Dr. Karen Chou

powered by
COS Expertise®
Michigan State University
College of Osteopathic Medicine
Adjunct ProfessorAppointed: 1997
Michigan State University
College of Agriculture & Natural Resources
Animal Science
Associate ProfessorAppointed: 1994
Professional Headshot of Karen  Chou

Mailing Address

2209E Anthony Hall
East Lansing, Michigan 48824
United States

Contact Information

Phone: (517) 432-1392
Fax: (517) 432-0190
chouk@msu.edu
http://www.msu.edu/~chouk/

Qualifications

Ph.D., University of Michigan, Toxicology, 1987.
M.S., Michigan State University, Dairy Science, 1980.
B.A., Fu-Jen University, Nutrition, 1973.

Expertise and Research Interests

Environmental Toxicology
Reproduction
Fertilization
Risk Assessment
Endocrine Disruptors


Keywords

COS Keywords:

Animal Science, Birth Or Congenital Defects, Dairy Science, Endocrinology, Environmental Toxicology, Food Safety, Gene Expression, Human Reproduction Or Fertility, Oxidative Stress, Reproduction, Risk Factor Analysis, Toxicology.

Additional Terms:

Arsenic, Birth Defect, Endocrine Disruptors, Environmental Contaminants, Fertility, Food Safety, Gene Expression, Organophosphates, Oxidative Stress, Reproduction, Risk/Toxicity Assessment, Sperm, Toxicology.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Association for the Advancement of Science
Phi Kappa Phi
Sigma Xi, The Scientific Research Society
Society for the Study of Reproduction
Society of Environmental Toxicology and Chemistry
Society of Toxicology

Honors and Awards

1998, Elected faculty member, Honor Society of Phi Kappa Phi, Michigan State University
1996, Women Achieving Excellence Michigan State University, Outstandng Accomplishment
1995, Excellence Award for Interdisciplinary Scholarship, Honor Society of Phi Kappa Phi

Previous Positions

1986-1987, Assistant Professor, Michigan State University, Natural Science

Patents

Method of Artificial Insemination by Timed Release of Sperm from Capsules or Solid Beads, Patent Number: 6596310, 2003, Institution, United States of America.
Method, Device, and Test Kit for Capacitation of Sperm, Patent Number: Patent 5834225, 1998, Institution-owned, United States.

Funding Received

  • National Pork Producers Council: Comprehensive Review on Human Health Effects of Pork Production Emissions, $25,000, 2001 to 2002.
  • National Institutes of Health (NIH): Training and Research in Environmental Health -- The Balkans, $1,000,000, 2001 to 2006.
  • Animal Initiative Industry Coalition: Prolonging Sperm Life Span in Storage with a Modified Semen Extender and Hydride Membrane Capsules, $ 33,000, 1999 to 1999.
  • Environmental Protection Agency (EPA): Developmental Exposure to Endocrine Disruptors: Fertility & Gene Expression Profile Effects, $ $ 728,000, 1999 to 2003.
  • Natinal Food Safety and Toxicology Center: , $ 25,000, 1998 to 1998.
  • Michgian State University Fundation: Developing a New Formulation of Boar Semen Extender to Prolong Sperm Life Span in Storage, $ 10,000, 1998 to 2000.
  • Michigan Great Lakes Protection Fund: , $242,000, 1998 to 2001.
  • NATO: Basic and Applied Research on Environmental Toxicants (Ochratoxin A & Arsenic) as Potential Causes of Balkan Endemic Nephropathy, $ 10,000, 1998 to .
  • Michigan Great Lakes Protection Fund: Roles of Carbohydrates and Free Radicals in Controlling Sperm Fertilizing Ability, $10,000, 1996 to 1997.
  • United States Department of Defense (DOD): In Defense of the Environment, $ 858,000, 1994 to 1996.

Publications

  • Fielden MR, Samy SM, Chou KC, Zacharewski TR, Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice, Food and Chemical Toxicology : an International Journal Published for the British Industrial Biologi, 41(4), 447-54, 2003 Abstract
  • Fielden MR, Halgren RG, Fong CJ, Staub C, Johnson L, Chou K, Zacharewski TR, Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression, Endocrinology, 143(8), 3044-59, 2002 Abstract
  • Fielden, M.R., R.G. Halgren, C.J. Fong, C. Staub, L. Johnson, K. Chou, T.R. Zacharewski, Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression, Endocrinology, 143(8), 3044-3059, 2002
  • Chou, K., C. Y. Lin, A. Huang, R. Inglis, and S. Lin, Great Lakes contaminants reduce sperm production and fertilizing ability in mice, Lakes & Reservoirs: Research & Management, 231-239, 2002
  • Chou, K., C. Y. Lin, A. Huang, R. Inglis, S. Lin, Great Lakes Contaminants Reduce Sperm Production and Fertilizing Ability in Mice, Lakes and Reservoirs: Research and Management, 7, 231-239, 2002
  • Long, D., G. Icopini, V. Ganev, E. Petropoulos, I. Havezov, T. Voice, K. Chou, A. Spassov, and A. S, Geochemistry of Bulgarian soils in villages affected and not affected by Balkan Endemic Nephropathy: A pilot study, Journal of Occupational Medicine and Environmental Health, V(14), 193-196, 2001
  • Long, D., G. Icopini, V. Ganev, E. Petropoulos, I. Havezov, T. Voice, K. Chou, Fingerprinting Balkan Endemic Nephropathy in the Bulgarian environment with geochemical markers: a pilot study, Proceedings of the 7th International Conference on Environmental Science and Technology, B, 541-546, 2001
  • 6. Long, D., G. Icopini, V. Ganev, E. Petropoulos, I. Havezov, T. Voice, K. Chou, A. Spassov, and A., Geochemistry of Bulgarian soils in villages affected and not affected by Balkan Endemic Nephropathy: A pilot study, Global Network of Environmental Science and Technology, 541-546, 2001
  • Fielden M.R., R.G. Halgren, K. Chou, and T.R. Zacharewski, Effects of Gestational and Lactational Exposure to Aroclor 1242 on Testicular Size and Sperm Quality in Early and Middle-Age Male Mice. In: Recent Advances in the Environmental Toxicology and Health E, Environmental Toxicology and Health Effects of PCBs. Eds. Robertson L.W. and Hansen L.G., University, 297-301, 2001
  • Fielden, M.R., R. G. Halgren, C. H.M. Tashiro, B. R. Yeo, K. Chou, and T. R. Zacharewski, Effects of gestational and lactational exposure to Aroclor 1242 on testicular size and sperm quality in early adult and middle-age mice, Reproductive Toxicology, 15, 281-292, 2001
  • Chou, K., A. Haug, and B. Shi, Arsenic and aluminum speciation in environmental toxicology -- a minireview in metal spceciation in the environment, Global Network of Environmental Science and Technology, 9-19, 1999
  • Huang, A, Powel, D. Chou K, Pre- and postnatal exposure to 3,3',4,4'-tetrachlorobiphenyl: I. Effects on breeding ability and sperm fertilizing ability in male mice, Archives of Environmental Contamination and Toxicology, 34, 204-208, 1998
  • Mousa M.A., Ganey P.E., Quensen J.F., Madhukar B.V., Chou K., Giesy J.P., Fischer L.J., S. A. Boyd, Altered biological activities of commercial PCB mixtures after microbial reductive dechlorination, Environmental Health Perspectives, 106(6), 1409-1418, 1998
  • Chou, K. and B. Salem (Ed. P. Wexler), Endocirne System, Encylcopedia of Toxicology, 531-535, 1998
  • Huang, A., Lin, S., Powell, D., Chou, K.,, Pre- and postnatal exposure to 3,3',4,4'-tetrachlorobiphenyl: II. Effects on the reproductive capacity and fertilizing ability of eggs in female mice, Archives of Environmental Contamination and Toxicology, 34, 209-214, 1998
  • Mousa, M.A., Quensen, J.H. III, Chou, K., Boyd, S.A., Microbial dechloriantion alleviates inhibitory effects of PCBs on mouse gamete fertilization in vitro, Environmental Science and Technology, 30(6), 2087-2092, 1996
  • Yang H H, Aulerich R J, Helferich W, Yamini B, Chou K C, Miller E R, Bursian S J, Effects of zearalenone and/or tamoxifen on swine and mink reproduction., Journal of Applied Toxicology, 15(3), 223-32, May 1995 Abstract
  • Chou K, Cook R M, Acetylcholine prevents toxic effects of paraoxon on mouse sperm., Bulletin of Environmental Contamination and Toxicology, 54(2), 251-7, February 1995 Abstract
  • Chou K C, Cook R M, Paraoxon inhibits fertilization of mouse gametes in vitro., Bulletin of Environmental Contamination and Toxicology, 53(6), 863-8, December 1994 Abstract
  • Kamrin M A, Carney E W, Chou K, Cummings A, Dostal L A, Harris C, Henck J W, Loch-Caruso R, Miller R K, Female reproductive and developmental toxicology: overview and current approaches., Toxicology Letters, 74(2), 99-119, November 1994 Abstract
  • Wei, K., Z. Dong, H. D. Stowe, and K. Chou, Interactive effects of selenium and copper on reproductive system of male rats, Journal of Guizhou Agricuulture College, 1(24), 28-31, 1994
  • Shi B, Chou K, Haug A, Aluminium impacts elements of the phosphoinositide signalling pathway in neuroblastoma cells., Molecular and Cellular Biochemistry, 121(2), 109-18, 21 Apr 1993 Abstract
  • Shi B, Chen L, Chou K, Haug A, Elevation of intracellular free calcium levels in sperm in response to long-term feeding of fungicides to mice., Journal of Environmental Science and health. Part B: Pesticides, Food Contaminants, and Agricultural, 27(1), 1-8, February 1992 Abstract
  • Shi B, Oswalt M D, Chou K, Haug A, Loss of inositol phospholipids in epididymal sperm following exposure of mice to long-term feeding of organophosphates., Pharmacology and Toxicology, 70(1), 75-6, January 1992 Abstract
  • Brondani A, Towns R, Chou K, Cook R M, Barradas H, Effects of isoacids, urea, and sulfur on ruminal fermentation in sheep fed high fiber diets., Journal of Dairy Science, 74(8), 2724-7, August 1991 Abstract
  • Zhou R, Shi B, Chou K C, Oswalt M D, Haug A, Changes in intracellular calcium of porcine sperm during in vitro incubation with seminal plasma and a capacitating medium., Biochemical and Biophysical Research Communications, 172(1), 47-53, 15 Oct 1990 Abstract
  • Chou K, Chen J, Yuan S X, Haug A, The membrane potential changes polarity during capacitation of murine epididymal sperm., Biochemical and Biophysical Research Communications, 165(1), 58-64, 30 Nov 1989 Abstract
  • Cosby, N., K. Chou, and W.R. Dukelow, Embryo production in B6D2-F1 mice using two superovulating regimens, Laboratory Animal Science, 39, 249-250, 1989
  • Wei, K., H.D. Stowe, A. House, K. Chou, and T. Thiel, Comparison of cupric and sulfate ion effects on chronic selenosis in rats, Journal of Animal Science, 4, 1467-1475, 1987

Profile Details

Last Updated: 9/8/2007

COS Expertise ID #1244340
Reference this profile directly: http://myprofile.cos.com/chouk