Chu Chen

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Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Epidemiology
Full MemberAppointed: 2005
University of Washington
School of Medicine
Otolaryngology: Head & Neck Surgery
Affiliate ProfessorAppointed: 2006
University of Washington
School of Public Health and Community Medicine
Epidemiology
Affiliate ProfessorAppointed: 2006
University of Washington
School of Public Health and Community Medicine
Epidemiology
Graduate School FacultyAppointed: 1997
Professional Headshot of Chu  Chen

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North, Mail Stop M5-C800
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact Information

Phone: (206) 667-6644
Fax: (206) 667-2537
cchen@fhcrc.org
http://www.fhcrc.org/labs/chen/

Qualifications

N.R.C.C., Clinical Chemistry, 1992.
D.A.B.C.C., Clinical Chemistry, 1992.
Clinical Chemistry Fellow, University of Washington, Laboratory Medicine, 1992.
Postdoc Research Associate, Fred Hutchinson Cancer Research Center, Molecular Virology, 1990.
Postdoc Fellow, Fred Hutchinson Cancer Research Center, Biochemistry Oncology, 1986.
Ph.D., University of Washington, Biochemistry, 1982.
M.S., Ohio State University, Botany, 1971.
B.S., National Taiwan University, Botany, 1968.

Expertise and Research Interests

For most recent work on differentially expressed genes in oral squamous cell carcinoma, please click the homepage link in the Contact Information section on this page.

A major emphasis of my research has been to understand the possible role of metabolic enzymes in the activation and detoxification of potential carcinogens in the environment, as well as steroid hormones and growth factors, in the etiology of cancer. Of particular interest is the contribution of genetic polymorphisms of these enzymes and receptor molecules for hormones and growth factors to susceptibility to cancer.

In collaboration with epidemiologists, my laboratory has been conducting molecular epidemiologic studies to examine the potential association of polymorphisms of certain genes (such as CYP2D6, CYP2E1, GSTM1, GSTP1, GSTT1, microsomal epoxide hydrolase, NAT1, NAT2, NQO1, etc.), that may play an important role in the activation or detoxification of potential carcinogens that are found in tobacco smoke or are derived from food sources, with the incidence of cancers of the oral cavity, nasopharynx, colon, anus, penis, cervix, vagina, and vulva, and of acute myelocytic leukemia. For cancers of the oral cavity, we are also examining their incidence in relation to alcohol consumption and polymorphisms of the alcohol dehydrogenase type 2 and type 3 genes. Recently, we have begun to use microarray technology to examine differential gene expression in oral cancers of different clinical stage.

Collaborative studies pertaining to hormonal carcinogenesis include: (1) polymorphisms of CYP17, CYP1A1, CYP1B1, catechol O-methyltransferase, glutathione S-transferases, and estrogen receptor in relation to the incidence of cancers of the breast and endometrium; (2) polymorphisms of the 5-alpha reductase type II gene (the 5-alpha reductase converts testosterone to a more potent androgen dihydrotestosterone) and the androgen receptor gene in relation to the incidence of prostate cancer; (3) polymorphisms of CYP11a, CYP17, 3-beta HSD type II, CYP3A4 and UGT2B15 and the incidence of testicular cancer.

Other studies pertain to the evaluation of prediagnostic levels of endogenous sex hormones (androstenedione, testosterone, 3 alpha diol glucuronide, estradiol), sex hormone binding globulin, and insulin-like growth factors and polymorphisms of insulin-like growth factor gene and insulin-like growth factor binding protein gene in relation to prostate cancer risk; the dietary influences on the activities of glutathione S-transferases, cytochrome 450 enzymes, and female hormone levels; the transcriptional regulation of glutathione S-transferases, and the evaluation of melatonin metabolism in relation to exposure to magnetic fields.

Keywords

COS Keywords:

Biochemistry, Breast Cancer, Cancer Genetics, Cancer or Carcinogenesis, Clinical Chemistry, Environmental Health, Enzymes, Etiology, Gene Expression, Hormones, Metastasis, Oral Diseases, Otolaryngology, Prostate Cancer, Steroids, Xenobiotics.

Additional Terms:

Endometrial Cancer, Genetic Expression Profiles of Oral Cancer, Genetic Susceptibility to Cancer, Oral Cancer, Steroid Hormones and Steroid Hormone Receptors, Testicular Cancer.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

Academy of Clinical Laboratory Physicians and Scientists
American Association for Cancer Research
American Association for Clinical Chemistry
Epidemiology of Endometrial Cancer Consortium
International Academy of Oral Oncology
International Head and Neck Cancer Epidemiology Consortium
International Lung Cancer Consortium
International Society for the Studies of Xenobiotics

Honors and Awards

2005, Honoree, Women of Color Empowered, Northwest Asian Foundation
1991, Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists
1983-1986, Postdoctoral Individual National Research Service Award, NCI, NIH

Previous Positions

2001-2006, Affiliate Associate Professor, University of Washington, School of Medicine, Otolaryngology: Head and Neck Surgery
2000-2006, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1999-2005, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
1999-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
1995-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Cancer Biology
1992-1997, Founder and Director of Core Laboratory, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Cancer Biology
1992-1993, Clinical Chemist, Providence Hospital
1974-1976, Research Technician II, Case Western Reserve University, Surgery, Opthalmology, Project: Chemistry of Rhodopsin
1972-1972, Medical Mycologist/Microbiologist, W.A. Foote Memorial Hospital, Clinical Laboratory
1972-1974, Senior Research Technician, Michigan State University, Atomic Energy Commission Plant Research Laboratory, Physiology of Abscisic Acid and Xanthoxin

Funding Received

  • NIH/NCI R01 CA85064: IGF-1 Levels and the Incidence of Prostate Cancer. PI: Noel S. Weiss, Role on Project: Co-Investigator, $722,389, 7/14/00 to 12/31/03.
  • NIH/NCI R01 CA75332: Diet, Cell Proliferation, and Breast Cancer in Shanghai. PI: David Thomas, Role on Project: Co-Investigator, $363,782, 7/01/97 to 6/30/02.
  • NIH/NCI R01 HD40398: Reproductive and Hormonal Risk Factors for Adenomyosis. PI: Victoria Holt, Role on Project: Co-Investigator, $1,984,349, 3/1/02 to 1/31/07.
  • NIH/NCI R01 CA111703: Molecular Epidemiology of Lung Cancer, Role on Project: Principal Investigator, $1,270,390, 2006 to 2010.
  • NIH/NCI R01 CA112523: Steroid Hormone Genes and Ovarian Cancer Risk, PI: MaryAnne Rossing, Role on Project: Co-Investigator, $1,913,589, 2006 to 2011.
  • NIH/NIEHS/NCI R01 CA104786: Environment, Gene & Testicular Cancer, PI: Tongzhang Zheng (Yale University), Role on Project: PI of Subcontract, $188,575, 2006 to 2011.
  • NIH/NCI, 5 R01 CA85914: Molecular Epidemiology of Testicular Carcinoma (Supplement), PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $2,844,513, 2005 to 2010.
  • NIH/NCI R01 CA105212: Molecular Epidemiology of Endometrial Cancer. Role on Project: Principal Investigator, $1,255,730, 2004 to 2008.
  • NIH/NCI R01 CA95419: Oral Cancer: Molecular Profiles & Clinical Outcomes. Role on Project: Principal Investigator, $2,523,488, 2003 to 2008.
  • NIH R01 CA97090: Night Shift Workers and Hormone Levels in Women, PI: Scott Davis, Role on Project: Co-Investigator, $1,471,412, 2002 to 2007.
  • NIH/NCI R03 CA99897: Insulin-like Growth Factors and Esophageal Adenocarcinoma. PI: Thomas Vaughan, Role on Project: Co-Investigator, $100,000, 2002 to 2004.
  • NIH/NCI R01 CA78812: Endogenous Sex Hormones, Genetics, and Prostate Cancer, Role on Project: Principal Investigator, $988,629, 1999 to 2003.
  • NIH/NCI N01 WH22110: Clinical Coordinating Center for the Clinical Trial and Observation of the Women's Health Initiative. PI: Ross Prentice, Role on Project: Investigator, $150,185,267, 1992 to 2007.
  • F32 CA07491, Recipient of Individual National Research Service Award: GM3 Sialytransferase and Cell Transformation. Role on Project: Principal Investigator, $59,736, 11/03/83 to 11/02/86.
  • NIH/NCI R03 CA80636: Endometrial Cancer and CYP1A1, GSTM1 & T1 Polymorphisms. Role on Project: Principal Investigator, $100,000, 10/01/98 to 8/31/01,.
  • NIH/NCI R01 CA95790: Persistent Organochlorines and Testicular Cancer Risk. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $800,000, 09/27/01 to 2006.
  • NIH R01 DE12609: Oral Cancer: DNA Polymorphisms in Carcinogen Metabolism. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $1,058,643, 09/01/98 to 06/30/02.
  • NIH R01 CA80346: 60-Hz Magnetic Fields and Hormone Levels in Women. PI: Scott Davis, Role on Project: Co-Investigator, $1,234,735, 09/01/98 to 3/31/02.
  • NIH/NIEHS R01 ES08305: Phytoestrogens, Organochlorines, and Fibroid Risk. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $665,420, 09/01/96 to 08/31/01.
  • NIH/NICHD R01 HD33792: Reproductive/Contraceptive Risk Factors & Endometriosis. PI: Victoria Holt, Role on Project: Co-Investigator, $445,874, 07/01/99 to 04/30/03.
  • NIH/NCI N01 HD23166: Breast Cancer & the Birth Control Pill: Case-Control Study of Perimenopausal & Past Oral Contraceptive Use. PI: Janet Daling, $7,811,162. Supplement: Genetic Susceptibility & Risk of Breast Cancer, PI: Kathleen Malone, Role on Project: Co-Investigator, $99,535, 07/01/98 to 9/29/03.
  • NIH/NCI R01 CA85914: Molecular Epidemiology of Testicular Carcinoma. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $2,941,143, 06/01/00 to 05/31/05.
  • NIH R01 ES06728: Glutathione S-transferases and Anogenital Cancers, Role on Project: Principal Investigator, $725,988, 05/1/94 to 04/30/97.
  • NIH/NCI R01 CA84141: Breast Cancer and Gene Polymorphisms in Chinese Women. Role on Project: Principal Investigator, $818,101, 04/01/01 to 2006.
  • NIH R03 CA91251: Adiposity Related Biomarkers and Breast Tumor Size, PI: Kathleen Malone, Role on Project: Co-Investigator, $171,905, 04/01/01 to 03/31/03.
  • EPA R829438: Persistent Organic Pollutants and Endometriosis Risk, PI: Victoria Holt, Role on Project: Co-Investigator, $966,841, 03/28/02 to 2006.
  • NCI Contract 263-MQ-822580: Prostate Cancer in Chinese Men, PI: Ann Hsing. Role on Project: Principal Investigator of Lab Component, $80,080, 02/01/99 to 08/31/99.
  • NIH/NCI R21 CA66186, Parent Project PI: David Thomas: Estrogen Receptor Polymorphisms and Breast Cancer in Young Women: A Pilot Project, Role on Project: Principal Investigator, $15,415, 01/01/98 to 12/31/98.
  • NIH/NCI R21 CA66186, Parent Project PI: David Thomas: Effects of Soy and Wheat Bran Feeding on Serum and Urinary Steroid Hormone Levels in Premenopausal Women: A Pilot Project, Role on Project: Principal Investigator, $15,000, 01/01/96 to 12/31/96.
  • NIH R01 CA70913: Glutathione Transferases in Humans: Dietary Influences, PI: Johanna Lampe, Role on Project: Co-Investigator, $1,877,846, 01/01/02 to 2006.

Publications

  • Holt SK, Rossing MA, Malone KE, Schwartz SM, Weiss NS, Chen C, Ovarian cancer risk and polymorphisms involved in estrogen catabolism, Cancer Epidemiology Biomarkers and Prevention, 16, 481-9, 2007
  • Mendez E, Fan W, Choi P, Aggoff SN, Whipple M, Farwell DG, Futran ND, Weymuller EA, Zhao LP, Chen C, Tumor-specific genetic expression profiles of metastatic oral squamous cell carcinoma, Head and Neck, 2007
  • Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Maso LD, Daudt AW, Fabianova E, Wunsch-Filho V, Franceschi S, Hayes R, Herrero R, Koifman S, Vecchia CL, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan A,, Alcohol drinking in non-tobacco users and cigarette smoking in nondrinkers: pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, Journal of the National Cancer Institute, 2007
  • McTiernan A, Wu L, Barnabei VM, Chen C, Hendrix S, Modugno FM, Rohan T, Stanczyk F, Wang CY, Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women, Breast Cancer Research and Treatment, 2007
  • Chen C, Doherty JA, Lewis SK, Ray RM, Gao DL, Stalsberg H, Feng Z, Thomas DB, Insulin-like growth factor 1, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women, International Journal of Cancer, 118, 2303-2309, 2006
  • Davis S, Mirick DK, Chen C, Stanczyk FZ, Effects of 60-Hz magnetic field exposure on nocturnal 6-sulphtoxymelatonin, estrogens, luteinizing hormone and follicle stimulating hormone in healthy reproductive-age women: Results of a cross-over trial, Annals of Epidemiology, 16, 622-31, 2006
  • Weiss JM, Siebold B, Doherty JA, Voigt LF, Chen C, Beresford SA, Hill DA, Weiss NS, Risk factors for the incidence of endometrial cancer according to the aggressiveness of disease, American Journal of Epidemiology, 164, 357-366, 2006
  • Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Chen C, Nucleotide excision repair genotype and the incidence of endometrial cancer: Effect of other risk factors on the association, Gynecologic Oncology, 103, 891-6, 2006
  • Chen Y-J, Chen C, Wu D-C, Lee C-H, Wu I-C, Lee J-M, Goan Y-G, Huang S-P, Lin C-C, Li T-C, Chou Y-P, Wu M-T, Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks, International Journal of Cancer, 119, 2827-31, 2006
  • McTiernan A, Wu L, Chen C, Chlebowski R, Massavar-Rahmani Y, Modugno F, Perri M, Stanczyk F, Van Horn L, Wang CY, and WHI Investigators, Relation of Body Mass Index and Physical Activity to Sex Hormones in Postmenopausal Women, Obesity, 14, 1662-77, 2006
  • Doherty JA, Cushing-Haughan KL, Saltzman BS, Voigt LF, Hill DA, Beresford SA, Chen C, Weiss NS, Long-term use of postmenopausal estrogen and progestin hormone therapies and risk of endometrial cancer, American Journal of Obstetric Gynecology, 2006
  • Chen C, Freeman R, Voigt LF, Fitzpatrick A, Plymate SR, Weiss NS, Prostate cancer risk in relation to selected genetic polymorphisms in insulin-like growth factor-1, insulin-like growth factor binding protein-3, and insulin-like growth factor-1 receptor, Cancer Epidemiology Biomarkers and Prevention, 15, 2461-6, 2006
  • Chen C, Lewis SK, Voigt L, Fitzpatrick A, Plymate SR, Weiss NS, Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor 1, insulin-like growth factor binding protein-3, and insulin, Cancer, 103, 76-84, 2005
  • Doherty JA, Weiss NS, Freeman RJ, Dightman DA, Thornton PJ, Houck JR, Voigt LF, Rossing MA, Schwartz SM, Chen C, Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer, Cancer Epidemiology Biomarkers and Prevention, 14, 357-366, 2005
  • Johnson MM, Houck J, Chen C, Screening for deleterious nonsynonymous single-nucleotide polymorphisms in genes involved in steroid hormone metabolism and response, Cancer Epidemiology Biomarkers and Prevention, 14, 1326-1329, 2005
  • Huang W-Y, Olshan AF, Schwartz SM, Berndt SI, Chen C, Llaca V, Chanock SJ, Fraumeni JF Jr, Hayes RB, Selected genetic polymorphisms in MGMT, XRCC1, XPD and XRCC3 and risk of head and neck cancer: a pooled analysis, Cancer Epidemiology Biomarkers and Prevention, 14, 1747-1753, 2005
  • Starr JR, Chen C, Doody DR, Hsu L, Ricks S, Weiss NS, Schwartz SM, Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome P450 genes involved in catechol estrogen metabolism, Cancer Epidemiology Biomarkers and Prevention, 14, 2183-2190, 2005
  • Choi P, Chen C, Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma [erratum in Cancer 104, 2532, 2005], Cancer, 104, 1113-1128, 2005
  • Nathanson KL, Kanetsky PA, Hawes R, Letrero R, Dudakia D, Vaughn DJ, Johnson L, Robertson K, Tucker K, Friedlander M, Phillips K-A, Hogg D, Jewett MAS, Lohynska R, Daugaard G, Richard S, Chompret A, Bonaïti-Pellié C, Heidenreich A, Olah E, Geczi L, Bodrogi I, Ormiston WJ, Daly PA, Oosterhuis JW, Gillis AJM, Leendert HJ, Looijenga LHJ, Guilford P, Fosså SD, Heimdal K, Tjulandin SA, Liubchenko L, Stoll H, Weber W, Rudd M, Huddart R, Crockford GP, Forman D, Oliver DT, Einhorn L, Weber BL, Kramer J, McMaster M, Greene MH, Pike M, Cortessis V, Chen C, Schwartz SM, Bishop DT, Easton DF, Stratton MR, Rapley EA, The Y deletion gr/gr and risk of testicular germ cell tumor, American Journal of Human Genetics, 77, 1034-1043, 2005
  • Weiss JM, Weiss NS, Ulrich CM, Doherty JA, Voigt LF, Chen C, Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer, Cancer Epidemiology Biomarkers and Prevention, 14, 2524-2530, 2005
  • Modugno FM, Roberta B, Ness RB, Chen C, Weiss NS, Inflammation and endometrial cancer: a hypothesis, Cancer Epidemiology Biomarkers and Prevention, 14, 2840-2847, 2005
  • Gal TJ, Huang W-Y, Yueh B, Chen C, Hayes RB, Schwartz SM, DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients, Laryngoscope, 115, 2221-2231, 2005
  • Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, Caporaso N, Chen C, Coutelle C, Diehl SR, Hayes RB, Olshan AF, Schwartz SM, Sturgis E, Wei Q, Zavras AI, Benhamou S, Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer-a HuGE review, American Journal of Epidemiology, 159, 1-16, 2004
  • Chlebowski RT, Wactawski-Wende J, Ritenbaugh C, Hubbell FA, Ascensao J, Rodabough RJ, Rosenberg C, Taylor V, Harris R, Chen C, Adams-Campbell LL, White E, Estrogen plus progestin and colorectal cancer in postmenopausal women: the Women's Health Initiative trial, New England Journal of Medicine, 350, 991-1004, 2004
  • Adams KF, Chen C, Newton KM, Potter JD, Soy isoflavones do not modulate prostate-specific antigen (PSA) concentrations in older men in a randomized controlled trial, Cancer Epidemiology Biomarkers and Prevention, 13, 644-648, 2004
  • Rosenblatt KA, Daling JR, Chen C, Sherman KJ, Schwartz SM, Marijuana use and risk of oral squamous cell carcinoma, Cancer Research, 64, 4049-4054, 2004
  • Whipple ME, Mendez E, Farwell DG, Agoff SN, Chen C, A log likelihood predictor for genomic classification of oral cancer using principle component analysis for feature selection, Medinfo, 2004, 823-828, 2004
  • Whipple ME, Mendez E, Farwell DG, Agoff SN, Chen C, A genomic predictor of oral squamous cell carcinoma, Laryngoscope, 114, 1346-1354, 2004
  • Lamharzi N, Etzioni R, Weiss NS, Dightman DA, Barnett M, Goodman G, Chen C, Polymorphic markers in the 5 alpha reductase type II gene and prostate cancer risk, International Journal of Cancer, 105, 480-483, 2003
  • Goodman GE, Schaffer S, Omenn GS, Chen C, King I, CARET Co-Investigators, The association between lung and prostate cancer risk and serum micronutrients: Results and lesson learned from CARET, Cancer Epidemiology Biomarkers and Prevention, 12, 518-526, 2003
  • Adams KF, Newton KM, Chen C, Emerson SS, Potter JD, White E, Lampe JW, Soy isoflavones do not modulate circulating insulin-like growth factor in an older population in a randomized controlled trial, Journal of Nutrition, 133(5), 1316-1319, 2003
  • Atkinson C, Skor HE, Fitzgibbons ED, Scholes D, Chen C, Wahala K, Schwartz SM, Lampe JW, Urinary equol excretion in relation to 2-Hydroxyestrone and 16alpha-Hydroxyestrone concentrations: an observational study of young to middle-aged women, Journal of Steroid Biochemistry and Molecular Biology, 86, 71-77, 2003
  • Chen C, Weiss NS, Stanczyk FZ, Lewis SK, DiTommaso D, Etzioni R, Barnett MJ, Goodman GE, Endogenous sex hormones and prostate cancer risk: A case-control study nested within the Carotene and Retinol Efficacy Trial, Cancer Epidemiology Biomarkers and Prevention, 12, 1410-1416, 2003
  • Kuo WP, Mendez E, Chen C, Whipple ME, Farwell G, Agoff N, Park PJ, Functional relationships between gene pairs in oral squamous cell carcinoma, Proc AMIA Symposium, 2003, 371-375, 2003
  • Atkinson C, Skor HE, Fitzgibbons ED, Scholes D, Chen C, Wahala K, Schwartz SM, Lampe JW, Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake [erratum appears in CEBP 11(11): 1511, 2002], Cancer Epidemiology, Biomarkers and Prevention, 11, 253-260, 2002
  • Chen C, Lamharzi N, Weiss NS, Etzioni R, Dightman DA, Barnett M, DiTommaso D, Goodman G., Androgen receptor polymorphisms and the incidence of prostate cancer, Cancer Epidemiology, Biomarkers and Prevention, 11, 1033-1040, 2002
  • Mendez E, Cheng C, Farwell G, Agoff SN, Futran N, Weymuller EA Jr, Maronian N, Zhao LP, Chen C, Transcriptional expression profiles of oral squamous cell carcinomas, Cancer, 95, 1482-1494, 2002
  • Chen C, Doherty JA, Genetic influences on the incidence of endometrial cancer, Molecular Epidemiology of Cancers (Sobti RC ed.), Netherlands, Kluwer Academic Publishers, 2002
  • Schwartz SM, Doody DR, Fitzgibbons, ED, Ricks S, Porter PL, Chen C., Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes, Cancer Epidemiology, Biomarkers and Prevention, 10, 1137-1144, 2001
  • Hsing AW, Chen C, Chokkalingam AP, Gao Y-T, Dightman DA, Nguyen HT, Deng J, Cheng J, Sesterhenn IA, Mostofi FK, Stanczyk FZ, and Reichardt JKV., Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study, Cancer Epidemiology, Biomarkers and Prevention, 10, 1077-1082, 2001
  • White E, Kristal AR, Shikany JM, Wilson AC, Chen C, Mares-Perlman JA, Masaki KH, Caan BJ., Correlates of serum alpha- and gamma-tocopherol in the Women's Health Initiative, Annals of Epidemiology, 11, 136-144, 2001
  • Chen C, Ricks S, Doody D, Fitzgibbons D, Porter PL, Schwartz SM, NAT2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk, Carcinogenesis, 22(12), 1993-1999, 2001
  • Chen C, Risk of prostate cancer in relation to polymorphisms of metabolic genes [review], Epidemiologic Reviews, 23, 30-35, 2001
  • Lampe JW, Skor HE, Li S, Wahala K, Howald WN, Chen C, Wheat bran and soy feeding do not alter urinary excretion of the isoflavan equol in premenopausal women, Journal of Nutrition, 131, 740-744, 2001
  • Davis S, Kaune WT, Mirick DK, Chen C, Steves RG, Residential magnetic fields, light-at-night, and nocturnal urinary 6-sulphatoxymelatonin in women, American Journal of Epidemiology, 154, 591-600, 2001
  • Lampe JW, King IB, Li S, Grate MT, Barale KV, Chen C, Feng Z, Potter JD, Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets, Carcinogenesis, 21(6), 1157-62, 2000
  • Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD, Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps, Cancer Epidemiology, Biomarkers and Prevention, 9(4), 427-33, 2000
  • Crump C, Chen C, Appelbaum FR ,Kopecky KJ, Schwartz SM, Willman CL, Slovak ML, Weiss NS., Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia, Cancer Epidemiology, Biomarkers and Prevention, 9, 457-460, 2000
  • Lampe JW, Chen C, Li S, Prunty J, Grate MT, Meehan DE, Barale KV, Dightman DA, Feng Z, Potter JD., Modulation of human glutathione S-transferases by botanically defined vegetable diets, Cancer Epidemiology, Biomarkers and Prevention, 9, 787-793, 2000
  • Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford AA, Yasui Y, Potter JD, Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?, Cancer Epidemiology, Biomarkers and Prevention, 8(8), 659-68, 1999
  • Nazar-Stewart V, Vaughan TL, Burt RD, Chen C, Berwick M, Swanson GM, Glutathione S-transferase M1 and susceptibility to nasopharyngeal carcinoma, Cancer Epidemiology, Biomarkers and Prevention, 8(6), 547-51, 1999
  • Chen C, Cook LS, Li XY, Hallagan S, Madeleine MM, Daling JR, Weiss NS, CYP2D6 genotype and the incidence of anal and vulvar cancer, Cancer Epidemiology, Biomarkers and Prevention, 8, 317-21, 1999
  • Chen C, Nirunsuksiri W, Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture, Carcinogenesis, 20(4), 699-703, April 1999
  • Chen C, Madeleine MM, Lubinski C, Weiss NS, Daling JR, Glutathione S-transferase M1 genotypes and the risk of squamous carcinoma of the cervix: a population-based case-control study, American Journal of Epidemiology, 150(6), 568-572, 1999
  • Chen C, Madeleine MM, Lubinski C, Weiss NS, Daling JR, Glutathione S-transferase M1 genotypes and the risk of vulvar cancer: a population-based case-control study, American Journal of Epidemiology, 150(5), 437-442, 1999
  • Satia JA, Patterson RE, Herrero R, Jin F, Dai Q, King IB, Chen C, Kristal AR, Prentice RL, Rossing MA, Study of diet, biomarkers and cancer risk in the United States, China and Costa Rica, International Journal of Cancer, 82(1), 28-32, 1999
  • Potter JD, Bigler J, Fosdick L, Bostick RM, Kampman E, Chen C, Louis TA, Grambsch P, Colorectal adenomatous and hyperplastic polyps: smoking and N-acetyltransferase 2 polymorphisms, Cancer Epidemiology, Biomarkers and Prevention, 8(1), 69-75, 1998
  • Bigler J, Chen C, Potter JD, Determination of human NAT2 acetylator genotype by oligonucleotide ligation assay, Biotechniques, 22(4), 682-4 686 688 passim, 1997
  • Chen C, Madeleine MM, Lubinski C, Weiss NS, Tickman EW, Daling JR, Glutathione S-transferase M1 genotypes and the risk of anal cancer: a population-based case-control study, Cancer Epidemiology, Biomarkers and Prevention, 5(12), 985-91, 1996
  • Chen C, Malone KE, Prunty J, Daling JR, Measurement of urinary estrogen metabolites using a monoclonal enzyme-linked immunoassay kit: assay performance and feasibility for epidemiological studies, Cancer Epidemiology, Biomarkers and Prevention, 5(9), 727-32, 1996
  • Chen C, Roby PV, Weiss NS, Wilson JA, Benedetti TJ, Tait JF, Clinical evaluation of the NBD-PC fluorescence polarization assay for prediction of fetal lung maturity, Obstetrics and Gynecology, 80, 688-692, 1992
  • Chen C, Fenderson BA, Andrews WP, Hakomori S-I, Glycolid-glycosyltransferases in human embryonic carcinoma cells during retinoic acid-induced differentiation, Biochemistry, 28, 2229-2238, 1989
  • Chen C, Biegalke BJ, Eisenman RN, Linial ML, FH3: a v-myc avian retrovirus with limited transforming ability, Journal of Virology, 63, 5092-5100, 1989
  • Chen C, Applegate KA, King WC, Glomset JA, Norum KR, Gjone E, A study of the small spherical high density lipoproteins of patients afflicted with familial lecithin:cholesterol acyltransferase deficiency, Journal of Lipid Research, 25, 269-282, 1984
  • Erkelens DW, Chen C, Mitchell CD and Glomset JA, Studies of the interaction between apolipoproteins A and C and triglycerol-rich particles, Biochemical Biophysical Acta, 665, 221-233, 1981
  • Rashke K, Pierce M, Chen C, Abscisic acid content and stomatal sensitivity to CO2 in leaves of Xanthium strumarium L. after pretreatment of warm and cold growth chambers, Plant Physiology, 57, 115-121, 1976
  • Cook LS, Doherty JA, Weiss NS, Chen C, Henderson BE, Ponder B, Ross RK, Endometrial Cancer: Epidemiology and Molecular Endocrinology, Hormones, Genes, and Cancer, New York, New York, Oxford University Press, 371-397, 2003
  • Atkinson C, Lampe JW, Scholes D, Chen C, Wahala K, Schwartz SM, Lignan and isoflavone excretion in relation to uterine fibroids: a case-control study amoung young to middle-aged women in the United States, American Journal of Clinical Nutrition, 84, 587-593, 2006

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Last Verified: 4/20/2007

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