Cynthia J. Gibas

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University of North Carolina at Charlotte
College of Computing and Informatics
Computer Science
Bioinformatics
Associate ProfessorAppointed: 2005
Professional Headshot of Cynthia J. Gibas

Mailing Address

333E Woodward Hall
9201 University City Blvd.
Charlotte, North Carolina 28223
United States

Contact Information

Phone: (704) 687-8378
Fax: (704) 687-6065
cgibas@uncc.edu

Qualifications

Ph.D., University of Illinois at Urbana-Champaign, Biophysics and Computational Biology, 1996.
B.A., Lawrence University, Chemistry, 1990.

Expertise and Research Interests

Whole genome comparison and comparative databases
DNA array design for comparative functional genomics and host-pathogen interaction experiments
Modeling and optimization of probe-target hybridization behavior on DNA arrays
Macromolecular structure, electrostatics, and diffusion-controlled behavior


Other Expertise

I have a significant background in biophysics, especially in bioenergetics and photosynthesis.

Future Research

Optimization of experimental design methodology for microarrays and other high-throughput experiments
Modeling structure and molecular interactions in complex nucleic acid mixtures
Development of a software system for comparison of multiple genomes and visualization of genome comparisons
Comparative study of genome diversity in viral and prokaryotic systems

Industrial Relevance

Bioinformatics methods are applicable in drug discovery, agricultural biotechnology, metabolic engineering, industrial processes, and medicine.

Keywords

COS Keywords:

Bioinformatics, Biophysics, Biotechnology, Computational Biology, Genomics, Molecular Physics, Protein Structure.

Additional Terms:

Bioinformatics, Biotechnology, Genomics, Macromolecular Interactions, Molecular Biophysics, Molecular Engineering, Protein Structure.

Memberships

International Society for Computational Biology

Previous Positions

1999-2005, Assistant Professor, Virginia Polytechnic Institute and State University, College of Science, Biology-Fralin Biotechnology Center
1998-1999, Research Programmer, National Center for Supercomputing Applications, Computational Biology
1996-1998, Postdoctoral Research Associate, University of Illinois at Urbana-Champaign, Molecular & Integrative Physiology

Funding Received

  • North Carolina Biotechnology Center: UNCC Functional Genomics Core Facility, $222,000, 2006 to 2007.
  • National Institutes of Health (NIH): Biophysical Optimization of Oligonucleotide Microarrays, $2,027,768, 2005 to 2010.

Publications

  • Gharaibeh, RZ, Fodor, AA, Gibas, CJ (2007) Using Probe Secondary Structure Information to Enhance Affymetrix GeneChip Background Estimates, Computational Biology and Chemistry, 31 (2), 92-8
  • Ratushna, VG, Sturgill, DM, Ramamoorthy, S, Reichow, SA, He, Y, Lathigra, R, Sriranganathan, N, Halling, SM, Boyle, SM, Gibas, CJ (2006) BMC Microbiology, Molecular targets for rapid identification of Brucella spp., 22 (6), 13
  • Karanam, RK, Ravindran, A, Mukherjee, A, Gibas, CJ, Wilkinson, BA (2006) Using FPGA-Based Hybrid Computers for Bioinformatics Applications, XCell Journal, 58, 80-83
  • Ratushna VG, Weller JW, Gibas CJ, Secondary Structure in the Target As a Confounding Factor in Synthetic, BMC Genomics, 6(1), 31, Mar 2005 Abstract
  • Kaluszka A, Gibas C, Interactive Gene-order Comparison for Multiple Small Genomes., Bioinformatics (oxford, England), 20(18), 3662-4, Dec 2004 Abstract
  • Halling S, Gibas C, Boyle S, Comparative genomics of Brucella melitensis, B. suis, and B. abortus, Frontier in the Molecular and Cellular Biology of Brucella. Ignacio Lopez-Goni et al., eds. Horizon Scientific Press., 2004
  • Gibas, C., Sturgill, D., and J. Weller, GenoMosaic: On-Demand Multiple Genome Comparison and Comparative Annotation, Proceedings of the 3rd IEEE Symposium on Bioinformatics and Bioengineering, 158, March 2003
  • Gibas C, Jambeck P, Developing Bioinformatics Computer Skills, Cambridge, MA: O'Reilly and Associates, April 2001
  • Gibas CJ, Jambeck P, Subramaniam S, Continuum electrostatic methods applied to pH-dependent properties of antibody-antigen association, Methods, 20(3), 292-309, March 2000 Abstract
  • Herrgard S, Gibas CJ, Subramaniam S, Role of an electrostatic network of residues in the enzymatic action of the Rhizomucor miehei lipase family, Biochemistry, 39(11), 2921-30, March 2000 Abstract
  • Gibas CJ, Subramaniam S, McCammon JA, Braden BC, Poljak RJ, pH dependence of antibody/lysozyme complexation, Biochemistry, 36(50), 15599-614, December 1997 Abstract
  • Gibas C, Subramaniam S, Knowledge-based design of a soluble bacteriorhodopsin, Protein Engineering, 10(10), 1175-90, October 1997 Abstract
  • Gibas C, Computer simulation of titration behavior in proteins, Ph. D. thesis, University of Illinois at Urbana-Champaign, August 1996
  • Gibas CJ, Subramaniam S, Explicit solvent models in protein pKa calculations, Biophysical Journal, 71(1), 138-47, July 1996 Abstract
  • Blackwell, M., Gibas, C., Gygax, S., Roman, D., Wagner, B., The plastoquinone diffusion coefficient in chloroplasts and its mechanistic implications, Biochimica et Biophysica Acta-Bioenergetics, 1183, 533-543, 1994
  • Nedbal, L., Gibas, C., Whitmarsh, J., Light saturation curves show competence of the water splitting complex in inactive photosystem-II reaction centers, Photosynthesis Research, 30, 85-94, 1991

Profile Details

Last Updated: 7/9/2008

COS Expertise ID #844570
Reference this profile directly: http://myprofile.cos.com/cgibas