy, The Journal of Infectious Diseases, 185(1), 20-7, Jan 2002 Abstract
  • Crippa F, Holmberg L, Carter RA, Hooper H, Marr KA, Bensinger W, Chauncey T, Corey L, Boeckh M, Infectious complications after autologous CD34-selected peripheral blood stem cell transplantation, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation., 8(5), 281-9, 2002 Abstract
  • Li, F, Kenyon, Kirby K, Fishbein D, Boeckh M, Limaye A, Incidence and Clinical Features of Ganciclovir-Resistant Cytomegalovirus in Heart Transplant Recipients., Clin. Infect. Dis, In Press
  • Vu D*, Peck A*, Englund J, Nichols W.G, Varley C, Corey L, Boeckh, M, (* Contributed Equally)., Oseltamivir Prophylaxis in Hematopoietic Cell Transplantation Recipients: A Case-Control Study, Clin. Inf. Dis., In Press
  • Peck A.J, Englund JA, Kuypers J, Guthrie KA, Corey L, Morrow R, Hackman RC, Cent A, Boeckh M, Respiratory Virus Infection among Hematopoietic Cell Transplantation Recipients: Evidence for Asymptomatic Parainfluenza Virus Infection, Blood, In Press
  • Erard V, Guthrie KA, Varley C, Heugel J, Wald A, Flowers ME, Corey L, Boeckh M, One-year acyclovir prophylaxis for preventing varicella-zoster virus (VZV) disease following hematopoietic cell transplantation: no evidence of rebound VZV disease after drug discontinuation, Blood, In Press
  • Erard V, Huang ML, Ferrenberg J, Nguy L, Stevens-Ayers TL, Hackman R, Corey L, Boeckh M, Quantitative Real-time PCR for Adenoviruses after T Cell-replete Hematopoietic Cell Transplantation: Viral Load as a Marker for Invasive Disease, Clin. Inf. Dis., In Press

Profile Details

Last Updated: 2/27/2008

COS Expertise ID #803087
Reference this profile directly: http://myprofile.cos.com/boeckh