Dr. Clifford R. Hume

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University of Washington
School of Medicine
Otolaryngology--Head and Neck Surgery
Assistant ProfessorAppointed: 2002
Professional Headshot of Clifford R. Hume

Mailing Address

Department of Otolaryngology-Head and Neck Surgery
University of Washington
Box 357923, CHDD, CD176
Virginia Merrill Bloedel Hearing Research Center
Seattle, Washington 98195
United States

Contact Information

Phone: (206) 616-4501
Fax: (206) 616-1828
hume@u.washington.edu

Qualifications

Resident, University of Washington, Otolaryngology-Head and Neck Surgery, 2002.
Internship, University of Washington, General Surgery, 1997.
M.D., Cornell University Medical College, 1996.
Ph.D., Cornell University, Immunology, 1989.
B.A., Carleton College, Biology, Science and Technology Policy, 1983.

Expertise and Research Interests

Otology
Neurotology
General Otolaryngology

Rehabilitation of hearing and balance disorders including:
Surgery for chronic ear infections
Otosclerosis
Cochlear implantation
Vertigo

Inner ear development in mammals
Gene therapy for inner ear disorders using viral and non-viral techniques
Optimization of the neural-prosthetic interface in cochlear implant design

Other Expertise

University of Washington, Seattle, WA. Department of Otolaryngology-Head and Neck Surgery. E. A. Weymuller, Jr, Chairman. 1997-2002. Resident in Otolaryngology.

University of Washington, Seattle, WA. Department of Surgery. C. Pellegrini, chairman. 1996-1997. Internship in General Surgery.

Future Research

Otolaryngology
Mammalian inner ear development
Gene therapy of hearing disorders

Keywords

COS Keywords:

Cochlear Implants or Hearing Aids, Developmental Neurobiology, Hearing, Hearing Disorders, Otolaryngology, Surgery.

Additional Terms:

Clinician Scientist, Cochlear Implants, Gene Therapy, Hearing, Neural Development, Translational Medicine.

Memberships

American Academy of Otolaryngology-Head and Neck Surgery
American College of Surgeons
American Medical Association
Association for Research in Otolaryngology

Honors and Awards

1996, James Moore Scholarship, Department of Otolaryngology, Cornell University Medical College
1995-1996, George N. Papanicolaou Fellow in Clinical Anatomy, Department of Cell Biology and Anatomy, Cornell University Medical College, Head and Neck Anatomy
1990-1993, Biomedical Research Fellow, Helen Hay Whitney Foundation, Columbia University, Developmental Neurobiology
1989-1990, Research Fellow, Columbia University Comprehensive Cancer Center
1988-1989, Research Fellow, Center for Neurobiology and Behavior, Columbia University, Developmental Neurobiology
1988, Young Investigator Paper, American Society for Histocompatibility and Immunogenetics, Genetics of HLA class II gene regulation
1987, Frank L. Horsfall Award, Cornell University Graduate School of Medical Sciences

Previous Positions

1992-1996, Medical Student, Cornell University, Weill Medical College
1988-1993, Postdoctoral Research Fellow, Columbia University, Physiology and Cellular Biophysics and the Center for Neurobiology and Behavior
1983-1988, Graduate Student, Sloan-Kettering Institute and Cornell University, Graduate School of Medical Sciences, Immunology Program

Funding Received

  • NIDCD: Afferent Innervation of the Postnatal Cochlea, 2004 to 2009.

Publications

  • Hume CR, Kirkegaard M, Oesterle EC, ErbB Expression: the Mouse Inner Ear and Maturation of the Mitogenic Response to Heregulin., Journal of the Association for Research in Otolaryngology : Jaro, 4(3), 422-43, Sep 2003
  • Oesterle EC, Hume CR, Growth factor regulation of the cell cycle in developing and mature inner ear sensory epithelia, Journal of Neurocytology, 28, 877-887, 1999
  • Shah SB, Skromne I, Hume CR, Kessler DS, Lee KJ, Stern CD, Dodd J, Misexpression of chick Vg1 in the marginal zone induces primitive streak formation, Development, 124(24), 5127-38, December 1997 Abstract
  • Popperl H, Schmidt C, Wilson V, Hume CR, Dodd J, Krumlauf R, Beddington RS, Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm, Development, 124(15), 2997-3005, August 1997 Abstract
  • Kuhel WI, Hume CR, Selesnick SH, Cancer of the external auditory canal and temporal bone, Otolaryngologic Clinics of North America, 29(5), 827-52, October 1996 Abstract
  • Hume CR, Dodd J, Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization, Development, 119(4), 1147-60, December 1993 Abstract
  • Mattioni T, Hume CR, Konigorski S, Hayes P, Osterweil Z, Lee JS, A cDNA clone for a novel nuclear protein with DNA binding activity, Chromosoma, 101(10), 618-24, October 1992 Abstract
  • Hume CR, Lee JS, Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro, Tissue Antigens, 36(3), 108-15, September 1990 Abstract
  • Hume CR, Lee JS, Genetics of HLA class II regulation, Immunologic Research, 9(2), 93-102, 1990 Abstract
  • Hume CR, Nocka KH, Sorrentino V, Lee JS, Fleissner E, Constitutive c-myc expression enhances the response of murine mast cells to IL-3, but does not eliminate their requirement for growth factors, Oncogene, 2(3), 223-6, March 1988 Abstract
  • Sorrentino V, McKinney MD, Drozdoff V, Hume CR, Fleissner E, Spontaneous or carcinogen-mediated amplification of a mutated ras gene promotes neoplastic transformation, Oncogene Research, 2(2), 189-95, 1988 Abstract
  • Hume CR, Accolla RS, Lee JS, Defective HLA class II expression in a regulatory mutant is partially complemented by activated ras oncogenes, Proceedings of the National Academy of Sciences (USA), 84(23), 8603-7, December 1987 Abstract
  • Lee JS, Cohen EB, Hume CR, Sartoris S, Organization, polymorphism, and regulation of class II genes of the major histocompatibility complex, Year in Immunology, 2, 205-21, 1986 Abstract

Profile Details

Last Updated: 5/29/2005

COS Expertise ID #906063
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