Dr. Eric H. Chudler

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University of Washington
School of Medicine
Bioengineering
Research Associate ProfessorAppointed: 2006
University of Washington
School of Medicine
Anesthesiology
Adjunct Research Associate ProfessorAppointed: 2006
Professional Headshot of Eric H. Chudler

Mailing Address

Box 355061
UWEB E/O
1705 NE Pacific St.
Dept. Bioengineering
Seattle, Washington 98195-5061
United States

Contact Information

Phone: (206) 616-6899
Fax: (206) 616-9763
chudler@u.washington.edu
http://faculty.washington.edu/chudler/ehc.html

Qualifications

Ph.D., University of Washington, Psychology, 1985.
M.S., University of Washington, Psychology, 1983.
B.S., University of California, Los Angeles, Psychobiology, 1980.

Expertise and Research Interests

My research interests currently focus on cortical and basal ganglia mechanisms of nociception and pain. Additional interests include how the cortex and basal ganglia process information from multiple sensory modalities (multisensory integration). Using behavioral and neurophysiological techniques, I explore the cerebral cortex and basal ganglia in attempts to understand how the central nervous system is involved with behaviors related to nociception and pain. More specifically, I have conducted electrophysiological studies that have demonstrated that the neostriatum (caudate-putamen; CPu) and globus pallidus (GP) are important sites for processing somatosensory and auditory information. Many neurons in the CPu and GP respond to both somatosensory and auditory stimulation; some neurons are activated by painful somatosensory stimulation. These studies have revealed that the CPu and GP are important for multisensory integration. It is possible that multisensory neurons in these locations are important for facilitating motor responses necessary for behaviors relating to orientation or escape from environmental stimuli.

Keywords

COS Keywords:

Anesthesiology, Biological Sciences, Brain, Central Nervous System, Clinical Trial, Medical Education, Nervous System, Neurobiology, Neurology, Pain.

Additional Terms:

Brain, Central Nervous System, Clinical Trials, Drug Studies, Education Programs, Medical Education, Nervous System, Neurobiology, Pain, Pain Behaviors.

Memberships

Faculty for Undergraduate Neuroscience
International Association for the Study of Pain
International Brain Research Organization
National Association of Health Science Education Partnerships
National Science Teachers Association
Society for Neuroscience

Honors and Awards

2006, Neuroscience Career Achievement Award, Faculty for Undergraduate Neuroscience
2004, Web Award, Science & Technology Web Award, Scientific American
2003, Science Educator Award, Society for Neuroscience
2002, MERLOT Award for Exemplary Online Learning Resources,
2002, B. Raymond Fink Research Award, Department of Anesthesiology, University of Washington
2002, Education Award, Association of Neuroscience Departments and Programs

Previous Positions

1998-2006, Research Associate Professor, University of Washington, School of Medicine, Anesthesiology
1991-1998, Research Assistant Professor, University of Washington, School of Medicine, Anesthesiology
1989-1991, Instructor, Massachusetts General Hospital
1989-1991, Instructor, Harvard University, Medical School
1986-1989, Postdoctoral Fellow, National Institute of Health (NIH), National Institute of Dental Research
1983, Teaching Assistant, University of Washington
1980-1986, Research Assistant, University of Washington

Publications

  • Chudler EH, Lu Y (Jun 2008) Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine., Brain research, 1213, 41-7 Abstract
  • Chudler, EH (2007) Inside Your Brain, New York, Chelsea House Publishers, 128 pages, ISBN=0791089444
  • Chudler EH, Byers MR (Mar 2005) Behavioural responses following tooth injury in rats., Archives of oral biology, 50 (3), 333-40 Abstract
  • Cameron W, Chudler E (Sep 2003) A role for neuroscientists in engaging young minds., Nature reviews. Neuroscience, 4 (9), 763-8 Abstract
  • Chudler EH, Anderson LC (Feb 2002) Behavioral and electrophysiological consequences of deafferentation following chronic constriction of the infraorbital nerve in adult rats., Archives of oral biology, 47 (2), 165-72 Abstract
  • Stewart H.L. and Chudler, E.H., Neuroscience in the Cinema, Science Scope, 25, 76-81, 2002
  • Chudler EH, Making sense of the senses, Children and Families, Spring, 28-32, 2001
  • Chudler EH and Bonica JJ, Supraspinal processing of nociceptive information, Bonica's Management of Pain, 3rd edition, edited by J.D. Loeser, Philadelphia: Lippin, 153-159, 2001
  • Byers MR, Chudler EH, Iadarola MJ (Apr 2000) Chronic tooth pulp inflammation causes transient and persistent expression of Fos in dynorphin-rich regions of rat brainstem., Brain research, 861 (2), 191-207 Abstract
  • Chudler EH, Buckland T., Cunningham S. and Williamson J., Brain awareness week open house: an interactive, hands-on experience to learn about the nervous system, Science Scope, 22, 54-55, 1999
  • Chudler EH (Nov 1998) Response properties of neurons in the caudate-putamen and globus pallidus to noxious and non-noxious thermal stimulation in anesthetized rats., Brain research, 812 (1-2), 283-8 Abstract
  • Chudler EH, Anderson LC, Byers MR (Nov 1997) Trigeminal ganglion neuronal activity and glial fibrillary acidic protein immunoreactivity after inferior alveolar nerve crush in the adult rat., Pain, 73 (2), 141-9 Abstract
  • Chudler EH, Anderson LC, Byers MR (Aug 1997) Nerve growth factor depletion by autoimmunization produces thermal hypoalgesia in adult rats., Brain research, 765 (2), 327-30 Abstract
  • Dong WK, Hayashi T, Roberts VJ, Fusco BM, Chudler EH (Mar 1996) Behavioral outcome of posterior parietal cortex injury in the monkey., Pain, 64 (3), 579-87 Abstract
  • Sugaya A, Chudler EH, Byers MR (Sep 1995) Axonal transport of fluorescent carbocyanine dyes allows mapping of peripheral nerve territories in gingiva., Journal of periodontology, 66 (9), 817-21 Abstract
  • Chudler EH, Sugiyama K, Dong WK (Mar 1995) Multisensory convergence and integration in the neostriatum and globus pallidus of the rat., Brain research, 674 (1), 33-45 Abstract
  • Chudler EH, Dong WK (Jan 1995) The role of the basal ganglia in nociception and pain., Pain, 60 (1), 3-38 Abstract
  • Dong WK, Chudler EH, Sugiyama K, Roberts VJ, Hayashi T (Aug 1994) Somatosensory, multisensory, and task-related neurons in cortical area 7b (PF) of unanesthetized monkeys., Journal of neurophysiology, 72 (2), 542-64 Abstract
  • Sugaya A, Chudler EH, Byers MR (Aug 1994) Uptake of exogenous fluorescent Di-I by intact junctional epithelium of adult rats allows retrograde labeling of trigeminal sensory neurons., Brain research, 653 (1-2), 330-4 Abstract
  • Sugiyama K, Dong WK, Chudler EH (Jul 1994) A simplified method for manufacturing glass-insulated metal microelectrodes., Journal of neuroscience methods, 53 (1), 73-80 Abstract
  • Chudler EH, Sugiyama K, Dong WK (Jun 1993) Nociceptive responses in the neostriatum and globus pallidus of the anesthetized rat., Journal of neurophysiology, 69 (6), 1890-903 Abstract
  • Dong WK, Shiwaku T, Kawakami Y, Chudler EH (May 1993) Static and dynamic responses of periodontal ligament mechanoreceptors and intradental mechanoreceptors., Journal of neurophysiology, 69 (5), 1567-82 Abstract
  • Chudler EH, Foote WE, Poletti CE (Oct 1991) Topography of C1 nerve- and trigeminal-evoked potentials in the ventrobasal complex of the cat thalamus., Neuroscience letters, 132 (1), 33-6 Abstract
  • Chudler EH, Foote WE, Poletti CE (Aug 1991) Responses of cat C1 spinal cord dorsal and ventral horn neurons to noxious and non-noxious stimulation of the head and face., Brain research, 555 (2), 181-92 Abstract
  • Nishimori T, Buzzi MG, Chudler EH, Poletti CE, Moskowitz MA, Uhl GR (Dec 1990) Preproenkephalin upregulation in nucleus caudalis: high and low intensity afferent stimulation differentially modulate early and late responses., The Journal of comparative neurology, 302 (4), 1002-18 Abstract
  • Dong WK, Chudler EH, Kawakami Y (Oct 1990) Tooth pulp-evoked potentials in the trigeminal brainstem nuclear complex., Brain research, 529 (1-2), 131-42 Abstract
  • Chudler EH, Anton F, Dubner R, Kenshalo DR (Mar 1990) Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval., Journal of neurophysiology, 63 (3), 559-69 Abstract
  • Chudler EH, Nahin RL, Kenshalo DR (Mar 1989) Distribution and size of GABAergic neurons in area 7b and the retroinsular cortex of the monkey., Brain research, 481 (2), 383-7 Abstract
  • Chudler EH, Pretel S, Kenshalo DR (Jul 1988) Distribution of GAD-immunoreactive neurons in the first (SI) and second (SII) somatosensory cortex of the monkey., Brain research, 456 (1), 57-63 Abstract
  • Kenshalo DR, Chudler EH, Anton F, Dubner R (Jun 1988) SI nociceptive neurons participate in the encoding process by which monkeys perceive the intensity of noxious thermal stimulation., Brain research, 454 (1-2), 378-82 Abstract
  • Chudler EH, Dong WK, Kawakami Y (Nov 1986) Cortical nociceptive responses and behavioral correlates in the monkey., Brain research, 397 (1), 47-60 Abstract
  • Chudler EH, Dong WK, Kawakami Y (Jul 1985) Tooth pulp-evoked potentials in the monkey: cortical surface and intracortical distribution., Pain, 22 (3), 221-33 Abstract
  • Dong WK, Chudler EH, Martin RF (May 1985) Physiological properties of intradental mechanoreceptors., Brain research, 334 (2), 389-95 Abstract
  • Dong WK, Chudler EH (May 1984) Origins of tooth pulp-evoked far-field and early near-field potentials in the cat., Journal of neurophysiology, 51 (5), 859-89 Abstract
  • Chudler EH, Dong WK (Dec 1983) Neuroma pain model: correlation of motor behavior and body weight with autotomy in rats., Pain, 17 (4), 341-51 Abstract
  • Chudler EH, Dong WK (Jul 1983) The assessment of pain by cerebral evoked potentials., Pain, 16 (3), 221-44 Abstract
  • Chudler EH, Dong WK (Dec 1981) Adjuvant-induced arthritis in rats: a possible model of chronic pain., Pain, 11 (3), 407-8 Abstract
  • Lewis JW, Cannon JT, Chudler EH, Liebeskind JC (Mar 1981) Effects of naloxone and hypophysectomy on electroconvulsive shock-induced analgesia., Brain research, 208 (1), 230-3 Abstract
  • Lewis JW, Chudler EH, Cannon JT, Liebeskind JC (1981) Hypophysectomy differentially affects morphine and stress analgesia., Proceedings of the Western Pharmacology Society, 24, 323-6 Abstract

Profile Details

Last Updated: 10/23/2008

COS Expertise ID #305883
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