William R. Clarke

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University of Iowa
College of Public Health
Biostatistics
ProfessorAppointed: 1999
University of Iowa
College of Public Health
Clinical Trials Statistical & Data Management Center (CTSDMC)
DirectorAppointed: 2000
Professional Headshot of William R. Clarke

Mailing Address

C22-M General Hospital
University of Iowa
Iowa City, Iowa 52242
United States

Contact Information

Phone: (319) 384-5027
Fax: (319) 384-5018
william-clarke@uiowa.edu
http://www.public-health.uiowa.edu/faculty-staff/faculty/directory/faculty-detail.asp?emailAddress=william-clarke@uiowa.edu

Qualifications

Ph.D., University of Iowa, Statistics, 1975.
M.S., University of Iowa, Statistics, 1967.
B.A., University of Oregon, Mathematics, 1964.

Expertise and Research Interests

Research Interest
1. Clinical Trials
2. Discriminant Analysis
3. Coronary Risk Factors in Children
4. Cardiovascular Disease Epidemiology
5. Longitudinal Data Analysis

Current Projects
1. Director- Clinical Trials and Statistical Data Management Center
2. Co-Principal Investigator - Hypothermia During Intracranial Aneurysm Surgery
3. Principal Investigator - Carotid Occlusion Surgery Study
4. Principal Investigator - A Comparison of Language Intervention Program
5. Investigator - Clinician Managed Interpersonal Psychotherapy

Other Expertise

I served as co-author, with RF Woolson, of Statistical Methods for the Analysis of Biomedical Data, Second Edition, published by John Wiley and Sons, New York, NY: 2002.

I have served as author or co-author of the following book chapters:
  • Lauer RM, Clarke WR. Tracing of coronary risk factors in children: The Muscatine Study. In: Atherosclerosis V Proceedings of the Fifth International Symposium on Atherosclerosis, AM Gotts, LC Smith, B Allen, Eds. New York, NY: Springer-Verlag, 1980.
  • Lauer RM, Clarke WR. Immediate and long-term prognostic significance of childhood blood pressure levels. In: Childhood Prevention of Atherosclerosis and Hypertension, 1980.
  • Lauer RM, Burns TL, Clarke WR. Epidmiologyof blood pressure in children. In: Early Pathogenesis of Primary Hypertension. A Hofman, DE Grobbee, MADP Schalekamp, Eds. Elsevier Science Publishers, 1987.
  • Woolson RF, Clarke WR, Leeper JD. Missing data in longitudinal studies. In: Statistical Models for Longitudinal Studies of Health. J Dwyer, M Feinlieb, Eds. Oxford University Press, 1991.
  • Hall DB, Woolson RF, Clarke WR, Jones MF. Cochran-Mantel-Haenszel Techniques: Applications Involving Epidemiologic Survey Data. In: Handbook of Statistics Volume 17: Bio-Environmental and Public Health Statistics. PK Sen and CR Rao, Eds. New York, NY: John Wiley and Sons, 1999.

Keywords

COS Keywords:

Clinical Trial, Data Analysis, Data Management or Analysis (Medical), Epidemiology, Risk Factor Analysis, Statistics.

Additional Terms:

Clinical Trial, Data Analysis, Data Management, Epidemiological Study, Risk Analysis, Risk Factor, Statistics.

Memberships

American Statistical Association
Biometric Society
Society for Controlled Clinical Trials
Society for Epidemiologic Research

Honors and Awards

2000-2001, Faculty Research Award, University of Iowa College of Public Health

Previous Positions

1989-2000, Associate Director, University of Iowa, Clinical Trials and Statistical Data Management Center
1986-1999, Professor, University of Iowa, Carver College of Medicine, Biostatistics, Preventive Medicine and Environmental Health
1980-1986, Associate Professor, University of Iowa, Carver College of Medicine, Preventive Medicine & Environmental Health
1975-1980, Assistant Professor, University of Iowa, Carver College of Medicine, Preventive Medicine & Environmental Health
1974-1975, Instructor, University of Iowa, Carver College of Medicine, Preventive Medicine & Environmental Health
1972-1974, Assistant in Instruction, University of Iowa, Carver College of Medicine, Preventive Medicine & Environmental Health
1967-1969, Instructor, Illinois State University, Mathementics

Funding Received

  • National Institutes of Health (NIH): Co-Investigator, Hypothermia During Intracranial Aneurysm Surgery Trial, Michael Todd, PI, $11,279,871, Sep 5, 1999 to May 31, 2004.
  • New England Medical Center / National Institutes of Health: Co-Investigator, Infrastructure to Facilitate Discovery of Autism Genes, Veronica Vieland, PI, $192,902, Sep 30, 2002 to May 31, 2007.
  • National Institutes of Health (NIH): Principal Investigator, Data Management Center for the Carotid Occlusion Surgery Study, $4,953,320, Sep 30, 2001 to Jul 31, 2006.
  • National Institutes of Health (NIH): Co-Investigator, Specialized Center Of Research In Hypertension, Allyn Mark, PI, $4,475,185, Sep 30, 1990 to Nov 30, 1996.
  • National Institutes of Health (NIH): Co-Investigator, Community Clinical Trial for Heavy Smokers - (Intervention Centers), Robert B. Wallace, PI, $100,052, Sep 30, 1986 to Mar 31, 1995.
  • National Institutes of Health (NIH): Co-Investigator, Clinician Managed Interpersonal Psychotherapy, Scott Stuart, PI, $2,738,869, Sep 28, 2001 to Aug 31, 2006.
  • National Institutes of Health (NIH): Co-Investigator, Lymphoma Specialized Program of Research Excellence (SPORE), George Weiner, PI, $11,693,792, Sep 11, 2002 to Jun 30, 2007.
  • University of Texas / National Institutes of Health: Principal Investigator, Data Management Center for 'A Comparison of Language Intervention Programs', $369,521, Sep 1, 2001 to Aug 31, 2005.
  • National Institutes of Health (NIH): Principal Investigator, Statistical Consult on Low Back, $9,900, Nov 15, 1984 to Apr 15, 1985.
  • Eli Lilly & Company: Principal Investigator, Coordination Center for ABCIXIMAB (Reopro TM) In Acute Ischemic Stroke: A Randomized Double-Blind Placebo-Controlled Phase II Escalation Study, $50,429, Mar 10, 1998 to Dec 31, 1999.
  • National Institutes of Health (NIH): Co-Investigator, Cancer Center Support Grant, George Weiner, PI, $6,478,748, Jul 14, 2000 to Jun 30, 2005.
  • Rhode Island Hospital / National Institutes of Health: Principal Investigator, Ancillary Studies in Heart, Lung and Blood Disease Trials, 92,591, Jul 1, 2001 to Jun 30, 2002.
  • National Institutes of Health (NIH): Co-Investigator, Data Management Center - Trial of ORG 10172 In Stroke, Robert B. Woolson, PI, $3,041,843, Jan 1, 1990 to Dec 31, 1998.
  • Bristol-Myers-Squibb Pharmaceutical: Principal Investigator, The Effect of Irbesartan on Morbidity in Hypertensive Patients with Type II Diabetes and Diabetic Nephropathy, $328,756, Feb 1, 1996 to Aug 31, 2001.
  • National Institutes of Health (NIH): Co-Investigator, Blood Coagulation in the Fetus: A Fetal Lamb Model, C. Thomas Kisker, PI, $158,120, Dec 1, 1978 to Aug 31, 1988.
  • NIMH: Co-Investigator, Placebo Controlled Trial of Sertraline and IPT for Post-partum Depression, Scott Stuart, PI, $881,424/1 year, 2007 to 2012.
  • NIAMS: Co-Investigator, BrAIST (Bracing in Adolescent Idiopathic Scoliosis), Stuart Weinstein, PI, $968,973/year 1, 2006 to 2011.
  • NINDS: Co-Investigator, Unruptured Intracranial Aneurysms: Neurologic Outcome (ISUIA), $1,308,673, 2004 to 2008.
  • NIH: PI, Clinical Islet Transplantation: Data Coordinating Center, $21,197,251, 2004 to 2009.
  • NINDS: Co-Investigator, Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON), Randolph Marshall, PI, 238,466, 2004 to 2009.
  • University of Michigan/NIH: PI, Cognitive Function after Aneurysm Surgery Trial, $211,255, 2003 to 2005.

Publications

  • Todd MM, Hindman BJ, Clarke WR, Torner JC, Weeks JB, Bayman EO, Shi Q, Spofford CM (May 2009) Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage., Neurosurgery, 64 (5), 897-908; discussion Abstract
  • Pasternak JJ, McGregor DG, Lanier WL, Schroeder DR, Rusy DA, Hindman B, Clarke W, Torner J, Todd MM (Feb 2009) Effect of Nitrous Oxide Use on Long-term Neurologic and Neuropsychological Outcome in Patients Who Received Temporary Proximal Artery Occlusion during Cerebral Aneurysm Clipping Surgery., Anesthesiology Abstract
  • Titler MG, Herr K, Brooks JM, Xie XJ, Ardery G, Schilling ML, Marsh JL, Everett LQ, Clarke WR (Feb 2009) Translating research into practice intervention improves management of acute pain in older hip fracture patients., Health services research, 44 (1), 264-87 Abstract
  • McGregor DG, Lanier WL, Pasternak JJ, Rusy DA, Hogan K, Samra S, Hindman B, Todd MM, Schroeder DR, Bayman EO, Clarke W, Torner J, Weeks J (Apr 2008) Effect of nitrous oxide on neurologic and neuropsychological function after intracranial aneurysm surgery., Anesthesiology, 108 (4), 568-79 Abstract
  • Pasternak JJ, McGregor DG, Schroeder DR, Lanier WL, Shi Q, Hindman BJ, Clarke WR, Torner JC, Weeks JB, Todd MM (Apr 2008) Hyperglycemia in patients undergoing cerebral aneurysm surgery: its association with long-term gross neurologic and neuropsychological function., Mayo Clinic proceedings. Mayo Clinic, 83 (4), 406-17 Abstract
  • Samra SK, Giordani B, Caveney AF, Clarke WR, Scott PA, Anderson S, Thompson BG, Todd MM (2007) Recovery of cognitive function after surgery for aneurismal subarachnoid hemorrhage, Stroke, 38 (6), 1864-72
  • Anderson SW, Todd MM, Hindman BJ, Clarke WR, Torner JC, Tranel D, Yoo B, Weeks J, Manzel KW, Samra S (2006) Effects of intraoperative hypothermia on neuropsychological outcomes after intracranial aneurysm surgery, Ann Neurol, 60 (5), 518-27
  • Leira EC, Lamb DL, Nugent AS, Ahmed A, Grimsman KJ, Clarke WR, Adams HP Jr (2006) Feasibility of acute clinical trials during aerial interhospital transfer, Stroke
  • Freeman LEB, Dennis LK, Lynch CE, Lowe JB, Clarke WR, Test-retest of Self-reported Exposure to Artificial Tanning Devices, Self-tanning Creams, and Sun Sensitivity Showed Consistency, Journal of Clinical Epidemiology, 58(4), 430-2, Apr 2005
  • Mason EE, Munns JR, Kealey GP, Wangler R, Clarke WR, Cheng HF, Printen KJ (2005) Cheng HF, Printen KJ., 1 (2), 155-60
  • Todd MM, Hindman BJ, Clarke WR, Torner JC, Chaloner K, Davis P, Howard M, Tranel D, Anderson S, Weeks J, Moss L, Winn J, Wichman M, Peters R, Hansen M, Anderson D, Lang J, Yoo B, Adams H, Clifton G,Gelb A et al, Mild Intraoperative Hypothermia During Surgery for Intracranial Aneurysm, New England Journal of Medicine, 352(2), 135-45, Jan 2005
  • Herr K, Titler MG, Schilling ML, Marsh JL, Xie X, Ardery G, Clarke WR, Everett LQ, Evidence-based assessment of acute pain in older adults: current nursing practices and perceived barriers, The Clinical Journal of Pain, 20(5), 331-40, 2004 Abstract
  • Ringman JM, Saver JL, Woolson RF, Clarke WR, Adams HP, Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort,, Neurology, 63(3), 468-74, 10 Aug 2004
  • Adams HP, Leclerc JR, Bluhmki E, ,Clarke W, Hansen MD, Hacke W, Measuring outcomes as a function of baseline severity of ischemic stroke, Cerebrovascular Diseases, 18(2), 124-9, 2004
  • Titler MG, Herr K, Schilling ML, Marsh JL, Xie XJ, Ardery G, Clarke WR, Everett LQ, Acute pain treatment for older adults hospitalized with hip fracture: Current nursing practices and perceived barriers, Applied Nursing Research : Anr, 16(4), 211-27, November 2003 Abstract
  • Ward MM, Doebbeling BN, Vaughn TE, Uden-Holman T, Clarke WR, Woolson RF, Letuchy E, Branch LG, Perlin J, Effectiveness of a nationally implemented smoking cessation guideline on provider and patient practices, Preventive Medicine, 36(3), 265-71, March 2003
  • Ward MM, Vaughn TE, Uden-Holman T, Doebbeling BN, Clarke WR, Woolson RF, Physician knowledge, attitudes and practices regarding a widely implemented guideline, Journal of Evaluation in Clinical Practice, 8(2), 155-62, May 2002 Abstract
  • Voelker MD, Saag KG, Schwartz DA, Chrischilles E, Clarke WR, Woolson RF, Doebbeling BN, Health-related quality of life in Gulf War era military personnel, American Journal of Epidemiology, 155(10), 899-907, May 2002 Abstract
  • Doebbeling BN, Jones MF, Hall DB, Clarke WR, Woolson RF, Torner JC, Burmeister LF, Snyders-Crumley T, Barrett DH, Falter KH, Merchant JA, Nusser S, Anderson D, Schwartz DA, Methodologic issues in a population-based health survey of Gulf War veterans, Journal of Clinical Epidemiology, 55(5), 477-87, May 2002 Abstract
  • Vaughn TE, Ward MM, Doebbeling BN, Uden-Holman T, Clarke WR, Woolson RF, Organizational and provider characteristics fostering smoking cessation practice guideline adherence: an empirical look, Journal of Ambulatory Care Management, 25(2), 17-31, 2002
  • Wilterdink JL, Bendixen B, Adams HP Jr, Woolson RF, Clarke WR, Hansen MD, Effect of prior aspirin use on stroke severity in the trial of Org 10172 in acute stroke treatment (TOAST), Stroke; a Journal of Cerebral Circulation, 32(12), 2836-40, December 2001 Abstract
  • Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I, Collaborative Study Group, Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes, The New England Journal of Medicine, 345(12), 851-60, September 2001 Abstract
  • Adams HP Jr, Powers WJ, Grubb RL Jr, Clarke WR, Woolson RF, Preview of a new trial of extracranial-to-intracranial arterial anastomosis: the carotid occlusion surgery study, Neurosurgery Clinics of North America, 12(3), 613-24, ix-x, July 2001 Abstract
  • Libman RB, Kwiatkowski TG, Hansen MD, Clarke WR, Woolson RF, Adams HP, Differences between anterior and posterior circulation stroke in TOAST, Cerebrovascular Diseases (basel, Switzerland), 11(4), 311-6, 2001 Abstract
  • Johnson JC, Reynolds SJ, Fuortes LJ, Clarke WR, Lead exposure among workers renovating a previously deleaded bridge: comparison of trades, work tasks, Aihaj : a Journal for the Science of Occupational and Environmental Health and Safety, 61(6), 815-9, 2000 Abstract
  • Zwerling C, Torner JC, Clarke WR, Voelker MD, Doebbeling BN, Barrett DH, Merchant JA, Woolson RF, Schwartz DA, Self-reported postwar injuries among Gulf War veterans, Public Health Reports (washington, D.c. : 1974), 115(4), 346-9, 2000 Abstract
  • Doebbeling BN, Clarke WR, Watson D, Torner JC, Woolson RF, Voelker MD, Barrett DH, Schwartz DA, Is there a Persian Gulf War syndrome? Evidence from a large population-based survey of veterans and nondeployed controls, The American Journal of Medicine, 108(9), 695-704, June 2000 Abstract
  • Black DW, Doebbeling BN, Voelker MD, Clarke WR, Woolson RF, Barrett DH, Schwartz DA, Multiple chemical sensitivity syndrome: symptom prevalence and risk factors in a military population, Archives of Internal Medicine, 160(8), 1169-76, April 2000 Abstract
  • Rodby RA, Rohde RD, Clarke WR, Hunsicker LG, Anzalone DA, Atkins RC, Ritz E, Lewis EJ, The Irbesartan type II diabetic nephropathy trial: study design and baseline patient characteristics. For the Collaborative Study Group, Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 15(4), 487-97, April 2000 Abstract
  • Black DW, Doebbeling BN, Voelker MD, Clarke WR, Woolson RF, Barrett DH, Schwartz DA, Quality of life and health-services utilization in a population-based sample of military personnel reporting multiple chemical sensitivities., Journal of Occupational and Environmental Medicine, 41(10), 928-33, October 1999 Abstract
  • Ahrens RC, Hendeles L, Clarke WR, Dockhorn RJ, Hill MR, Vaughan LM, Lux C, Han SH, Therapeutic equivalence of Spiros dry powder inhaler and Ventolin metered dose inhaler. A bioassay using methacholine, American Journal of Respiratory and Critical Care Medicine, 160(4), 1238-43, October 1999 Abstract
  • Chaturvedi S, Adams HP, Woolson RF, Clarke WR, Circadian rhythm in stroke outcome, Stroke, September 1999
  • Adams HP Jr, Bendixen BH, Leira E, Chang KC, Davis PH, Woolson RF, Clarke WR, Hansen MD, Antithrombotic treatment of ischemic stroke among patients with occlusion or severe stenosis of the internal carotid artery: A report of the Trial of Org 10172 in Acute Stroke Treatment \(TOAST\)., Neurology, 53(1), 122-5, 13 Jul 1999 Abstract
  • Adams HP Jr, Davis PH, Leira EC, Chang KC, Bendixen BH, Clarke WR, Woolson RF, Hansen MD, Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment \(TOAST\)., Neurology, 53(1), 126-31, 13 Jul 1999 Abstract
  • Bruno A, Biller J, Adams HP Jr, Clarke WR, Woolson RF, Williams LS, Hansen MD, Acute blood glucose level and outcome from ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators, Neurology, 52(2), 280-4, Jan 1999 Abstract
  • The TOAST Study Group, Results of a randomized, placebo-controlled trial of the low molecular weight heparinoid ORG 10172 in improving outcome after acute ischemic stroke, JAMA, 279, 1265-1272, 1998
  • Lauer R M, Clarke W R, Burns T L, Obesity in childhood: the Muscatine Study., Chung-hua Min Kuo Hsiao Erh Ko I Hsueh Hui Tsa Chih, 38(6), 432-7, November 1997 Abstract
  • Adams HP Jr, Woolson RF, Clarke WR, Davis PH, Bendixen BH, Love BB, Wasek PA, Grimsman KJ, Design of the Trial of Org 10172 in Acute Stroke Treatment (TOAST), Controlled Clinical Trials, 18(4), 358-77, August 1997 Abstract
  • The Iowa Persian Gulf War Group, Self-reported illness and health status among Gulf War veterans, JAMA, 227, 238-245, 1997
  • Hall D, Woolson RF, Clarke WR, Jones MF, Statistical Techniques Used in the Health Assessment of Persian Gulf War Veterans from Iowa, The University of Iowa Technical Report No. 96-1, November 1996
  • Thal LJ, Carta A, Clarke WR, Ferris SH, Friedland RP, Petersen RC, Pettegrew JW, Pfeiffer E, Raskind MA, Sano M, Tuszynski MH, Woolson RF, A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease, Neurology, 47(3), 705-11, September 1996 Abstract
  • Davis PH, Clarke WR, Bendixen BH, Adams HP Jr, Woolson RF, Culebras A, Silent cerebral infarction in patients enrolled in the TOAST Study, Neurology, 46(4), 942-8, April 1996 Abstract
  • Madden KP, Karanjia PN, Adams HP Jr, Clarke WR, Accuracy of initial stroke subtype diagnosis in the TOAST study. Trial of ORG 10172 in Acute Stroke Treatment., Neurology, 45(11), 1975-9, November 1995 Abstract
  • Woolson RF, Jones MF, Clarke WR, Torner JC, Discussion of 'Inclusion of women and minorities in clinical trials and the NIH Revitalization Act of 1993 - the perspective of NIH clinical trialists', Controlled Clinical Trials, 16, 301-303, 1995
  • Albanese M A, Clarke W R, Adams H P Jr, Woolson R F, Ensuring reliability of outcome measures in multicenter clinical trials of treatments for acute ischemic stroke. The program developed for the Trial of Org 10172 in Acute Stroke Treatment (TOAST)., Stroke, 25(9), 1746-51, September 1994 Abstract
  • Lauer R M, Clarke W R, Mahoney L T, Witt J, Childhood predictors for high adult blood pressure. The Muscatine Study., Pediatric Clinics of North America, 40(1), 23-40, February 1993 Abstract
  • Kisker CT, Bohlken D, Clarke WR, Thyroxine and fetal blood coagulation: a fetal lamb study, Journal of Developmental Physiology, 19(2), 57-9, February 1993 Abstract
  • Clarke W R, Lauer R M, Does childhood obesity track into adulthood?, Critical Reviews In Food Science and Nutrition, 33(4-5), 423-30, 1993 Abstract
  • Gordon DL, Bendixen BH, Adams HP Jr, Clarke WR, Kappelle LJ, Woolson RF, and the TOAST Investigators, Interphysician agreement in the diagnosis of subtypes of acute ischemic stroke: implications for clinical trials, Neurology, 43, 1021-1027, 1993
  • Adams HP Jr, Woolson RF, Biller J, Clarke W, Studies of Org 10172 in patients with acute ischemic stroke. TOAST Study Group, Haemostasis, 22(2), 99-103, 1992 Abstract
  • Lauer RM, Clarke WR, Use of cholesterol measurements in childhood for the prediction of adult hypercholesterolemia, JAMA, 264, 3034-3038, 1992
  • Mahoney L T, Clarke W R, Burns T L, Lauer R M, Childhood predictors of high blood pressure., American Journal of Hypertension, 4(11), 608S-610S, November 1991 Abstract
  • Lauer R M, Burns T L, Clarke W R, Mahoney L T, Childhood predictors of future blood pressure., Hypertension, 18(3 Suppl), I74-81, September 1991 Abstract
  • Pierotti Stephen E, Brand Richard A, Gabel Ronald H, Pedersen Douglas R, Clarke William R, Are leg electromyogram profiles symmetrical?, Journal of Orthopaedic Research, 9(5), 720-729, 1991
  • Mahoney L T, Lauer R M, Lee J, Clarke W R, Factors affecting tracking of coronary heart disease risk factors in children. The Muscatine Study., Annals of The New York Academy of Sciences, 623, 120-32, 1991 Abstract
  • Adams HP Jr, Gordon DL, Clarke W, for the TOAST Study Group, The determination of subtypes of acute ischemic stroke, Neurology, 41(Suppl 1), 328, 1991
  • Golden JC, Janz KF, Clarke WR, Mahoney LT, New protocol for submaximal and peak exercise values for children and adolescents: The Muscatine Study, Pediatric Exercise Science, 3, 129-140, 1991
  • Lauer R M, Clarke W R, Use of cholesterol measurements in childhood for the prediction of adult hypercholesterolemia. The Muscatine Study, Jama, 264(23), 3034-8, 19 Dec 1990 Abstract
  • Lauer R M, Lee J, Clarke W R, Predicting adult cholesterol levels from measurements in childhood and adolescence: the Muscatine Study., Bulletin of The New York Academy of Medicine, 65(10), 1127-42; discussion, December 1989 Abstract
  • Lauer RM, Clarke WR, Childhood risk factors for high adult blood pressure: the Muscatine Study, Pediatrics, 84(4), 633-41, October 1989 Abstract
  • Lauer RM, Lee J, Clarke WR, Factors affecting the relationship between childhood and adult cholesterol levels: the Muscatine Study, 82(3), 309-18, September 1988 Abstract
  • Mahoney LT, Schieken RM, Clarke WR, Lauer RM, Left ventricular mass and exercise responses predict future blood pressure. The Muscatine Study, 12(2), 206-13, August 1988 Abstract
  • Lauer RM, Clarke WR, A longitudinal view of blood pressure during childhood: the Muscatine Study, 7(1-2), 47-57, 1988 Abstract
  • Lee J, Lauer RM, Clarke WR, Lipoproteins in the progeny of young men with coronary artery disease: children with increased risk, 78(2), 330-7, August 1986 Abstract
  • Clarke WR, Woolson RF, Lauer RM, Changes in ponderosity and blood pressure in childhood: the Muscatine Study, 124(2), 195-206, August 1986 Abstract
  • Lauer RM, Mahoney LT, Clarke WR, Tracking of blood pressure during childhood: the Muscatine Study, 8(4-5), 515-37, 1986 Abstract
  • Schieken RM, Lauer RM, Clarke WR, Hemodynamics in childhood hypertension, 8(4-5), 703-20, 1986 Abstract
  • Clarke WR, Schrott HG, Burns TL, Sing CF, Lauer RM, Aggregation of blood pressure in the families of children with labile high systolic blood pressure. The Muscatine Study, 123(1), 67-80, January 1986 Abstract
  • Lauer RM, Burns TL, Clarke WR, Assessing children's blood pressure--considerations of age and body size: the Muscatine Study, 75(6), 1081-90, June 1985 Abstract
  • Hsu SY, Xu ST, He YX, Shi FH, Shen W, Hsu HF, Osborne JW, Clarke WR, Vaccination of bovines against schistosomiasis japonica with highly irradiated schistosomula in China, 33(5), 891-8, September 1984 Abstract
  • He YX, Hsu SY, Hsu HF, Clarke WR, Immunogenicity of secretion materials of the acetabular glands of Schistosoma mansoni cercariae, 2(3), 176-8, 1984 Abstract
  • Hanis CL, Sing CF, Clarke WR, Schrott HG, Multivariate models for human genetic analysis: aggregation, coaggregation, and tracking of systolic blood pressure and weight, 35(6), 1196-210, November 1983 Abstract
  • Vargish T, Clarke WR, Young RA, Jensen A, The ankle injury--indications for the selective use of X-rays, 14(6), 507-12, May 1983 Abstract
  • Hsu SY, Hsu HF, Xu ST, Shi FH, He YX, Clarke WR, Johnson SC, Vaccination against bovine schistosomiasis japonica with highly X-irradiated schistosomula, 32(2), 367-70, March 1983 Abstract
  • Schieken RM, Clarke WR, Lauer RM, The cardiovascular responses to exercise in children across the blood pressure distribution. The Muscatine study, 5(1), 71-8, 1983 Abstract
  • Kisker CT, Robillard JE, Clarke WR, Blood coagulation changes following hypoxemia in the near-term fetal lamb, 16(9), 732-9, September 1982 Abstract
  • Schieken RM, Clarke WR, Prineas R, Klein V, Lauer RM, Electrocardiographic measures of left ventricular hypertrophy in children across the distribution of blood pressure: the Muscatine study, 66(2), 428-32, August 1982 Abstract
  • Tannous R, Kisker CT, Clarke WR, Development of chemotactic factor inactivation - a fetal lamb model, 16(7), 538-42, July 1982 Abstract
  • Lauer RM, Akers RL, Massey J, Clarke WR, Evaluation of cigarette smoking among adolescents: the Muscatine study, 11(4), 417-28, July 1982 Abstract
  • Tannous R, Spitzer RE, Clarke WR, Goplerud CP, Cavendar-Zylich N, Decreased chemotactic activity in activated newborn plasma, 99(3), 331-41, March 1982 Abstract
  • Mahoney LT, Clarke WR, Mark AL, Lauer RM, Forearm vascular resistance in the upper and lower quintiles of blood pressure in adolescent boys: The Muscatine Study, 16(2), 163-5, February 1982 Abstract
  • Schrott HG, Clarke WR, Abrahams P, Wiebe DA, Lauer RM, Coronary artery disease mortality in relatives of hypertriglyceridemic school children: the Muscatine study, 65(2), 300-5, February 1982 Abstract
  • Bucher KD, Schrott HG, Clarke WR, Lauer RM, The Muscatine Cholesterol Family Study: familial aggregation of blood lipids and relationship of lipid levels to age, sex and hormone use, 35(5), 375-84, 1982 Abstract
  • Bucher KD, Schrott HG, Clarke WR, Lauer RM, The Muscatine Cholesterol Family Study: distribution of cholesterol levels within families of probands with high, low and middle cholesterol levels, 35(5), 385-400, 1982 Abstract
  • Kalnitsky G, Singh H, Kuo T, Ihnen J, Clarke WR, Ratajczak HV, Richerson HB, Intracellular protease changes in acute experimental hypersensitivity pneumonitis, 160(5), 245-56, 1982 Abstract
  • Weismann DN, Clarke WR, Postnatal age-related renal responses to hypoxemia in lambs, 49(6), 1332-8, December 1981 Abstract
  • Schieken RM, Clarke WR, Lauer RM, Left ventricular hypertrophy in children with blood pressures in the upper quintile of the distribution. The Muscatine Study, 3(6), 669-75, 1981 Abstract
  • Wallace RB, Lee J, Gerber WL, Clarke WR, Lauer RM, Vasectomy and coronary disease in men less than 50 years old: absence of association, 126(2), 182-4, August 1981 Abstract
  • Wallace RB, Lee J, Gerber WL, Clarke WR, Lauer RM, Vasectomy and coronary disease in men less than 50 years old: absence of association, Journal of Urology, 126(2), 182-4, August 1981
  • Kisker CT, Robillard JE, Clarke WR, Development of blood coagulation--a fetal lamb model, 15(7), 1045-50, July 1981 Abstract
  • Gerber L, Wallace RB, Lee J, Clarke WR, Vasectomy as a risk factor for atherosclerosis (author's transl), 12(3), 117-8, May 1981 Abstract
  • Stehbens JA, Ford ME, Kisker CT, Clarke WR, Strayer F, WISC-R verbal/performance discrepancies in pediatric cancer patients, 6(1), 61-8, March 1981 Abstract
  • Lee J, Lauer RM, Clarke WR, Coronary risk factors in children, 11(2), 1-9, 1981 Abstract
  • Martin RK, Albright JP, Clarke WR, Niffenegger JA, Load-carrying effects on the adult beagle tibia, 13(5), 343-9, 1981 Abstract
  • Martin RK, Albright JP, Jee WS, Taylor GN, Clarke WR, Bone loss in the beagle tibia: influence of age, weight, and sex, 33(3), 233-8, 1981 Abstract
  • Lachenbruch PA, Clarke WR, Discriminant analysis and its applications in epidemiology, 19(4), 220-6, October 1980 Abstract
  • Leimert JT, Burns CP, Wiltse CG, Armitage JO, Clarke WR, Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia, 56(3), 510-5, September 1980 Abstract
  • Kron JM, Laing JA, Sines JO, Clarke WR, Lauer RM, Personality and casual blood pressure in school age children, 24(2), 75-7, 1980 Abstract
  • Schieken RM, Clarke WR, Mahoney LT, Lauer RM, Measurement criteria for group echocardiographic studies, 110(4), 504-14, October 1979 Abstract
  • Schrott HG, Clarke WR, Wiebe DA, Connor WE, Lauer RM, Increased coronary mortality in relatives of hypercholesterolemic school children: the Muscatine study, 59(2), 320-6, February 1979 Abstract
  • Schrott HG, Bucher KA, Clarke WR, Lauer RM, The Muscatine hyperlipidemia family study program, 32, 619-46, 1979 Abstract
  • Clarke WR, Schrott HG, Leaverton PE, Connor WE, Lauer RM, Tracking of blood lipids and blood pressures in school age children: the Muscatine study, 58(4), 626-34, October 1978 Abstract
  • Lauer RM, Rames LK, Clarke WR, Blood pressure and its significance in childhood, 54(629), 206-11, March 1978 Abstract
  • Rames LK, Clarke WR, Connor WE, Reiter MA, Lauer RM, Normal blood pressure and the evaluation of sustained blood pressure elevation in childhood: the Muscatine study, 61(2), 245-51, February 1978 Abstract
  • Lauer RM, Filer LJ, Reiter MA, Clarke WR, Blood pressure, salt preference, salt threshold, and relative weight, 130(5), 493-7, May 1976 Abstract
  • Lauer RM, Connor WE, Leaverton PE, Reiter MA, Clarke WR, Coronary heart disease risk factors in school children: the Muscatine study, 86(5), 697-706, May 1975 Abstract
  • Buckwalter JA, Kent TH, Clarke WR, Scholastic ability versus attitude, time, and performance on programmed instruction, 49(6), 584-8, June 1974 Abstract

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Last Updated: 5/6/2009

COS Expertise ID #323383
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