Dr. Leslie D. Bourquin

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Michigan State University
National Food Safety and Toxicology Center
Associate ProfessorAppointed: 2002
Michigan State University
College of Human Ecology
Food Science and Human Nutrition
Associate ProfessorAppointed: 2002

Mailing Address

Department of Food Science and Human Nutrition
Michigan State University
139A G. M. Trout FSHN Building
East Lansing, Michigan 48824-1224
United States

Contact Information

Phone: (517) 355-8474, ext. 112
Fax: (517) 353-8963
bourqui1@msu.edu

Qualifications

Ph.D., University of Illinois at Urbana-Champaign, Nutritional Sciences, 1993.
M.S., University of Illinois at Urbana-Champaign, Animal Sciences, 1989.
B.S., Oklahoma State University, Agriculture, 1987.

Expertise and Research Interests

Dr. Bourquin's research focuses on the influence of diet and dietary components on normal colonic development and colon cancer. Research projects currently under investigation by Dr. Bourquin's group include:

1) Studying the influence of plant foods(including soy foods, fruits, vegetables, and fermentable carbohydrates) on the development of small intestinal and colonic adenomas in Min mice, a murine model of human colon cancer development.

2) Studies on the mechanisms whereby plant foods and their components can influence colonic epithelial cellular proliferation, differentiation, and programmed cell death.

3) Determining the potential of indigestible, but fermentable, carbohydrates to influence colonic development and chronic disease risk.

This research utilizes a variety of techniques including animal studies, cancer cell culture, immunohistichemistry, and flow cytometry, as well as human clinical studies.

Keywords

COS Keywords:

Animal Models, Carbohydrates, Cell Biology, Cell Differentiation, Cell Proliferation, Food Safety, Food Sciences, Nutrition Or Dietetics.

Additional Terms:

Animal Models, Carbohydrates, Carcinogenesis, Cell Biology, Cell Differentiation, Cell Proliferation, Colon Cancer, Dietary Fiber, Food Safety, Functional Foods, Nutrition, Phytochemicals, Plant Foods, Programmed Cell Death.

Memberships

American Society for Nutritional Sciences
Institute of Food Technologists
International Association for Food Protection
Phi Kappa Phi
Sigma Xi, The Scientific Research Society

Honors and Awards

2002, Alex Malaspina Future Leader Award, International Life Sciences Institute, North America
2002, Outreach Award, College of Human Ecology, Michigan State University

Previous Positions

1996-2002, Assistant Professor, Michigan State University, National Food Safety and Toxicology Center
1996-2002, Assistant Professor, Michigan State University, College of Human Ecology, Food Science and Human Nutrition

Patents

Method for treating tumors caused by APC gene mutation with anthocyanins and cyanidin, Patent Number: 6,656,914, 2003, Institution-owned, United States.

Funding Received

  • United States Department of Agriculture (USDA): Apple Juice and HACCP: Hazard Surveillance, Training, and Perceptions, $299,684, Sep 30, 2001 to Sep 29, 2004.
  • United States Department of Agriculture (USDA): Fresh Juice HACCP Alliance and Train-the-Trainer Program, $109,900, Sep 14, 1999 to Sep 14, 2003.
  • Michigan Department of Agriculture: A Comprehensive Food Safety Education Program for Michigan Consumers, $450,000, Oct 1, 2001 to Sep 30, 2004.
  • United States Department of Agriculture (USDA): Antioxidant, Anti-Inflammatory, and Anticancer Compounds from Tart Cherries, $210,000, Oct 1, 1999 to Sep 30, 2003.
  • W. K. Kellogg Foundation: Voices and Visions for Food and Food Safety – Domain Planning and Expertise Team Creation and Implementation, $160,000, Jan 1, 1999 to Dec 31, 2001.
  • International Life Sciences Institute, North America: Dietary Influences on Colon Cancer Risk and Colonic Epithelial Cell Cytokinetics, $30,000, Apr 1, 2002 to Jun 30, 2004.

Publications

  • Kang SY, Seeram NP, Nair MG, Bourquin LD, Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells, Cancer Letters, 194(1), 13-9, May 2003 Abstract
  • Tjardes KE, Buskirk DD, Allen MS, Ames NK, Bourquin LD, Rust SR, Neutral detergent fiber concentration of corn silage and rumen inert bulk influences dry matter intake and ruminal digesta kinetics of growing steers, Journal of Animal Science, 80(3), 833-40, March 2002 Abstract
  • Tjardes KE, Buskirk DD, Allen MS, Tempelman RJ, Bourquin LD, Rust SR, Neutral detergent fiber concentration in corn silage influences dry matter intake, diet digestibility, and performance of Angus and Holstein steers, Journal of Animal Science, 80(3), 841-6, March 2002 Abstract
  • Seeram NP, Bourquin LD, Nair MG, Degradation products of cyanidin glycosides from tart cherries and their bioactivities, Journal of Agricultural and Food Chemistry, 49(10), 4924-9, October 2001 Abstract
  • Seeram NP, Momin RA, Nair MG, Bourquin LD, Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries, Phytomedicine : International Journal of Phytotherapy and Phytopharmacology., 8(5), 362-9, September 2001 Abstract
  • Tjardes KE, Buskirk DD, Allen MS, Ames NK, Bourquin LD, Rust SR, Brown midrib-3 corn silage improves digestion but not performance of growing beef steers, Journal of Animal Science, 78(11), 2957-65, November 2000 Abstract
  • Thiagarajan DG, Bennink MR, Bourquin LD, Kavas FA, Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium, The American Journal of Clinical Nutrition, 68(6 Suppl), 1394S-1399S, December 1998 Abstract
  • Bourquin LD, Titgemeyer EC, Fahey GC Jr., Fermentation of various dietary fiber sources by human fecal bacteria, Nutrition Research, 16, 1119-1131, 1996
  • Sunvold GD, Titgemeyer EC, Bourquin LD, Fahey GC Jr, Garleb KA, Alteration of the fiber and lipid components of a defined-formula diet: effects on stool characteristics, nutrient digestibility, mineral balance, and energy metabolism in humans, American Journal of Clinical Nutrition, 62(6), 1252-60, December 1995 Abstract
  • Sunvold GD, Fahey GC Jr, Merchen NR, Bourquin LD, Titgemeyer EC, Bauer LL, Reinhart GA, Dietary fiber for cats: in vitro fermentation of selected fiber sources by cat fecal inoculum and in vivo utilization of diets containing selected fiber sources and their blends, Journal of Animal Science, 73(8), 2329-39, August 1995 Abstract
  • Cremin JD Jr, McLeod KR, Harmon DL, Goetsch AL, Bourquin LD, Fahey GC Jr, Portal and hepatic fluxes in sheep and concentrations in cattle ruminal fluid of 3-(4-hydroxyphenyl)propionic, benzoic, 3-phenylpropionic, and trans-cinnamic acids, Journal of Animal Science, 73(6), 1766-75, June 1995 Abstract
  • Sunvold GD, Fahey GC Jr, Merchen NR, Titgemeyer EC, Bourquin LD, Bauer LL, Reinhart GA, Dietary fiber for dogs: IV. In vitro fermentation of selected fiber sources by dog fecal inoculum and in vivo digestion and metabolism of fiber-supplemented diets, Journal of Animal Science, 73(4), 1099-109, April 1995 Abstract
  • Sunvold GD, Titgemeyer EC, Bourquin LD, Fahey GC Jr, Reinhart GA, Fermentability of selected fibrous substrates by cat fecal microflora, Journal of Nutrition, 124(12 Suppl), 2721S-2722S, December 1994 Abstract
  • Bourquin LD, Fahey GC Jr, Ruminal digestion and glycosyl linkage patterns of cell wall components from leaf and stem fractions of alfalfa, orchardgrass, and wheat straw, Journal of Animal Science, 72(5), 1362-74, May 1994 Abstract
  • Bourquin LD, Titgemeyer EC, Merchen NR, Fahey GC Jr, Forage level and particle size effects on orchardgrass digestion by steers: I. Site and extent of organic matter, nitrogen, and cell wall digestion, Journal of Animal Science, 72(3), 746-58, March 1994 Abstract
  • Bourquin LD, Titgemeyer EC, Van Milgen J, Fahey GC Jr, Forage level and particle size effects on orchardgrass digestion by steers: II. Ruminal digestion kinetics of cell wall components, Journal of Animal Science, 72(3), 759-67, March 1994 Abstract
  • Bourquin LD, Titgemeyer EC, Fahey GC Jr, Vegetable fiber fermentation by human fecal bacteria: cell wall polysaccharide disappearance and short-chain fatty acid production during in vitro fermentation and water-holding capacity of unfermente, Journal of Nutrition, 123(5), 860-9, May 1993 Abstract
  • Bourquin LD, Titgemeyer EC, Fahey GC Jr, Garleb KA, Fermentation of dietary fibre by human colonic bacteria: disappearance of, short-chain fatty acid production from, and potential water-holding capacity of, various substrates, Scandinavian Journal of Gastroenterology, 28(3), 249-55, March 1993 Abstract
  • Bourquin LD, Titgemeyer EC, Garleb KA, Fahey GC Jr, Short-chain fatty acid production and fiber degradation by human colonic bacteria: effects of substrate and cell wall fractionation procedures, Journal of Nutrition, 122(7), 1508-20, July 1992 Abstract
  • Titgemeyer EC, Bourquin LD, Fahey GC Jr, Garleb KA, Fermentability of various fiber sources by human fecal bacteria in vitro, American Journal of Clinical Nutrition, 53(6), 1418-24, June 1991 Abstract
  • Titgemeyer EC, Cameron MG, Bourquin LD, Fahey GC Jr, Digestion of cell wall components by dairy heifers fed diets based on alfalfa and chemically treated oat hulls, Journal of Dairy Science, 74(3), 1026-37, March 1991 Abstract
  • Garleb KA, Bourquin LD, Hsu JT, Wagner GW, Schmidt SJ, Fahey GC Jr, Isolation and chemical analyses of nonfermented fiber fractions of oat hulls and cottonseed hulls, Journal of Animal Science, 69(3), 1255-71, March 1991 Abstract
  • Bourquin LD, Garleb KA, Merchen NR, Fahey GC Jr, Effects of intake and forage level on site and extent of digestion of plant cell wall monomeric components by sheep, Journal of Animal Science, 68(8), 2479-95, August 1990 Abstract

Profile Details

Last Updated: 1/12/2004

COS Expertise ID #440727
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