Dr. Robert Bonnah

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Oregon Health & Science University
School of Medicine (SOM)
Vaccine & Gene Therapy Institute
Research Assistant ProfessorAppointed: 2001
Professional Headshot of Robert Bonnah

Mailing Address

3181 S.W. Sam Jackson Park Rd. L220
Oregon Health Sciences University
Dept. of Molecular Microbiology & Immunology
Portland, Oregon 97239
United States

Contact Information

Phone: (503) 494-6840
Fax: (503) 494-6862
BONNAHR@OHSU.EDU

Qualifications

Research Assistant Professor, Vaccine & Gene Therapy Institute, 2001.
Postdoctoral Fellow, Oregon Health Sciences University, Molecular Microbiology and Immunology, 1998.
Ph.D., University of Calgary, Microbiology and Infectious Diseases, 1997.
Postdoctoral Fellow, University of Calgary, Microbiology and Infectious Diseases, 1997.
M.Sc., University of Alberta, Medical Microbiology and Infectious Diseases, 1991.
B.Sc., University of Alberta, Biology and Chemistry, 1989.

Expertise and Research Interests

Bacterial pathogenesis
Cellular microbiology
Iron
Iron acquisition
Bacteria
Microbiology
Siderophores
Transferrin
Transferrin binding proteins
Lactoferrin
Lactoferrin binding proteins
Heme
Hemoglobin
Iron regulatory proteins
PCR
Cloning
Mutations
Haptoglobin
Haptoglobin binding proteins

Other Expertise

RT-PCR
Unique Cloning Strategies

Future Research

Identify Bacterial Factors Responsible For Altering Host Transferrin Receptor Cycling and Downregulation of Host Transferrin Receptors

Industrial Relevance

The bacterial factors responsible for altering host transferrin receptor recycling may be an Achilles heel for the bacteria. Targeting this bacterial factor may lead to a unique vaccination target that may prevent the crucial acquisition of iron by the bacteria. In addition, bacterial factors that slow down cycling of transferrin receptors have not yet been described. It is possible these factors may also provide a unique therapy strategy for iron overload disorders such as hemachromatosis, a disorder that affects a large number of individuals worldwide.

Keywords

COS Keywords:

Gene Therapy, Immunology, Infectious Diseases or Agents, Membranes, Microbiology, Molecular Cloning, Vaccine.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Society for Microbiology
International BioIron Society

Honors and Awards

2004-2005, MRF of Oregon, Medical Research Foundation of Oregon, Oregon Health & Science University, Intracellular Iron Acquisition by Meningococci
2004, International Reviewers Panel, Medical Science Monitor, International Scientific Literature, Inc. 1125 Willis Ave Albertson, New York 11507 USA
2003-2006, National Eye Institute R03, National Institutes of Health, Oregon Health & Science University, Alteration of iron homeostasis by Neisseria gonorrhoeae
1999-2000, Tartar Fellowship, Tartar Foundation, Oregon Health Sciences University
1994-1995, Graduate Research Scholarship, Faculty of Graduate Studies, University of Calgary
1994-1994, Graduate Travel Scholarship, Faculty of Graduate Studies, University of Calgary
1991-1992, Graduate Research Scholarsip, Faculty of Graduate Studies, University of Alberta
1991-1991, Graduate Research Scholarship (Declined), Department of Biophysics, University of Southern California Medical School
1990-1990, Graduate Travel Scholarship, Faculty of Graduate Studies, University of Alberta
1990-1991, Graduate Teaching Assistantship, Department of Medical Microbiology & Infectious Diseases, University of Alberta
1989-1990, Undergraduate Teaching Assistantship, Department of Microbiology, University of Alberta
1985-1985, Summer Student Research Scholarship, Government of Canada, Concordia College
1984-1985, Major Athletic Award, Concordia College Athletic Department, Concordia College

Previous Positions

1998, Postdoctoral Fellow, Oregon Health Sciences University, Molecular Microbiology & Immunology
1997-1998, Postdoctoral Fellow, University of Calgary, Microbiology & Infectious Diseases

Patents

Lactoferrin Receptor Proteins, Patent Number: 2162193, 1995, Robert A. Bonnah and Anth, Canada.
Lactoferrin Receptor Proteins, Patent Number: 08552232, 1995, Robert A. Bonnah & Anthon, United States of America.
Lactoferrin Receptor Proteins, Patent Number: 6211343 B1, 1995, Self-owned, United States of America.
Lactoferrin Receptor Proteins, Patent Number: 6048539, 1995, Self-owned, United States of America.
Lactoferrin Receptor Proteins, Patent Number: 6344200 B1, 1995, Self-owned, United States of America.
Lactoferrin Receptor Proteins, Patent Number: 6348198 B1, 1995, Self-owned, United States of America.

Funding Received

  • National Eye Institute: Alteration of Iron Homeostasis by Neisseria gonorrhoeae, Sep 1, 2003 to Aug 31, 2006.
  • N.L. Tartar Foundation Oregon Health Sciences University: Tartar Fellowship, May 1999 to May 2000.
  • Medical Research Foundation of Oregon: Intracellular Iron Acquisition by Pathogenic Neisseria, Mar 1, 2004 to Feb 28, 2005.

Publications

  • Bonnah, RA, Hoelter, J, Steeghs, L, Enns, CA, So, M and Muckenthaler, MU, LOS-independent alteration of cellular homeostasis in Neisseria meningitidis-infected epithelial cells, Cellular Microbiology, 11 Feb 2005
  • Brito BE, Zamora DO, Bonnah RA, Pan Y, Planck SR, Rosenbaum JT., Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. , Experimental Eye Research, 79(2), 203-8, August 2004
  • Bonnah RA, Muckenthaler MU, Carlson H, Minana B, Enns CA, Hentze MW, So M, Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis, Cellular Microbiology, 6(5), 473-84, May 2004 Abstract
  • Lee SW, Bonnah RA, Higashi DL, Atkinson JP, Milgram SL, So M, CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae, The Journal of Cell Biology, 156(6), 951-7, Mar 2002 Abstract
  • Bonnah RA, Lee SW, Vasquez BL, Enns CA, So M, Alteration of epithelial cell transferrin-iron homeostasis by Neisseria meningitidis and Neisseria gonorrhoeae, 2(3), 207-18, June 2000 Abstract
  • Yu RH, Bonnah RA, Ainsworth S, Schryvers AB, Analysis of the immunological responses to transferrin and lactoferrin receptor proteins from Moraxella catarrhalis, Infection and Immunity, 67(8), 3793-9, August 1999 Abstract
  • Bonnah RA, Wong H, Loosmore SM, Schryvers AB, Characterization of Moraxella (Branhamella) catarrhalis lbpB, lbpA, and lactoferrin receptor orf3 isogenic mutants, Infection and Immunity, 67(3), 1517-20, March 1999 Abstract
  • Bonnah RA, Schryvers AB, Preparation and characterization of Neisseria meningitidis mutants deficient in production of the human lactoferrin-binding proteins LbpA and LbpB, Journal of Bacteriology, 180(12), 3080-90, June 1998 Abstract
  • Bonnah R A, Yu R H, Wong H, Schryvers A B, Biochemical and immunological properties of lactoferrin binding proteins from Moraxella (Branhamella) catarrhalis, Microbial Pathogenesis, 24(2), 89-100, February 1998 Abstract
  • Schryvers AB, Bonnah R, Yu RH, Wong H, Retzer M, Bacterial lactoferrin receptors, Advances in Experimental Medicine and Biology, 443, 123-33, 1998 Abstract
  • Bonnah, R.A., Yu, R-H. and Schryvers, A.B., Hutchens, T.W. and Lonnerdal, B. ed, Bacterial Lactoferrin Receptors, Lactoferrin Structure and Function, 277-301, 1997
  • Bonnah R A, Yu R, Schryvers A B, Biochemical analysis of lactoferrin receptors in the Neisseriaceae: identification of a second bacterial lactoferrin receptor protein, Microbial Pathogenesis, 19(5), 285-97, November 1995 Abstract
  • Tyrrell GJ, Peppler MS, Bonnah RA, Clark CG, Chong P, Armstrong GD, Lectinlike properties of pertussis toxin, Infection and Immunity, 57(6), 1854-7, June 1989 Abstract

Profile Details

Last Updated: 4/8/2005

COS Expertise ID #426275
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