Bruce E. Clurman

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Fred Hutchinson Cancer Research Center
Clinical Research and Human Biology
MemberAppointed: 2003
University of Washington
School of Medicine
Medicine
Oncology
ProfessorAppointed: 2003
Professional Headshot of Bruce E. Clurman

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
P.O. Box 19024
D2-100
Seattle, Washington 98109-1024
United States

Contact Information

bclurman@fhcrc.org

Qualifications

M.D., Cornell University, Medicine, 1989.
Ph.D., Cornell University, Medical Sciences, 1988.

Expertise and Research Interests

My research focuses on normal cell cycle control in mammalian cells, and how loss of this regulation contributes to tumorigenesis. Protein phosphorylation and the ubiquitin-proteasome system are among our major areas of study.

Other Expertise

Stem Cell Transplantation
Medical Oncology

Keywords

COS Keywords:

Bone Marrow, Bone Marrow Transplantation, Cell Cycle, Cell Proliferation, Clinical Research Or Studies, Oncology, Tumors.

Additional Terms:

Bone Marrow Transplantation, Proteolysis, Ubiquitin.

Memberships

American Society for Clinical Investigation

Honors and Awards

2006-2011, Scholar in Translational Research, Burroughs Welcome Fund, Fred Hutchinson Cancer Research Center
1999-2005, Distinguished Young Scholar in Medical Research, W.M. Keck Foundation, Fred Hutchinson Cancer Research Center
1997-2000, James S. McDonnell Foundation Scholar, James S. McDonnell Foundation, Fred Hutchinson Cancer Research Center
1994, Jose Carreras Fellowship, Jose Carreras Foundation, Fred Hutchinson Cancer Research Center
1994, Young Investigator Award, American Society of Clinical Oncology, Fred Hutchinson Cancer Research Center
1994-1999, Clinical Investigator Award, National Cancer Institute, Fred Hutchinson Cancer Research Center
1985, Horsfall Award for Outstanding Academic Achievement, Memorial Sloan-Kettering Cancer Center, Cornell University
1981-1988, Rudin Foundation Medical Scientist Fellowship, Sloan Kettering Institute, Cornell University

Publications

  • Liu H, Huang J, Wang J, Jiang S, Bailey AS, Goldman DC, Welcker M, Bedell V, Slovak ML, Clurman B, Thayer M, Fleming WH, Epner E (Aug 2008) Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma., The Journal of experimental medicine, 205 (8), 1843-58 Abstract
  • Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE (Jun 2008) Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase., The Journal of cell biology, 181 (6), 913-20 Abstract
  • Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE (Jun 2008) Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo., Genes & development, 22 (12), 1677-89 Abstract
  • Welcker M, Clurman BE (Feb 2008) FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation., Nature reviews. Cancer, 8 (2), 83-93 Abstract
  • Garrett-Engele CM, Tasch MA, Hwang HC, Fero ML, Perlmutter RM, Clurman BE, Roberts JM (Dec 2007) A mechanism misregulating p27 in tumors discovered in a functional genomic screen., PLoS genetics, 3 (12), e219 Abstract
  • Minella AC, Grim JE, Welcker M, Clurman BE (Oct 2007) p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability., Oncogene, 26 (48), 6948-53 Abstract
  • O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT (Aug 2007) FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors., The Journal of experimental medicine, 204 (8), 1813-24 Abstract
  • Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME, Sandmaier BM, Witherspoon RP, Nash RA, Sanders JE, Bedalov A, Hansen JA, Clurman BE, Storb R, Appelbaum FR, Deeg HJ (Aug 2007) Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic d, Blood, 110 (4), 1379-87 Abstract
  • Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM (Jul 2007) Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype., Genes & development, 21 (14), 1731-46 Abstract
  • Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM (Jun 2007) Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome., Molecular cell, 26 (6), 843-52 Abstract
  • Welcker M, Clurman BE (2007) Fbw7/hCDC4 dimerization regulates its substrate interactions., Cell division, 2, 7 Abstract
  • Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P (Jan 2007) Kinase-independent function of cyclin E., Molecular cell, 25 (1), 127-39 Abstract
  • Gustafson MP, Xu C, Grim JE, Clurman BE, Knudsen BS (Aug 2006) Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue., Cell and tissue research, 325 (2), 263-76 Abstract
  • Neiman PE, Burnside J, Elsaesser K, Hwang H, Clurman BE, Kimmel R, Delrow J (2006) Analysis of gene expression, copy number and palindrome formation with a Dt40 enriched cDNA microarray., Sub-cellular biochemistry, 40, 245-56 Abstract
  • Gustafson MP, Welcker M, Hwang HC, Clurman BE (Dec 2005) Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins., Biochemical and biophysical research communications, 338 (3), 1359-67 Abstract
  • Welcker M, Clurman B (Oct 2005) Cell cycle: how cyclin E got its groove back., Current biology : CB, 15 (19), R810-2 Abstract
  • Minella AC, Clurman BE (Oct 2005) Mechanisms of tumor suppression by the SCF(Fbw7)., Cell cycle (Georgetown, Tex.), 4 (10), 1356-9 Abstract
  • Loeb KR, Kostner H, Firpo E, Norwood T, D Tsuchiya K, Clurman BE, Roberts JM (Jul 2005) A mouse model for cyclin E-dependent genetic instability and tumorigenesis., Cancer cell, 8 (1), 35-47 Abstract
  • Minella AC, Welcker M, Clurman BE (Jul 2005) Ras activity regulates cyclin E degradation by the Fbw7 pathway., Proceedings of the National Academy of Sciences of the United States of America, 102 (27), 9649-54 Abstract
  • Hwang HC, Clurman BE (Apr 2005) Cyclin E in normal and neoplastic cell cycles., Oncogene, 24 (17), 2776-86 Abstract
  • Welcker M, Clurman BE (Mar 2005) The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4., The Journal of biological chemistry, 280 (9), 7654-8 Abstract
  • Thomas DM, Johnson SA, Sims NA, Trivett MK, Slavin JL, Rubin BP, Waring P, McArthur GA, Walkley CR, Holloway AJ, Diyagama D, Grim JE, Clurman BE, Bowtell DD, Lee JS, Gutierrez GM, Piscopo DM, Carty SA, Hinds PW (Dec 2004) Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma., The Journal of cell biology, 167 (5), 925-34 Abstract
  • Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM (Dec 2004) N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1)., Molecular cell, 16 (5), 839-47 Abstract
  • Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW (Nov 2004) Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase., The Journal of biological chemistry, 279 (48), 50110-9 Abstract
  • Welcker M, Orian A, Grim JE, Grim JA, Eisenman RN, Clurman BE (Oct 2004) A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size., Current biology : CB, 14 (20), 1852-7 Abstract
  • Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A (Oct 2004) Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression., Molecular and cellular biology, 24 (20), 8813-22 Abstract
  • Welcker M, Orian A, Jin J, Grim JE, Grim JA, Harper JW, Eisenman RN, Clurman BE (Jun 2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation., Proceedings of the National Academy of Sciences of the United States of America, 101 (24), 9085-90 Abstract
  • Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM (Aug 2003) Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation., Molecular cell, 12 (2), 381-92 Abstract
  • Grim JE, Clurman BE (Aug 2003) Cycling without CDK2?, Trends in cell biology, 13 (8), 396-9 Abstract
  • Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla-Favera R, Monnat RJ (Jul 2003) Werner syndrome protein limits MYC-induced cellular senescence., Genes & development, 17 (13), 1569-74 Abstract
  • Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE (Oct 2002) p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation., Current biology : CB, 12 (21), 1817-27 Abstract
  • Lindsay ME, Plafker K, Smith AE, Clurman BE, Macara IG (Aug 2002) Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import., Cell, 110 (3), 349-60 Abstract
  • Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero M, Clurman BE (Aug 2002) Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis., Proceedings of the National Academy of Sciences of the United States of America, 99 (17), 11293-8 Abstract
  • Platzbecker U, Gooley T, Anasetti C, Appelbaum FR, Clurman B, Doney K, Chauncey T, Flowers ME, Myerson D, Radich JP, Storb R, Witherspoon RP, Deeg HJ (Jul 2002) Curative therapy of advanced essential thrombocythemia or polycythemia vera by hemopoietic stem cell transplantation., Leukemia & lymphoma, 43 (7), 1409-14 Abstract
  • Smitherman M, Lee K, Swanger J, Kapur R, Clurman BE (Aug 2000) Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex., Molecular and cellular biology, 20 (15), 5631-42 Abstract
  • Guan T, Kehlenbach RH, Schirmer EC, Kehlenbach A, Fan F, Clurman BE, Arnheim N, Gerace L (Aug 2000) Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export., Molecular and cellular biology, 20 (15), 5619-30 Abstract
  • Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE (Feb 2000) Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination., Molecular cell, 5 (2), 403-10 Abstract
  • Singer JD, Gurian-West M, Clurman B, Roberts JM (Sep 1999) Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells., Genes & development, 13 (18), 2375-87 Abstract
  • Stirewalt DL, Clurman B, Appelbaum FR, Willman CL, Radich JP (Jul 1999) p73 mutations and expression in adult de novo acute myelogenous leukemia., Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 13 (7), 985-90 Abstract
  • Clurman BE, Porter P (Dec 1998) New insights into the tumor suppression function of P27(kip1), Proceedings of the National Academy of Sciences of the United States of America, 95 (26), 15158-60 Abstract
  • Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM, Ross R (Mar 1998) Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade., Molecular cell, 1 (4), 553-63 Abstract
  • Clurman BE, Groudine M (Mar 1998) The CDKN2A tumor-suppressor locus--a tale of two proteins., The New England journal of medicine, 338 (13), 910-2 Abstract
  • Clurman B, Groudine M (Sep 1997) Tumour-suppressor genes. Killer in search of a motive?, Nature, 389 (6647), 122-3 Abstract
  • Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE (Jun 1997) Cyclin E-CDK2 is a regulator of p27Kip1., Genes & development, 11 (11), 1464-78 Abstract
  • Neiman PE, Clurman BE, Lobanenkov VV (1997) Molecular pathogenesis of myc-initiated B-cell lymphomas in the bursa of Fabricius., Current topics in microbiology and immunology, 224, 231-8 Abstract
  • Clurman BE, Sheaff RJ, Thress K, Groudine M, Roberts JM (Aug 1996) Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation., Genes & development, 10 (16), 1979-90 Abstract
  • Clurman BE, Roberts JM, Groudine M (Jul 1996) Deregulation of cell cycle control in hematologic malignancies., Current opinion in hematology, 3 (4), 315-20 Abstract
  • Clurman BE, Roberts JM (Oct 1995) Cell cycle and cancer., Journal of the National Cancer Institute, 87 (20), 1499-501 Abstract
  • Clurman BE, Hayward WS (Jun 1989) Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events., Molecular and cellular biology, 9 (6), 2657-64 Abstract

Profile Details

Last Verified: 8/8/2008

COS Expertise ID #768593
Reference this profile directly: http://myprofile.cos.com/clurmana