Dr. Karin E. Bornfeldt

powered by
COS Expertise®
University of Washington
School of Medicine
Pathology
ProfessorAppointed: 2007
University of Washington
Diabetes and Obesity Center of Excellence
Appointed: 2007
Professional Headshot of Karin E. Bornfeldt

Mailing Address

Box 357470
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 543-1681
Fax: (206) 543-3644
bornf@u.washington.edu

Qualifications

Ph.D., Linkoping University, 1991.
B.S., Linkoping University, 1985.

Expertise and Research Interests

People with type 1 or type 2 diabetes have a greater risk of developing cardiovascular disease (myocardial infarction, stroke, and peripheral cardiovascular disease that can lead to the necessity to amputate limbs) caused by atherosclerosis. These complications also develop earlier in life than in people without diabetes. Risk factors for cardiovascular disease associated with diabetes include sub-optimal metabolic control and lipid abnormalities, such as increased levels of triglycerides and decreased levels of HDL. Our work focuses on understanding the mechanisms of diabetes-accelerated atherosclerosis so that these complications can be treated or prevented.

We have shown, using a mouse model of diabetes-accelerated atherosclerosis (Renard et al. 2004; Johansson et al. 2008) that type 1 diabetes stimulates both initiation of lesions of atherosclerosis and progression to advanced lesions. Our working hypothesis is that diabetes stimulates lesion initiation and progression by increasing macrophage recruitment and arterial inflammation.

Our work is, or has been, funded by the National Heart, Lung, and Blood Institute, the American Heart Association, the American Diabetes Association, Seattle Foundation, the Royalty Research Fund at the University of Washington, and the Juvenile Diabetes Research Foundation.

Other Expertise

Circulation Research Editorial Board
Diabetes Editorial Board
J Biol Chem Editorial Board
J Clin Invest Consulting Editor

1998-2001, American Heart Association Midwest Study Section 2
1999-2003, American Heart Association Molecular Signaling Study Section 2.
2000-2003, Juvenile Diabetes Research Foundation, Complications Study Section, Member
2002, American Heart Association Vascular Wall Biology 2 Study Section, Ad hoc reviewer
2003-2006, Juvenile Diabetes Research Foundation, Complications Study Section, Ad hoc reviewer
2004, NIH/NIDDK Special Emphasis Panel "Innovative Partnerships in Type 1 Diabetes Research", Member
2004, NIH/NHLBI Special Panel "Progression of Cardiovascular Disease in Type I Diabetes", Member
2005 winter, spring, NIH/NHLBI Atherosclerosis and Inflammation of the Cardiovascular System (AICS) Study Section, Ad hoc reviewer
2005-2006, Juvenile Diabetes Research Foundation, Innovative Grant Study Section, Member
2006, NIH/NHLBI Program Project Grant application review, Member
2007-2008, Juvenile Diabetes Research Foundation, Innovative Grant Study Section, Member
2007, NHLBI Special Emphasis Review Panel "Atherosclerosis and lipoprotein receptors", Member
2008, Juvenile Diabetes Research Foundation, Innovative Grant Study Section, Ad hoc
2007-present, NHLBI Program Project Parent Review Committee (HLBP), Member

Keywords

COS Keywords:

Biological Sciences, Cardiology, Cardiovascular Biology, Cardiovascular Diseases, Cell Biology, Cell Differentiation, Diabetes, Endocrinologic Diseases, Endocrinology, Enzymes, Gene Expression, Gene Regulation, Growth Factor Receptors, Growth Factors, Pathobiology, Receptors, Signal Transduction, Stroke, Vascular Biology.

Additional Terms:

Cardiovascular Biology, Cell Biology, Cell Differentiation, Cell Growth, Diabetes, Endocrinologic Diseases, Endocrinology, Gene Expression, Gene Regulation, Growth Factor Receptors, Growth Factors, Pathobiology, Signal Transduction, Vascular Biology.

Memberships

American Diabetes Association
American Society for Cell Biology
American Society for Investigative Pathology

Previous Positions

2001-2007, Associate Professor, University of Washington, School of Medicine, Pathology
1998-2001, Assistant Professor, University of Washington, School of Medicine, Pathology
1995-1998, Research Assistant Professor, University of Washington, School of Medicine, Pathology
1991-1995, Postdoctoral Fellow, University of Washington, School of Medicine, Pathology
1987-1990, Lecturer, Linkoeping University, Sweden, Biology
1987-1991, Instructor, Linkoeping University, Sweden, Pharmacology

Publications

  • Zeng H, Horie K, Madisen L, Pavlova MN, Gragerova G, Rohde AD, Schimpf BA, Liang Y, Ojala E, Kramer F, Roth P, Slobodskaya O, Dolka I, Southon EA, Tessarollo L, Bornfeldt KE, Gragerov A, Pavlakis GN, Gaitanaris GA (May 2008) An inducible and reversible mouse genetic rescue system., PLoS genetics, 4 (5), e1000069 Abstract
  • Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE (Feb 2008) Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice., Proceedings of the National Academy of Sciences of the United States of America, 105 (6), 2082-7 Abstract
  • Shen X, Bornfeldt KE (Apr 2007) Mouse models for studies of cardiovascular complications of type 1 diabetes., Annals of the New York Academy of Sciences, 1103, 202-17 Abstract
  • Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE (Apr 2007) Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages., Diabetes, 56 (4), 1143-52 Abstract
  • Kanter JE, Johansson F, LeBoeuf RC, Bornfeldt KE (Mar 2007) Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques?, Circulation research, 100 (6), 769-81 Abstract
  • Bornfeldt KE (Oct 2006) A single second messenger: several possible cellular responses depending on distinct subcellular pools., Circulation research, 99 (8), 790-2 Abstract
  • MacDougall ED, Kramer F, Polinsky P, Barnhart S, Askari B, Johansson F, Varon R, Rosenfeld ME, Oka K, Chan L, Schwartz SM, Bornfeldt KE (Jun 2006) Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice, The American journal of pathology, 168 (6), 2064-73 Abstract
  • Bornfeldt KE (Mar 2006) Nuclear signaling in smooth muscle cells: cyclic nucleotide phosphodiesterase 1A moves in., Circulation research, 98 (6), 720-2 Abstract
  • Nitert MD, Chisalita SI, Olsson K, Bornfeldt KE, Arnqvist HJ (Jan 2005) IGF-I/insulin hybrid receptors in human endothelial cells., Molecular and cellular endocrinology, 229 (1-2), 31-7 Abstract
  • Lamharzi N, Renard CB, Kramer F, Pennathur S, Heinecke JW, Chait A, Bornfeldt KE (Dec 2004) Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL., Diabetes, 53 (12), 3217-25 Abstract
  • Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT (Oct 2004) Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family., Journal of lipid research, 45 (10), 1958-61 Abstract
  • Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE (Sep 2004) Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions., The Journal of clinical investigation, 114 (5), 659-68 Abstract
  • Oram JF, Bornfeldt KE (May 2004) Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes., Frontiers in bioscience : a journal and virtual library, 9, 1240-53 Abstract
  • Renard CB, Askari B, Suzuki LA, Kramer F, Bornfeldt KE (Dec 2003) Oleate, not ligands of the receptor for advanced glycation end-products, promotes proliferation of human arterial smooth muscle cells., Diabetologia, 46 (12), 1676-87 Abstract
  • Schwartz SM, Bornfeldt KE (Sep 2003) How does diabetes accelerate atherosclerotic plaque rupture and arterial occlusion?, Frontiers in bioscience : a journal and virtual library, 8, s1371-83 Abstract
  • Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA (Aug 2003) Cyclic GMP phosphodiesterases and regulation of smooth muscle function., Circulation research, 93 (4), 280-91 Abstract
  • Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL (Mar 2003) Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes., Diabetes, 52 (3), 838-45 Abstract
  • Bornfeldt KE (Mar 2003) The cyclin-dependent kinase pathway moves forward., Circulation research, 92 (4), 345-7 Abstract
  • Askari B, Renard CB, Bornfeldt KE (Oct 2002) Regulation of smooth muscle cell accumulation in diabetes-accelerated atherosclerosis., Histology and histopathology, 17 (4), 1317-28 Abstract
  • Askari B, Carroll MA, Capparelli M, Kramer F, Gerrity RG, Bornfeldt KE (Sep 2002) Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells., The Journal of biological chemistry, 277 (39), 36338-44 Abstract
  • Suzuki LA, Poot M, Gerrity RG, Bornfeldt KE, Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels, Diabetes, 50(4), 851-60, April 2001 Abstract
  • Koyama H, Bornfeldt KE, Fukumoto S, Nishizawa Y, Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation, Journal of Cellular Physiology, 186(1), 1-10, Jan 2001 Abstract
  • Bornfeldt KE, Stressing Rac, Ras, and downstream heat shock protein 70, Circulation Research, 86(11), 1101-3, 2000 Abstract
  • Rybalkin SD, Bornfeldt KE, Cyclic nucleotide phosphodiesterases and human arterial smooth muscle cell proliferation., Thrombosis and Haemostasis, 82(2), 424-34, 1999 Abstract
  • Bornfeldt KE, Krebs EG, Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle, Cellular Signalling, 11(7), 465-77, July 1999 Abstract
  • Zhao AZ, Bornfeldt KE, Beavo JA, Leptin inhibits insulin secretion by activation of phosphodiesterase 3B, Journal of Clinical Investigation, 102(5), 869-73, September 1998 Abstract
  • Sonnenburg W K, Rybalkin S D, Bornfeldt K E, Kwak K S, Rybalkina I G, Beavo J A, Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases, Methods, 14(1), 3-19, Jan 1998 Abstract
  • Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG, Beavo JA, Calmodulin-stimulated cyclic nucleotide phosphodiesterase \(PDE1C\) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype., Journal of Clinical Investigation, 100(10), 2611-21, 15 Nov 1997 Abstract
  • Bornfeldt K E, Campbell J S, Koyama H, Argast G M, Leslie C C, Raines E W, Krebs E G, Ross R, The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets, Journal of Clinical Investigation, 100(4), 875-85, 15 Aug 1997 Abstract
  • Graves L M, Bornfeldt K E, Krebs E G, Historical perspectives and new insights involving the MAP kinase cascades, Advances In Second Messenger and Phosphoprotein Research, 31, 49-62, 1997 Abstract
  • Koyama H, Raines E W, Bornfeldt K E, Roberts J M, Ross R, Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors, Cell, 87(6), 1069-78, 13 Dec 1996 Abstract
  • Graves L M, Bornfeldt K E, Sidhu J S, Argast G M, Raines E W, Ross R, Leslie C C, Krebs E G, Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells, Journal of Biological Chemistry, 271(1), 505-11, 5 Jan 1996 Abstract
  • Arnqvist H J, Bornfeldt K E, Chen Y, Lindstrom T, The insulin-like growth factor system in vascular smooth muscle: interaction with insulin and growth factors, Metabolism: Clinical and Experimental, 44(10 Suppl 4), 58-66, October 1995 Abstract
  • Bornfeldt K E, Raines E W, Graves L M, Skinner M P, Krebs E G, Ross R, Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation, Annals of The New York Academy of Sciences, 766, 416-30, 7 Sep 1995 Abstract
  • Graves L M, Bornfeldt K E, Argast G M, Krebs E G, Kong X, Lin T A, Lawrence J C Jr, cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells, Proceedings of the National Academy of Sciences (USA), 92(16), 7222-6, 1 Aug 1995 Abstract
  • Bornfeldt K E, Graves L M, Raines E W, Igarashi Y, Wayman G, Yamamura S, Yatomi Y, Sidhu J S, Krebs E G, Hakomori S, et al, Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction, Journal of Cell Biology, 130(1), 193-206, July 1995 Abstract
  • Chen Y, Arner A, Bornfeldt K E, Uvelius B, Arnqvist H J, Development of smooth muscle hypertrophy is closely associated with increased gene expression of insulin-like growth factor binding protein-2 and -4, Growth Regulation, 5(1), 45-52, March 1995 Abstract
  • Graves, L.M., Bornfeldt, K.E., Argast, G.M., Krebs, E.G., Kong, X., Lin, T.A., Lawrence, J.S., Jr, cAMP- and rapamycin-sensitive regulation of phosphorylated heat-and acid stable protein I and eukaryotic initiation factor 4E association in aortic smoothmuscle cells., Proceedings of the National Academy of Sciences (USA), In Pr 1995
  • Bornfeldt, K.E., Graves, L.M., Raines, E.W., Igarashi, Y., Wayman, G., Yamamura, S., Yatomi, Y., Sidhu, J.S., Krebs, E.G., Hakomori, S., Ross, R, Spingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemotactic signal transduction, Journal of Cell Biology, In Pr 1995
  • Christoffersen C T, Bornfeldt K E, Rotella C M, Gonzales N, Vissing H, Shymko R M, ten Hoeve J, Groffen J, Heisterkamp N, De Meyts P, Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor, Endocrinology, 135(1), 472-5, July 1994 Abstract
  • Bornfeldt K E, Raines E W, Nakano T, Graves L M, Krebs E G, Ross R, Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation, Journal of Clinical Investigation, 93(3), 1266-74, March 1994 Abstract
  • Chen Y, Bornfeldt K E, Arner A, Jennische E, Malmqvist U, Uvelius B, Arnqvist H J, Increase in insulin-like growth factor I in hypertrophying smooth muscle, American Journal of Physiology, 266(2 Pt 1), E224-9, February 1994 Abstract
  • Chen, Y., Bornfeldt, K.E., Arner, J., Jennische, E., Malmqvist, U., Uvelius, B., Arnqvist, H.J, Increase in insulin-like growth factor I in hypertrophying smooth muscle, American Journal of Physiology, 266, 1994
  • Bornfeldt, K.E., Raines, E.W., Nakano, T., Graves, L.M., Krebs, E.G., ross, R., Insulin-like growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are different from thos of proliferation, Journal of Clinical Investigation, 93, 1266-1274, 1994
  • Graves L M, Bornfeldt K E, Raines E W, Potts B C, Macdonald S G, Ross R, Krebs E G, Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells, Proceedings of the National Academy of Sciences (USA), 90(21), 10300-4, 1 Nov 1993 Abstract
  • Graves, L.M., Bornfeldt, K.E., Raines, E.W., Potts, B.C., Macdonald, S.G., Ross, R., Krebs, E.G, Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells., Proceedings of the National Academy of Sciences, 90, 10300-10304, 1993
  • Bornfeldt K E, Skottner A, Arnqvist H J, In-vivo regulation of messenger RNA encoding insulin-like growth factor-I (IGF-I) and its receptor by diabetes, insulin and IGF-I in rat muscle, Journal of Endocrinology, 135(2), 203-11, November 1992 Abstract
  • Flyvbjerg A, Marshall S M, Frystyk J, Rasch R, Bornfeldt K E, Arnqvist H, Jensen P K, Pallesen G, Orskov H, Insulin-like growth factor I in initial renal hypertrophy in potassium-depleted rats, American Journal of Physiology, 262(6 Pt 2), F1023-31, June 1992 Abstract
  • Bornfeldt K E, Arnqvist H J, Capron L, In vivo proliferation of rat vascular smooth muscle in relation to diabetes mellitus insulin-like growth factor I and insulin, Diabetologia, 35(2), 104-8, February 1992 Abstract
  • Flyvbjerg A, Bornfeldt K E, Orskov H, Arnqvist H J, Effect of insulin-like growth factor I infusion on renal hypertrophy in experimental diabetes mellitus in rats, Diabetologia, 34(10), 715-20, October 1991 Abstract
  • Bornfeldt K E, Gidlof R A, Wasteson A, Lake M, Skottner A, Arnqvist H J, Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities, Diabetologia, 34(5), 307-13, May 1991 Abstract
  • Bornfeldt K E, Arnqvist H J, Norstedt G, Regulation of insulin-like growth factor-I gene expression by growth factors in cultured vascular smooth muscle cells, Journal of Endocrinology, 125(3), 381-6, June 1990 Abstract
  • Flyvbjerg A, Bornfeldt K E, Marshall S M, Arnqvist H J, Orskov H, Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats, Diabetologia, 33(6), 334-8, June 1990 Abstract

Profile Details

Last Updated: 5/15/2008

COS Expertise ID #307323
Reference this profile directly: http://myprofile.cos.com/bornfelk23