Trudy L. Burns

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University of Iowa
College of Public Health
Epidemiology
ProfessorAppointed: 2007
University of Iowa
College of Nursing
Parent, Child & Family
Professor (Secondary)Appointed: 2004
University of Iowa
College of Public Health
Genetics
ProfessorAppointed: 2003
University of Iowa
Carver College of Medicine
Pediatrics
Professor (Secondary)Appointed: 2000
Professional Headshot of Trudy L. Burns

Mailing Address

2199 WL
University of Iowa
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 335-9620
Fax: (319) 353-3038
trudy-burns@uiowa.edu
http://www.public-health.uiowa.edu/faculty-staff/faculty/directory/faculty-detail.asp?emailAddress=trudy-burns@uiowa.edu

Qualifications

Ph.D., University of Michigan, Biostatistics, 1982.
M.P.H., University of Michigan, Biostatistics, 1976.
B.A., Oakland University, Mathematics/Biology, 1973.

Expertise and Research Interests

Childhood obesity is predictive of adult obesity and the degree of ponderosity in adults has been shown to be an important predictor of morbidity as well as mortality from atherosclerotic cardiovascular disease. A family study was conducted in Muscatine,Iowa of 1,580 individuals in 284 families to evaluate the genetic contribution to familial clustering of levels of the body mass index (BMI) and found evidence that the segregation of two alleles at a recessive locus explains 35%, while polygenic loci explain 42% of the variability in BMI in this population.

Several rodent models of recessive obesity have also been identified and the traits have been mapped to rodent chromosomal regions which are synthenic with regions on human chromosomes 1 and 7. These results suggest that a search for human genes that are responsible for the variability in BMI is now an important venture.

Our current focus is on answering the question: ''Are there human genes or DNA sequences which have measurable effects on quantitative indices of obesity or on quantitative traits that are associated with obesity among families from Muscatine?'' This study should add to an understanding of the genetic factors involved in the determination of obesity and may lead to early identification of individuals and families at high risk for the chronic diseases that are associated with obesity.

Atherosclerotic heart disease has been shown to have its origins in childhood and young adult life. The Muscatine Study of school-age children, which began almost 25 years ago, provides a unique longitudinal population for study of coronary risk factors obtained during childhood and young adult life with repect to their predictive value for the development and progression of the atheroscleroticprocess in the fourth decade of life.

We are currently examining the relationship of coronary risk factor levels measured in childhood and young adult life to the presence and quantity of coronary artery calcification, a marker of the atherosclerotic process. Results from these investigations may establish whether coronary artery calcification, detected in young adult life, is an indicator in asymptomatic young adults of accelerated atherosclerosis.

In humans, excess blood pressure and body size are associated with increased cardiovascular risk. The association between hypertension and obesity is well established, however, the pathophysiologic relationship remains poorly understood. Both hypertension and obesity are multifactorial phenotypes whose etiologies clearly involve the effects of major genes and polygenes, as well as the effects of numerous environmental factors.

We are using measured-genotype and marker-association methods of analysis to estimate the magnitude of the effects of STRP loci at 20 cM intervals throughout the genome on the determination of blood pressure and body size in 500 unselected Muscatine nuclear families. We are also using affected-pedigree-member methods of linkage analysis to identify genetic loci from throughoutthe genome in a Bedouin tribe with multiple hypertensive members.

Other Expertise

I have contributed the following book chapters:
- Friedman BA, Burns TL, Schork MA and Kalton G. A description and analysis of current blood transfusion practices in the United States with applications for the hospital transfusion committee. In ClinicalLaboratory Annual, HA Homburger and JG Batsakis, eds. New York: Appleton-Century-Crofts, 1982. pp. 147-169.
- Burns TL. Study design: Necessity, principles and applications. In: Statistics for Blood Bankers, SS Ellisor and PA Morel, eds. Arlington, VA: American Association of Blood Banks, 1983. pp 59-87.
- Lee J, Burns TL. Genetic dyslipoproteinemias associated with cornoary atherosclerosis. In: The Genetics of Cardiovascular Disease, MEM Pierpont and JH Moller, eds. Boston: Martinus Nijhoff, 1987. pp 161-191.
- Burns TL, Lauer RM. Blood pressure in children. In: The Genetics of Cardiovascular Disease, MEM Pierpont and JH Moller, eds. Boston: Martinus Nijhoff, 1987. pp 305-317.
- Lauer RM, Burns TL, Clarke WR. Epidemiology of blood pressure in childhood. In: Proceedings of the International Symposium on the Early Pathogenesis of Primary Hypertension, Rotterdam, September 9-10, 1986, A Hofman, DE Grobbee and MADH Schalekamp, eds. Amsterdam: Elsevier Science, 1987.
- Lauer RM, Burns TL, Clare WR. The significance of blood presure in childhood. In: The Pediatrician of the '90s - Issues Related to Children's Health Care, sponsored by an educational grant from Wyeth Laboratories, Biomedical Information Corporation, McGraw-Hill Healthcare Group, 1987. pp 32-36.
- Lauer RM, Lee J, Clarke WR, Burns TL. Cholesterol screening in childhood: The Muscatine Study. Ninety-fifth Ross Conference on Pediatric Research, Prevention of Adult Atherosclerosis During Childhood, RM Lauer and L Finberg, eds. Columbus, OH: Ross Laboratories, 1988.
- Lauer RM, Burns TL, Mahoney LT, Tipton CM. Blood pressure in children. In: Youth, Exercise and Sports, Vol. II, D Lamb and CV Gisolfi, eds. Indianapolis, IN: Benchmark Press, Inc, 1989. pp 431-463.
- Ionasescu V, Burns TL, Searby C, Ionasescu R. Linkage analysis of Charcot-Marie-Tooth neuropathy type 1A (CMT1A) using DNA probes GBA, APOA2, AT3, REN and FY. In: Charcot-Marie-Tooth Disorders: Pathophysiology, Molecular Genetics, and Therapy, Alan R. Liss, Inc, 1990. pp 279-292.
-Burns TL, Moll PP, Lauer RM. Genetics of obesity. In: Proceedings of the International Conference on the Prevention of Atherosclerosis and Hypertension Beginning in Youth, Orlando, May 21-23, 1992, RM Lauer, - RV Luepker, LJ Filer, eds. Malvern, PA: Lea & Febiger, 1994. pp 180-185.
- Mahoney LT, Janz KF, Lauer RM, Burns TL. Impact of body composition, physical fitness, and physical activity on blood lipids in children The Muscatine Study. In: Proceedings of the International Conference on the Prevention of Atherosclerosis and Hypertension Beginning in Youth, RM Lauer, RV Luepker, LJ Filer, eds. Malvern, PA: Lea & Febiger, 1994. pp 209-210.
- Burns TL, Moll PP, Lauer RM. The Muscatine Ponderosity Family Study. In: Pennington Center Nutrition Series, Vol. 5 Molecular and Genetic Aspects of Obesity, GA Bray and DH Ryan, eds. Louisiana State University Press, 1996. pp 482-495.
- Burns TL. Developmental aspects of obesity: Genetic influences. In: Obesity: Impact on Cardiovascular Disease, GF Fletcher, SM Grundy, LL Haymen, eds. AHA Monograph Series. Futura Publishing Co, Inc, 1999.
- Peyser PA and Burns TL. Approaches to Quantify the Genetic Component of and Identify Genes for Complex Traits. In: Human Genome Epidemiology: Scientific Foundations for Using Genetic Information to Improve Health and Prevent Disease, MJ Khoury, J Little and W Burke, eds. Oxford University Press, pp. 38-57, 2004.
- Mahoney LT, Burns TL, Bielak LF & Peyser PA. Relationship between cardiovascular risk factors and coronary artery calcification. In: Pediatric Prevention of Atherosclerotic Cardiovascular Disease. RM Lauer, TL Burns and SR Daniels (eds.). Oxford University Press, pp 63-83, 2006.
- Burns TL, Peyser PA & Donohoue PA. The Epidemiology of Childhood Overweight. In: Pediatric Prevention of Atherosclerotic Cardiovascular Disease. RM Lauer, TL Burns and SR Daniels (eds.). Oxford University Press, pp 233-53, 2006.
- Burns TL, & Daniels SR. The Epidemiology of Childhood Blood Pressure. In: Pediatric Prevention of Atherosclerotic Cardiovascular Disease. RM Lauer, TL Burns and SR Daniels (eds.). Oxford University Press, pp 165-83, 2006.

I have contributed the following books/monographs:
- Pediatric Prevention of Atheroscience Cardiovascular Disease. Ronald M. Lauer, Truy L. Burns and Stephen R. Daniels (eds). Oxford University Press, New York, NY, 2006. Reviewed in Circulation 115:43-4,2007.

Member, International Biometrics Society Eastern North American Region

Keywords

COS Keywords:

Animal Models, Arteriosclerosis or Atherosclerosis, Biometry, Biostatistics, Birth or Congenital Defects, Cardiovascular Diseases, Clinical Research or Studies, Data Analysis, Data Management or Analysis (Medical), Dermatology, Epidemiology, Etiology, Genetics, Hypertension, Obesity, Pediatrics, Public Health.

Additional Terms:

Biometry, Biostatistics, Birth Defects, Cardiovascular Disease, Coronary Risk Factors, Data Analysis, Data Management, Epidemiologic Analysis, Epidemiology, Genetic Epidemiology, Obesity.

Memberships

American Heart Association
American Society of Human Genetics
American Statistical Association
International Biometrics Society
International Genetic Epidemiology Society
Society for Epidemiologic Research

Honors and Awards

2008, Peyser Family Foundation for Population Health, Board of Directors
2006, Paul Harris Fellows, Rotary International
2005-2009, Member, Data Safety and Monitoring Board for Adolescent Bariatrics: Assessing Health Benefits & Risks (Teen-LABS), NIDDK
2001-2002, Career Development Award, University of Iowa
1998-2002, Member, Observational Study Monitoring Board of the Jackson Heart Study, National Heart, Lung, and Blood Institute
1998-2000, Member, VA Merit Review Commitee for Epidemiology
1993-2002, Fellow, American Heart Association High Blood Pressure Council
1992-1996, Member, Epidemiology and Disease Control - 1 Study Section
1977-1982, National Research Service Award for Biostatistical Training in Heart and Vascular Disease,
1975-1976, Public Health Service Award,

Previous Positions

2000-2006, (secondary), University of Iowa, College of Public Health, Epidemiology
2000-2003, Professor, University of Iowa, College of Public Health, Biostatistics, Statistical Genetics
1999-2000, Professor, University of Iowa, College of Public Health, Biostatistics
1993-1999, Director, University of Iowa, Iowa Birth Defects Registry
1993-1999, Professor, University of Iowa, Carver College of Medicine, Preventive Medicine and Environmental Health, Epidemiology
1993-1999, Professor, University of Iowa, Carver College of Medicine, Preventive Medicine and Environmental Health, Biostatistics
1987-1993, Associate Professor, University of Iowa, Carver College of Medicine, Preventive Medicine & Environmental Health
1982-1987, Assistant Professor, University of Iowa, Carver College of Medicine, Preventive Medicine & Environmental Health
1976-1976, Lecturer, University of Michigan, Public Health, Biostatistics
1976-1977, Research Associate, University of Michigan, Medical School, Dermatology
1975-1976, Research Assistant, University of Michigan, Medical School, Dermatology

Funding Received

  • Centers for Disease Control and Prevention: Co-Investigator, Center for Birth Defects Research and Prevention, Paul Romitti, PI, $9,725,724, Sep 30, 1996 to Aug 31, 2007.
  • National Institutes of Health (NIH): Co-Investigator, Epidemiology of Carotid Artery Atherosclerosis in Youth, Patricia Davis, PI, $5,361,044, Sep 30, 1995 to 2008.
  • National Institutes of Health (NIH): Co-Investigator, Environmental Health Sciences Research Center, Peter S. Thorne, PI, $17,442,862, Sep 29, 1990 to 2007.
  • National Institutes of Health (NIH): Co-Investigator, 3D & 4D Coronary Hemodynamics and Local Atherosclerosis, Milan Sonka, PI, $2,307,232, Sep 15, 1999 to 2009.
  • National Institutes of Health (NIH): Co-Investigator, Specialized Center of Research in Pediatric Cardiovascular Disease, Ronald M. Lauer, PI, $4,759,574, Jan 1, 1999 to Dec 31, 2003.
  • American Heart Association (AHA): Principal Investigator, Iron and Low-Density Lipoprotein Particle Size: New Risk Factors for the Development of Atherosclerosis, $165,000, Jan 1, 1998 to Dec 31, 2002.
  • National Institutes of Health (NIH): Co-Investigator, Specialized Center of Research for Molecular Genetics of Hypertension, Curt D. Sigmund, PI, $18,390,953, Feb 1, 1996 to Jan 31, 2006.
  • National Institutes of Health (NIH): Co-Investigator, Arterial Endothelial Function - An Epidemiologic Study, Ronald M .Lauer, PI, $7,259,198, Dec 15, 1998 to 2009.
  • National Institutes of Health (NIH): Co-Investigator, Postdoctoral Training in Clinical Genetics Research, Janet Williams, PI, $1,731,521, Aug 1, 2001 to 2011.
  • National Institutes of Health (NIH): Principal Investigator, The Genetic Epidemiology of Childhood Obesity, $5,984,464, Aug 1, 1992 to 2006.
  • National Institutes of Health (NIH): Co-Investigator, CT Vascular Calcium, An Epidemiologic Study in the Young -- The Muscatine Study, Larry T. Mahoney, PI, $6,291,173, Apr 1, 1992 to 2007.
  • NICHD: Co-Investigator, National Children's Study (NCS) - Polk County, Iowa, Jeffrey Murray, PI, 2008 to 2013.
  • Children's Miracle Network: Sponsor, Epidemiology of Total Anomalous Pulmonary Venous Return, Sonali Patel, PI, 2008 to 2009.
  • Department of Defense: Co-PI of the Iowa TRIM field site, Troop Recruit Improvement (TRIM) Planning Grant, Russell Pate, PI, 2007 to 2008.
  • NHLBI: Co-Investigator, Genetic Markers of Von Willebrand Disease, Jorge Di Paola, PI, $1,831,022, 2006 to 2012.
  • NHLBI: Co-Investigator, Highly Automated Analysis of 4-D Cardiovascular MR Data, $1,388,551, 2003 to 2008.
  • Children's Hospital & Research Center at Oakland: Co-Investigator, Smoking and Variation of Cardiovascular Disease Genes, Ronald M. Lauer, PI, $20,000, 2003 to 2005.
  • NIEHS: Core Co-Director, Environmental Health Sciences Research Center - Environmental Epidemiology Core, J A Merchant, Center Director, $54,248 (Core), 2001 to 2006.
  • Fogarty International Center: Training Faculty Member, International Maternal and Child Health Research and Training, $934,667, 2001 to 2006.
  • National Institutes of Health (NIH): Co-Investigator, Fluoride and Other Factors in Childhood Bone Development, Steven M. Levy, PI, $6,984,512, 1998 to 2007.

Publications

  • Burns TL, Letuchy EM, Paulos R, Witt J (Sep 2009) Childhood predictors of the metabolic syndrome in middle-aged adults: the muscatine study., The Journal of pediatrics, 155 (3), S5.e17-26 Abstract
  • Janz KF, Kwon S, Letuchy EM, Eichenberger Gilmore JM, Burns TL, Torner JC, Willing MC, Levy SM (May 2009) Sustained Effect of Early Physical Activity on Body Fat Mass in Older Children., American journal of preventive medicine Abstract
  • Wakefield BJ, Holman JE, Ray A, Scherubel M, Burns TL, Kienzle MG, Rosenthal GE (2009) Outcomes of a home telehealth intervention for patients with heart failure., Journal of telemedicine and telecare, 15 (1), 46-50 Abstract
  • Mendoza MCB, Burns TL, Jones MP (2009) Case-deletion diagnostics for maximum likelihood multipoint quantitative trait locus linkage analysis, Hum Hered, 67, 276-86
  • Burns TL, Letuchy EM, Paulos R, Witt J (2009) Childhood predictors of the metabolic syndrome in middle-aged adults: The Muscatine Study, J Pediatr, In Press
  • Schubert CM, Sunn SS, Burns TL, Morrison JA, Huang TTK (2009) Predictive ability of childhood metabolic components for adult metabolic syndrome and type 2 diabetes, J Pediatr, In Press
  • Janz KF, Medema-Johnson HC, Letuchy EM, Burns TL, Gilmore JM, Torner JC, Willing M, Levy SM (Aug 2008) Subjective and objective measures of physical activity in relationship to bone mineral content during late childhood: the Iowa Bone Development Study., British journal of sports medicine, 42 (8), 658-63 Abstract
  • Wakefield BJ, Ward MM, Holman JE, Ray A, Scherubel M, Burns TL, Kienzle MG, Rosenthal GE (2008) Burns TL, Kienzle MG, Rosenthal GE. Evaluation of home telehealth following hospitalization for heart failure: A randomized trial, Telemedicine e-Health, 14, 753-61
  • O'Leary BM, Davis SG, Smith MF, Brown B, Kemp MB, Almabrazi H, Grundstad JA, Burns T, Leontiev V, Andorf J, Clark AF, Sheffield VC, Casavant TL, Scheetz TE, Stone EM, Braun TA (Dec 2007) Transcript annotation prioritization and screening system (TrAPSS) for mutation screening., Journal of bioinformatics and computational biology, 5 (6), 1155-72 Abstract
  • Janz KF, Eichenberger-Gilmore JM, Levy SM, Letuchy EM, Burns TL, Beck TJ (2007) Physical activity and femoral neck bone strength during childhood: The Iowa Bone Development Study, Bone, 41 (2), 216-22
  • Bartlett HL, Atkins DL, Burns TL, Engelkes KJ, Powell SJ, Hills CB, Moller JH (2007) Early outcomes of tricuspid valve replacement in young children, Circulation, 115 (3), 319-25
  • Iovannisci DM, Lammer EJ, Steiner L, Cheng S, Mahoney LT, Davis PH, Lauer RM, Burns TL (2006) Association between a leukotriene C4 synthase gene promoter polymorphism and coronary artery calcium in young women. The Muscatine Study, Arterioscler Thromb Vasc Biol, PMID:17110605
  • Janz KF, Gilmore JM, Burns TL, Levy SM, Torner JC, Willing MC, Marshall TA (2006) Physical activity augments bone mineral accrual in young children: The Iowa bone development study, J Pediatr, 148 (6), 793-9
  • Kennedy CM, Nygaard IE, Saftlas A, Burns TL, Torner JC, Galask RP, Vulvar Disease: a Pelvic Floor Pain Disorder?, American Journal of Obstetrics and Gynecology, 192(6), 1829-34; discussion, Jun 2005 Abstract
  • Janz KF, Burns TL, Levy SM (2005) Tracking of activity and inactivity during middle childhood: The Iowa bone density study, Am J Prev Med, 29 (3), 171-8
  • Willing MC, Torner JC, Burns TL, Janz KF, Marshall TA, Gilmore J, Warren JJ, Levy SM (2005) Percentile distributions of bone measures in Iowa children: The Iowa bone development study, J Clin Densitomitry, 8, 39-47
  • Jeronimo SMB, Duggal P, Braz RFS, Cheng C, Monteiro GRG, Nascimento ET, Martins DRA, Karplus TM, Ximenes MFFM, Oliveira CCG, Pinheiro VG, Pereira W, Peralta JM, Sousa JMA, Medeiros IM, Pearson RD, Burns TL, Pugh EW, Wilson ME, An emerging peri-urban pattern of infection with Leishmania chagasi, the protozoan causing visceral leishmaniasis in northeast Brazil, Scandinavian Journal of Infectious Diseases, 36, 6-7, July 2004
  • Janz KF, Burns TL, Levy SM, Torner JC, Willing MC, Beck TJ, Gilmore JM, Marshall TA, Everyday activity predicts bone geometry in children: the iowa bone development study, Medicine and Science in Sports and Exercise, 36(7), 1124-31, July 2004 Abstract
  • Stanford W, Thompson BH, Burns TL, Heery SD, Burr MC, Coronary artery calcium quantification at multi-detector row helical CT versus electron-beam CT, Radiology, 230(2), 397-402, 2004 Abstract
  • Stanford W, Burns TL, Thompson BH, Witt JD, Lauer RM, Mahoney LT, Influence of body size and section level on calcium phantom measurements at coronary artery calcium CT scanning, Radiology, 230(1), 198-205, 2004 Abstract
  • Marshall TA, Levy SM, Broffitt B, Warren JJ, Eichenberger-Gilmore JM, Burns TL, Stumbo PJ, Dental caries and beverage consumption in young children, Pediatrics, 112(3 Pt 1), e184-91, September 2003 Abstract
  • Willing MC, Torner JC, Burns TL, Janz KF, Marshall T, Gilmore J, Deschenes SP, Warren JJ, Levy SM, Gene polymorphisms, bone mineral density and bone mineral content in young children:the Iowa bone development study, Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa., 14(8), 650-8, August 2003 Abstract
  • Nygaard I, Turvey C, Burns TL, Crischilles E, Wallace R, Urinary incontinence and depression in middle-aged United States women, Obstetrics and Gynecology, 101(1), 149-56, January 2003 Abstract
  • Janz KF, Levy SM, Burns TL, Torner JC, Willing MC, Warren JJ, Fatness, physical activity, and television viewing in children during the adiposity rebound period: the Iowa Bone Development Study, Preventive Medicine, 35(6), 563-71, December 2002 Abstract
  • Karplus TM, Jeronimo SM, Chang H, Helms BK, Burns TL, Murray JC, Mitchell AA, Pugh EW, Braz RF, Bezerra FL, Wilson ME, Association between the tumor necrosis factor locus and the clinical outcome of Leishmania chagasi infection, Infection and Immunity, 70(12), 6919-25, December 2002 Abstract
  • Hobbs CA, Cleves MA, Lauer RM, Burns TL, James SJ, Preferential transmission of the MTHFR 677 T allele to infants with Down syndrome: implications for a survival advantage, American Journal of Medical Genetics, 113(1), 9-14, November 2002 Abstract
  • Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sorensen TI, Behn P et al, A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference, International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity., 26(5), 640-6, May 2002 Abstract
  • Heo M, Leibel RL, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sorensen TI, Behn P et al, Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity, Genetics, 159(3), 1163-78, November 2001 Abstract
  • Caldarone CA, Raghuveer G, Hills CB, Atkins DL, Burns TL, Behrendt DM, Moller JH, Long-term survival after mitral valve replacement in children aged <5 years: a multi-institutional study, Circulation, 104(12 Suppl 1), I143-7, September 2001 Abstract
  • Mahoney LT, Burns TL, Stanford W, Thompson BH, Witt JD, Rost CA, Lauer RM, Usefulness of the Framingham risk score and body mass index to predict early coronary artery calcium in young adults (Muscatine Study), The American Journal of Cardiology, 88(5), 509-15, September 2001 Abstract
  • Janz KF, Burns TL, Torner JC, Levy SM, Paulos R, Willing MC, Warren JJ, Physical activity and bone measures in young children: the Iowa bone development study, Pediatrics, 107(6), 1387-93, June 2001 Abstract
  • Janz KF, Burns TL, Torner JC, Levy SM, Paulos R, Willing MC, Warren JJ, Physical activity predicts bone measures in young children, Medicine and Science in Sports and Exercise, 33(6), 2001
  • Vandenberg BF, Lindower PD, Lewis J, Burns TL, Reproducibility of left ventricular measurements with acoustic quantification: the influence of training, Echocardiography (mount Kisco, N.y.), 17(7), 631-7, October 2000 Abstract
  • Raymond MH, Schutte BC, Torner JC, Burns TL, Willing MC, Osteocalcin: genetic and physical mapping of the human gene BGLAP and its potential role in postmenopausal osteoporosis, Genomics, 60(2), 210-7, 1999 Abstract
  • Romitti PA, Lidral AC, Munger RG, Daack-Hirsch S, Burns TL, Murray JC, Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study, Teratology, 59(1), 39-50, Jan 1999 Abstract
  • Wang HM, Jones MP, Burns TL, Regression diagnostics for the class A regressive model with quantitative phenotypes, Genetic Epidemiology, 17(3), 174-87, 1999 Abstract
  • Janz KF, Burns TL, Witt JD, Mahoney LT, Longitudinal analysis of scaling VO2 for differences in body size during puberty: the Muscatine Study, Medicine and Science in Sports and Exercise, 30(9), 1436-44, September 1998 Abstract
  • Smith JM, Cadoret RJ, Burns TL, Troughton EP, Asthma and allergic rhinitis in adoptees and their adoptive parents, Annals of Allergy, Asthma, and Immunology, 81(2), 135-9, August 1998 Abstract
  • Willing M, Sowers M, Aron D, Clark M K, Burns T, Bunten C, Crutchfield M, D'Agostino D, Jannausch M, Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction., Journal of Bone and Mineral Research, 13(4), 695-705, April 1998 Abstract
  • Romitti P A, Munger R G, Murray J C, Daack-Hirsch S, Hanson J W, Burns T L, The effect of follow-up on limiting non-participation bias in genetic epidemiologic investigations., European Journal of Epidemiology, 14(2), 129-38, February 1998 Abstract
  • Romitti P A, Burns T L, Murray J C, Maternal interview reports of family history of birth defects: evaluation from a population-based case-control study of orofacial clefts., American Journal of Medical Genetics, 72(4), 422-9, 12 Nov 1997 Abstract
  • Lauer R M, Clarke W R, Burns T L, Obesity in childhood: the Muscatine Study., Chung-hua Min Kuo Hsiao Erh Ko I Hsueh Hui Tsa Chih, 38(6), 432-7, November 1997 Abstract
  • Willing M C, Torner J C, Burns T L, Segar E T, Werner J R, Determinants of bone mineral density in postmenopausal white Iowans., Journals of gerontology. Series A, Biological Sciences and Medical, 52(6), M337-42, November 1997 Abstract
  • Romitti P A, Burns T L, Feasibility of collecting disease reports from relatives for genetic epidemiologic investigations., Human Heredity, 47(6), 351-7, November 1997 Abstract
  • Vandenberg B F, Oren R M, Lewis J, Aeschilman S, Burns T L, Kerber R E, Evaluation of color kinesis, a new echocardiographic method for analyzing regional wall motion in patients with dilated left ventricles., American Journal of Cardiology, 79(5), 645-50, 1 Mar 1997 Abstract
  • Munger R, Isacson P, Hu S, Burns T, Hanson J, Lynch CF, Cherryholmes K, Van Dorpe P, Hausler WJ Jr, Intrauterine growth retardation in Iowa communities with herbicide-contaminated drinking water supplies [published erratum appears in Environ Health Perspect 1997 Jun;105\(6\):570, Environmental Health Perspectives, 105(3), 308-14, 1997 Abstract
  • Sheffield V C, Pierpont M E, Nishimura D, Beck J S, Burns T L, Berg M A, Stone E M, Patil S R, Lauer R M, Identification of a complex congenital heart defect susceptibility locus by using DNA pooling and shared segment analysis., Human Molecular Genetics, 6(1), 117-21, January 1997 Abstract
  • Trigg ME, Morgan D, Burns TL, Kook H, Rumelhart SL, Holida MD, Giller RH, Successful program to prevent aspergillus infections in children undergoing marrow transplantation: use of nasal amphotericin., Bone Marrow Transplantation, 19(1), 43-7, 1997 Abstract
  • Vandenberg B F, Rossen J D, Grover-McKay M, Shammas N W, Burns T L, Rezai K, Evaluation of diabetic patients for renal and pancreas transplantation: noninvasive screening for coronary artery disease using radionuclide methods., Transplantation, 62(9), 1230-5, 15 Nov 1996 Abstract
  • Munger R G, Romitti P A, Daack-Hirsch S, Burns T L, Murray J C, Hanson J, Maternal alcohol use and risk of orofacial cleft birth defects., Teratology, 54(1), 27-33, July 1996 Abstract
  • Mahoney L T, Burns T L, Stanford W, Thompson B H, Witt J D, Rost C A, Lauer R M, Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: the Muscatine Study., Journal of The American College of Cardiology, 27(2), 277-84, February 1996 Abstract
  • Ely J W, Dawson J D, Mehr D R, Burns T L, Understanding logistic regression analysis through example [see comments], Family Medicine, 28(2), 134-40; discussion 1, February 1996 Abstract
  • Zittergruen M M, Murray J C, Lauer R M, Burns T L, Sheffield V C, Molecular analysis of nondisjunction in Down syndrome patients with and without atrioventricular septal defects., Circulation, 92(10), 2803-10, 15 Nov 1995 Abstract
  • Vandenberg B F, Ayres R W, Lindower P D, Burns T L, Kerber R E, Reproducibility and variability of the amount of tricuspid regurgitation with color Doppler echocardiography., American Journal of Cardiology, 76(3), 198-9, 15 Jul 1995 Abstract
  • Janz K F, Burns T L, Mahoney L T, Predictors of left ventricular mass and resting blood pressure in children: the Muscatine Study., Medicine and Science In Sports and Exercise, 27(6), 818-25, June 1995 Abstract
  • Vandenberg B F, Weiss R M, Kinzey J, Acker M, Stark C A, Stanford W, Burns T L, Marcus M L, Kerber R E, Comparison of left atrial volume by two-dimensional echocardiography and cine-computed tomography., American Journal of Cardiology, 75(10), 754-7, 1 Apr 1995 Abstract
  • White M L, Grover-McKay M, Weiss R M, Vandenberg B F, Burns T L, Winniford M D, Stanford W, McKay C R, Prediction of change in mitral valve area after mitral balloon commissurotomy using cine computed tomography., Investigative Radiology, 29(9), 827-33, September 1994 Abstract
  • Grover-McKay M, Weiss R M, Vandenberg B F, Burns T L, Weidner G J, Winniford M D, Stanford W, McKay C R, Assessment of cardiac volumes and left ventricular mass by cine computed tomography before and after mitral balloon commissurotomy., American Heart Journal, 128(3), 533-9, September 1994 Abstract
  • Muhonen L E, Burns T L, Nelson R P, Lauer R M, Coronary risk factors in adolescents related to their knowledge of familial coronary heart disease and hypercholesterolemia: the Muscatine Study., Pediatrics, 93(3), 444-51, March 1994 Abstract
  • Cousineau A J, Lauer R M, Pierpont M E, Burns T L, Ardinger R H, Patil S R, Sheffield V C, Linkage analysis of autosomal dominant atrioventricular canal defects: exclusion of chromosome 21 [see comments], Human Genetics, 93(2), 103-8, February 1994 Abstract
  • Lindower P D, Rath L, Preslar J, Burns T L, Rezai K, Vandenberg B F, Quantification of left ventricular function with an automated border detection system and comparison with radionuclide ventriculography., American Journal of Cardiology, 73(2), 195-9, 15 Jan 1994 Abstract
  • Ayres R W, Burns T L, Stuhlmuller J, Kerber R E, Vandenberg B F, Physician use of transesophageal echocardiography varies with time after introduction into a hospital setting., American Journal of Cardiology, 72(17), 1330-1, 1 Dec 1993 Abstract
  • Malcolm D D, Burns T L, Mahoney L T, Lauer R M, Factors affecting left ventricular mass in childhood: the Muscatine Study., Pediatrics, 92(5), 703-9, November 1993 Abstract
  • Hata J S, Ayres R W, Biller J, Adams H P Jr, Stuhlmuller J E, Burns T L, Kerber R E, Vandenberg B F, Impact of transesophageal echocardiography on the anticoagulation management of patients admitted with focal cerebral ischemia., American Journal of Cardiology, 72(9), 707-10, 15 Sep 1993 Abstract
  • Ciniglio R, Kime M, Burns T L, Vandenberg B F, Rapid resolution of hyperkinesis after exercise. Two-dimensional echocardiographic studies in normal subjects., Chest, 104(3), 712-7, September 1993 Abstract
  • Gazzaniga J M, Burns T L, Relationship between diet composition and body fatness, with adjustment for resting energy expenditure and physical activity, in preadolescent children., American Journal of Clinical Nutrition, 58(1), 21-8, July 1993 Abstract
  • Burns T L, Moll P P, Lauer R M, Genetic models of human obesity--family studies., Critical Reviews In Food Science and Nutrition, 33(4-5), 339-43, 1993 Abstract
  • Stuhlmuller J E, Olson J D, Burns T L, Skorton D J, Effect of varying fibrinogen and hematocrit concentrations on magnetic resonance relaxation times of thrombus., Investigative Radiology, 27(5), 341-5, May 1992 Abstract
  • Stuhlmuller J E, Skorton D J, Burns T L, Melton H E Jr, Vandenberg B F, Reproducibility of quantitative backscatter echocardiographic imaging in normal subjects., American Journal of Cardiology, 69(5), 542-6, 15 Feb 1992 Abstract
  • Burns T L, Moll P P, Lauer R M, Increased familial cardiovascular mortality in obese schoolchildren: the Muscatine Ponderosity Family Study., Pediatrics, 89(2), 262-8, February 1992 Abstract
  • Sowers M R, Boehnke M, Jannausch M L, Crutchfield M, Corton G, Burns T L, Familiality and partitioning the variability of femoral bone mineral density in women of child-bearing age., Calcified Tissue International, 50(2), 110-4, February 1992 Abstract
  • Anderson R A, Burns T L, Wallace R B, Folsom A R, Sprafka J M, Genetic markers associated with high density lipoprotein cholesterol levels in a biracial population sample., Genetic Epidemiology, 9(2), 109-21, 1992 Abstract
  • Moll P P, Burns T L, Lauer R M, The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study., American Journal of Human Genetics, 49(6), 1243-55, December 1991 Abstract
  • Stuhlmuller J E, Fleagle S R, Burns T L, Skorton D J, Effects of instrument adjustments on quantitative echocardiographic gray level texture measures., Journal of The American Society of Echocardiography, 4(6), 533-40, November 1991 Abstract
  • Mahoney L T, Clarke W R, Burns T L, Lauer R M, Childhood predictors of high blood pressure., American Journal of Hypertension, 4(11), 608S-610S, November 1991 Abstract
  • Lauer R M, Burns T L, Clarke W R, Mahoney L T, Childhood predictors of future blood pressure., Hypertension, 18(3 Suppl), I74-81, September 1991 Abstract
  • Stuhlmuller J E, Scholz T D, Olson J D, Burns T L, Skorton D J, Magnetic resonance characterization of blood coagulation in vitro. Effect of platelet depletion., Investigative Radiology, 26(4), 343-7, April 1991 Abstract
  • Grover-McKay M, Scholz T D, Burns T L, Skorton D J, Myocardial collagen concentration and nuclear magnetic resonance relaxation times in the spontaneously hypertensive rat., Investigative Radiology, 26(3), 227-32, March 1991 Abstract
  • Jordan D K, Burns T L, Divelbiss J E, Woolson R F, Patil S R, Variability in expression of common fragile sites: in search of a new criterion., Human Genetics, 85(5), 462-6, October 1990 Abstract
  • Kwon J M, Boehnke M, Burns T L, Moll P P, Commingling and segregation analyses: comparison of results from a simulation study of a quantitative trait., Genetic Epidemiology, 7(1), 57-68, 1990 Abstract
  • Scholz T D, Fleagle S R, Burns T L, Skorton D J, Nuclear magnetic resonance relaxometry of the normal heart: relationship between collagen content and relaxation times of the four chambers., Magnetic Resonance Imaging, 7(6), 643-8, November 1989 Abstract
  • Scholz TD, Fleagle SR, Burns TL, Skorton DJ, Tissue determinants of nuclear magnetic resonance relaxation times. Effect of water and collagen content in muscle and tendon, Investigative Radiology, 24(11), 893-8, November 1989 Abstract
  • Jordan D K, Divelbiss J E, Waziri M H, Burns T L, Patil S R, Fragile site expression in families with von Hippel-Lindau disease., Cancer Genetics and Cytogenetics, 39(2), 157-66, June 1989 Abstract
  • Anderson RA, Burns TL, Lee J, Swenson D, Bristow JL, Restriction fragment length polymorphisms associated with abnormal lipid levels in an adolescent population, Atherosclerosis, 77(2-3), 227-37, June 1989 Abstract
  • Burns TL, Moll PP, Lauer RM, The relation between ponderosity and coronary risk factors in children and their relatives. The Muscatine Ponderosity Family Study, American Journal of Epidemiology, 129(5), 973-87, May 1989 Abstract
  • Chandrasekaran K, Aylward PE, Fleagle SR, Burns TL, Seward JB, Tajik AJ, Collins SM, Skorton DJ, Feasibility of identifying amyloid and hypertrophic cardiomyopathy with the use of computerized quantitative texture analysis of clinical echocardiographic data, Journal of the American College of Cardiology, 13(4), 832-40, 1989 Abstract
  • Ionasescu VV, Burns TL, Searby C, Ionasescu R, X-linked dominant Charcot-Marie-Tooth neuropathy with 15 cases in a family genetic linkage study, Muscle and Nerve, 11(11), 1154-6, November 1988 Abstract
  • Kuperman S, Black DW, Burns TL, Excess mortality among formerly hospitalized child psychiatric patients, Archives of General Psychiatry, 45(3), 277-82, March 1988 Abstract
  • Kuperman S, Black DW, Burns TL, Excess suicide among formerly hospitalized child psychiatry patients, Journal of Clinical Psychiatry, 49(3), 88-93, March 1988 Abstract
  • Ionasescu V, Anderson R, Burns TL, Searby C, Ionasescu R, Ferrell R, Evidence for linkage of Charcot-Marie-Tooth neuropathy (CMT1) to apolipoprotein A2 (Apo-A2), American Journal of Human Genetics, 42(1), 74-6, January 1988 Abstract
  • Burns TL, Moll PP, Rost CA, Lauer RM, Mothers remember birthweights of adolescent children: the Muscatine Ponderosity Family Study, International Journal of Epidemiology, 16(4), 550-5, December 1987 Abstract
  • Ionasescu V, Murray JC, Burns TL, Ionasescu R, Ferrell R, Searby C, Chirgwin J, Linkage analysis of Charcot-Marie-Tooth neuropathy (HMSN type I), Journal of the Neurological Sciences, 80(1), 73-8, August 1987 Abstract
  • Collison DW, Burns TL, Stewart ME, Downing DT, Strauss JS, Evaluation of a method for measuring the sustainable rate of sebaceous wax ester secretion, Archives of Dermatological Research, 279(4), 266-9, 1987 Abstract
  • Edward AM, Schork MA, Harburg E, Moll PP, Burns TL, Ozgoren F, Sources of variability in quantitative levels of alcohol use in a total community: sociodemographic and psychosocial correlates, International Journal of Epidemiology, 15(1), 82-90, March 1986 Abstract
  • Sowers MR, Burns TL, Wallace RB, Familial resemblance of bone mass in adult women, Genetic Epidemiology, 3(2), 85-93, 1986 Abstract
  • Clarke WR, Schrott HG, Burns TL, Sing CF, Lauer RM, Aggregation of blood pressure in the families of children with labile high systolic blood pressure. The Muscatine Study, American Journal of Epidemiology, 123(1), 67-80, January 1986 Abstract
  • Anderson RA, Benda TJ, Wallace RB, Eliason SL, Lee J, Burns TL, Prevalence and associations of apolipoprotein A-I linked DNA polymorphisms: results from a population study, Genetic Epidemiology, 3(6), 385-97, 1986 Abstract
  • Lauer RM, Burns TL, Clarke WR, Assessing children's blood pressure--considerations of age and body size: the Muscatine Study, Pediatrics, 75(6), 1081-90, June 1985 Abstract
  • Kuperman S, Beeghly JH, Burns TL, Tsai LY, Serotonin relationships of autistic probands and their first-degree relatives, Journal of the American Academy of Child Psychiatry, 24(2), 186-90, March 1985 Abstract
  • Smith EM, Burns TL, The effects of breast self-examination in a population-based cancer registry. A report of differences in extent of disease, Cancer, 55(2), 432-7, 1985 Abstract
  • Burns TL, Moll PP, Schork MA, Comparisons of different sampling designs for the determination of genetic transmission mechanisms in quantitative traits, American Journal of Human Genetics, 36(5), 1060-74, September 1984 Abstract
  • Smith EM, Sowers MF, Burns TL, Effects of smoking on the development of female reproductive cancers, Journal of the National Cancer Institute, 73(2), 371-6, August 1984 Abstract
  • Lauer RM, Anderson AR, Beaglehole R, Burns TL, Factors related to tracking of blood pressure in children. U.S. National Center for Health Statistics Health Examination Surveys Cycles II and III, Hypertension, 6(3), 307-14, 1984 Abstract
  • Moll PP, Harburg E, Burns TL, Schork MA, Ozgoren F, Heredity, stress and blood pressure, a family set approach: the Detroit Project revisited, Journal of Chronic Diseases, 36(4), 317-28, 1983 Abstract
  • Williams GW, Burns TL, Schork MA, The distribution of selected hematology measurements in the CAP survey, American Journal of Clinical Pathology, 74(4 Suppl), 595-9, October 1980 Abstract
  • Margolis FJ, Burt BA, Schork MA, Bashshur RL, Whittaker BA, Burns TL, Fluoride supplements for children. A survey of physicians' prescription practices, American Journal of Diseases of Children, 134(9), 865-8, September 1980 Abstract
  • Friedman BA, Burns TL, Schork MA, An analysis of blood transfusion of surgical patients by sex: a question for the transfusion trigger, Transfusion, 20(2), 179-88, 1980 Abstract
  • Stawiski MA, Rusin LJ, Burns TL, Weinstein GD, Voorhees JJ, Ro 20-1724: an agent that significantly improves psoriatic lesions in double-blind clinical trials, Journal of Investigative Dermatology, 73(4), 261-3, October 1979 Abstract
  • Friedman BA, Burns TL, Schork MA, A study of blood utilization by diagnosis, month of transfusion, and geographic region of the United States, Transfusion, 19(5), 511-25, 1979 Abstract

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