Prof. Stephen J. Challacombe

powered by
COS Expertise®
King's College London
Dental Institute at Guys, King's College & St Thomas Hospitals
Oral Medicine & Immunology
Clinical Professor and Vice DeanAppointed: 2005
King's College London
Health Schools
Dean for External Affairs Health SchoolsAppointed: 2007
King's College London
King's College London Dental Institute
Oral Medicine & Immunology
External Development & Strategy
Director of External StrategyAppointed: 2004
King's College London
King's College London Dental Institute at Guys Hospital
Oral Microbiology
Clinical Diagnostic Sciences
Consultant Clinical Oral MicrobiologistAppointed: 1992
Professional Headshot of Stephen J. Challacombe

Mailing Address

Oral Medicine & Immunology
King's College London Dental Institute
Guys Kings & St Thomas' Hospitals
Central Office, Floor 22, Guys Tower, Guys Hospital
London, SE1 9RT
United Kingdom

Contact Information

Phone: +44 20 7188 4373
Fax: +44 20 7188 1159
stephen.challacombe@kcl.ac.uk

Qualifications

Ph.D..
B.D.S..
LDS, RCS.
FDSRCS.
F Med Sci.
FDSRCS (Ed).
F.R.C. (Path).

Expertise and Research Interests

Research Areas:
Mucosal immunity
Immunological, dermatological and microbiological aspects of oral diseases
Oral medicine
Candida infections
Immunological aspects of dental caries, oral manifestations of HIV infection, oral tolerance

Other Expertise

Academic and Public Committees:
-President European Association for Oral Medicine 2008-2010
- President of International Association of Dental Research (IADR) 2003 (Vice-president IADR 2001, President-elect 2002)
- President of Experimental Pathology Group IADR 1998
- Programme co-ordinator 1997 (Minneapolis, Nice)
- Symposium organizer Nice, Chairman, IADR Nominations Committee, (1997-99)
- Committees for IADR Basic Research in Oral Science (1983-86), for IADR Experimental Pathology prize (1999-2001)
- British Society for Dental Research/British Division of IADR: Council member (1975-79, 1985-90)
- Assistant Treasurer (1990-1992)
- Treasurer (1993-2000) and President (2000-02)
- Chairman of Oral Microbiology & Immunology Group BSDR 1982-86
- President British Society for Oral Medicine (1996-98), member of council (1992-99) President: Odontological section of Royal Society of Medicine (1997-98), member of Council (1985-87), Honorary treasurer (1990-1993), Vice-President (1993-1995)
- President of the British Dental Association (BDA) Metropolitan Branch (2000), Chairman BDA Infection Control products accreditation panel (1996-2003)
- Member Central Committee of University Teachers and Research Workers (1991-96), BDA, Executive 1992-6
- Member of General Dental Council Task Group on Additional DentalSpecialties, (1996-7)
- Treasurer, European Association for Oral Medicine 1998- Co-chairman, International workshops on the oral manifestations of HIV infection, 3rd London (1996), 4th South Africa (2000)
- Chairman, International steering committee for Oral Health & Disease in AIDS (2000-)
- Organizing Committees for International Congress on Mucosal Immunology (5th London 1989), 7th Congress Prague (1992), 8th San Diego (1995)
- Member of council of British Sjogren's Syndrome Association (1988-1997) Organising Committee for International Congress in Oral Medicine (London 1987)
- Academy of Medical Sciences: Member of fellowship committee, (1999-2002), Clinical Academic Training Committee (2000-02), Chairman, Mucosal immunology group of the British Society for Immunology (1987-1992)
- Invited scientific lectures in Australia, Canada, Denmark, France, Germany, Greece, Holland, Hong Kong, India, Indonesia, Ireland, Israel, Italy, Korea, Japan, Malaysia, Norway, South Africa, Spain, Sweden, Uruguay, USA, Vietnam

Research Profile:
Author or co-author of over 200 peer reviewed papers and 160 other publications on: Mucosal immunity; Immunological, dermatological and microbiological aspects of oral diseases; Oral medicine; Candida infections; Immunological aspects of Dental Caries, Oral manifestations of HIV infection, Oral Tolerance. Editor or co-editor of 7 books on Food Allergy, Food Allergy & Intolerance, Practical and Theoretical aspects of Elisa, Oral Aids Research; Immunology of OralDiseases. Head of Mucosal Diseases Research Group, Member of Research Committees of Dental Institute, Medical School, Kings College London; Member of UK Medical Research Council Research Studentships awards panels on Molecular Biology, and Infection & Immunity 1995-2000. Member of UK MRC Clinical research fellowships awards panel, (1996-2000), Member of UK MRC Joint Dental Committee (1989-1994), Member of UK MRC Research Advisory Board (1998-present), Member of UK Higher Education Funding Council for England Research Assessment Panel for Dentisstry, 1996 and 2001; Supervisor of ten successful PhD studentships, two MD studentships. Examiner for 23 PhDs in UK, Indonesia, Australia.
Member of the editorial boards of: Journal of Oral Pathology and Medicine,Oral Diseases, Journal of Immunological Methods. Past member of the editorial board of Immunology, Microbial Ecology in Health and Disease. Collaborative research with USA, Indonesia, South Africa, Zaire, and Australia

46 grants, 3.7 million pounds, Wellcome Trust, MRC, BBSRC, NIH, NIDCR, Charities, 1980-2008

Future Research

Mucosal immunology and oral diseases, especially HIV, candida infections, oral aspects of dermatological bullous diseases, gastrointestinal diseases.

Future research in these areas and in vaccines against pathogens at mucosal surfaces including candidiasis

Industrial Relevance

Adjuvants for mucosal system, mucosal vaccines

Keywords

COS Keywords:

Caries, Dentistry, Dermatology, HIV, Immunology, Medical Microbiology, Microbiology, Oral Diseases, Pathology, Radiology.

Additional Terms:

Aphthous Stomatitits, Bullous Diseases, Mucosal Immunity, Oral Diseases, Oral Medicine, Salivary IgA.

Memberships

Academy of Medical Sciences
British Society for Dental Research
British Society for Immunology
British Society for Oral Pathology
British Society of Oral Medicine
European Association for Oral Medicine
International Association for Dental Research
International Association for Oral Pathology
International Society for Mucosal Immunology
Royal College of Pathologists
Royal College of Surgeons, Edinburgh
Royal Society of Medicine

Honors and Awards

2003, President, International Association for Dental Research
1997, Distinguished Scientist Award for Experimental Pathology, IADR
1981, Basic Research in Oral Science Award, IADR
1978, Kendall-Hench Research Fellowship, Mayo Clinic, Minnesota, USA
1977, Colgate (Hatton) Research Prize, British Division, IADR

Previous Positions

1995, Visiting Professor, University of California, San Francisco, Oral Biology
1984-1991, External Consultant, University of Iowa, Institute of Dental Research, College of Dentistry, Specialized Caries Research Centre
1983-1987, Guy's Hospital Medical and Dental Schools, Sub-dean of Dental Studies
1978-1979, Senior Research Fellow, Mayo Foundation for Medical Education and Research, Immunology
1978-1979, Assistant Professor, Mayo Foundation for Medical Education and Research, Immunology

Funding Received

  • NIDCR: SICCA: Sjogrens International Clinical Collaborative Alliance, 138,000 pounds, 2007 to 2009.
  • NIDCR: The oral mucosal proteome: perturbation in HIV infection and Candida coinfection., $1.25 million, 2006 to 2011.

Publications

  • Barone F, Bombardieri M, Rosado MM, Morgan PR, Challacombe SJ, De Vita S, Carsetti R, Spencer J, Valesini G, Pitzalis C (Apr 2008) CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization., Journal of immunology (Baltimore, Md. : 1950), 180 (7), 5130-40 Abstract
  • Moutasim KA, Poate TW, Setterfield JF, Challacombe SJ (Mar 2008) A case of vulvovaginal gingival lichen planus in association with Good's syndrome., Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 105 (3), e57-60 Abstract
  • Escudier M, Ahmed N, Shirlaw P, Setterfield J, Tappuni A, Black MM, Challacombe SJ (Oct 2007) A scoring system for mucosal disease severity with special reference to oral lichen planus., The British journal of dermatology, 157 (4), 765-70 Abstract
  • Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Challacombe S, De Vita S, Valesini G, Spencer J, Pitzalis C (Oct 2007) Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome., Journal of immunology (Baltimore, Md. : 1950), 179 (7), 4929-38 Abstract
  • Rahman D, Mistry M, Thavaraj S, Challacombe SJ, Naglik JR (Apr 2007) Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions., Microbes and infection / Institut Pasteur, 9 (5), 615-22 Abstract
  • Klanrit P, Sperandio M, Brown AL, Shirlaw PJ, Challacombe SJ, Morgan PR, Odell EW (Mar 2007) DNA ploidy in proliferative verrucous leukoplakia., Oral oncology, 43 (3), 310-6 Abstract
  • Woo SB, Challacombe SJ (Mar 2007) Management of recurrent oral herpes simplex infections., Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 103 Suppl, S12.e1-18 Abstract
  • Ship JA, Vissink A, Challacombe SJ (Mar 2007) Use of prophylactic antifungals in the immunocompromised host., Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 103 Suppl, S6.e1-14 Abstract
  • Chiandussi S, Tappuni AR, Watson TF, White A, Escudier MP, Sanderson JD, Challacombe SJ (Jan 2007) Lip impressions: a new method for monitoring morphological changes in orofacial granulomatosis., Oral diseases, 13 (1), 93-8 Abstract
  • Naglik JR, Fostira F, Ruprai J, Staab JF, Challacombe SJ, Sundstrom P (Oct 2006) Candida albicans HWP1 gene expression and host antibody responses in colonization and disease., Journal of medical microbiology, 55 (Pt 10), 1323-7 Abstract
  • Kazmi SH, Naglik JR, Sweet SP, Evans RW, O'Shea S, Banatvala JE, Challacombe SJ (Oct 2006) Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids., Clinical and vaccine immunology : CVI, 13 (10), 1111-8 Abstract
  • Setterfield JF, Neill S, Shirlaw PJ, Theron J, Vaughan R, Escudier M, Challacombe SJ, Black MM (Jul 2006) The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele., Journal of the American Academy of Dermatology, 55 (1), 98-113 Abstract
  • White A, Nunes C, Escudier M, Lomer MC, Barnard K, Shirlaw P, Challacombe SJ, Sanderson JD (Jun 2006) Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet., Inflammatory bowel diseases, 12 (6), 508-14 Abstract
  • Reljic R, Clark SO, Williams A, Falero-Diaz G, Singh M, Challacombe S, Marsh PD, Ivanyi J (Mar 2006) Intranasal IFNgamma extends passive IgA antibody protection of mice against Mycobacterium tuberculosis lung infection., Clinical and experimental immunology, 143 (3), 467-73 Abstract
  • Challacombe SJ, Naglik JR (2006) The effects of HIV infection on oral mucosal immunity., Advances in dental research, 19 (1), 29-35 Abstract
  • Challacombe S, Coogan M, Williams D, Greenspan J (2006) Overview and research agenda arising from the 5th World Workshop on Oral Health and Disease in AIDS., Advances in dental research, 19 (1), 5-9 Abstract
  • Oyama N, Setterfield JF, Powell AM, Sakuma-Oyama Y, Albert S, Bhogal BS, Vaughan RW, Kaneko F, Challacombe SJ, Black MM (Jan 2006) Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity., The British journal of dermatology, 154 (1), 90-8 Abstract
  • Frost PM, Shirlaw PJ, Challacombe SJ, Fernandes-Naglik L, Walter JD, Ide M (Jan 2006) Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients., Oral diseases, 12 (1), 57-62 Abstract
  • Sanderson J, Nunes C, Escudier M, Barnard K, Shirlaw P, Odell E, Chinyama C, Challacombe S (Sep 2005) Oro-facial granulomatosis: Crohn's disease or a new inflammatory bowel disease?, Inflammatory Bowel Diseases, 11 (9), 840-6 Abstract
  • Coogan MM, Greenspan J, Challacombe SJ (Sep 2005) Oral lesions in infection with human immunodeficiency virus., Bulletin of the World Health Organization, 83 (9), 700-6 Abstract
  • Barone F, Bombardieri M, Manzo A, Blades MC, Morgan PR, Challacombe SJ, Valesini G, Pitzalis C (Jun 2005) Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren's syndrome., Arthritis and Rheumatism, 52 (6), 1773-84 Abstract
  • Pankhurst CL, Coulter W, Philpott-Howard JN, Surman-Lee S, Warburton F, Challacombe S (Apr 2005) Evaluation of the potential risk of occupational asthma in dentists exposed to contaminated dental unit waterlines., Primary Dental Care :, 12 (2), 53-9 Abstract
  • Naglik JR, Scott J, Rahman D, Mistry M, Challacombe SJ (Feb 2005) Serum and saliva antibodies do not inhibit Candida albicans Sap2 proteinase activity using a BSA hydrolysis assay., Medical Mycology :, 43 (1), 73-7 Abstract
  • AR Tappuni, T Kovacevic, P J Shirlaw and S J Challacombe., Clinical Assessment of Disease Severity in Recurrent Aphthous Stomatitis, Oral Biosciences & Medicine, 2, 5-13, 2005
  • Reljic R, Di Sano C, Crawford C, Dieli F, Challacombe S, Ivanyi J (Jan-Mar 2005) Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice., Tuberculosis (edinburgh, Scotland), 85 (1-2), 81-8 Abstract
  • Tarelli E, Smith AC, Hendry BM, Challacombe SJ, Pouria S (Sep 2004) Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry., Carbohydrate Research, 339 (13), 2329-35 Abstract
  • Pouria S, Corran PH, Smith AC, Smith HW, Hendry BM, Challacombe SJ, Tarelli E (Jul 2004) Glycoform composition profiling of O-glycopeptides derived from human serum IgA1 by matrix-assisted laser desorption ionization-time of flight-mass spectrometry., Analytical Biochemistry, 330 (2), 257-63 Abstract
  • Reljic R, Crawford C, Challacombe S, Ivanyi J (Apr 2004) Mouse IgA inhibits cell growth by stimulating tumor necrosis factor-alpha production and apoptosis of macrophage cell lines., International Immunology, 16 (4), 607-14 Abstract
  • Reljic R, Crawford C, Challacombe S, Ivanyi J (Apr 2004) Mouse monoclonal IgA binds to the galectin-3/Mac-2 lectin from mouse macrophage cell lines., Immunology Letters, 93 (1), 51-6 Abstract
  • Savage NW, Barnard K, Shirlaw PJ, Rahman D, Mistry M, Escudier MP, Sanderson JD, Challacombe SJ (Mar 2004) Serum and salivary IgA antibody responses to Saccharomyces cerevisiae, Candida albicans and Streptococcus mutans in orofacial granulomatosis and Crohn's disease., Clinical and Experimental Immunology, 135 (3), 483-9 Abstract
  • Williams A, Reljic R, Naylor I, Clark SO, Falero-Diaz G, Singh M, Challacombe S, Marsh PD, Ivanyi J (Mar 2004) Passive protection with immunoglobulin A antibodies against tuberculous early infection of the lungs., Immunology, 111 (3), 328-33 Abstract
  • Pankhurst CL, Coulter W, Philpott-Howard JJ, Harrison T, Warburton F, Platt S, Surman S, Challacombe S (Nov 2003) Prevalence of legionella waterline contamination and Legionella pneumophila antibodies in general dental practitioners in London and rural Northern Ireland., British Dental Journal, 195 (10), 591-4; discussion 58 Abstract
  • Naglik JR, Challacombe SJ, Hube B, Candida albicans secreted aspartyl proteinases in virulence and pathogenesis, Microbiology and Molecular Biology Reviews : MMBR, 67(3), 400-28,, September 2003
  • Challacombe S (2003) Global perspectives for the IADR and dental research, Journal of Dental Research, 82 (9), 671
  • Naglik JR, Challacombe SJ, Hube B (Sep 2003) Candida albicans secreted aspartyl proteinases in virulence and pathogenesis., Microbiology and Molecular Biology Reviews : Mmbr, 67 (3), 400-28, table of con Abstract
  • Naglik JR, Rodgers CA, Shirlaw PJ, Dobbie JL, Fernandes-Naglik LL, Greenspan D, Agabian N, Challacombe SJ (Aug 2003) Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections., The Journal of Infectious Diseases, 188 (3), 469-79 Abstract
  • Harman KE, Setterfield JF, Shirlaw PJ, Black MM, Challacombe SJ (Jul 2003) Clinicopathological case 1: mucous membrane pemphigoid, epidermolysis bullosa acquisita and linear immunoglobulin A disease., Clinical and Experimental Dermatology, 28 (4), 461-2 Abstract
  • Oyama N, Setterfield JF, Gratian MJ, Bhogal BS, Shirlaw P, Challacombe SJ, Black MM (Mar 2003) Oral and genital lichenoid reactions associated with circulating autoantibodies to desmoplakins I and II: a novel target antigen or example of epitope spreading?, Journal of the American Academy of Dermatology, 48 (3), 433-8 Abstract
  • Frost PM, Shirlaw PJ, Walter JD, Challacombe SJ (Oct 2002) Patient preferences in a preliminary study comparing an intra-oral lubricating device with the usual dry mouth lubricating methods., British Dental Journal, 193 (7), 403-8 Abstract
  • Harman KE, Gratian MJ, Shirlaw PJ, Bhogal BS, Challacombe SJ, Black MM (Apr 2002) The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris., The British Journal of Dermatology, 146 (4), 684-7 Abstract
  • Challacombe SJ, Sweet SP, Oral mucosal immunity and HIV infection: current status, Oral Diseases, 8 Suppl 2, 55-62, 2002
  • Challacombe SJ, Coogan MM, Williams DM, Overview of the Fourth International Workshop on the Oral Manifestations of HIV Infection, Oral Diseases, 8 Suppl 2, 9-14, 2002
  • Scully C, Challacombe SJ, Pemphigus vulgaris: update on etiopathogenesis, oral manifestations, and management, Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists., 13(5), 397-408, 2002
  • Challacombe SJ & Czerkinsky C (2002) Oral Tolerance: probable mechanisms and possible therapeutic applications (Chapter 16) In Brostoff J and Challacombe SJ (eds), Food Allergy and Intolerance, Eds Brostoff J and Challacombe SJ, 2nd Edition, 259-266 pages (bookchapter)
  • Challacombe SJ, Sweet SP (2002) Oral mucosal immunity and HIV infection: current status., Oral Diseases, 8 Suppl 2, 55-62 Abstract
  • Scully C, Challacombe SJ (2002) Pemphigus vulgaris: update on etiopathogenesis, oral manifestations, and management., Critical Reviews in Oral Biology and Medicine :, 13 (5), 397-408 Abstract
  • Shugars DC, Sweet SP, Malamud D, Kazmi SH, Page-Shafer K, Challacombe SJ (2002) Saliva and inhibition of HIV-1 infection: molecular mechanisms., Oral Diseases, 8 Suppl 2, 169-75 Abstract
  • Brostoff J and Challacombe S J. (2002) Food Allergy and Intolerance, 2nd Edition, London, England, W.B. Saunders
  • Challacombe SJ, Coogan MM, Williams DM ( 2002) Overview of the Fourth International Workshop on the Oral Manifestations of HIV Infection, , , 9-14 pages
  • Fernandes-Naglik L, Downes J, Shirlaw P, Wilson R, Challacombe SJ, Kemp GK, Wade WG (Sep 2001) The clinical and microbiological effects of a novel acidified sodium chlorite mouthrinse on oral bacterial mucosal infections., Oral Diseases, 7 (5), 276-80 Abstract
  • Setterfield J, Theron J, Vaughan RW, Welsh KI, Mallon E, Wojnarowska F, Challacombe SJ, Black MM (Sep 2001) Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production., The British Journal of Dermatology, 145 (3), 406-14 Abstract
  • Challacombe SJ, Setterfield J, Shirlaw P, Harman K, Scully C, Black MM (Aug 2001) Immunodiagnosis of pemphigus and mucous membrane pemphigoid., Acta Odontologica Scandinavica, 59 (4), 226-34 Abstract
  • Sweet SP, Denbury AN, Challacombe SJ (Apr 2001) Salivary calprotectin levels are raised in patients with oral candidiasis or Sjogren's syndrome but decreased by HIV infection., Oral Microbiology and Immunology, 16 (2), 119-23 Abstract
  • Harman KE, Seed PT, Gratian MJ, Bhogal BS, Challacombe SJ, Black MM (Apr 2001) The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels., The British Journal of Dermatology, 144 (4), 775-80 Abstract
  • Kassimos DG, Panayl GS, Challacombe S, Dry eyes and dry mouth in patients with generalized nodal osteoarthritis., Archives of Internal Medicine, 161(4), 615, Feb 2001 Abstract
  • Setterfield JF, Shirlaw PJ, Challacombe SJ, Black MM (Feb 2001) Pyoderma gangrenosum associated with severe oropharyngeal involvement and IgA paraproteinaemia., The British Journal of Dermatology, 144 (2), 393-6 Abstract
  • Kassimos DG, Panayl GS, Challacombe S (Feb 2001) Dry eyes and dry mouth in patients with generalized nodal osteoarthritis, Archives of Internal Medicine, 161 (4), 615

Profile Details

Last Verified: 5/29/2008

COS Expertise ID #1004332
Reference this profile directly: http://myprofile.cos.com/challacombe1