Kathryn Chaloner

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University of Iowa
College of Public Health
Biostatistics
HeadAppointed: 2002
University of Iowa
College of Public Health
Biostatistics
ProfessorAppointed: 2002
University of Iowa
College of Liberal Arts and Sciences
Statistics & Actuarial Sciences
Professor
Professional Headshot of Kathryn Chaloner

Mailing Address

C22N-1 General Hospital
University of Iowa
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 384-5029
Fax: (319) 335-9200
kathryn-chaloner@uiowa.edu
http://www.public-health.uiowa.edu/faculty-staff/faculty/directory/faculty-detail.asp?emailAddress=kathryn-chaloner@uiowa.edu

Qualifications

Ph.D., Carnegie Mellon University, Statistics, 1982.
M.Sc., London University, Statistics, 1976.
B.A., Oxford University, Mathematics, 1975.

Expertise and Research Interests

My current research interests include:
Clinical trials
Bayesian statistics
Experimental design
HIV/AIDS research
Viral dynamics

Other Expertise

I have served as co-author of the following book:
  • Berry DA, Chaloner K, Geweke J, Eds. Bayesian Analysis in Statistics nad Econometrics. New York, NY: Wiley, 1996.


I have contributed the following book chapters:
  • Chaloner K. An approach to design for generalized linear models. In: Model Oriented Data Analysis; lecture notes in Economics and Methematical Systems, VV Fedorov and H Lauter, Eds. Berlin: Springer-Verlag, 1987.
  • Chaloner K, Larntz K. Software for logistic regression experiment design. In: Optimal Design and Analysis of Experiments. Dodge, VV Federov, HP Wynn, Eds. Amsterdam: North-Holland, 1988.
  • Chaloner K. Residual analysis and outliers in Bayesian hierarchical models. In: Aspects of Uncertainty. AFM Smith, PR Freema, Eds. Chichester, UK: Wiley, 1994.
  • Carlin BP, Chaloner KM, Louis TA, Rhame FS. Elicitation, monitoring and alaysis for an AIDS clinical trial (with discussion). In: Case Studies in Bayesian Statistics, 2. C Gatsonis C, Hodges JS, Kass RE, Singpurwalla ND, Eds. New York, NY: Springer-Verlag, 1995.
  • Korzun A, Chaloner K. Protocol development. In: AIDS Clinical Trials. DM Finkelstein and DA Schoenfeld, Eds. New York: Wiley, 1995.
  • Chaloner K. The Elicitation of Prior Distributions. In: Bayesian Biostatistics. D Stangle, DA Berry, M Dekker, Eds. New York, 1995.
  • Agin M, Chaloner K. Optimal Bayesian design for a logistic regression model: geometric and algebraic approaches. In: Multivariate Analysis, Design of Experiments and Survey Sampling. S Ghosh, M Dekker, Eds. New York, 1999.
  • Fan S, Chaloner K. Optimal Designs for a Continuation-ratio Model. In: u>Model Oriented Data Analysis 6. AC Atkinson, P Hackl, WG Muller, Eds. Heidelberg: Physica, 2001.
  • Tsai C, Chaloner K. Using prior opinions to examine sample size in a clinical trial: two examples. In: Case Studies in Bayesian Statistics 5. RE Kass et al, Eds. New York, NY: Springer-Verlag, 2002.
  • Han C, Chaloner K, Perelson AS. Bayesian Analysis of Populationi HIV Dynamic Model. In: Case Studies in Bayesian Statistics 6. RE Kass et al, Eds. New York, NY: Springer-Verlag, 2002.
  • Han C, Chaloner K, Design of Population Studies of HIV Dynamics. In: Determination and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention. Tan W-Y and Wu H, Eds. Fitchburg, MA: World Scientific Publishing Company, 2005.
  • Fan KS and Chaloner K, Design for a Trinomial Response to Dose. In: Response Surface Methodology and Related Topics. Khuri Al (ed). World Scientific Publishing Co., Hackensack, NJ, pp. 225-250, 2006.

Keywords

COS Keywords:

AIDS, Biostatistics, HIV, Statistics.

Additional Terms:

Bayesian Methods, Clinical Trials, Design of Experiments, Infectious Diseases.

Memberships

American Association for the Advancement of Science
American Public Health Association
American Statistical Association
Association for the Advancement of Science
Institute of Mathematical Statistics
International Biometric Society
International Statistical Institute
Royal Statistical Society
Society for Clinical Trials

Honors and Awards

2003, Elected Fellow in the American Association for the Advancement of Science,
1995, Elected Member of the International Statistical Institute,
1994, Elected Fellow of the American Statistical Association,

Previous Positions

1996-2002, Professor, University of Minnesota, School of Statistics
1988-1996, Associate Professor, University of Minnesota, School of Statistics
1982-1982, Statistician, University of Pittsburgh, Graduate School of Public Health, Epidemiology
1982-1988, Assistant Professor, University of Minnesota, School of Statistics
1977-1978, Statistician, Department of Employment, London, UK

Funding Received

  • NINDS: Hypothermia During Intracranial Aneurysm Surgery, $535,999, Sep 1, 2002 to Mar 31, 2004.
  • NIH: Carotid Occlusion Surgery Study (COSS) Data Management Center, W Clarke, PI, $3,386,784, Sep 1, 2002 to Jun 30, 2006.
  • NSF: Workshop in New Directions in Experimental Design, D Majumdar, PI, $24,000, May 1, 2003 to Sep 1, 2003.
  • NIH: Airway Physiology and Pathophysiology in a Porcine CF Model, Welsh, PI, $1,520,097, 2008 to 2009.
  • NIH/NIGMS: Statistics in Microbiology, Infectious Diseases and Bioinformatics, Chaloner, PI, $65,746, 2006 to 2007.
  • Amgen, Inc: PhD Fellowship, $75,000, 2006 to 2009.
  • NIH: Clinical Islet Transplantation: Data Coordinating Center, Clarke, PI, $21,197,251, 2004 to 2009.
  • NIH: GBV-C Natural History, Epidemiology and HIV, J Stapleton, PI, $2,203,615, 2004 to 2008.
  • US DOD, National Security Agency: Bayesian Experimental Design, $36,196, 2004 to 2005.
  • NIH: Basic and Clinical Approaches to Controlling Human Respiratory Pathogens, MA Apicella, PI, $30,790,999, 2003 to 2010.
  • National Security Agency: Multivariate, Multiple Decision Maker and Multi-Objective Design, $45,856, 2000 to 2002.
  • NIH: Graduate Training Program in Clinical Research, $926,000, 2000 to 2010.
  • National Security Agency: Design for Nonlinear Problems, $21,088, 1997 to 1999.
  • National Science Foundation (NSF): Computing Equipment, G Oehlert, PI, $73,770, 1994 to 1994.
  • National Institutes of Health (NIH): Training Grant, graduate training in biostatistics, T Louis and R Tweedie, Principal Investigators, 1994 to 2004.
  • Government of Italy: Visiting Professor program with the University of Perugia, 1991 to 1991.
  • AMS-NSF: Travel to Bulgaria, $1,000, 1990 to 1990.
  • National Institutes of Health (NIH): Cooperative agreement for 'Community Programs for Clinical Research on AIDS,' Statistical Center, J Neaton, PI, 1990 to 2002.
  • National Science Foundation (NSF): Computing Equipment, L. Tierney, PI, $42,000, 1989 to 1989.
  • National Science Foundation (NSF): Optimal Bayesian design for non-linear problems, $110,000, 1987 to 1989.
  • National Science Foundation (NSF): Grant for Computing Equipment, K Larntz, PI, $33,250, 1984 to 1984.
  • Apple: MinnieMac Grant for educational software development. Summer Research Fellowship, $5,000, 1983 to 1983.

Publications

  • Zhang W, Zhang Y, Chaloner K, Stapleton JT (2009) Imputation Methods for Doubly Censored HIV Data, Journal of statistical Computation and Simulation, 79 (10), 1245-57
  • Stapleton JT, Chaloner K, Zhang J, Klinzman D, Souza IE, Xiang J, Landay A, Fahey J, Pollard R, Mitsuyasu R (Jan 2009) GBV-C viremia is associated with reduced CD4 expansion in HIV-infected people receiving HAART and interleukin-2 therapy., AIDS (London, England) Abstract
  • Zhang W, Chaloner K, Cowles MK, Zhang Y, Stapleton JT (Feb 2008) A Bayesian analysis of doubly censored data using a hierarchical Cox model., Statistics in medicine, 27 (4), 529-42 Abstract
  • Chaloner K (2008) Comments on 'Bayesians in clinical trials: Asleep at the switch' by Lemuel A. Moyé, Statistics in Medicine Stat Med, 27 (4), 483-7
  • Zhang W, Chaloner K, Tillmann H, Williams C, Stapleton J (2006) Effect of early and late GM virus C viraemia on survival of HIV-infected indivdiuals: a meta-analysis, HIV Med, 7 (3), 173-80
  • Chen C, Chaloner K (2006) A Bayesian stopping rule for a single arm study: with a case study of stem cell transplantation, Statistics in Medicine, 25, 2956-66
  • Souza IE, Allen JB, Xiang J, Klinzman D, Diaz R, Zhang S, Chaloner, Zdunek D, Hess G, Williams F, Benning L, Stapleton JT (2006) Effect of primer selection on estimates of GB virus C (DBV-C) prevalence and response to antiretroviral therapy for optimal testing for GBV-C viremia, Journal of Clinical Microbiology, 44 (9), 3105-13
  • Souza IE, Zhang W, Diaz RS, Chaloner K, Klinzman D, Stapleton JT (2006) Effect of GB virus C on response to antiretroviral therapy in HIV infected Brazilians, HIV Medicine, 7, 25-31
  • Stapleton JT, Chaloner K, Williams CF, GB Virus C Infection and Survival in the Amsterdam Cohort Study, Journal of Infectious Diseases, 191(12), 1257-8, 15 Jun 2005
  • Todd MM, Hindman BJ, Clarke WR, Torner JC, Chaloner K, Davis P, Howard M, Tranel D, Anderson S, Weeks J, Moss L, Winn J, Wichman M,Peters R, Hansen M, Anderson D, Lang J,Yoo B, Adams H, Clifton G,Gelb A et al, Mild Intraoperative Hypothermia During Surgery for Intracranial Aneurysm, New England Journal of Medicine, 352(2), 135-45, Jan 2005
  • Stapleton JT, Chaloner K, GB Virus C and Survival in HIV-positive People., Aids (london, England), 18(17), 2343-4; author reply, Nov 2004 Abstract
  • Han C, Chaloner K, Bayesian experimental design for nonlinear mixed-effects models with application to HIV dynamics, Biometrics, 60, 25-33, March 2004
  • Han C, Chaloner K, Statistics and Probability Letters A note on optimal design for two or more treatment groups, Statistics and Probability Letters, 69, 2004
  • Fan S, Chaloner K, Optimal designs and limiting optimal designs for a trinomial response, Journal of Statistical Planning and Inference, 126, 347-60, 2004
  • Fan SK, Chaloner K, A geometric method for singular optimal designs, Journal of Statistical Planning and Inference, 113, 249-57, 2003
  • Han C, Chaloner K, Perelson AS, Bayesian analysis of a population HIV dynamic model, In Case Studies in Bayesian Statistics, 6, RE Kass et al (eds), Springer-Verlay, New York, 223-37, 2003
  • Han C, Chaloner K, D-and c-optimal designs for exponential regression models used in pharmacokinetics and viral dynamics, Journal of Statistical Planning and Inference, 115, 585-601, 2003
  • Han C, Chaloner K, Bayesian experimental design for nonlinear mixed-effects models with application to HIV dynamics, Biometrics, (in press), 2003
  • Clyde MA, Chaloner K, Constrained design strategies for improving normal approximations in nonlinear regression problems, Journal of Statistical Planning and Inference, 104(175-196), 2002
  • Fisher EJ, Chaloner K, Cohn DL, Grant LB, Alston B, Brosgart CL, Schmetter B, El-Sadr WM, Sampson J, Terry Beirn Community Programs for Clinical Research on AIDS, The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial, Aids (london, England), 15(13), 1695-700, September 2001 Abstract
  • Chaloner K, Rhame FS, Quantifying and documenting prior beliefs in clinical trials, Statistics in Medicine, 20(4), 581-600, February 2001 Abstract
  • Rhame FS, Chaloner K, Quantifying and documenting prior beliefs in clinical trials, Statistics in Medicine, 20, 581-600, 2001
  • Gjerdingen DK, Neff JA, Wang M, Chaloner K, Older persons' opinions about life-sustaining procedures in the face of dementia, Archives of Family Medicine, 8(5), 421-5, 1999 Abstract
  • Shlay JC, Chaloner K, Max MB, Flaws B, Reichelderfer P, Wentworth D, Hillman S, Brizz B, Cohn DL, Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS, JAMA: The Journal of the American Medical Association, 280(18), 1590-5, November 1998 Abstract
  • Gjerdingen DK, Tran D, Chaloner K, Shorter ultrasonic femur lengths in Hmong fetuses, International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 63(2), 191-3, November 1998 Abstract
  • Gjerdingen DK, Ireland M, Chaloner KM, Growth of Hmong children, Archives of Pediatrics and Adolescent Medicine, 150(12), 1295-8, December 1996 Abstract
  • Clyde MA, Chaloner K, The equivalence of constrained and weighted designs in multiple objective design problems, Journal of the American Statistical Association, 91, 1236-1244, 1996
  • Gjerdingen DK, McGovern PM, Chaloner KM, Street HB, Women's postpartum maternity benefits and work experience, Family Medicine, 27(9), 592-8, October 1995 Abstract
  • Gjerdingen DK, Chaloner KM, Vanderscoff JA, Family practice residents' maternity leave experiences and benefits, Family Medicine, 27(8), 512-8, September 1995 Abstract
  • Chaloner K, Verdinelli I, Bayesian experimental design: a review, Statistical Science, 10, 273-304, 1995
  • Gjerdingen DK, Chaloner KM, The relationship of women's postpartum mental health to employment, childbirth, and social support, Journal of Family Practice, 38(5), 465-72, May 1994 Abstract
  • Gjerdingen DK, Chaloner K, Mothers' experience with household roles and social support during the first postpartum year, Women and Health, 21(4), 57-74, 1994 Abstract
  • Atkinson AC, Chaloner K, Herzberg AM, Juritz J, Optimum experimental designs for properties of a compartmental model, Biometrics, 49(2), 325-37, June 1993 Abstract
  • Gjerdingen DK, Froberg DG, Chaloner KM, McGovern PM, Changes in women's physical health during the first postpartum year, Archives of Family Medicine, 2(3), 277-83, March 1993 Abstract
  • Chaloner K, A note on Bayesian optimal design for nonlinear problems, Journal of Statistical Planning and Inference, 37, 229-235, 1993
  • Chaloner KM, Church T, Matts JP, Louis TA, Graphical elicitation of a prior distribution for a clinical trial, The Statistician, 42, 341-353, 1993
  • Carliin B, Chaloner KM, Church T, Matts JP, Louis TA, Bayesian approaches for monitoring clinical trials with an application to Toxoplasmic encephalitis prophylaxis, The Statistician, 42, 355-367, 1993
  • Chaloner K, Larntz K, Optimal Bayesian design for accelerated life testing experiments, Journal of Statistical Planning and Inference, 33, 245-259, 1992
  • Chaloner K, Bayesian residual analysis in the presence of censoring, Biometrika, 78, 637-644, 1991
  • Chaloner K, Larntz K, Optimal Bayesian design applied to logistic regression experiments, Journal of Statistical Planning and Inference, 21, 191-208, 1989
  • Chaloner K, Bayesian design for estimating the turning point of a quadratic regression, Communications in Statistics: Theory and Methods, 18, 1385-1400, 1989
  • Chaloner K, Brant R, A Bayesian approach to outlier detection and residual analysis, Biometrika, 75, 651-659, 1988
  • Chaloner K, Duncan GT, Some properties of the Dirichlet-multinomial distribution and its use in prior elicitation, Communications in Statistics: Theory and Methods, 16, 511-523, 1987
  • Chaloner K, A Bayesian approach to the estimation of variance components for the unbalanced one-way random model, Technometrics, 29, 322-337, 1987
  • Dicostanzo A, Meiske JC, Plegge SD, Chaloner KM, Influence of manganese, copper and zinc on reproductive performance of beef cows, Nutrition Reports International, 34, 287-293, 1986
  • Chaloner K, Optimal Bayesian experimental design for linear models, Annals of Statistics, 12, 283-300, 1984
  • Chaloner KM, Duncan GT, Assessment of a beta prior distribution: PM elicitation, The Statistician, 32, 174-180, 1983

Profile Details

Last Updated: 10/16/2009

COS Expertise ID #1035932
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