David N. Brindley

(Reading, Writing, Speaking)

Canadian Institutes of Health Research (CIHR): 'Regulation of angiogenesis by lipid mediators', Oct. 01/01 to Sept. 30/06.
National Institutes of Health (NIH): 'Oxidant-mediated endothelial toxicity & lipid signalling'. (collaboration with Dr. V. Natarajan), Mar. 01/99 to July 31/03.
Canadian Diabetes Association: 'Regulation of hepatic triglyceride synthesis in diabetes', July 1/03 to June 30/04.
(joint with Dr. D. English): 'Angiogenesis in the pulmonary microvasculature', July 1/03 to June 30/08.
Heart and Stroke Foundation of Canada (HSFC): 'Edothelial & smooth muscle cell regulation by tumor necrosis factor-alpha', July 1/02 to June 30/05.
Canadian Diabetes Association: 'Signal transduction & insulin resistance & tumor necrosis factor-alpha', July 1/01 to June 30/03.
Heart and Stroke Foundation of Canada (HSFC): 'Mechanisms & consequences of cardiac insulin resistance', July 01/99 to June 30/02.
National Institutes of Health (NIH): 'Neutrophil signalling by pulmonary endothelial PA'. (collaboration with Dr. D. English), Feb. 01/99 to Jan. 31/03.
Canadian Institutes of Health Research (CIHR): 'Regulation of mammalian lipid phosphate phosphohydrolases', Apr. 01/99 to Mar. 31/04.

• J Mei, C-N Wang, L O'Brien, DN Brindley., Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes, Int. J. Obes. Relat. Metab. Disord., 27, 31-39, 2003
• DN Brindley, D English, C Pilquil, K Buri, Z-C Ling., Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids, Biochimica et Biophysica Acta, 1582, 33-44, 2002
• J Mie, LS Holst, TR Landstrom, C Holm, DN Brindley, V Manganiello, E Degerman., C2-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes, Diabetes, 51, 631-637, 2002
• D English, DN Brindley, S Spiegel, JGN Garcia., Lipid mediators of angiogenesis and the signalling pathways they initiate, Biochimica et Biophysica Acta, 1582, 228-239, 2002
• A Abousalham, TC Hobman, J Dewald, M Garbutt, DN Brindley., Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in CHO compared to MDCK cells through preventing the membrane association of ADP ribosylation factor, Biochemical Journal, 361, 653-661, 2002
• L Mantha, DN Brindley, JC Russell, Y Deshaies., Developmental changes in adipose tissue and muscle lipoprotein lipase in the obese, atherosclerosis-prone JCR:LA-corpulent rat, Int. J. Obesity, 26, 308-317, 2002
• SG Bourgoin, MG Houle, IN Singh, D Harbour, S Gagnon, AJ Morris, DN Brindley, ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells, Journal of Leukocyte Biology, 71, 718-728, 2002
• G Boguslawski, JR Grogg, Z Welch, S Ciechanowicz, D Silva, AT Kovala, P McGlynn, DN Brindley, RA Rhoades, D English., Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response, Experimental Cell Research, 274, 264-274, 2002
• D Wang, H Du, JH Jagger, DN Brindley, GJ Tigyi, MA Watsky., Injury-elicited differential transcriptional regulation of phospholipid growth factor receptors in the cornea, American Journal of Physiology, 283, C1646-1654, 2002
• Y Mitani, A Mutlu, JC Russell, DN Brindley, J DeAlmeida, M Rabinovitch., Dexfenfluramine protects against pulmonary hypertension in rats, Journal of Applied Physiology, 93, 1770-1778, 2002
• D English, JGN Garcia, DN Brindley., Platelet-released phospholipids link haemostasis and angiogenesis, Cardiovascular Research, 49, 588-599, 2001
• C Pilquil, I Singh, Q-X Zhang, Z-C Ling, K Buri, LM Love, J Dewald, DN Brindley., Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling. , Prostaglandins and Lipid Mediators, 64, 83-92, 2001
• A Hanna, L Berthiaume, Y Kikuchi, D Begg, S Bourgoin, DN Brindley., Tumor necrosis factor-a induces stress fiber formation through ceramide production: Role of sphingosine kinase., Molecular Biology of the Cell, 12, 3618-3630, 2001
• IN Singh, LM Stromberg, SG Bourgoin, VA Sciorra, AJ Morris, DN Brindley, Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-biphosphate., Biochemistry, 40, 11227-11233, 2001
• J Xu, L Love, I Singh, Q-X Zhang, J Dewald, DA Wang, DJ Fisher, G Tigyi, LG Berthiaume, DW Waggoner, DN Brindley., Lipid phosphate phosphatase-1 and Ca2+ control lysophosphatidate signaling through EDG-2 receptors, Journal of Biological Chemistry, 275, 27520-27530, 2000
• J Xu, Q-X Zhang, CS Pilquil, LG Berthiaume, DW Waggoner, DN Brindley, Lipid phosphate phosphatase-1 in the regulation of lysophosphatidate signaling, Annals of the New York Academy of Sciences, 905, 81-90, 2000
• D English, Z Welch, AT Kovala, K Harvey, OV Volpert, DN Brindley, JGN Garcia., Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenes, FASEB Journal, 14, 2255-2265, 2000
• QX Zhang, CS Pilquil, J Dewald, LG Berthiaume, DN Brindley., Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action, Biochemical Journal, 345, 181-184, 2000
• D English, AT Kovala, Z Welch, KA Harvey, RA Siddiqui, DN Brindley, JGN Garcia., Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogene, Journal of Hematotherapy and Stem Cell Research, 8, 627-634, 1999
• D English, Y Cui, R Siddiqui, C Patterson, V Natarajan, DN Brindley, JGN Garcia., Induction of endothelial monolayer permeability by phosphatidate, Journal of Cellular Biochemistry, 75, 105-117, 1999
• A Hanna, EYW Chan, J Xu, JC Stone, DN Brindley., A novel pathway for tumor necrosis factor-a and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and phosphatidylinositol 3-kinase, Journal of Biological Chemistry, 274, 12722-12728, 1999
• SG Payne, DN Brindley, LJ Guilbert., Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts, Journal of Cell Physiology, 180, 263-270, 1999
• DW Waggoner, J Xu, I Singh, R Jasinska, QX Zhang, DN Brindley., Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction, Biochimica et Biophysica Acta, 1439, 299-316, 1999
• R Jasinska, Q-X Zhang, C Pilquil, I Singh, J Xu, J Dewald, DA Dillon, LG Berthiaume, GM Carman, DW Waggoner, D.N. Brindley., Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters, Biochemical Journal, 340, 677-686, 1999
• DN Brindley, DW Waggoner., Mammalian lipid phosphate phosphohydrolases, Journal of Biological Chemistry, 273, 24281-24284, 1998
• C-N Wang, L O'Brien, DN Brindley., Effects of cell-permeable ceramides and tumor necrosis factor-a on insulin signaling and glucose uptake in 3T3-L1 adipocytes, Diabetes, 47, 24-31, 1998