Dr. Donald G. Buerk

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University of Pennsylvania
Medicine, Engineering
Physiology, Bioengineering
Institute for Environmental Medicine, Institute for Medicine in Engineering
Research Associate ProfessorAppointed: 1990
Departments of Physiology and Bioengineering
University of Pennsylvania
Biomedical Engineering
Professional Headshot of Donald G. Buerk

Mailing Address

B400 Richards Building
3700 Hamilton Walk
Philadelphia, Pennsylvania 19104-6085
United States

Contact Information

Phone: (215) 898-9097
buerk@seas.upenn.edu

Qualifications

Ph.D., Northwestern University, Chemical Engineering, 1980.

Expertise and Research Interests

Artificial blood substitutes, Brain injury, Carbon monoxide poisioning, Chemosensory mechanisms in brain and carotid body, Control of blood flow and oxygen delivery, Electrochemical microsensors for oxygen, nitric oxide, and catecholamines, Hyperbaric oxygen therapy, Laser Doppler flowmetry, Mathematical modeling of biotransport phenomena, Metabolism, Nitric oxide, Oxygen transport to tissue, Reperfusion injury, Signaling mechanisms, Tumor biology.


Other Expertise

Jazz saxophonist, cartoonist and film-maker

Industrial Relevance

Consultant, AstraZeneca Discovery

Keywords

COS Keywords:

Biomedical Engineering, Blood Flow, Brain Injury, Chemical Engineering, Electrochemistry, Tumors.

Additional Terms:

Biotransport Modeling, Blood Flow, Nitric Oxide, Oxygen.

Memberships

American Physiological Society
Biomedical Engineering Society
International Society of Oxygen Transport to Tissue
Microcirculatory Society
Sigma Xi, The Scientific Research Society

Previous Positions

1987-1990, Research Associate Professor, Drexel University, College of Engineering, Biomedical Engineering and Science Institute
1982-1987, Associate Professor, Louisiana Technical University, Engineering, Biomedical Engineering

Funding Received

  • Office of Naval Research: Oxygen signaling to the brain, 2001 to 2004.
  • National Institutes of Health (NIH): Microelectrode and blood flow studies in optic nerve, 1991 to 2002.
  • National Science Foundation (NSF): Microbiosensors for evaluating free radical activity in tissue, 1990 to 1993.
  • National Institutes of Health (NIH): Arterial wall O2 at bifurcations and stenoses, 1986 to 1990.

Publications

  • Thom SR, Fisher D, Zhang J, Bhopale VM, Cameron B, Buerk DG, Neuronal nitric oxide synthase and N-methyl-D-aspartate neurons in experimental carbon monoxide poisoning, Toxicology & Applied Pharmacology, 194, 280-295, 2004
  • Buerk DG, Measuring tissue PO2 with microelectrodes, Methods in Enzymology, 381, 665-689, 2004
  • Buerk DG, Recessed oxygen microelectrodes: Getting more than PO2, Advances in Experimental Medicine and Biology, 510, 175-179, 2003
  • Buerk DG, Ances BM, Greenberg JH, Detre JA, Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats, NeuroImage, 18, 1-9, 2003
  • Buerk DG, Lamkin-Kennard K, Jaron D, Modeling the influence of superoxide dismutase on superoxide and nitric oxide interactions including reversible inhibition of oxygen consumption, Free Radical Biology and Medicine, 34, 1488-1503, 2003
  • Kozower BD, Christofidou-Solomidou M, Sweitzer TD, Muru S, Buerk DG, Solomides CC, Albelda SM, Patterson GA, Muzykantov VR, Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury, Nature Biotechnology, 21, 392-398, 2003
  • Lamkin-Kennard K, Jaron D, Buerk DG, Modeling the regulation of oxygen consumption by nitric oxide, Advances in Experimental Medicine and Biology, 510, 145-149, 2003
  • Thom SR, Fisher D, Zhang J, Bhopale V, Ohnishi ST, Kotake Y, Ohnishi T, Buerk DG, Stimulation of perivascular nitric oxide synthesis by oxygen, American Journal of Physiology, 284, H1230-H1239, 2003
  • Menon C, Polin GM, Prabakaran I, Hsi A, Cheung C, Culver JP, Pingpank JF, Sehgal CS, Yodh AG, Buerk DG, Fraker DL, An integrated clinically relevant approach to measuring tumor oxygen status using human melanoma xenografts as a model, Cancer Research, 63, 7232-7240, 2003
  • Buerk DG, Riva CE, Adenosine enhances functional activation of blood flow in cat optic nerve head during photic stimulation independently from nitric oxide, Microvascular Research, 64, 254-264, 2002
  • Kelley ST, Menon C, Buerk DG, Bauer TW, Fraker DL, Acidosis plus melphalan induces nitric oxide mediated tumor regression in an isolated limb perfusion human melanoma xenograft model, Surgery, 132, 252-258, 2002
  • Thom SR, Bhopale V, Fisher D, Manevich Y, Huang PL, Buerk DG, Stimulation of nitric oxide synthase in cerebral cortex due to elevated partial pressures of oxygen: an oxidative stress response, Journal of Neurobiology, 51, 85-100, 2002
  • Ances BM, Buerk DG, Greenberg JH, Detre JA, Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats, Neuroscience Letters, 306, 106-110, 2001
  • Buerk DG, Can we model NO biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities, Annual Review of Biomedical Engineering, 3, 109-143, 2001
  • Fukamura D, Gohongi T, Kadambi A, Ang J, Yun C-O, Buerk DG, Huang PL, Jain RK, Predominant role of endothelial nitric oxide synthase in VEGF-induced angiogenesis and vascular permeability, Proceedings of the National Academy of Sciences (USA), 98(5), 2604-09, 2001
  • Lahiri S, Rozanov C, Roy A, Storey B, Buerk DG, Regulation of oxygen sensing in peripheral arterial chemoreceptors, International Journal of Biochemistry and Cell Biology, 33, 755-774, 2001
  • Buerk DG, Lahiri S, Evidence that nitric oxide plays a role in O2 sensing from tissue NO and PO2 measurements in cat carotid body, Advances in Experimental Medicine and Biology, 475, 337-47, 2000
  • Buerk DG, Osanai S, Mokashi A, Lahiri S, Dopamine and sensory discharge CO2-O2 stimulus-interaction in cat carotid body, Journal of Applied Physiology, 85, 1719-26, 1998
  • Buerk DG, Riva CE, Vasomotion and spontaneous low frequency oscillations in blood flow and nitric oxide in cat optic nerve head, Microvascular Research, 55, 103-12, 1998
  • Buerk DG, Tsai AG, Intaglietta M, Johnson PC, In vivo tissue pO2 measurements in hamster skinfold by recessed pO2 microelectrodes and phosphorescence quenching are in agreement, Microcirculation, 5, 219-25, 1998
  • Riva CE, Buerk DG, Dynamic coupling of blood flow to function and metabolism in the optic nerve head, Neuro-Ophthalmology, 20, 45-54, 1998
  • Roy A, Rozanov C, Buerk DG, Mokashi A, Lahiri A, Supression of glomus cell K+ conductance by 4-aminopyridine is not related to [Ca2+]i, dopamine release and chemosensory discharge from cat carotid body, Brain Research, 785, 228-35, 1998
  • Rozanov C, Buerk DG, Chugh D, Mokashi A, Lahiri S, Inhibition of dopamine release with simultaneous chemosensory excitation by hypercapnia with and without [Ca2+]0 in the cat carotid body, Journal of the Autonomic Nervous System, 69, 184-89, 1998
  • Tsai AG, Friesenecker B, Mazzoni MC, Kerger H, Buerk DG, Johnson PC, Intaglietta M, Microvascular and tissue oxygen gradients in the rat mesentery, Proceedings of the National Academy of Sciences (USA), 95, 6590-95, 1998
  • Ye G-F, Jaron D, Buerk DG, Chou M-C, Shi W, O2-Hb reaction kinetics and the Fähraeus effect during stagnant, hypoxic and anemic supply deficit, Annals of Biomedical Engineering, 26, 60-75, 1998
  • Ye G-F, Park JW, Basude R, Buerk DG, Jaron D, Incorporating O2-Hb reaction kinetics and the Fähraeus effect into a microcirculatory O2-CO2 transport model, IEEE Transactions on Biomedical Engineering, 45, 26-35, 1998
  • Buerk DG, Chugh DK, Osanai S, Mokashi A, Lahiri S, Dopamine increases in the cat carotid body during excitation by carbon monoxide: Implications for a chromophore theory of chemoreception, Journal of the Autonomic Nervous System, 67, 130-36, 1997
  • Buerk DG, Riva CE, Cranstoun SD, Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli, Microvascular Research, 52, 13-26, 1996
  • Buerk DG, Lahiri S, Chugh D, Mokashi A, Electrochemical detection of rapid dopamine release kinetics during hypoxia in perfused/superfused cat carotid bodies, Journal of Applied Physiology, 78, 830-37, 1995
  • Buerk DG, Riva CE, Cranstoun SD, Frequency and luminance dependent blood flow and K+ ion changes during flicker stimuli in cat optic nerve head, Investigative Ophthalmology and Visual Science, 36, 2216-27, 1995
  • Buerk DG, Itturiaga R, Lahiri S, Testing the metabolic hypothesis of O2 chemoreception in the cat carotid body in vitro, Journal of Applied Physiology, 76, 1317-23, 1994
  • Buerk DG, Nair P, PtiO2 and CMRO2 changes in cortex and hippocampus of aging gerbil brain, Journal of Applied Physiology, 74, 1723-28, 1993
  • Buerk DG, Shonat RD, Riva CE, O2 gradients and countercurrent exchange in the cat vitreous humor near retinal arterioles and veins, Microvascular Research, 45, 134-48, 1993
  • Buerk DG, Goldstick TK, Spatial variation of aortic wall oxygen diffusion coefficient from transient polarographic measurements, Annals of Biomedical Engineering, 20, 629-46, 1992

Profile Details

Last Updated: 2/25/2004

COS Expertise ID #859000
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