Dr. Robert S. Chapkin

powered by
COS Expertise®
Texas A&M University
Faculty of Nutrition
Center for Environmental and Rural Health
Professor
Texas A&M University
Faculty of Nutrition
Center for Environmental and Rural Health
University Faculty Fellow
Texas A&M Health Science Center
Hematology/Oncology
Scott & White Hospital/Clinic
Member
Texas A&M University
Genomics and Bioinformatics Facility Core
Center for Environmental and Rural Health
Director
Professional Headshot of Robert S. Chapkin

Mailing Address

218 Kleberg Center
2253 TAMU
College Station, Texas 77843-2253
United States

Contact Information

Phone: (979) 845-0419
Fax: (979) 862-2378
r-chapkin@tamu.edu

Qualifications

Ph.D., University of California, Davis, Nutrition and Physiological Chemistry, 1986.
M.Sc., University of Guelph, Nutrition, 1983.
B.Sc., University of Guelph, Nutrition and Biochemistry, 1981.

Expertise and Research Interests

Nutrition
Molecular biology
Nutritional genomics
Colon cancer
Lipid biochemistry
T-cell biology

Other Expertise

Postdoctoral Fellow, University of California, Davis, Cell Biology, 1988
Editorial Board, Journal of Nutrition, 2002-2004
Editorial Board of Prostaglandins, Leukotrienes and Essential Fatty Acids, Current
Editorial Board, Chemistry and Physics of Lipids, 2005-2008
Standing Member of the Chemo/Dietary Prevention Study Section and Metabolic Pathology Study Section, NIH

Future Research

Lead Scientist, Cologenomics Inc.- Noninvasive detection of colon cancer biomarkers

Keywords

COS Keywords:

Anatomy, Biochemistry, Biochemistry, Lipids, Cancer or Carcinogenesis, Genomics, Molecular Biology, Nutrition or Dietetics, Public Health.

Memberships

American Association for Cancer Research
American Association of Immunologists
American Society for Cell Biology
American Society for Nutritional Sciences
Federation of American Societies for Experimental Biology
Sigma Xi

Honors and Awards

2007, Senior Faculty Fellow, Texas A&M University
2006, Sigma Xi Distinguished Scientist Award, Texas A & M University Chapter
2005-2008, Editorial Board, Chemistry and Physics of Lipids
2004-2008, Director, Genomics & Bioinformatics Facility Core, Center for Environmental and Rural Health
2002-2004, Chair, Intercollegiate Faculty of Nutrition, Texas A&M University
2002-2005, Member, Metabolic Pathology Study Section, National Cancer Institute, NIH
2002-2004, Editorial Board, Journal of Nutrition
2001, NIH Panel Temporary Member, National Institute of Health, Metabolic Pathology Study Section
2001-2006, University Faculty Fellow Texas A&M University
2000, NIH Panel Temporary Member, National Institute of Health, SSS-T Special Emphasis Panel
2000, Texas Agricultural Experimentation Station Faculty Fellow,
1999-2000, Chair, American Society for Nutritional Sciences, Diet-Cancer Research Interest Section
1999-2000, Chair of Pilot Project Program, Center for Environmental and Rural Health, NIEHS/Texas A&M University
1999-2000, Grant Review Panel Member American Institute for Cancer Research
1998, External Reviewer, National Institute of Health/National Cancer Institute, Innovative technologies for the molecular analysis of cancer, SBIR/STTR initiative
1998, Panel Member, National Institute of Health/National Cancer Institute, Reproductive endocrinology, SBIR/STTR initiative
1996, Bio Service Award, American Society for Nutritional Sciences, Experimental Animal Nutrition
1995, Outstanding Paper Presentation, American Oil Chemists' Society
1993-1999, Associate Editor, American Society for Nutritional Sciences Newsletter
1991-1992, Pew National Nutrition Program Faculty Scholar,
1989-1994, First Award, National Institute of Health
1989-2007, Editorial Board, Prostaglandins, Leukotrienes and Essential Fatty Acids
2007, Senior Faculty Fellow, Texas A & M University
2006, Sigma Xi Distinguished Scientist Award, Texas A & M University Chapter
1995, American Oil Chemists' Society, Outstanding Paper Presentation

Previous Positions

1994-1999, Associate Professor, Texas A&M University, Veterinary Anatomy and Public Health and Animal Science
1992-1992, Sabbatical with Dr. Jorge Moscat, Hospital Gregorio Maranon, Molecular Biology
1988-1993, Assistant Professor, Texas A&M University, Texas Cooperative Extension, Animal Science, Human Nutrition and Molecular and Cell Biology Sections
1986-1988, Postdoctoral Fellow, University of California, Davis, School of Medicine, Cell Biology and Human Anatomy, Basic Science

Patents

Noninvasive detection of colonic biomarkers using fecal mRNA, Patent Number: PCT/US98/06698, 2002, Institution, United States of America.

Publications

  • Q. Jia, J. R. Lupton, R. Smith, B. Weeks, E. Callaway, L. A. Davidson, W. Kim, Y. Y. Fan, P. Yang, R. Newman, J. Kang, D. N. McMurray and R. S. Chapkin (2008) Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice., Cancer Research, 68: (3985-3991)
  • J. Vanamala, A. Glagolenko, P. Yang, R. J. Carroll, M. E. Murphy, R. A. Newman, R. S. Chapkin and J. R. Lupton (2008) Dietary fish oil and pectin enhance colonocyte apoptosis in irradiated rats in part by suppressing protumorigenic signaling., Carcinogensis, 29: (790-796)
  • R. S. Chapkin, N. Wang, Y.Y. Fan, J. R. Lupton and I. A. Prior. (2008) Docosahexaenoic acid alters the size and distribution of cell surface microdomains., Biophysica Acta-Biomembranes, 1778: (466-471)
  • R. S. Chapkin, J. Seo, D. N. McMurray and J. R. Lupton (2008) Mechanisms by which docosahexaeonic acid and related fatty acid compounds reduce colon cancer risk and inflammatory disorders of the intestine, Chemistry and Physics of Lipids, 153: (14-23)
  • T. V. Apanasovich, D. Ruppert, J. R. Lupton, N. Popovic, N. D. Turner, R. S. Chapkin and R. J. Carroll (2007) Aberrant crypt foci and semiparametric modeling of correlated binary data, Biometrics, 64: (490-500)
  • R. S. Chapkin (2008) Reappraisal of the essential fatty acids, Fatty Acids in Food and Their Health Implications, 3rd Edition, CRC Press (Chow, C. K. ed.), 675-691 pages (bookchapter)
  • R. S. Chapkin, D. N. McMurray and J. R. Lupton (2007) Colon Cancer, fatty acids and anti-inflammatory compounds, Current Opinion in Gastroenterology, 23:48-54
  • S. S. Kolar, R. Barhoumi, E. S. Callaway, Y. Y. Fan, N. Wang, J. R. Lupton and R. S. Chapkin (2007) Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in human colon cancer cells and primary cultures of rat colonic crypts, American Journal of Physiology: GI and Liver Physiology, 293: (G935-G943)
  • S. S. Kolar, R. Barhoumi, J. R. Lupton and R. S. Chapkin (2007) Docosahexaenoic acid and butyrate synergistically induce coloncyte apoptosis by enhancing mitochondrial Ca2+ accumulation, Cancer Research, 67:561-568
  • R. S. Chapkin, L..A. Davidson, L, Ly, B. R. Weeks, J. R. Lupton and D. N. McMurray (2007) Immunomodulatory effects of omega-3 fatty acids; Putative link to inflammation and colon cancer, Journal of Nutrition, 137:200S-204S
  • P. Zang, W. Kim, R. L. Zhou, N. Wang, L. H. Ly, D. N. McMurray and R. S. Chapkin (2006) Dietary fish oil inhibits antigen-specific Th1 cell development by suppression of clonal expansion, Journal of Nutrition, 136, 2391-2398
  • J. Seo, R. Barhoumi, A.E. Johnson, J.R. Lupton and R.S. Chapkin (2006) Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins, FASEB Journal, 10 (1096/fj.05-4683fje), 20:770-772
  • J. Vanamala, T. Leonardi, B.S. Patil, S.S. Taddeo, M.E. Murphy, L.M. Pike, R.S. Chapkin, J.R. Lupton and N.D. Turner (2006) Suppression of colon carcinogenesis by bioactive compounds in grapefruit, Carcinogenesis, 27, 1257-1265
  • L.H. Ly, R. Smith, K.C. Switzer, R.S. Chapkin and D.N. McMurray (2006) Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells, Prostaglandins, Leukotrienes and Essential Fatty Acids, 74, 29-37
  • N. D. Turner, J. Vanamala, T. Leanardi, B. s. Patil, M. Murphy, Y. C. Liu, N. Wang, I. Pike, R. S. Chapkin and J. R. Lupton (2006) Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer, Potential Health Benefits of Citrus, Washington, D. C., American Chemical Society Symposium 936, pp. 121-129 pages (bookchapter)
  • W. Stillwell, S. R. Shaikh, D. LoCascio, R. A. Siddiqui, J. Seo, R. S. Chapkin and S. R. Wassall (2006) Docosahexaenoic acid. An influential membrane-altering omega-3 fatty acid, Frontiers in Nutrition Research, Chapter 8 Edition, Hauppauge, NY, Nova Science Publishers, Inc., pp. 249-271 pages (bookchapter)
  • Y. Ng, R. Barhoumi, R.B. Tjalkens, Y.Y. Fan, S. Kolar, N. Wang, J.R. Lupton and R.S. Chapkin (2005) The role of docosahexaenoic acid mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes, Carcinogenesis, 26, 1914-1921
  • L.D. Liu, N. Wang, J.R. Lupton, N.D. Turner, R.S. Chapkin and L.A. Davidson (2005) A two-stage normalization method for partially degraded mRNA microarray data, Bioinformatics, 21, 4000-4006
  • M.Y. Hong, L.K. Bancroft, N.D. Turner, L.A. Davidson, M.E. Murphy, R.J. Carroll, R.S. Chapkin and J.R. Lupton (2005) Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon, Nutrition & Cancer, 52, 166-175
  • M.Y. Hong, N.D. Turner, R.J. Carroll, R.S. Chapkin and J.R. Lupton (2005) Differential response to oxidative DNA damage may explain aspects of the cancer susceptibility between small and large intestine, Experimental Biology and Medicine, 230, 464-471
  • P. Zhang, R. Smith, R.S. Chapkin and D.N. McMurray (2005) Dietary n-3 Polyunsaturated fatty acids modulate the Th1/Th2 balance towards the Th2 pole by suppression of Th1 development, Journal of Nutrition, 135, 1745-1751
  • G.D. Zhou, N. Popovic, J.R. Lupton, N.D. Turner, R.S. Chapkin and K.C. Donnelly (2005) Tissue-specific attenuation of endogenous DNA I-compounds in rats by carcinogen azoxynethane: possible role of fish oil in colon cancer prevention, Cancer Epidemiology Biomarkers & Prevention, 14, 1230-1235
  • M. Leyk, D.V. Nguyen, S.N. Atoor, E.R. Dougherty, N.D. Turner, L.K. Bancroft, R.S. Chapkin, J.R. Lupton and R.J. Carroll (2005) Comparing automatic and manual image processing in FLARE assay analysis for colon carcinogenesis, Statistical Applications in Genetics and Molecular Biology, 4, 1-18
  • D.W.L. Ma, R.H. Finnell, L.A. Davidson, E.S. Callaway, O. Spiegelstein, J.A. Piedrahita, J.M. Salbaum, C. Kappen, B. Weeks, J. James, D. Bozinov, J.R. Lupton and R.S. Chapkin. (2005) Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis, Cancer Research, 65, 887-897
  • L.H. Ly, R. Smith, R.S. Chapkin and D.N. McMurray (2005) Dietary n-3 polyunsaturated fatty acids suppress splenic CD4+ T-cell function in IL-10(-/-) mice, Clinical & Experimental Immunology, 139, 202-209
  • K.C. Switzer, Y-Y. Fan, N. Wang, D.M. McMurray and R.S. Chapkin, Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in the Th1-polarized murine CD4+ T-cells, Journal of Lipid Research, 45, 1482-1492, 2004
  • L.M. Sanders, C.E. Henderson, M.Y. Hong, R. Barhoumi, R.C. Burghardt, R.J. Carroll, N.D. Turner, R.S. Chapkin and J.R. Lupton, Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility, Cancer Letters, 208, 155-161, 2004
  • D.W.L. Ma, J. Seo, L.A. Davidson, E.S. Callaway, Y.Y. Fan, J.R. Lupton and R.S. Chapkin, n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon, Faseb Journal, April 2004, 10.1096/fj.03-0604fje, 18, 1040-1042, 6 2004
  • R.C. Zangar, Y.Y. Fan and R.S. Chapkin, Interactions of phospholipase D and cytochrome P450 protein stability, Biochemical Pharmacology, 68, 503-512, 2004
  • D.W.L. Ma, J. Seo, K.C. Switzer, Y.Y. Fan, D.N. McMurray, J.R. Lupton and R.S. Chapkin, n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research, Journal of Nutritional Biochemistry, 15, 700-706, 2004
  • Y.Y. Fan, L.H. Ly, R. Barhoumi, D.N. McMurray and R.S. Chapkin, Dietary docosahexaenoic acid suppresses T-cell protein kinase C-theta lipid raft recruitment and interleukin-2 production, Journal of Immunology, 173, 6151-6160, 2004
  • L.M. Sanders, C.E. Henderson, M.Y. Hong, R. Barhouim, R.C. Burghardt, N. Wang, C.M. Spinka, R.J. Carroll, N.D. Turner, R.S. Chapkin and J.R. Lupton, An Increase in Reactive Oxygen Species by Dietary Fish Oil Coupled with the Attenuation of Antioxidant Defenses by Dietary Pectin Enhances Rat Colonocyte Apoptosis, Journal of Nutrition, 134, 3233-3238, 2004
  • L.A. Davidson, D.V. Nyuyen, R.M. Hokanson, E.S. Callaway, R.B. Isett, N.D. Turner, E.R. Dougherty, J.R. Lupton, R.J. Carroll and R.S. Chapkin, Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat, Cancer Research, 64, 6797-6804, 2004
  • Davidson LA, Lupton JR, Miskovsky E, Fields AP and Chapkin RS, Quantification of human intestinal gene expression profiles using exfoliated colonocytes: A pilot study, Biomarkers, 8(1), 51-61, 2003
  • Switzer KC, McMurray DN, Morris JS and Chapkin RS, Dietary n-3 polyunsaturated fatty acids selectively promote activation-induced cell death in T-lymphocytes, Journal of Nutrition, 133, 496-503, 2003
  • Apanasovich TV, Sheather S, Lupton JR, Popovic N, Turner ND, Chapkin RS and Carroll RJ, Testing for spatial correlation in binary data with application to aberrant crypt foci in colon carcinogenesis, Biometrics, 59, 752-761, 2003
  • Bancroft LK, Lupton JR, Davidson LA, Taddeo SS, Murphy ME, Carroll RJ and Chapkin RS, Dietary fish oil reduces oxidative DNA damage in rat colonocytes, Free Radical Biology and Medicine, 35, 149-159, 2003
  • Hong MH, Chapkin RS, Davidson LA, Turner ND, Morris JS, Carroll RJ and Lupton JR, Fish oil enhances targeted apoptosis during colon tumor initiation in part by down regulating BCL-2, 46, 44-51, 2003
  • K.C. Switzer, D.N. McMurray, J.S. Morris and R.S. Chapkin, Dietary n-3 polyunsaturated fatty acids selectively promote activation-induced cell death in T-lymphocytes, Journal of Nutrition, 133, 496-503, 2003
  • Y.Y. Fan, D.N. McMurray, L.H. Ly and R.S. Chapkin, Dietary n-3 polyunsaturated fatty acids remodel mouse T cell lipid rafts, Journal of Nutrition, 133, 1913-1920, 2003
  • L.K. Bancroft, J.R. Lupton, L.A. Davidson, S.S. Taddeo, M.E. Murphy, R.J. Carroll and R.S. Chapkin, Dietary fish oil reduces oxidative DNA damage in rat colonocytes, Free Radical Biology & Medicine, 35, 149-159, 2003
  • Y.Y. Fan, T.E. Spencer, N. Wang, M.P. Moyer and R.S. Chapkin, Chemopreventive n-3 fatty acids activate RXRa in colonocytes, Carcinogenesis, 24, 1-8, 2003
  • Chapkin RS, Hong MY, Fan YY, Davidson LA, Sanders LM, Henderson CE, Turner ND, Barhoumi R., Burghardt RC, and Lupton JR, Dietary n-3 fatty acids alter colonocyte mitochondrial membrane composition and function, Lipids, 37, 193-199, 2002
  • Murray NR, Weems C, Chen L, Leon J, Yu W, Davidson LA, Jamieson L, Chapkin RS, Protein kinase CbetaII and TGFbetaRII in w-3 fatty acid-mediated inhibition of colon carcinogenesis, Journal of Cell Biology, 157, 915-920, 2002
  • Turner ND, Zhang J. , Davidson LA , Lupton JR and Chapkin RS, Oncogenic ras alters sensitivity of mouse colonocytes to butyrate and fatty acid mediated growth arrest and apoptosis, Cancer Letters, 186, 29-35, 2002
  • Chapkin RS, Arrington JL , Apanasovich TV , Carroll RJ and McMurray ON, Dietary n-3 PUFA affect TcR-mediated activation of purified murine T cells and accessory cell function in co-cultures, Clinical and Experimental Immunology, 130, 12-18, 2002
  • Hong MY, Chapkin RS , Barhoumi R , Burghardt RC, Turner ND , Henderson CE , Sanders LM , Fan YY , Davidson LA , M. Murphy, Carroll RJ and Lupton JR, Fish oil feeding increases the unsaturation index in mitochondrial phospholipids, enhancing reactive oxygen species generation and initiating apoptosis in rat colonocytes, Carcinogenesis, 1831-1834, 2002
  • Morris JS, Wang N, Lupton JR, Chapkin RS, Turner ND, Hong MY and Carroll RJ, A Baysian analysis of colonic crypt structure and signaling incorporating missing crypts, Biostatistics, 3, 529-546, 2002
  • Arrington JL, Switzer KC, Fan YY, McMurray DN, Chapkin RS, Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor function in primary murine and Jurkat T cells, Journal of Nutrition, 131, 1147-1153, 2001
  • Collett ED, Davidson LA, Lupton JR and Chapkin RS, n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic ras activation in colonocytes, American Journal of Physiology. Cell Physiology, 280, C1066-C1075, 2001
  • Fan YY , Ramos KS and Chapkin RS, Dietary primrose oil containing gammalinolenic acid suppressessmooth muscle proliferation and reduces atheriosclerosis in Apo E knock-out mice, Journal of Nutrition, 131, 1675-1681, 2001
  • Arrington JL, Chapkin RS, Switzer KC, Morris JS and McMurray DN, Dietary n-3 polyunsaturated fatty acids modulate purified murine T cell subset activation, Clinical and Experimental Immunology, 125, 499 - 507, 2001
  • Morris JS, Wang N, Lupton JR, Chapkin RS, Turner ND, Hong MY and Caroll RJ, Parametric and non parametric methods for understaning the relationship between carcinogen-induced DNA adduct levels in distal and proximal regions of the colon, Journal of the American Statistical Association, 96, 816 - 826, 2001
  • Hong MY, Chapkin RS, Morris JS, Wang N, Caroll RJ, Turner ND, Chang WC, Davidson LA and Lupton JR, Anatomical site-specific response to DNA damage is related to later tumor development in the rat AOM colon carcinogenesis model, Carcinogenesis, 22, 1831-1835, 2001
  • Hong MY, Lupton JR, Morris JS, Wang N, Carroll NJ, Davidson LA, Elder RH, and Chapkin RS, Dietary fish oil reduces DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation, Cancer Epidemiology, Biomarkers and Prevention, 9, 819-826, 2000
  • Davidson LA, Brown RE, Chang WC, Lupton JR, Morris JS, Wang N, Carroll RJ, Turner ND, and Chapkin RS, Morphodensitometric analysis of protein kinase C-beta-II expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis, Carcinogenesis, 21, 1513-1519, 2000
  • Chapkin RS, Fan YY, and Lupton JR, Effect of diet on colonic programmed cell death: molecular mechanism of action, Toxicology Letters, 112-113, 411-414, 2000
  • Collett ED, Davidson LA, Lupton JR, and Chapkin RS, Dietary fish oil reduces colon cancer risk, Current Organic Chemistry: Omega-3-Fatty Acids and Health, 4, 945-957, 2000
  • McMurray DN, Jolly CA, and Chapkin RS, Effect of dietary n-3 fatty acids on T cell activation and T cell receptor mediated signalling in a murine model, Journal of Infectious Disease, 182 (Supplement 1), S103-S107, 2000
  • Davidson LA, Lupton JR, Jiang YH, and Chapkin RS, Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics, Carcinogenesis, 20, 785-791, 1999
  • Murray NR, Davidson LA, Chapkin RS, Gustafson WC, Schattenberg DG, and Fields AP, Overexpression of protein kinase C-beta-II in the colonic epithelium causes hyperproliferation and increased sensitivity to colon carcinogenesis, Journal of Cell Biology, 145, 699-711, 1999
  • Lupton JR, Chang W-CL, Hong MY, and Chapkin RS, Fat/fiber interactions on colonic cytokinetics: relationship to colon cancer, Asia Pacific Journal of Clinical Nutrition, Supplement, S37-S40, 1999
  • Fan YY, Turner N, Zhang J, Barhoumi R, Burghardt RC, Lupton JR, and Chapkin RS, Antagonism of CD95 (APO-1/Fas) signaling blocks butyrate induction of apoptosis in young adult mouse colonic (YAMC) cells, American Journal of Physiology, Cell Physiology 46, C310-C319, 1999
  • Fields AP and Chapkin RS, Signaling to colon cancer, Gastroenterology, 117, 1499-1500, 1999
  • Hong MY, Chapkin RS, Morris JS, Wang N, Carroll RJ, Turner ND, and Lupton JR, Relationship between DNA adduct levels, repair enzyme and apoptosis as a function of DNA alkylation by azoxymethane, Cell Growth and Differentiation, 10, 749-758, 1999
  • Fan YY, Ramos KS, and Chapkin RS, Modulation of atherogenesis by dietary gamma-linolenic acid, Eicosinoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases, 469, 485-492, 1999
  • Chapkin RS and Lupton JR, Colonic cell proliferation and apoptosis in rodent species: modulation by diet, Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms, 470, 105-118, 1999
  • Chapkin RS, Reappraisal of the essential fatty acids, Fatty Acids in Food and Their Health Implications, 2nd edition, 557-568, 1999
  • Chapkin RS, McMurray DN, and Jolly CA, Dietary n-3 polyunsaturated fatty acids modulate T-lymphocyte activation: Clinical relevance in treating diseases of chronic inflammation, Nutrition and Immunology: Principles and Practice, 121-134, 1999
  • Chang W-CL, Chapkin RS, and Lupton JR, Fish oil blocks azoxymethane-induced tumorigenesis by increased cell differentiation and apoptosis rather than decreased cell proliferation, Journal of Nutrition, 128, 491-497, 1998
  • Jolly CA, McMurray DN, and Chapkin RS, Effect of dietary n-3 fatty acids on interleukin-2, interleukin-2 recepter alpha expression in activated murine lymphocytes, Prostaglandins Leukotrienes and Essential Fatty Acids, 58, 289-293, 1998
  • Zhang J, Wu G, Chapkin RS, and Lupton JR, Energy metabolism of colonocytes changes during the tumorigenesis process and is dependent on diet and carcinogen, Journal of Nutrition, 128, 1262-1269, 1998
  • Chapkin RS, Clark AE, Davidson LA, Schroeder F, and Lupton JR, Dietary fiber differentially alters cellular fatty acid binding protein expression in exfoliated colonocytes during tumor development, Nutrition and Cancer, 32, 107-112, 1998
  • Davidson LA, Aymond CM, Jiang YH, Turner ND, Lupton JR, and Chapkin RS, Noninvasive detection of fecal protein kinase C-beta-II and zeta messenger RNA: putative biomarkers for colon cancer, Carcinogenesis, 19, 253-257, 1998
  • Fan YY and Chapkin RS, Significance of dietary gamma-linolenic acid (invited review), Journal of Nutrition, 128, 1411-1414, 1998
  • Lupton JR, Chang WCL, Hong MY, and Chapkin RS, Diet effects on apoptosis during colon carcinogenesis, Apoptosis in Cancer, 37-40, 1998
  • Aukema HM, Davidson LA, Pence BC, Jiang YH, Lupton JR, and Chapkin RS, Butyrate alters activity of specific cAMP-receptor proteins in a transgenic mouse colonic cell line, Journal of Nutrition, 127, 18-24, 1997
  • Jolly CA, Jiang YH, Chapkin RS, and McMurray DN, Dietary n-3 polyunsaturated fatty acid modulation of murine lymphoproliferation and interleukin-2 secretion: correlation with alteration in diacylglycerol and ceramide mass, Journal of Nutrition, 127, 37-43, 1997
  • Zoran DL, Barhoumi R, Burghardt RC, Chapkin RS, and Lupton JR, Diet and carcinogen alter luminal buytrate concentration and intracellular pH in isolated rat colonocytes, Nutrition and Cancer, 27, 222-230, 1997
  • Jiang YH, Lupton JR, and Chapkin RS, Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes, Carcinogenesis, 18, 351-357, 1997
  • Maciorowski KG, Turner ND, Lupton JR, Chapkin RS, Shermer CL, Ha SD, and Ricke SC, Diet and carcinogen alter the fecal microbial population of rats, Journal of Nutrition, 127, 449-457, 1997
  • Chang W-CL, Chapkin RS, and Lupton JR, Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis, Carcinogenesis, 18, 721-730, 1997
  • Hong MW, Chang W-CL, Chapkin RS, and Lupton JR, Relationship between colonocyte proliferation, differentiation and apoptosis as a function of diet and carcinogen, Nutrition and Cancer, 28, 20-29, 1997
  • Fan YY, Ramos KS, and Chapkin RS, Dietary gamma-linolenic acid enhances release of macrophage-derived prostaglandin E1 leading to inhibition of mouse vascular smooth muscle cell proliferation, Journal of Nutrition, 127, 1765-1771, 1997
  • Weber TJ, Fan YY, Chapkin RS, and Ramos KS, Growth-related signaling in vascular smooth muscle cells is deregulated by TCDD during G0/G1 transition, Journal of Toxicology and Environmental Health, 51, 369-386, 1997
  • Zoran DL, Turner ND, Taddeo SS, Chapkin RS, and Lupton JR, Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations, Journal of Nutrition, 127, 2217-2225, 1997
  • Chang W-CL, Chapkin RS, and Lupton JR, Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis, Carcinogenesis, 18, 721-730, 1997
  • Jiang YH, Lupton JR, and Chapkin RS, Chemopreventive effects of dietary fat and fiber on azoymethane-induced alteration in colonic PKC lambda expression, Journal of Nutrition, 127, 1938-1943, 1997
  • Laurenz JC, Gunn JM, Jolly CA, and Chapkin RS, Alteration of glycerolipid and sphingolipid-derived second messenger kinetics in ras transformed 3T3 cells, Biochimica et Biophysica Acta, 1299, 146-154, 1996
  • Jiang YH, Davidson LA, Lupton JR, and Chapkin RS, Rapid competitive PCR determination of relative gene expression in limiting tissue samples, Clinical Chemistry, 42, 227-231, 1996
  • Jolly CA, Laurenz JC, McMurray DN, and Chapkin RS, Diacylglycerol and ceramide kinetics in primary cultures of activated T-lymphocytes, Immunology Letters, 49, 43-48, 1996
  • Fan YY, Ramos KS, and Chapkin RS, Cell cycle-dependent inhibition of DNA synthesis in vascular smooth muscle cells by prostaglandin E1: relationship to intracellular cAMP levels, Prostaglandins Leukotrienes and Essential Fatty Acids, 54, 101-107, 1996
  • Jiang YH, Davidson LA, Lupton JR, and Chapkin RS, Rapid competitive PCR determination of relative gene expression in limiting tissue samples, Clinical Chemistry, 42(2), 227-231, 1996 Abstract
  • Jiang YH, Lupton JR, Jolly CA, Davidson LA, Aukema HM, and Chapkin RS, Dietary fat and fiber differentially regulate intracellular second messengers during tumor development in rat colon, Carcinogenesis, 17, 1227-1233, 1996
  • Ramos KS, Zhang Y, Sadhu DN, and Chapkin RS, The induction of proliferative vascular smooth muscle cell phenotypes by benzo (a) pyrene is characterized by up-regulation of inositol phospholipid metabolism and c-Ha-ras gene expression, Archives of Biochemistry and Biophysics, 332, 213-222, 1996
  • Fan YY, Chapkin RS, and Ramos KS, Dietary lipid source alters macrophage/vascular smooth muscle cell interactions in vitro, Journal of Nutrition, 126, 2083-2088, 1996
  • Weber TJ, Chapkin RS, Davidson LA, and Ramos KS, Modulation of protein kinase C (PKC)-related signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits cell cycle-dependence, Archives of Biochemistry and Biophysics, 328, 227-232, 1996
  • Jiang YH, Aukema HM, Davidson LA, Lupton JR, and Chapkin RS, Localization of protein kinase C isozymes in rat colon, Cell Growth and Differentiation, 6(11), 1381-1386, November 1995 Abstract
  • Pickering JS, Lupton JR, and Chapkin RS, Dietary fat, fiber and carcinogen alter fecal diacyl glycerol composition and mass, Cancer Research, 55, 2293-2298, 1995
  • Fan YY, Chapkin RS, and Ramos KS, A macrophage-smooth muscle cell co-culture model: applications in the study of atherogenesis, In Vitro Cellular and Developmental Biology, 31, 492-493, 1995
  • Davidson LA, Jiang YH, Lupton JR, and Chapkin RS, Non-invasive detection of putative biomarkers for colon cancer using fecal mRNA, Cancer Epidemiology, 4, 643-647, 1995
  • Fan YY, Ramos KS, and Chapkin RS, Dietary gammalinolenic acid modulates macrophage-vascular smooth muscle cell interactions: evidence for a macrophage-derived soluble which downregulates DNA synthesis in smooth muscle cells, Arteriosclerosis, Thrombosis, and Vascular Biology, 15, 1397-1403, 1995
  • Davidson LA, Jiang YH, Lupton JR, and Chapkin RS, Noninvasive detection of putative biomarkers for colon cancer using fecal messenger RNA, Cancer Epidemiology, Biomarkers and Prevention, 4(6), 643-647, 1995 Abstract
  • Jiang YH, Davidson LA, Lupton JR, and Chapkin RS, A rapid RT-PCR method for detection of intact RNA in formalin-fixed paraffin-embedded tissues, Nucleic Acids Research, 23, 3071-3072, 1995
  • Ou X, Chapkin RS, and Ramos KS, Interference with PKC-related mitogenic signal transduction by benzo (a) pyrene is associated with inhibition of quail aortic smooth muscle cell proliferation, Archives of Biochemistry and Biophysics, 318, 122-130, 1995
  • R. S. Chapkin, W. Kim, J. R. Lupton and D. N. McMurray., Dietary docosahexanoic and eicosapentaenoic acid: Emerging mediators of inflammation., Am. J. Clin. Nutr., In Press
  • V. E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G. G. Borienko, Y. Y. Tyurina, P. Wipf, J. Atkinson, J. S. Greenberger, R. S. Chapkin and N. A. Belikova, Mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes: A new strategy in anti-apoptotic drug discovery., Molecular Nutrition, In Press
  • K. L. Covert, L. Sanders, M. Y. Hong, S. Taddeo, N. D. Turner, R. S. Chapkin and J. R Lupton., Upregulation of p21 waf1/cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromovtive depending on the lipid component of the diet., Carcinogenesis, In Press
  • R. S, Chapkin, D. N. McMurray, L. A. Davidson, B. S. Patil, Y. Y. Fan and J. R. Lupton, Bioactive dietary long chain fatty acids: Emerging mechanisms of action., British Journal of Nutrition, In Press
  • L.A. Davidson, D.V. Nyuyen, R.M. Hokanson, E.S. Callaway, R.B. Isett, N.D. Turner, E.R. Dougherty, J.R. Lupton, R.J. Carroll and R.S. Chapkin., Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat, Cancer Research
  • D.W.L. Ma, R.H. Finnell, L.A. Davidson, E.S. Callaway, O. Spiegelstein, J.A. Piedrahita, J.M. Salbaum, C. Kappen, B. Weeks, J. James, D. Bozinov, J.R. Lupton and R.S. Chapkin, Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis, Cancer Research, (In press)
  • L.H. Ly, R. Smith, R.S. Chapkin and D.N. McMurray, Dietary n-3 polyunsaturated fatty acids suppress splenic CD4+ T-cell function in IL-10(-/-) mice, Clinical and Experimental Immunology, (In press)
  • K.C. Switzer, D.N. McMurray and R.S. Chapkin, Effects of dietary n-3 polyunsaturated fatty acids on T cell membrane composition and function: a unifying hypothesis, Lipids, (In Press)

Profile Details

Last Updated: 7/13/2008

COS Expertise ID #427939
Reference this profile directly: http://myprofile.cos.com/chapkin39