Daniel F. Bowen-Pope

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University of Washington
School of Medicine
Pathology
ProfessorAppointed: 1992
University of Washington
School of Medicine
Pathology
Graduate FacultyAppointed: 1984
Professional Headshot of Daniel F. Bowen-Pope

Mailing Address

P.O. Box 357470
University of Washington
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 685-2148
Fax: (206) 543-3644
bp@u.washington.edu

Qualifications

Ph.D., University of California, Berkeley, Molecular Biology, 1979.
B.A., University of California, San Diego, Biology, 1973.

Expertise and Research Interests

My general interests are in vascular biology and molecular regulation of vascular (and other tissue) response to injury. My lab currently has three project areas:

1. Using a system of conditional reporters and cell-type-specific markers in transgenic mice to test the hypothesis that new blood vessel formation and remodeling in adult tissue includes vascular cell derivation from undifferentiated “stem cells”, and “transdifferentiation” from other cell types, in addition to the canonical origins from proliferation and migration of existing vascular cells.

2. We have developed a system for regulating apoptosis of vascular smooth muscle cells (SMCs) in vivo, and have used this system to determine that SMC apoptosis initiated by FADD overexpression includes a specific program of expression of pro-inflammatory genes that results in recruitment of macrophages. Binding of Fas ligand (FasL) to cultured human SMCs initiates a comparable program. We are attempting to further define this program of gene expression, determine the signaling mechanisms through which it is regulated, and further investigate the consequences of SMC apoptosis in vivo.

3. PTPRQ is a protein tyrosine phosphatase (PTPase)-like protein that we initially identified and cloned based on its upregulation in a rat model of renal injury. We have found that PTPRQ is a very unusual member of the PTPase superfamily in that its biological activity is due to its activity as a phosphatidylinositol phosphatase (PIPase) rather as a PTPase. PTPRQ has broader PIPase activity than does the tumor suppressor PTEN, the first PTPase shown to have PI 3-phosphatase activity, but it has a more restricted pattern of expression. The receptor-like form of PTPRQ protein appears to be largely localized to specialized regions of non-proliferating cell types (including podocytes, inner ear hair cells and Sertoli cells) that are involved in cell-cell or cell-matrix interactions. Targeted disruption of PTPRQ in mice results in deafness and altered response to renal injury. We are testing hypothesis that subcellular localization of PTPRQ in specialized membrane regions plays a role in regulation of local membrane PIP composition, and that this plays a role in regulating specialized cell architecture and function by altering the local binding and/or activity of PIP-binding proteins.

Keywords

COS Keywords:

Cancer Biology, Cardiovascular Biology, Cell Biology, Cell Differentiation, Cytokines, Developmental Biology, Embryology, Gene Expression, Gene Regulation, Growth Factor Receptors, Growth Factors, Molecular Biology, Molecular Cellular Entities, Morphogenesis, Oncology, Pathology, Receptors, Stem Cells, Trauma, Cell Biology, Vascular Biology.

Additional Terms:

Cardiovascular Biology, Cell Biology, Cell Differentiation, Cell Growth, Developmental Biology, Embryology, Gene Expression, Gene Regulation, Growth Factor Receptors, Growth Factors, Morphogenesis, Muscle, System Development, Vascular Biology, Vascular Disease/Injury, Vascular Grafts, Vessel Wall Biology.

Languages

(Reading, Writing, Speaking)

French: (Functional, None, None)

Memberships

American Association for the Advancement of Science
American Association of Pathologists
American Federation for Medical Research
American Heart Association
American Society for Cell Biology
Federation of American Societies for Experimental Biology

Previous Positions

1987-1987, Associate Professor, University of Washington, School of Medicine, Pathology
1986-1986, Assistant Professor, University of Washington, School of Medicine, Pathology
1982-1986, Research Assistant Professor, University of Washington, School of Medicine, Pathology
1979-1982, Postdoctoral fellow, University of Washington, School of Medicine, Pathology

Funding Received

  • National Institutes of Health (NIH): Vascular cell origins and fates in ganulation tissue, Jul 1, 2003 to Jun 30, 2008.
  • National Institutes of Health (NIH): Function of Mesangial Cell Tyrosine Phosphatase in Renal Disease, Jul 1, 1999 to Feb 30, 2004.
  • National Institutes of Health (NIH): Smooth muscle apoptosis, Dec 1, 2001 to Nov 30, 2005.

Publications

  • Goodyear RJ, Legan PK, Wright MB, Marcotti W, Oganesian A, Coats SA, Booth CJ, Kros CJ, Seifert RA, Bowen-Pope DF, Richardson GP, A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles, The Journal of Neuroscience : the Official Journal of the Society for Neuroscience., 23(27), 9208-19, October 2003 Abstract
  • Buetow BS, Tappan KA, Crosby JR, Seifert RA, Bowen-Pope DF, Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury, American Journal of Pathology, 163(3), 979-84, September 2003 Abstract
  • Schaub FJ, Liles WC, Ferri N, Sayson K, Seifert RA, Bowen-Pope DF, Fas and Fas-associated death domain protein regulate monocyte chemoattractant protein-1 expression by human smooth muscle cells through caspase- and calpain-dependent release of interleuki, Circulation Research, 93(6), 515-22, September 2003 Abstract
  • Seifert RA, Coats SA, Oganesian A, Wright MB, Dishmon M, Booth CJ, Johnson RJ, Alpers CE, Bowen-Pope DF, PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein, Experimental Cell Research, 287(2), 374-86, July 2003 Abstract
  • Oganesian A, Poot M, Daum G, Coats SA, Wright MB, Seifert RA, Bowen-Pope DF, Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation, Proceedings of the National Academy of Sciences of the United States of America., 100(13), 7563-8, June 2003 Abstract
  • Herren B, Garton KJ, Coats S, Bowen-Pope DF, Ross R, Raines EW, ADAM15 overexpression in NIH3T3 cells enhances cell-cell interactions, Experimental Cell Research, 271(1), 152-60, November 2001 Abstract
  • Buetow BS, Crosby JR, Kaminski WE, Ramachandran RK, Lindahl P, Martin P, Betsholtz C, Seifert RA, Raines EW, Bowen-Pope DF, Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization, American Journal of Pathology, 159(5), 1869-76, November 2001 Abstract
  • Goessl A, Bowen-Pope DF, Hoffman AS, Control of shape and size of vascular smooth muscle cells in vitro by plasma lithography, Journal of Biomedical Materials Research, 57(1), 15-24, October 2001 Abstract
  • Kaminski, W.E., Lindahl, P., Lin, N.L., Broudy, V.C., Crosby, J.R., Hellstrom, M.,Swolin, B., Bowen-Pope, D.F., Martin, P.J., Ross, R, Betsholtz, C., and Raines. E.W., Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice, Blood, 97, 1990-1998, 2001
  • Bowen-Pope DF, Schaub FJ, Apoptosis of smooth muscle cells is not silent: Fas/FADD initiates a program of inflammatory gene expression, Trends in Cardiovascular Medicine, 11(1), 42-5, Jan 2001 Abstract
  • Crosby JR, Kaminski WE, Schatteman G, Martin PJ, Raines EW, Seifert RA, Bowen-Pope DF, Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation, Circulation Research [computer File], 87(9), 728-30, 2000 Abstract
  • Schaub FJ, Han DK, Conrad Liles W, Adams LD, Coats SA, Ramachandran RK, Seifert RA, Schwartz SM, Bowen-Pope DF, Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells, Nature Medicine, 6(7), 790-6, July 2000 Abstract
  • Wright MB, Seifert RA, Bowen-Pope DF, Protein-tyrosine phosphatases in the vessel wall: differential expression after acute arterial injury [see comments], Arteriosclerosis, Thrombosis, and Vascular Biology, 20(5), 1189-98, May 2000 Abstract
  • Mason DP, Kenagy RD, Hasenstab D, Bowen-Pope DF, Seifert RA, Coats S, Hawkins SM, Clowes AW, Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery., Circ. Res., 85(12), 1179-85, 3 Dec 1999 Abstract
  • Mason DP, Kenagy RD, Hasenstab D, Bowen-Pope DF, Seifert RA, Coats S, Hawkins SM, Clowes AW, Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery, Circulation Research, 85(12), 1179-85, December 1999 Abstract
  • Ritchie KA, Aprikyan AA, Bowen-Pope DF, Norby-Slycord CJ, Conyers S, Bartelmez S, Sitnicka EH, Hickstein DD, The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice, Leukemia, 13(11), 1790-803, November 1999 Abstract
  • Crosby JR, Tappan KA, Seifert RA, Bowen-Pope DF, Chimera analysis reveals that fibroblasts and endothelial cells require platelet-derived growth factor receptorbeta expression for participation in reactive connective tissue formation in adults but n, American Journal of Pathology, 154(5), 1315-21, May 1999 Abstract
  • Wright M B, Hugo C, Seifert R, Disteche C M, Bowen-Pope D F, Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis., Journal of Biological Chemistry, 273(37), 23929-37, 11 Sep 1998 Abstract
  • Seifert RA, Alpers CE, Bowen-Pope DF, Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney, Kidney International, 54(3), 731-46, September 1998 Abstract
  • Crosby J R, Seifert R A, Soriano P, Bowen-Pope D F, Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages., Nature Genetics, 18(4), 385-8, April 1998 Abstract
  • Hugo C, Shankland S J, Bowen-Pope D F, Couser W G, Johnson R J, Extraglomerular origin of the mesangial cell after injury. A new role of the juxtaglomerular apparatus., Journal of Clinical Investigation, 100(4), 786-94, 15 Aug 1997 Abstract
  • Floege J, Hudkins K L, Seifert R A, Francki A, Bowen-Pope D F, Alpers C E, Localization of PDGF alpha-receptor in the developing and mature human kidney., Kidney International, 51(4), 1140-50, April 1997 Abstract
  • Li L, Schatteman G C, Oppenheim R W, Lei M, Bowen-Pope D F, Houenou L J, Altered development of spinal cord in the mouse mutant (Patch) lacking the PDGF receptor alpha-subunit gene., Brain research. Developmental Brain Research, 96(1-2), 204-9, 23 Oct 1996 Abstract
  • Barrett T B, Seifert R A, Bowen-Pope D F, Regulation of platelet-derived growth factor receptor expression by cell context overrides regulation by cytokines., Journal of Cellular Physiology, 169(1), 126-38, October 1996 Abstract
  • Borges L G, Seifert R A, Grant F J, Hart C E, Disteche C M, Edelhoff S, Solca F F, Lieberman M A, Lindner V, Fischer E H, Lok S, Bowen-Pope D F, Cloning and characterization of rat density-enhanced phosphatase-1, a protein tyrosine phosphatase expressed by vascular cells., Circulation Research, 79(3), 570-80, September 1996 Abstract
  • Kudla A J, John M L, Bowen-Pope D F, Rainish B, Olwin B B, A requirement for fibroblast growth factor in regulation of skeletal muscle growth and differentiation cannot be replaced by activation of platelet-derived growth factor signaling pathways., Molecular and Cellular Biology, 15(6), 3238-46, June 1995 Abstract
  • Schatteman G C, Motley S T, Effmann E L, Bowen-Pope D F, Platelet-derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis., Teratology, 51(6), 351-66, June 1995 Abstract
  • Seifert R A, Coats S A, Raines E W, Ross R, Bowen-Pope D F, Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -i, Journal of Biological Chemistry, 269(19), 13951-5, 13 May 1994 Abstract
  • Floege J, Eng E, Young B A, Alpers C E, Barrett T B, Bowen-Pope D F, Johnson R J, Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats., Journal of Clinical Investigation, 92(6), 2952-62, December 1993 Abstract
  • Kraiss L W, Raines E W, Wilcox J N, Seifert R A, Barrett T B, Kirkman T R, Hart C E, Bowen-Pope D F, Ross R, Clowes A W, Regional expression of the platelet-derived growth factor and its receptors in a primate graft model of vessel wall assembly., Journal of Clinical Investigation, 92(1), 338-48, July 1993 Abstract
  • Seifert R A, van Koppen A, Bowen-Pope D F, PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction., Journal of Biological Chemistry, 268(6), 4473-80, 25 Feb 1993 Abstract
  • Alpers C E, Seifert R A, Hudkins K L, Johnson R J, Bowen-Pope D F, PDGF-receptor localizes to mesangial, parietal epithelial, and interstitial cells in human and primate kidneys., Kidney International, 43(2), 286-94, February 1993 Abstract
  • Fingerle J, Faulmuller A, Muller G, Bowen-Pope D F, Clowes M M, Reidy M A, Clowes A W, Pituitary factors in blood plasma are necessary for smooth muscle cell proliferation in response to injury in vivo., Arteriosclerosis and Thrombosis, 12(12), 1488-95, December 1992 Abstract
  • Alpers C E, Seifert R A, Hudkins K L, Johnson R J, Bowen-Pope D F, Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis., Kidney International, 42(2), 390-9, August 1992 Abstract
  • Morrison-Graham K, Schatteman G C, Bork T, Bowen-Pope D F, Weston J A, A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells., Development, 115(1), 133-42, May 1992 Abstract
  • Schatteman G C, Morrison-Graham K, van Koppen A, Weston J A, Bowen-Pope D F, Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis., Development, 115(1), 123-31, May 1992 Abstract
  • Johnson R, Iida H, Yoshimura A, Floege J, Bowen-Pope D F, Platelet-derived growth factor: a potentially important cytokine in glomerular disease., Kidney International, 41(3), 590-4, March 1992 Abstract
  • Jawien A, Bowen-Pope D F, Lindner V, Schwartz S M, Clowes A W, Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty., Journal of Clinical Investigation, 89(2), 507-11, February 1992 Abstract
  • Floege J, Burns M W, Alpers C E, Yoshimura A, Pritzl P, Gordon K, Seifert R A, Bowen-Pope D F, Couser W G, Johnson R J, Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model., Kidney International, 41(2), 297-309, February 1992 Abstract
  • Palman C, Bowen-Pope D F, Brooks J J, Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors., Laboratory Investigation, 66(1), 108-15, January 1992 Abstract
  • Bowen-Pope D F, van Koppen A, Schatteman G, Is PDGF really important? Testing the hypotheses., Trends In Genetics, 7(11-12), 413-8, Autumn 1991 Abstract
  • Yoshimura A, Gordon K, Alpers C E, Floege J, Pritzl P, Ross R, Couser W G, Bowen-Pope D F, Johnson R J, Demonstration of PDGF B-chain mRNA in glomeruli in mesangial proliferative nephritis by in situ hybridization., Kidney International, 40(3), 470-6, September 1991 Abstract
  • Iida H, Seifert R, Alpers C E, Gronwald R G, Phillips P E, Pritzl P, Gordon K, Gown A M, Ross R, Bowen-Pope D F, et al, Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat., Proceedings of the National Academy of Sciences (USA), 88(15), 6560-4, 1 Aug 1991 Abstract
  • Kelly J D, Haldeman B A, Grant F J, Murray M J, Seifert R A, Bowen-Pope D F, Cooper J A, Kazlauskas A, Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation., Journal of Biological Chemistry, 266(14), 8987-92, 15 May 1991 Abstract
  • Stephenson D A, Mercola M, Anderson E, Wang C Y, Stiles C D, Bowen-Pope D F, Chapman V M, Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation., Proceedings of the National Academy of Sciences (USA), 88(1), 6-10, 1 Jan 1991 Abstract
  • Wang C, Kelly J, Bowen-Pope D F, Stiles C D, Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene., Molecular and Cellular Biology, 10(12), 6781-4, December 1990 Abstract
  • Battegay E J, Raines E W, Seifert R A, Bowen-Pope D F, Ross R, TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop., Cell, 63(3), 515-24, 2 Nov 1990 Abstract
  • Majesky M W, Reidy M A, Bowen-Pope D F, Hart C E, Wilcox J N, Schwartz S M, PDGF ligand and receptor gene expression during repair of arterial injury., Journal of Cell Biology, 111(5 Pt 1), 2149-58, November 1990 Abstract
  • Yablonka-Reuveni Z, Balestreri T M, Bowen-Pope D F, Regulation of proliferation and differentiation of myoblasts derived from adult mouse skeletal muscle by specific isoforms of PDGF., Journal of Cell Biology, 111(4), 1623-9, October 1990 Abstract
  • Gronwald R G, Adler D A, Kelly J D, Disteche C M, Bowen-Pope D F, The human PDGF receptor alpha-subunit gene maps to chromosome 4 in close proximity to c-kit., Human Genetics, 85(3), 383-5, August 1990 Abstract
  • Schwartz S M, Foy L, Bowen-Pope D F, Ross R, Derivation and properties of platelet-derived growth factor-independent rat smooth muscle cells., American Journal of Pathology, 136(6), 1417-28, June 1990 Abstract
  • Hart C E, Bowen-Pope D F, Platelet-derived growth factor receptor: current views of the two-subunit model., Journal of Investigative Dermatology, 94(6 Suppl), 53S-57S, June 1990 Abstract
  • Lee K H, Bowen-Pope D F, Reed R R, Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium., Molecular and Cellular Biology, 10(5), 2237-46, May 1990 Abstract
  • Ross R, Bowen-Pope D F, Raines E W, Platelet-derived growth factor and its role in health and disease., Philosophical Transactions of The Royal Society of london. Series B: Biological Sciences, 327(1239), 155-69, 12 Mar 1990 Abstract
  • Mercola M, Wang C Y, Kelly J, Brownlee C, Jackson-Grusby L, Stiles C, Bowen-Pope D, Selective expression of PDGF A and its receptor during early mouse embryogenesis., Developmental Biology, 138(1), 114-22, March 1990 Abstract
  • Ferns G A, Sprugel K H, Seifert R A, Bowen-Pope D F, Kelly J D, Murray M, Raines E W, Ross R, Relative platelet-derived growth factor receptor subunit expression determines cell migration to different dimeric forms of PDGF., Growth Factors, 3(4), 315-24, 1990 Abstract
  • Anzano M A, Rieman D, Prichett W, Bowen-Pope D F, Greig R, Growth factor production by human colon carcinoma cell lines., Cancer Research, 49(11), 2898-904, 1 Jun 1989 Abstract
  • Seifert R A, Hart C E, Phillips P E, Forstrom J W, Ross R, Murray M J, Bowen-Pope D F, Two different subunits associate to create isoform-specific platelet-derived growth factor receptors., Journal of Biological Chemistry, 264(15), 8771-8, 25 May 1989 Abstract
  • Gronwald R G, Seifert R A, Bowen-Pope D F, Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-beta., Journal of Biological Chemistry, 264(14), 8120-5, 15 May 1989 Abstract
  • Bowen-Pope D F, Hart C E, Seifert R A, Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor., Journal of Biological Chemistry, 264(5), 2502-8, 15 Feb 1989 Abstract
  • Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ, Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class, Proceedings of the National Academy of Sciences (USA), 85(10), 3435-9, May 1988 Abstract
  • Hart CE, Seifert RA, Ross R, Bowen-Pope DF, Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody, Journal of Biological Chemistry, 262(22), 10780-5, August 1987 Abstract
  • Walker LN, Bowen-Pope DF, Ross R, Reidy MA, Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury, Proceedings of the National Academy of Sciences (USA), 83(19), 7311-5, October 1986 Abstract
  • Harlan JM, Thompson PJ, Ross RR, Bowen-Pope DF, Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells, Journal of Cell Biology, 103(3), 1129-33, September 1986 Abstract
  • Ross R, Raines EW, Bowen-Pope DF, The biology of platelet-derived growth factor, Cell, 46(2), 155-69, July 1986 Abstract
  • Seifert RA, Schwartz SM, Bowen-Pope DF, Developmentally regulated production of platelet-derived growth factor-like molecules, Nature, 311(5987), 669-71, October 1984 Abstract
  • Bowen-Pope DF, Malpass TW, Foster DM, Ross R, Platelet-derived growth factor in vivo: levels, activity, and rate of clearance, Blood, 64(2), 458-69, August 1984 Abstract
  • DiCorleto PE, Bowen-Pope DF, Cultured endothelial cells produce a platelet-derived growth factor-like protein, Proceedings of the National Academy of Sciences (USA), 80(7), 1919-23, April 1983 Abstract
  • Cooper JA, Bowen-Pope DF, Raines E, Ross R, Hunter T, Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins, Cell, 31(1), 263-73, November 1982 Abstract
  • Kudla, A.J., John, M.L., Bowen-Pope, D.F., Rainish, B, and Olwin, B.B. FGF represses skeletal muscle differentiation through a distinct signal transduction pathway that cannot be replaced by activation of PDGF signalling pathways. Molec. Cell. Biol. 15:3238-3246, 1995
  • Schatteman, G.C., Motley, T., Effmann, E.L. and Bowen-Pope, D.F. The PDGFRa-deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis. Teratology 51:351-366, 1995
  • Seifert, R.A., Coats, S., Raines, E.W., Ross, R., and Bowen-Pope, D.F. PDGFRa-mutant and reconstituted cell lines demonstrate that TGF-b can be mitogenic through PDGF A-chain-dependent and -independent pathways. J. Biol. Chem. 269:13951-13955, 1994
  • Bowen-Pope, D. F. and Seifert, R.A. PDGF in Development. In: Growth Factors and Signal Transduction in Development. pp51-69 (Ed: M. Nilsen-Hamilton) Wiley-Liss, 1994
  • Floege, J., Eng, E., Young, B.A., Alpers, C.E., Barrett, T.B., Bowen-Pope, D.F., Couser, W.G., and Johnson, R.J. Infusion of platelet derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. J. Clin. Invest. 92:2952-2962, 1993

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