Bruce E. Clurman

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Fred Hutchinson Cancer Research Center
Clinical Research and Human Biology
Associate MemberAppointed: 2003
University of Washington
School of Medicine
Medicine
Oncology
Associate ProfessorAppointed: 2003
Professional Headshot of Bruce E. Clurman

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
P.O. Box 19024
D2-100
Seattle, Washington 98109-1024
United States

Contact Information

bclurman@fhcrc.org

Qualifications

M.D., Cornell University, Medicine, 1989.
Ph.D., Cornell University, Medical Sciences, 1988.

Expertise and Research Interests

My research focuses on normal cell cycle control in mammalian cells, and how loss of this regulation contributes to tumorigenesis. Protein phosphorylation and the ubiquitin-proteasome system are among our major areas of study.

Other Expertise

Stem Cell Transplantation
Medical Oncology

Keywords

COS Keywords:

Bone Marrow, Bone Marrow Transplantation, Cell Cycle, Cell Proliferation, Clinical Research Or Studies, Oncology, Tumors.

Additional Terms:

Bone Marrow Transplantation, Proteolysis, Ubiquitin.

Memberships

American Society for Clinical Investigation

Honors and Awards

2006-2011, Scholar in Translational Research, Burroughs Welcome Fund, Fred Hutchinson Cancer Research Center
1999-2005, Distinguished Young Scholar in Medical Research, W.M. Keck Foundation, Fred Hutchinson Cancer Research Center
1997-2000, James S. McDonnell Foundation Scholar, James S. McDonnell Foundation, Fred Hutchinson Cancer Research Center
1994, Jose Carreras Fellowship, Jose Carreras Foundation, Fred Hutchinson Cancer Research Center
1994, Young Investigator Award, American Society of Clinical Oncology, Fred Hutchinson Cancer Research Center
1994-1999, Clinical Investigator Award, National Cancer Institute, Fred Hutchinson Cancer Research Center
1985, Horsfall Award for Outstanding Academic Achievement, Memorial Sloan-Kettering Cancer Center, Cornell University
1981-1988, Rudin Foundation Medical Scientist Fellowship, Sloan Kettering Institute, Cornell University

Publications

  • O'Neil J (2007) Abstract FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to {gamma}-secretase inhibitors, J Exp Med.
  • Besson A (2007) Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype, Mol Cell, 21 (14), 1731
  • Chen, X. (2007) Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome, Mol Cell, 26 (6), 843
  • Chen, X. (2007) Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome, Mol Cell, 26 (6), 843
  • Minella (2007) p53 and SCF(Fbw7) cooperatively restrain cyclin E-associated genome instability, Oncogene
  • Welcker, M. (2007) Fbw7/hCDC4 dimerization regulates its substrate interactions, Cell Div, 13 (2), 7
  • Geng, Y (2007) Kinase-independent function of cyclin E, Mol Cell, 12 (25), 127
  • Gustafson, MP (2006) Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue, Cell Tissue Res., 325 (2), 263
  • Gustafson, MP (2005) Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins, Biochem Biophys Res Commun, 338 (3), 1359
  • Welcker, M. (2005) Cell cycle: how cyclin E got its groove back, Current Biology, 11 (15), 810
  • Minella, A. (2005) Mechanisms of tumor suppression by the SCF(Fbw7), Cell Cycle, 4 (10), 1356
  • Welcker M, Clurman B (Oct 2005) Cell cycle: how cyclin E got its groove back, Current Biology : Cb, 15 (19), R810-2
  • Loeb, K, A Mouse Model for Cyclin E-dependent Genetic Instability and Tumorigenesis., Cancer Cell, 8(1), 35-47, 8 Jul 2005
  • Minella, A, Ras Activity Regulates Cyclin E Degradation By the Fbw7 Pathway, PNAS, 102(27), 9649-9654, 5 Jul 2005
  • Hwang HC, Clurman BE, Cyclin E in Normal and Neoplastic Cell Cycles., Oncogene, 24(17), 2776-86, Apr 2005 Abstract
  • Welcker M, Clurman BE, The SV40 Large T Antigen Contains a Decoy Phosphodegron That Mediates Its Interactions With Fbw7/hCdc4., The Journal of Biological Chemistry, 280(9), 7654-8, Mar 2005 Abstract
  • Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM, N-acetylation and Ubiquitin-independent Proteasomal Degradation Of P21(Cip1)., Molecular Cell, 16(5), 839-47, Dec 2004 Abstract
  • Welcker M, Orian A, Grim JA, Eisenman RN, Clurman BE, A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates C-Myc and Cell Size., Current Biology : Cb, 14(20), 1852-7, Oct 2004 Abstract
  • Welcker M, Orian A, Jin J, Grim JA, Harper JW, Eisenman RN, Clurman BE, The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation, Proceedings of the National Academy of Sciences of the United States of America., 101(24), 9085-90, June 2004 Abstract
  • Grim JE, Clurman BE, Cycling without CDK2?, Trends in Cell Biology, 13(8), 396-9, August 2003 Abstract
  • Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM, Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation, Molecular Cell, 12(2), 381-92, August 2003 Abstract
  • Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla-Favera R, Monnat RJ Jr, Werner syndrome protein limits MYC-induced cellular senescence, Genes & Development, 17(13), 1569-74, July 2003 Abstract
  • Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE, p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation, Current Biology : Cb, 12(21), 1817-27, October 2002 Abstract
  • Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero M, Clurman BE, Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis, Proceedings of the National Academy of Sciences (USA), 99(17), 11293-8, Aug 2002 Abstract
  • Lindsay ME, Plafker K, Smith AE, Clurman BE, Macara IG, Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import, Cell, 110(3), 349-60, Aug 2002 Abstract
  • Platzbecker U, Gooley T, Anasetti C, Appelbaum FR, Clurman B, Doney K, Chauncey T, Flowers ME, Myerson D, Radich JP, Storb R, Witherspoon RP, Deeg HJ, Curative therapy of advanced essential thrombocythemia or polycythemia vera by hemopoietic stem cell transplantation, Leukemia & Lymphoma, 43(7), 1409-14, July 2002 Abstract
  • Smitherman M, Lee K, Swanger J, Kapur R, Clurman BE, Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex, Molecular and Cellular Biology, 20(15), 5631-42, August 2000 Abstract
  • Guan T, Kehlenbach RH, Schirmer EC, Kehlenbach A, Fan F, Clurman BE, Arnheim N, Gerace L, Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export, Molecular and Cellular Biology, 20(15), 5619-30, August 2000 Abstract
  • Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE, Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination, Molecular Cell, 5(2), 403-10, February 2000 Abstract
  • Clurman BE, Porter P, New insights into the tumor suppression function of P27(kip1), Proceedings of the National Academy of Sciences (USA), 95(26), 15158-60, December 1998 Abstract
  • Clurman BE, Groudine M, The CDKN2A tumor-suppressor locus--a tale of two proteins, New England Journal of Medicine, 338(13), 910-2, March 1998 Abstract
  • Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM, Ross R, Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade, Molecular Cell, 1(4), 553-63, March 1998 Abstract
  • Clurman B, Groudine M, Tumour-suppressor genes. Killer in search of a motive?, Nature, 389(6647), 122-3, September 1997 Abstract
  • Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE, Cyclin E-CDK2 is a regulator of p27Kip1, Genes and Development, 11(11), 1464-78, June 1997 Abstract
  • Neiman PE, Clurman BE, Lobanenkov VV, Molecular pathogenesis of myc-initiated B-cell lymphomas in the bursa of Fabricius, Current Topics in Microbiology and Immunology, 224, 231-8, 1997 Abstract
  • Clurman BE, Sheaff RJ, Thress K, Groudine M, Roberts JM, Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation, Genes and Development, 10(16), 1979-90, August 1996 Abstract
  • Clurman BE, Roberts JM, Groudine M, Deregulation of cell cycle control in hematologic malignancies, Current Opinion in Hematology, 3(4), 315-20, July 1996 Abstract
  • Clurman BE, Roberts JM, Cell cycle and cancer [editorial; comment], Journal of the National Cancer Institute, 87(20), 1499-501, October 1995 Abstract
  • Clurman BE, Hayward WS, Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events, Molecular and Cellular Biology, 9(6), 2657-64, June 1989 Abstract

Profile Details

Last Verified: 7/29/2007

COS Expertise ID #768593
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