Prof. Christoph H. Kindler |
|
Kantonsspital Aarau AG Perioperative Medicine Anesthesia and Critical Care Medicine Professor |  |
Mailing AddressProfessor and Chairman Clinic of Anesthesia Director Department of Perioperative Medicine Kantonsspital Aarau AG Aarau, CH-5001Switzerland | Contact Information |
Qualifications
DEAA, European Academy of Anesthesiology.
FMGEMS, Foreign Medical Graduate Examination in the Medical Sciences.
Certificate of Registration, The Medical Board of California.
FMH Intensivmedizin, Schweizerische Gesellschaft für Intensivmedizin SGI.
FMH Anästhesiologie, Schweizerische Gesellschaft für Anästhesiologie und Reanimation SGAR.
Expertise and Research Interests
1 Mechanisms of anesthectic action
We are investigating the cellular and molecular mechanisms of general and local anesthesia. Despite extensive attempts to elucidate the molecular mechanisms of anesthesia and over 150 years of clinical practice, the exact molecular targets for general anesthetic agents remain unknown. The idea that general anesthetics produce unconsciousness and amnesia by interfering with communication between neurones is conceptually appealing, and today there has been good evidence accumulated for considering ligand-gated ion channels as important molecular targets for general anesthetics. The main putative targets for anesthetic action are therefore the GABAA, glutamate and neuronal acetylcholine receptors, which are all sensitive to general anesthetic agents. However, other ion channels and receptors such as sodium, potassium (K+) and calcium channels, glycine, purinergic, and metabotropic receptors, and intracellular phosphatases and protein kinases are also included in the list of potential anesthetic target sites. Specifically, we are investigating the field of K+ channels that have been identified as new, potential molecular targets for volatile anesthetics. Our focus is on the unique structural class of K+ channels known as tandem pore (2P) domain K+ channels that mediate background or leak K+ currents in excitable tissues. The structural orientation of these 2P K+ channel subunits consists of four transmembrane segments and two pore-forming domains in tandem within their primary amino acid sequence with amino- and carboxy terminals arrayed intracellularly. As of today, 14 human 2P K+ channels have been identified, but functional expression has only been demonstrated for eleven such channels (http://www.gene.ucl.ac.uk/nomenclature/genefamily/KCN.shtml). Background K+ currents display the following characteristics: (1) lack of voltage dependence indicated by instantaneous or near-instantaneous activation with membrane voltage change; (2) non-inactivation, i.e., K+ currents that pass through the channels remain stable over time; (3) resistance to classical K+ channel blockers such as tetraethyl ammonium and 4-aminopyridine; (4) passage of currents over the range of voltage closely predicted by the Goldman-Hodgkin-Katz equation for ion conduction through a passive, K+-selective pore. The abundance of resting currents in a given cell will determine important aspects of its excitability such as the resting membrane potential, the repolarizing effect, and the resistance to depolarization. In principle, specific enhancement of these currents provides a very plausible mechanism by which volatile anesthetics reduce neuronal signaling within the central nervous system. The first cloned K+ channel with electrophysiological properties resembling those of background K+ currents was the yeast K+ channel TOK1, first identified in 1995. Subsequently, another 2P K+ channel (ORK1) was isolated in Drosophila (ORK1) that displays open rectification properties. These channels produce pure leak currents, acting as open conduits for the movement of K+ ions across the cellular membrane as determined by electro-chemical gradients. Because of the similarity of TOK1 and ORK1 to the properties of the volatile anesthetic-activated molluscan current IKAN, we hypothesized that volatile anesthetic activation would occur for the novel mammalian 2P K+ channels. We are investigating the effect of volatile and local anesthetics on 2P K+ channels with electrophysiological and immunohistochemical methods.
2 "Scientometrics" in anesthetic literature
The public, funding agencies, and academic institutions are today increasingly interested in measuring the research quality and productivity of individual scientists as an indication of their scholarly excellence. Political or independent institutions evaluate and compare the scientific activities of individuals, departments, and universities and publish rankings as, for example, "The List of the Worldwide Champions League of Research Institutions" (http://www.cest.ch/en/) in order to use such "scientific" information for policy decisions. The growing field of studying the output of scientific and technological literature is termed "Scientometrics" and includes all quantitative aspects of the science of science.
A popular method for measuring the impact on the scientific community of an article or a researcher is the citation rating, which has become the modern "sales figure" for scientists. When publication A refers to publication B in the reference list, then publication A is the citing article and publication B becomes the cited article. Citation analysis is the area of bibliometrics that examines these relationships. The number of citations (i.e., how many times a given article is counted in the reference lists of subsequent articles) is seen as a direct measure of the recognition that this publication has had in its scientific field; in some circumstances, it is also used as a measure of quality by granting bodies. One criticism of citation analysis is that the databases do not distinguish between positive or negative credits or citations. Although there is obviously considerable debate about the value of citation rates used to assess the quality of research, analysis of citation rates may allow for the identification of seminal advances in a specialty.
In addition to citation rates, the identification and analysis of highly dynamic areas of research is becoming a more and more important task within the context of science policy and research development. The study proposed here will present insights into the highly dynamic specialty of anesthesia and will produce a detailed documentation including a co-citation map of highly cited documents, a journal profile, the most important actors on institutional and national level, and the most important publications from the research fronts.
3 Non-technical skills of anesthesiologists
3.1. Physician-patient communication
Effective physician-patient communication is increasingly recognized to influence a variety of patient behaviours such as patient satisfaction and understanding of medical advice. Good communication also contributes to achieve desired health care outcomes. In a recent attempt to define and assess the professional competence of physicians, Epstein and Hundert established basic communication skills as an important dimension of professional cognitive competence. The Accreditation Council for Graduate Medical Education in the United States specifies interpersonal skills and communication as general competencies of graduate medical education and the Council's Outcome Project documents the assessment of such competencies by American residency programs. The same is true for The Royal College of Anesthetists and The Royal College of Surgeons both of which now require an assessment of communication skills for their certificates of specialist training. Historically, anesthetic training was primarily directed at acquiring technical skills and most of today's attending anesthetists received little formal training in communication and might lack the skills required to deal effectively with patients' psychosocial and information needs during the pre-operative visit. It is therefore not surprising that communication skills are increasingly viewed as a key component both in the medical curriculum and in the postgraduate training for specialists. In the past, communication skills training as a component of formal training was only emphasised for general practitioners and internists, but the importance of such non-technical skills is now also recognized in anesthesia and critical care medicine. For this purpose, simulator-based modular human factor and communication training has recently been made available for anesthetists.
Since pre-operative anxiety is often directed towards the anesthesia itself, an anesthetist is best able to reduce a patient's anxiety. Our aim is to improve the anesthetist's ability to elicit and respond to the patient's concerns and questions during the pre-operative anesthetic visit. In order to define more precisely those skills which would best help an anesthetist to become a more professional communicator, the current project investigates the anesthetist-patient interaction.
3.2. OR Management
Application of Information Technology, Resource Allocation and Management Science Tools on the environment of the operating rooms within a medical center.
We are investigating the cellular and molecular mechanisms of general and local anesthesia. Despite extensive attempts to elucidate the molecular mechanisms of anesthesia and over 150 years of clinical practice, the exact molecular targets for general anesthetic agents remain unknown. The idea that general anesthetics produce unconsciousness and amnesia by interfering with communication between neurones is conceptually appealing, and today there has been good evidence accumulated for considering ligand-gated ion channels as important molecular targets for general anesthetics. The main putative targets for anesthetic action are therefore the GABAA, glutamate and neuronal acetylcholine receptors, which are all sensitive to general anesthetic agents. However, other ion channels and receptors such as sodium, potassium (K+) and calcium channels, glycine, purinergic, and metabotropic receptors, and intracellular phosphatases and protein kinases are also included in the list of potential anesthetic target sites. Specifically, we are investigating the field of K+ channels that have been identified as new, potential molecular targets for volatile anesthetics. Our focus is on the unique structural class of K+ channels known as tandem pore (2P) domain K+ channels that mediate background or leak K+ currents in excitable tissues. The structural orientation of these 2P K+ channel subunits consists of four transmembrane segments and two pore-forming domains in tandem within their primary amino acid sequence with amino- and carboxy terminals arrayed intracellularly. As of today, 14 human 2P K+ channels have been identified, but functional expression has only been demonstrated for eleven such channels (http://www.gene.ucl.ac.uk/nomenclature/genefamily/KCN.shtml). Background K+ currents display the following characteristics: (1) lack of voltage dependence indicated by instantaneous or near-instantaneous activation with membrane voltage change; (2) non-inactivation, i.e., K+ currents that pass through the channels remain stable over time; (3) resistance to classical K+ channel blockers such as tetraethyl ammonium and 4-aminopyridine; (4) passage of currents over the range of voltage closely predicted by the Goldman-Hodgkin-Katz equation for ion conduction through a passive, K+-selective pore. The abundance of resting currents in a given cell will determine important aspects of its excitability such as the resting membrane potential, the repolarizing effect, and the resistance to depolarization. In principle, specific enhancement of these currents provides a very plausible mechanism by which volatile anesthetics reduce neuronal signaling within the central nervous system. The first cloned K+ channel with electrophysiological properties resembling those of background K+ currents was the yeast K+ channel TOK1, first identified in 1995. Subsequently, another 2P K+ channel (ORK1) was isolated in Drosophila (ORK1) that displays open rectification properties. These channels produce pure leak currents, acting as open conduits for the movement of K+ ions across the cellular membrane as determined by electro-chemical gradients. Because of the similarity of TOK1 and ORK1 to the properties of the volatile anesthetic-activated molluscan current IKAN, we hypothesized that volatile anesthetic activation would occur for the novel mammalian 2P K+ channels. We are investigating the effect of volatile and local anesthetics on 2P K+ channels with electrophysiological and immunohistochemical methods.
2 "Scientometrics" in anesthetic literature
The public, funding agencies, and academic institutions are today increasingly interested in measuring the research quality and productivity of individual scientists as an indication of their scholarly excellence. Political or independent institutions evaluate and compare the scientific activities of individuals, departments, and universities and publish rankings as, for example, "The List of the Worldwide Champions League of Research Institutions" (http://www.cest.ch/en/) in order to use such "scientific" information for policy decisions. The growing field of studying the output of scientific and technological literature is termed "Scientometrics" and includes all quantitative aspects of the science of science.
A popular method for measuring the impact on the scientific community of an article or a researcher is the citation rating, which has become the modern "sales figure" for scientists. When publication A refers to publication B in the reference list, then publication A is the citing article and publication B becomes the cited article. Citation analysis is the area of bibliometrics that examines these relationships. The number of citations (i.e., how many times a given article is counted in the reference lists of subsequent articles) is seen as a direct measure of the recognition that this publication has had in its scientific field; in some circumstances, it is also used as a measure of quality by granting bodies. One criticism of citation analysis is that the databases do not distinguish between positive or negative credits or citations. Although there is obviously considerable debate about the value of citation rates used to assess the quality of research, analysis of citation rates may allow for the identification of seminal advances in a specialty.
In addition to citation rates, the identification and analysis of highly dynamic areas of research is becoming a more and more important task within the context of science policy and research development. The study proposed here will present insights into the highly dynamic specialty of anesthesia and will produce a detailed documentation including a co-citation map of highly cited documents, a journal profile, the most important actors on institutional and national level, and the most important publications from the research fronts.
3 Non-technical skills of anesthesiologists
3.1. Physician-patient communication
Effective physician-patient communication is increasingly recognized to influence a variety of patient behaviours such as patient satisfaction and understanding of medical advice. Good communication also contributes to achieve desired health care outcomes. In a recent attempt to define and assess the professional competence of physicians, Epstein and Hundert established basic communication skills as an important dimension of professional cognitive competence. The Accreditation Council for Graduate Medical Education in the United States specifies interpersonal skills and communication as general competencies of graduate medical education and the Council's Outcome Project documents the assessment of such competencies by American residency programs. The same is true for The Royal College of Anesthetists and The Royal College of Surgeons both of which now require an assessment of communication skills for their certificates of specialist training. Historically, anesthetic training was primarily directed at acquiring technical skills and most of today's attending anesthetists received little formal training in communication and might lack the skills required to deal effectively with patients' psychosocial and information needs during the pre-operative visit. It is therefore not surprising that communication skills are increasingly viewed as a key component both in the medical curriculum and in the postgraduate training for specialists. In the past, communication skills training as a component of formal training was only emphasised for general practitioners and internists, but the importance of such non-technical skills is now also recognized in anesthesia and critical care medicine. For this purpose, simulator-based modular human factor and communication training has recently been made available for anesthetists.
Since pre-operative anxiety is often directed towards the anesthesia itself, an anesthetist is best able to reduce a patient's anxiety. Our aim is to improve the anesthetist's ability to elicit and respond to the patient's concerns and questions during the pre-operative anesthetic visit. In order to define more precisely those skills which would best help an anesthetist to become a more professional communicator, the current project investigates the anesthetist-patient interaction.
3.2. OR Management
Application of Information Technology, Resource Allocation and Management Science Tools on the environment of the operating rooms within a medical center.
Other Expertise
Effects of neuromuscular blocking agents, acetylcholine receptors
Keywords
COS Keywords:
Anesthesiology, Central Nervous System, Electrophysiology, Immunohistochemistry, Receptors.Additional Terms:
Actelycholine Receptor, Mechanisms of Anesthesia, Non-technical Skills, Physician-Patient Communication, Scientometrics.Languages
(Reading, Writing, Speaking)
English: (Fluent, Fluent, Fluent)
Memberships
European Society of Anesthesiologists
International Anesthesia Research Society
Swiss Society of Anesthesiology and Resuscitation
Swiss Society of Intensive Care Medicine
Verbindung der Schweizer Aerzte
Previous Positions
2006-2007, Professor,
University Hospitals Basel, Medical School, Department of Anesthesia
2001-2006, Attending Physician, Privatdozent,
University Hospitals Basel,
Medical School,
Department of Anesthesia
1998-2000, Assistant Professor,
University of California, San Francisco,
Department of Anesthesia & Perioperative Care
1997, Assistant Adjunct Professor,
University of California, San Francisco,
Department of Anesthesia & Perioperative Care
1993-1996, Attending Physician,
University Hospitals Basel,
Medical School,
Department of Anesthesia
Publications
- Lehmann M, Monte K, Barach P, Kindler CH (2010) Postoperative patient complaints. A prospective interview study of 12,276 patients, J Clin Anesth, In Press
- Breidthardt T, Kindler CH, Schindler C, Futterer M, Yonekawa K, Müller C (2010) B-type natriuretic peptide in patients undergoing orthopedic surgery. A prospective cohort study, Eur J Anaesth, In Press
- Kindler CH, Harms C (2010) Anästhesiologie (Kapitel 71), Uexküll. Psychosomatische Medizin. Modelle ärztlichen Denkens und Handelns, 7. Edition, D-München, Urban & Fischer Verlag, In Press (bookchapter)
- Kopp Lugli A, Yost CS, Kindler CH (Oct 2009) Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia., European Journal of Anaesthesiology, 26 (10), 807-20
- Harms C, Kindler CH (Jul 2009) [The preoperative anaesthetic visit], Therapeutische Umschau. Revue thérapeutique, 66 (7), 503-8
- Jankovic MP, Kaufmann M, Kindler CH (May 2008) Active research fields in anesthesia: a document co-citation analysis of the anesthetic literature, Anesthesia and Analgesia, 106 (5), 1524-33
- Harms C, Nübling M, Langewitz W, Kindler CH (Feb 2007) Patient satisfaction with continued versus divided anesthetic care., Journal of Clinical Anesthesia, 19 (1), 9-14
- Schreiber K, Kindler CH (Nov 2005) [Bibliometric analysis of anaesthetic molecular biology research in Germany, Austria and Switzerland], Der Anaesthesist, 54 (11), 1094-9
- Keshavaprasad B, Liu C, Au JD, Kindler CH, Cotten JF, Yost CS (Oct 2005) Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK, Anesthesia and Analgesia, 101 (4), 1042-9
- Paul M, Callahan R, Au J, Kindler CH, Yost CS (Sep 2005) Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors, Anesthesia and Analgesia, 101 (3), 715-21
- Schäfer M, Elke R, Young JR, Gancs P, Kindler CH (Aug 2005) Safety of one-stage bilateral hip and knee arthroplasties under regional anaesthesia and routine anaesthetic monitoring, The Journal of Bone and Joint Surgery. British Volume, 87 (8), 1134-9
- Derrer F, Gisin S, Linka A, Kindler CH, [Shone's Anomaly Fallbericht Und Hintergrund], Der Anaesthesist, 54(1), 29-34, Jan 2005
- Kindler CH, Szirt L, Sommer D, Hausler R, Langewitz W, A Quantitative Analysis of Anaesthetist-patient Communication During The Pre-operative Visit, Anaesthesia, 60(1), 53-9, Jan 2005
- Kindler CH, Yost CS (2005) Two-pore domain potassium channels: new sites of local anesthetic action and toxicity, Regional Anesthesia and Pain Medicine, 30 (3), 260-74
- Schwab HS, Seeberger MD, Eger EI, Kindler CH, Filipovic M, Sevoflurane Decreases Bispectral Index Values More Than Does Halothane At Equal MAC Multiples, Anesthesia and Analgesia, 99(6), 1723-7, Dec 2004
- Strebel S, Gurzeler JA, Schneider MC, Aeschbach A, Kindler CH, Small-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response study, Anesthesia and Analgesia, 99(4), 1231-8, October 2004
- Schreiber K, Girard T, Kindler CH, Bibliometric Analysis of Original Molecular Biology Research In
Anaesthesia., Anaesthesia, 59(10), 1002-7, Oct 2004
- Nuebling M, Kindler CH, Langewitz W, Preoperative visits in anesthesia: communication patterns and sequences:
application of an explorative analysis, Patient Education and Counseling, 54(3), 379-81, September 2004
- Kindler CH, Another use for the LOCKIT epidural catheter clamp, Anaesthesia, 59(8), 836, August 2004
- Strebel S, Mendelowitsch A, Kindler CH, Rupture of a giant intracranial aneurysm while starting cardiopulmonary bypass for hypothermic circulatory arrest, Journal of Neurosurgical Anesthesiology, 16(3), 263-5, July 2004
- Baltussen A, Kindler CH, Citation classics in critical care medicine, Intensive Care Medicine, 30(5), 902-10, May 2004
- Baltussen A, Kindler CH, Citation classics in anesthetic journals, Anesthesia and Analgesia, 98(2), 443-51, February 2004
- Harms C, Young JR, Amsler F, Zettler C, Scheidegger D, Kindler CH, Improving anaesthetists' communication skills, Anaesthesia, 59(2), 166-72, February 2004
- Mhatre AN, Li J, Chen AF, Yost CS, Smith RJ, Kindler CH, Lalwani AK, Genomic structure, cochlear expression, and mutation screening of KCNK6, a
candidate gene for DFNA4, Journal of Neuroscience Research, 75(1), 25-31, January 2004
- Kindler CH (2004) A response and reply to "Improving anaesthetists communication skills", Anaesthesia, 59, 522-3
- Girard T, Kindler CH (2004) Pharmacogenetics and anaesthesiology, Current Pharmacogenomics, 2, 119-35
- Kindler CH, Harms C, Langewitz W, Consistency in anaesthetic care: segmentation of anaesthetic care is not inherently bad, Br Med J, 327(7420), 931, October 2003
- Kindler CH, Paul M, Zou H, Liu C, Winegar BD, Gray AT, Yost CS, Amide local anesthetics potently inhibit the human tandem pore domain
background K+ channel TASK-2 (KCNK5), The Journal of Pharmacology and Experimental Therapeutics, 306(1), 84-92, July 2003
- Kindler CH, Harms C, Alber C, [The patients' perception of the anaesthetist in a Swiss university
hospital], Der Anaesthesist, 51(11), 890-6, November 2002
- Paul M, Fokt RM, Kindler CH, Dipp NC, Yost CS, Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic acetylcholine receptor, Anesthesia and Analgesia, 95(2), 362-7, Aug 2002
- Kindler ChH, [Mechanisms of action of inhalation anesthesia: from Meyer-Overton into the new millenium], Schweizerische Rundschau Medizin Praxis = Revue Suisse De Medecine Praxis, 91(21), 920-4, May 2002
- Kindler CH, Girard T, Gong D, Urwyler A, The differential effect of halothane and 1,2-dichlorohexafluorocyclobutane on in vitro muscle contractures of patients susceptible to malignant hyperthermia, Anesthesia and Analgesia, 94(4), 1028-33, April 2002
- Paul M, Kindler CH, Fokt RM, Dipp NC, Yost CS, Isobolographic analysis of non-depolarising muscle relaxant interactions
at their receptor site, European Journal of Pharmacology, 438(1-2), 35-43, March 2002
- Paul M, Kindler CH, Fokt RM, Dresser MJ, Dipp NC, Yost CS, The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors, Anesthesia and Analgesia, 94(3), 597-603, March 2002
- Gabriel A, Abdallah M, Yost CS, Winegar BD, Kindler CH, Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the
rat central nervous system, Brain Research. Molecular Brain Research, 98(1-2), 153-63, January 2002
- Kindler CH (2002) Nonimmobilizers do not cause muscle contractures in patients susceptible to malignant hyperthermia, Molecular and basic mechanisms of anesthesia, D-Lengerich, Pabst Science Publishers, 299-305 pages (bookchapter)
- Yost CS, Kindler CH (2002) Tandem pore (2P) domain K+ channels as anesthetic targets, Molecular and basic mechanisms of anesthesia, D-Lengerich, Pabst Science Publishers, 203-210 pages (bookchapter)
- Kindler CH, Yost CS (2001) How to use gene expression systems, Conducting research in anaesthesia and intensive care medicine, Oxford, Butterworth-Heinemann, 515-538 pages (bookchapter)
- Kindler CH, Pietruck C, Yost CS, Sampson ER, Gray AT, Localization of the tandem pore domain K+ channel TASK-1 in the rat
central nervous system, Brain Research. Molecular Brain Research, 80(1), 99-108, August 2000
- Gray AT, Zhao BB, Kindler CH, Winegar BD, Mazurek MJ, Xu J, Chavez RA, Forsayeth JR, Yost CS, Volatile anesthetics activate the human tandem pore domain baseline K+
channel KCNK5, Anesthesiology, 92(6), 1722-30, June 2000
- Kindler CH, Harms C, Amsler F, Ihde-Scholl T, Scheidegger D, The visual analog scale allows effective measurement of preoperative
anxiety and detection of patients' anesthetic concerns, Anesthesia and Analgesia, 90(3), 706-12, March 2000
- Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS, Additive inhibition of nicotinic acetylcholine receptors by
corticosteroids and the neuromuscular blocking drug
vecuronium, Anesthesiology, 92(3), 821-32, March 2000
- Eilers H, Kindler CH, Bickler PE, Different effects of volatile anesthetics and polyhalogenated alkanes on
depolarization-evoked glutamate release in rat cortical brain
slices, Anesthesia and Analgesia, 88(5), 1168-74, May 1999
- Kindler CH, Yost CS, Gray AT, Local anesthetic inhibition of baseline potassium channels with two pore
domains in tandem, Anesthesiology, 90(4), 1092-102, April 1999
- Kindler CH, Eilers H, Donohoe P, Ozer S, Bickler PE, Volatile anesthetics increase intracellular calcium in cerebrocortical and
hippocampal neurons, Anesthesiology, 90(4), 1137-45, April 1999
- Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS, TWIK-2, a new weak inward rectifying member of the tandem pore domain
potassium channel family, Journal of Biological Chemistry, 274(12), 7887-92, March 1999
- Gray AT, Kindler CH, Sampson ER, Yost CS, Assignment of KCNK6 encoding the human weak inward rectifier potassium
channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid
mapping, Cytogenetics and Cell Genetics, 84(3-4), 190-1, 1999
- Kindler CH, Seeberger MD, Staender SE, Epidural abscess complicating epidural anesthesia and analgesia. An
analysis of the literature, Acta Anaesthesiologica Scandinavica, 42(6), 614-20, July 1998
- Strebel SP, Kindler C, Bissonnette B, Tschaler G, Deanovic D, The impact of systemic vasoconstrictors on the cerebral circulation of
anesthetized patients, Anesthesiology, 89(1), 67-72, July 1998
- Seeberger MD, Staender S, Oertli D, Kindler CH, Marti W, Efficacy of specific aseptic precautions for preventing propofol-related
infections: analysis by a quality-assurance programme using the explicit
outcome method, Journal of Hospital Infection, 39(1), 67-70, May 1998
- Ummenhofer WC, Kindler C, Tschaler G, Hampl KF, Drewe J, Urwyler A, Propofol reduces succinylcholine induced increase of masseter muscle tone, Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 45(5 Pt 1), 417-23, May 1998
- Leonoudakis D, Gray AT, Winegar BD, Kindler CH, Harada M, Taylor DM, Chavez RA, Forsayeth JR, Yost CS, An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum, The Journal of Neuroscience, 18(3), 868-77, February 1998
- Seeberger MD, Skarvan K, Kindler CH, Friedli D, [Long-term electrocardiography. Detection of low-grade myocardial
infarction: sensitivity of 9 bipolar leads], Der Anaesthesist, 46(6), 528-31, June 1997
- Tränkle P, Kindler CH (1997) General practice case. Acute hepatitis A infection. Symptomatic and icteric course, Schweiz Rundsch Med Prax, 86, 957-9
- Sven Staender, Christoph Kindler (1997) Memorix Anaesthesiologie, Erste Edition, D-69469 Weinheim, Deutschland, Chapman & Hall GmbH, 375 pages, ISBN=3-8261-0117-0
- Kindler CH, Bircher AJ, Anaphylactoid reactions to protamine, Anesthesiology, 85(5), 1209-10, November 1996
- Kindler CH, Schumacher PG, Schneider MC, Urwyler A, Effects of intravenous lidocaine and/or esmolol on hemodynamic responses
to laryngoscopy and intubation: a double-blind, controlled clinical
trial, Journal of Clinical Anesthesia, 8(6), 491-6, September 1996
- Kindler CH, Seeberger MD, Infectious complications after epidural anesthesia, Anesthesiology, 85(2), 444-5, August 1996
- Kindler C, Seeberger M, Siegemund M, Schneider M, Extradural abscess complicating lumbar extradural anaesthesia and
analgesia in an obstetric patient, Acta Anaesthesiologica Scandinavica, 40(7), 858-61, August 1996
- Kindler C, Bircher A, Stulz P, Protamine-induced fulminating non-cardiogenic pulmonary edema following cardiopulmonary bypass, European Journal of Cardio-thoracic Surgery, 10(6), 463-6, 1996
- Matter P, Kindler CH (1989) Angst und Schmerz, Chirurgisches Handeln. Fragen - Ueberlegungen - Antworten, Stuttgart, Georg Thieme Verlag, 60-64 pages (bookchapter)
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